Aberrant aging-associated p62 autophagic cascade in biopsied olfactory neuronal cells from patients with psychosis

Schizophrenia (Heidelb). 2025 Apr 23;11(1):68. doi: 10.1038/s41537-025-00617-x.

ABSTRACT

Sequestosome-1/p62, a key mediator in the clearance of damaged organelles and macromolecules during autophagy, serves as a marker of biological aging. We demonstrate elevated p62 in biopsied neuronal cells in patients with psychosis compared to healthy controls. In healthy controls, p62-indicated biological/autophagic age is positively correlated with chronological age over time, whereas in patients, neuronal p62-indicated biological/autophagic age shows no correlation with chronological age, being significantly higher than chronological age from the onset of the disease.

PMID:40268926 | DOI:10.1038/s41537-025-00617-x