Pictorial representation of illness and self measure (PRISM): A putative transdiagnostic tool for evaluating therapeutic effects of psychedelic treatments
J Psychopharmacol. 2025 May 5:2698811251330763. doi: 10.1177/02698811251330763. Online ahead of print.
ABSTRACT
BACKGROUND: Patients with refractory conditions often identify themselves with their illness, which affects multiple aspects of their lives. The pictorial representation of illness and self measure (PRISM) is a tool used to assess the enmeshment of individuals’ perception of self with a particular medical condition, broadly termed self-condition enmeshment.
AIMS: This study aimed to evaluate changes in PRISM scores and how these changes relate to symptom changes following naturalistic psychedelic use.
METHODS: In this survey, we retrospectively assessed changes in PRISM scores in 297 individuals who self-engaged in naturalistic psychedelic use for therapeutic purposes. Participants also completed the Patient Global Impression of Change (PGIC) scale to report symptom changes resulting from their perceived most salient psychedelic experience (MSPE).
RESULTS: PGIC scores indicated that the majority of participants with depression (95.4%), posttraumatic stress disorder (98.36%), and anxiety (94.87%) reported symptom improvement following naturalistic psychedelic use. There was a significant decrease (p = 4.65 × 10-25) in PRISM scores after MSPE compared to their PRISM scores before MSPE, indicating that individuals experienced a reduced identification of their identity with their condition following psychedelic use. PRISM change scores were also correlated with PGIC scores across all conditions (ρ = 0.41, p = 1.64 × 10-11), indicating that reductions in self-condition enmeshment were associated with symptom improvement.
CONCLUSIONS: Our results suggest that PRISM has transdiagnostic sensitivity for investigating the effects of psychedelics on self-perception. Interpretation is limited by convenience sampling, potential positive bias, retrospective reporting, and unclear doses and settings with natural psychedelic use.
Dialogues Clin Neurosci. 2025 Dec;27(1):98-111. doi: 10.1080/19585969.2025.2499458. Epub 2025 May 6.ABSTRACTThe global population is ageing rapidly, with the number of individuals aged 60 and older...
Mil Med. 2025 May 6:usaf162. doi: 10.1093/milmed/usaf162. Online ahead of print.ABSTRACTINTRODUCTION: Concerns regarding suicide rates and declining mental health among service members highlight the need...
Niger J Clin Pract. 2025 Feb 1;28(2):174-180. doi: 10.4103/njcp.njcp_72_24. Epub 2025 Mar 27.ABSTRACTBACKGROUND: Understanding the dynamics of suicide attempts during the pandemic, especially in vulnerable...
J Agromedicine. 2025 May 6:1-11. doi: 10.1080/1059924X.2025.2498339. Online ahead of print.ABSTRACTOBJECTIVES: Globally, suicide is presented as a significant concern within agricultural communities. However, there is...
JAMA Netw Open. 2025 May 1;8(5):e252919. doi: 10.1001/jamanetworkopen.2025.2919.ABSTRACTIMPORTANCE: While available evidence suggests there are not major psychosocial harms of return of research results, there are...
Psychiatr Q. 2025 May 6. doi: 10.1007/s11126-025-10156-4. Online ahead of print.ABSTRACTThe present study investigated whether repetitive transcranial magnetic stimulation (rTMS) for depression reduced trauma-based intrusive...
