Evidence
Expert Rev Clin Pharmacol. 2023 Dec 11:1-6. doi: 10.1080/17512433.2023.2294007. Online ahead of print.
ABSTRACT
BACKGROUND: This study aimed to determine the clinical impact associated with adverse drug reactions (ADRs) in patients with dementia.
RESEARCH DESIGN AND METHODS: This case-control, propensity score-matched study utilized administrative data of people with dementia admitted to major public hospitals in Tasmania, Australia, from July 2010 to December 2019.
RESULTS: Acute renal failure constituted the most common ADR. The length of hospital stay was greater for people with an ADR index admission, versus non-ADR index admission (median [IQR]: 9 [4-18] versus 6 [2-12]; p < 0.001). In-hospital mortality and combined in-hospital and post-hospital mortality within 30, 60 and 90 days were higher for those whose index admission was ADR-related (in-hospital: HR 1.40, 95% CI 1.11-1.77, p-value <0.001; 30 days: HR 1.25, 95% CI 1.05-1.49, p-value <0.001; 60 days: HR 1.27, 95% CI 1.08-1.49, p-value <0.001; 90 days: HR 1.29, 95% CI 1.10-1.50, p-value <0.001). Subsequent ADR admission within 30, 60 and 90 days of index discharge was 9 to 10 times greater for people with dementia (30 days: OR 10.0, 95% CI 6.04-16.8, p-value <0.001; 60 days: OR 8.96, 95% CI 5.57-14.4, p-value <0.001; 90 days: OR 9.31, 95% CI 5.79-14.9, p-value <0.001).
CONCLUSION: Safe prescribing and vigilant monitoring of ADRs is pivotal to mitigate adverse outcomes in people with dementia.
PMID:38078438 | DOI:10.1080/17512433.2023.2294007
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Adverse clinical outcomes associated with drug-related hospitalizations in people with dementia
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- The Association of Dementia With Incident Adverse Drug Reactions in Hospitalized Older Adults
- Impact of the COVID-19 pandemic on care-quality outcomes in older adults admitted to hospital with altered mental status
- The individual and combined impacts of pre-existing diabetes and dementia on ischemic stroke outcomes: a registry-based cohort study
- Association of Dementia with Adverse Outcomes in Older Patients with Acute Myocardial Infarction in the ICU
- Geriatric Trauma Intensive Care Unit Admission Guideline is Associated With Reduction in Unplanned Intensive Care Unit Admissions
- Clozapine-associated adverse drug reactions in 38,349 psychiatric inpatients: drug surveillance data from the AMSP project between 1993 and 2016
- Dementia-Friendly Hospital-The Perspective of Professional Dementia Experts
- Schizophreniform Disorder Related Hospitalizations: A Clinical and Demographic Analysis of a National Hospitalization Database
- Mortality in people living with dementia who self-harmed: An Australian data linkage study
- Comfort feeding in hospitalised people with dementia: a retrospective study of survival following comfort feeding recommendations
- In-hospital outcomes in COVID-19 patients with non-alcoholic fatty liver disease by severity of obesity: Insights from national inpatient sample 2020
- Secondary carnitine deficiency during refeeding in severely malnourished patients with eating disorders: a retrospective cohort study
- Screening for Cognitive Impairment in Movement Disorders: Comparison of the Montreal Cognitive Assessment and Quick Mild Cognitive Impairment Screen in Parkinson's Disease and Lewy Body Dementia
- Young Onset Dementia in New South Wales, Australia in 1891: What has Changed Since Then?
- Total knee arthroplasty in schizophrenia patients: early complications and cost in a propensity-matched national database study
- The association between rurality, places of care and the location of death of long-term care home residents with dementia: A population-based study
- Age- and Sex-Specific Analysis of Stroke Hospitalization Rates, Risk Factors, and Outcomes From German Nationwide Data
- Impact of a Delirium Protocol on Deliriogenic Medication Use in Hospitalized Older Veterans
- Impact of a Delirium Protocol on Deliriogenic Medication Use in Hospitalized Older Veterans
- Rehabilitation of Frail Older Adults after Hip Fracture Surgery: Predictors for the Length of Geriatric Rehabilitation Stay at a Skilled Nursing Home
- Physical restraint and associated agitation
- Proactive integrated consultation-liaison psychiatry and time spent in hospital by older medical inpatients in England (The HOME Study): a multicentre, parallel-group, randomised controlled trial
- Out-of-hospital paramedic interactions with people living with dementia: a scoping review
- Trends in Hospital Stay, Complication Rate, and Mortality in Hip Fracture Patients: A Two-Decade Comparison at a National Tertiary Referral Center
- Disproportionality Analysis From World Health Organization Data on Semaglutide, Liraglutide, and Suicidality
- Dementia Care Partner Preparedness and Desire to Seek Long-Term Care at Hospital Discharge: Mediating Roles of Care Receiver Clinical Factors
- Assessment of co-ingestion effects on poisoning patterns, drug-drug interactions, and adverse outcomes in acute toxic exposure
- Characteristics, Complications, and Outcomes of Critical Illness in Patients with Parkinson Disease
- Assessment of the impact of resting heart rate on the risk of major adverse cardiovascular events after ischemic stroke: a retrospective observational study
- Assessment of the impact of resting heart rate on the risk of major adverse cardiovascular events after ischemic stroke: a retrospective observational study
- Factors associated with cognitive impairment before intracerebral haemorrhage: community-based neuropathological study
- Intoxication cases in the Emergency Department at a Norwegian University Hospital 2019-20
- Association Between Frailty and Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock
- Alzheimer Dementia Among Individuals With Down Syndrome
- Comparing hospitalized adult patients with chronic anorexia nervosa with versus without prior hospitalizations
- Hypertension control and risk of age-associated dementia in people with hiv infection
- Characterization of older adult patients admitted to an acute unit of a high complexity hospital in Bogotá, Colombia
- Mortality and Function After Widowhood Among Older Adults With Dementia, Cancer, or Organ Failure
- The geriatric trauma hospitalist service: An analysis of a management strategy for injured older adults
- National Case Volumes and Gender Disparities in Emergency Department Utilization for Psychiatric Emergencies: A Population-Based Claims Data Analysis
- Pre-procedural nursing home length of stay and outcomes of transcatheter aortic valve replacement
- Understanding Dementia Carer Experiences Before Admission to a Residential Aged Care Facility: Implications for Integrated Care
- The effects of singing interventions on quality of life, mood and levels of agitation in community-dwelling people living with dementia: A quantitative systematic review
- The effects of singing interventions on quality of life, mood and levels of agitation in community-dwelling people living with dementia: A quantitative systematic review
- The effects of singing interventions on quality of life, mood and levels of agitation in community-dwelling people living with dementia: A quantitative systematic review
- Healthcare utilisation and associated costs for methadone versus buprenorphine recipients: Examination of interlinked primary and secondary care electronic health records in England
- Characteristics of Informal Caregivers and Social Participation of People with Dementia
- Characteristics of people diagnosed with dementia vs lung cancer and cardiovascular disease at commencement of community palliative care: a population-based study
- Risk factors and prognostic value of endotoxemia in patients with acute myocardial infarction
- Initiation of lipid-lowering therapy as primary prevention of cardiovascular disease in the elderly
- Inequity in cardiometabolic hospital admissions and blood screening in New Zealand Indigenous Māori with psychosis
- Primary Total Knee and Total Hip Arthroplasty in the Rural Patient
- Incidence and risk factors of delirium following brain tumor resection: A retrospective National Inpatient Sample database study
- Denial of Desire for Death in Dementia: Why Is Dementia Excluded from Australian Voluntary Assisted Dying Legislation?
- Denial of Desire for Death in Dementia: Why Is Dementia Excluded from Australian Voluntary Assisted Dying Legislation?
- Education Program for Enhancing Health Care Students' Attitudes Toward People Living With Dementia: Protocol for a Single-Arm Pre-Post Study
- Relationship of sociodemographic and clinical characteristics to mechanical restraint used in a psychiatric hospital in Spain
- Development and validation of a model to predict ceiling of care in COVID-19 hospitalized patients
- Heat Exposure and Dementia-Related Mortality in China
- Drug burden index of people ageing with intellectual disability and cognitive complaints attending a specialist memory service
- Severity and outcome of a first episode of idiopathic acute pancreatitis is not more severe than pancreatitis of other etiologies
- Diabetic Ketoacidosis and Adverse Outcomes Among Pregnant Individuals With Pregestational Diabetes in the United States, 2010-2020
- Diabetic Ketoacidosis and Adverse Outcomes Among Pregnant Individuals With Pregestational Diabetes in the United States, 2010-2020
- Epidemiology of civilian's gunshot wound injuries admitted to intensive care unit: A retrospective, multi-center study
Evidence Blueprint
Adverse clinical outcomes associated with drug-related hospitalizations in people with dementia
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Adverse clinical outcomes associated with drug-related hospitalizations in people with dementia
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Predictors of Adverse Drug Reaction-Related Hospitalisations Among People with Dementia: A Retrospective Case-Control Study
- The Association of Dementia With Incident Adverse Drug Reactions in Hospitalized Older Adults
- Adverse Drug Event-Related Hospital Admissions Among Australian Aged Care Residents: A Cross-Sectional Study
- Dementia is associated with worse procedural outcomes after mitral valve transcatheter edge-to-edge repair
- Adverse drug reactions in paediatric surgery: prospective study on frequency and risk related factors
- Adverse drug reactions in paediatric surgery: prospective study on frequency and risk related factors
- Adverse drug reactions in paediatric surgery: prospective study on frequency and risk related factors
- Clinical characteristics and outcomes of COVID-19 patients with preexisting dementia: a large multicenter propensity-matched Brazilian cohort study
- Impact of the COVID-19 pandemic on care-quality outcomes in older adults admitted to hospital with altered mental status
- Outcomes for Young Adults With Suicide Admitted to Adult Versus Pediatric Hospitals
- Mining Real-World Big Data to Characterize Adverse Drug Reaction Quantitatively: Mixed Methods Study
- Mortality Among the Dementia Population in Not-For-Profit Hospitals with Better Nursing Resources
- Assessing Pharmacokinetic Correlates of Escitalopram-Related Adverse Drug Reactions
- Comprehensive dissection of prevalence rates, sex differences, and blood level-dependencies of clozapine-associated adverse drug reactions
- Factors Associated with Costly Hospital Care among Patients with Dementia and Acute Respiratory Failure
- Accountable Care Organization Attribution and Post-Acute Skilled Nursing Facility Outcomes for People Living With Dementia
- The individual and combined impacts of pre-existing diabetes and dementia on ischemic stroke outcomes: a registry-based cohort study
- Association of Dementia with Adverse Outcomes in Older Patients with Acute Myocardial Infarction in the ICU
- A comparison of changes in drug burden index between older inpatients who fell and people who have not fallen: A case-control study
- "I'm still in the lap of the gods I don't know whether I'm going to improve or not": listening to people with dementia or cognitive impairment and their support people, talking about inpatient rehabilitation experiences
- Geriatric Trauma Intensive Care Unit Admission Guideline is Associated With Reduction in Unplanned Intensive Care Unit Admissions
- Clozapine-associated adverse drug reactions in 38,349 psychiatric inpatients: drug surveillance data from the AMSP project between 1993 and 2016
- Dementia-Friendly Hospital-The Perspective of Professional Dementia Experts
- Outcomes in Clinical Subgroups of Patients With Alcohol-Related Hospitalizations
- Schizophreniform Disorder Related Hospitalizations: A Clinical and Demographic Analysis of a National Hospitalization Database
- Risk of long-term care admissions among Medicare beneficiaries treated with pimavanserin or quetiapine for Parkinson's disease psychosis in USA: a retrospective administrative claims database analysis
- Development of a decision-support framework to support professionals and promote comfort among older hospital inpatients living with dementia
- Mortality in people living with dementia who self-harmed: An Australian data linkage study
- Replacing the Clinical Institute Withdrawal Assessment-Alcohol revised with the modified Richmond Agitation and Sedation Scale for alcohol withdrawal to support management of alcohol withdrawal symptoms: potential impact on length of stay and…
- Inpatient Palliative Care and Healthcare Utilization Among Older Patients With Alzheimer's Disease and Related Dementia (ADRD) and High Risk of Mortality in U.S. Hospitals
- Comfort feeding in hospitalised people with dementia: a retrospective study of survival following comfort feeding recommendations
- Attempted Suicide Is Independently Associated with Increased In-Hospital Mortality and Hospital Length of Stay among Injured Patients at Community Tertiary Hospital in Japan: A Retrospective Study with Propensity Score Matching Analysis
- Multiple Casualty Incidents at a Level I Trauma Center: A 15-year Analysis
- Exploring the correlates of frailty among hospitalized older adults: A cross-sectional study in a Saudi teaching hospital
- Patterns of inappropriate prescribing and clinical characteristics in patients at admission to an acute care of the elderly unit
- Cholinesterase inhibitors and memantine are associated with a reduced mortality in nursing home residents with dementia: a longitudinal observational study
- Hospitalized Patients With Delirium and 28-Day Unplanned Hospital Readmissions: A Longitudinal Retrospective Cohort Study
- Lower odds of successful community discharge after medical hospitalization for Veterans with schizophrenia: A retrospective cohort study of national data
- Delirium is more common and associated with worse outcomes in Parkinson's disease compared to older adult controls: results of two prospective longitudinal cohort studies
- Incidence and risk factors of postoperative delirium following hepatic resection: a retrospective national inpatient sample database study
- Incidence and risk factors of postoperative delirium following hepatic resection: a retrospective national inpatient sample database study
- Effect of cognitive impairment at admission on activities of daily living at discharge in older patients with heart failure
- Nonopioid analgesic use in older patients admitted for orthopedic rehabilitation
- Prognostic implications of delirium after Left Ventricular Assist Device (LVAD) implantation: A retrospective study
- Early sedation in traumatic brain injury: a multicentre international observational study
- In-hospital outcomes in COVID-19 patients with non-alcoholic fatty liver disease by severity of obesity: Insights from national inpatient sample 2020
- Impact of dementia special care units for short-stay nursing home patients
- A Retrospective Analysis of Early 20(th) Century Asylum Records of Patients with Dementia Praecox
- Greater rate of weight loss predicts paediatric hospital admission in adolescent typical and atypical anorexia nervosa
- A study protocol for identifying aging trajectories toward chronic neurodegenerative diseases by means of Marche regional administrative databases - TREND project
- Validation of the de Morton mobility index (DEMMI) among acute stroke patients aged ≥65 years: a register study
- Variation in Home Health Care Use by Dementia Status among a National Cohort of Older Adults
- Drug clustering to anticipate new aspects of drug safety profile: application to gabapentinoids and other voltage-gated calcium channel ligand drugs
- Frailty and In-Hospital Outcomes for Management of Cardiogenic Shock without Acute Myocardial Infarction
- Secondary carnitine deficiency during refeeding in severely malnourished patients with eating disorders: a retrospective cohort study
- Analysis of the incidence and risk factors of blood transfusion in total knee revision: a retrospective nationwide inpatient sample database study
- Screening for Cognitive Impairment in Movement Disorders: Comparison of the Montreal Cognitive Assessment and Quick Mild Cognitive Impairment Screen in Parkinson's Disease and Lewy Body Dementia
- Hypotensive episodes at 24-h ambulatory blood pressure monitoring predict adverse outcomes in Parkinson's disease
- Sleep Disorders and Dementia Risk in Older Patients with Kidney Failure: A Retrospective Cohort Study
- Chronic obstructive pulmonary disease affects outcome in surgical patients with perioperative organ injury: a retrospective cohort study in Germany
- Hip Fracture Treatment and Outcomes Among Community-Dwelling People Living With Dementia
- Young Onset Dementia in New South Wales, Australia in 1891: What has Changed Since Then?
- Effectiveness of a Community-Based Intensive Case Management Model on Reducing Hospitalization for People With Severe Mental Illness in Seoul
- Total knee arthroplasty in schizophrenia patients: early complications and cost in a propensity-matched national database study