“Other” Substance Use Among American Indian Reservation-Area High School Youth

J Stud Alcohol Drugs. 2025 May 20. doi: 10.15288/jsad.25-00090. Online ahead of print.

ABSTRACT

OBJECTIVE: High school youth have an elevated risk of substance use. Some substances (e.g., inhalants, MDMA) used by youth are overlooked or grouped in an “other” category. Compared to other racial/ethnic groups, American Indian (AI) youth may be at higher risk of using these substances. The purpose of this study is to examine the prevalence and patterns of use of “other” substances among youth living on or near reservations.

METHOD: This study uses data from Our Youth Our Future, a national probability sample survey of substance use among reservation-based youth (n = 14,769) to examine prevalence rates of use across sex (51% male), AI identity (61% AI), and their intersection within seven geographic regions of the United States.

RESULTS: Results indicate AI youth largely did not endorse “other” substance use at significantly higher rates than non-AI youth, although in two regions they held higher odds of use of any “other” substance compared to non-AI participants. In the Southeast and Northwest, AI youth were less likely to use prescription opioids and over-the-counter cold medicines than non-AI youth, respectively. Notable effects for sex emerged such that males in the Southwest were more likely to use inhalants, hallucinogens, and tranquilizers than female participants. Participants in the Southern Plains reported the highest prevalence of “other” substance use.

CONCLUSIONS: While overall risk of using “other” substances is similar between AI and non-AI youth in many regions, differences in use patterns by AI identity and sex can help target prevention and intervention efforts.

PMID:40391457 | DOI:10.15288/jsad.25-00090