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Sublingual use of atropine eye drops for the treatment of clozapine induced sialorrhea

Ind Psychiatry J. 2025 Jan-Apr;34(1):123-125. doi: 10.4103/ipj.ipj_352_24. Epub 2025 Jan 15.

ABSTRACT

Clozapine is the drug of choice for patients with treatment-resistant schizophrenia. However, it has a variety of adverse effects. Sialorrhea is a bothersome side effect that can have an impact on both medical and psychosocial aspects. There is limited literature on the use of 1% atropine eye drops sublingually for the treatment of clozapine-induced sialorrhea (CIS). In this case series, we report three patients of CIS treated successfully with 1% atropine eye drops given sublingually.

PMID:40376653 | PMC:PMC12077623 | DOI:10.4103/ipj.ipj_352_24

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