Association of neutrophil-to-lymphocyte ratio with antipsychotic administration in schizophrenia: A longitudinal study
Ind Psychiatry J. 2025 Jan-Apr;34(1):108-113. doi: 10.4103/ipj.ipj_6_25. Epub 2025 Apr 18.
ABSTRACT
BACKGROUND: Studies have hypothesized the role of the immune-inflammatory process behind the pathophysiology of psychiatric disorders like schizophrenia. Antipsychotic medication has been shown to suppress inflammatory response via complex mechanisms alleviating psychiatric symptoms.
AIM: To assess the relation of neutrophil-to-lymphocyte ratio (NLR) with antipsychotic administration and clinical symptomatology severity.
MATERIALS AND METHODS: A longitudinal study was performed among 34 inpatients who fulfilled inclusion and exclusion criteria. Sociodemographic details were collected, and the brief psychiatric rating scale (BPRS) was applied during admission. Blood sampling was performed during baseline and at discharge for the NLR ratio (neutrophil count/lymphocyte count) with the application of BPRS.
RESULTS: The mean ± SD age of the population was 38.91 ± 11.44 years, with male gender predominance (N = 25, 73.5%). The median duration of illness and duration of treatment were 10 months and 40 days, respectively. Twelve (35.3%) subjects were antipsychotic naïve. The mean ± SD of BPRS and NLR during admission was 49.94 ± 5.33 and 2.49 ± 0.92 and during discharge was 26.76 ± 6.04 and 2.08 ± 0.72, respectively.
CONCLUSION: The results confirmed the NLR-lowering effect of antipsychotics alongside lowering of clinical symptomatology. NLR has the potential to be a biomarker indicating antipsychotic treatment response.
Appetite. 2025 May 15;213:108051. doi: 10.1016/j.appet.2025.108051. Online ahead of print.ABSTRACTCognitive processes play a central role in the development, maintenance, and remission of mental disorders, like...
J Med Internet Res. 2025 May 16;27:e70711. doi: 10.2196/70711.ABSTRACTResearch efforts are growing rapidly in the digital health industry, but with this growth comes increasing ethical...
JMIR Aging. 2025 May 16;8:e67267. doi: 10.2196/67267.ABSTRACTBACKGROUND: Cognitive training for older adults is crucial before cognitive impairment emerges. During periods of social distancing like the...
JMIR Med Inform. 2025 May 16;13:e66917. doi: 10.2196/66917.ABSTRACTBACKGROUND: The capabilities of large language models (LLMs) to self-assess their own confidence in answering questions within the...
PLoS One. 2025 May 16;20(5):e0323369. doi: 10.1371/journal.pone.0323369. eCollection 2025.ABSTRACTBACKGROUND: First-degree relatives (FDRs) of hereditary colorectal cancer are at an increased risk of cancer and receiving...
