Network temperature as a metric of stability in depression symptoms across adolescence

Nat Ment Health. 2025;3(5):548-557. doi: 10.1038/s44220-025-00415-5. Epub 2025 Apr 29.

ABSTRACT

Depression is characterized by diverse symptom combinations that can be represented as dynamic networks. While previous research has focused on central symptoms for targeted interventions, less attention has been given to whole-network properties. Here we show that ‘network temperature’, a novel measure of psychological network stability, captures symptom alignment across adolescence-a critical period for depression onset. Network temperature reflects system stability, with higher values indicating less symptom alignment and greater variability. In three large longitudinal adolescent cohorts (total N = 35,901), we found that network temperature decreases across adolescence, with the steepest decline during early adolescence, particularly in males. This suggests that depression symptom networks stabilize throughout development via increased symptom alignment, potentially explaining why adolescence is a crucial period for depression onset. These findings highlight early adolescence as a key intervention window and underscore the importance of sex-specific and personalized interventions.

PMID:40365462 | PMC:PMC12066352 | DOI:10.1038/s44220-025-00415-5