Elevated amputation rates in COVID-19 survivors: Insights from a large-scale Japanese cohort study

J Diabetes Investig. 2025 May 23. doi: 10.1111/jdi.70078. Online ahead of print.

ABSTRACT

OBJECTIVE: COVID-19 has been linked to increased vascular complications, but its long-term impact on amputation rates is unclear. This study evaluated amputation risk post-COVID-19 using a nationwide insurance claims database in Japan.

METHODS: We conducted a retrospective cohort study using data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan. COVID-19 cases were identified via insurance payment waivers, and amputations were defined by procedure codes. Propensity score matching created balanced cohorts of COVID-19 exposed and unexposed individuals. Matched cohorts were compared for amputation incidence, calculating incidence rate ratios (IRRs), and differences (IRDs). Sensitivity analyses examined outcomes at different time points, and subgroup analyses stratified results by key characteristics.

RESULTS: This study included 3,098,948 matched pairs. Over a median follow-up of 7 months, 286 amputations occurred in the COVID-19 group vs 123 in controls (IRR 2.33, 95% CI 1.88-2.90; IRD 5.57 per 1,000,000 person-months, 95% CI 4.22-6.92). The elevated risk persisted beyond 2 years post infection (IRR 2.03, 95% CI 1.31-3.20). Subgroup analyses showed higher risks in individuals with higher comorbidity burden (Charlson Comorbidity Index [CCI] ≥2; IRR 2.45 95% CI 1.92, 2.79) vs lower comorbidity burden (CCI 0-1; IRR 0.71 95%CI 0.29, 1.71) with significant interaction (P = 0.04).

CONCLUSIONS: Amputation rates increased among COVID-19 survivors, persisting for over 2 years post infection. The interaction between COVID-19 and comorbidity burden highlights the need for vigilant long-term monitoring and management of vascular complications in COVID-19 survivors, particularly those with multiple comorbidities.

PMID:40405606 | DOI:10.1111/jdi.70078