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Self-Poisoning With Prazosin and Its Off-Label Use in Australia, 2014-2024: Analysis of NSW Poisons Information Centre Data

AI Summary

1030 deliberate prazosin self-poisonings in NSW from 2014-2024, annual cases rising from 13 to 170.
Incidents predominated among young women, likely linked to expanded off-label psychiatric prescribing of prazosin.
Rising harms highlight need for stronger evidence on benefits of off-label psychiatric use before continued expansion.

Med J Aust. 2026 Jul;224(7):e70242. doi: 10.5694/mja2.70242.

ABSTRACT

NSW Poisons Information Centre data identified 1030 deliberate prazosin self-poisonings over 11 years, rising from 13 to 170 per year (2014-2024). Young women predominated, likely due to expanded off-label (but accepted) psychiatric use of prazosin. Better evidence on benefits of off-label use is needed to justify increasing risks.

PMID:42387257 | DOI:10.5694/mja2.70242

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