Central nervous system-derived extracellular vesicles: the next generation of neural circulating biomarkers?

20 June 2024

Evidence

Transl Neurodegener. 2024 Jun 19;13(1):32. doi: 10.1186/s40035-024-00418-9.

ABSTRACT

The central nervous system (CNS) is integrated by glial and neuronal cells, and both release extracellular vesicles (EVs) that participate in CNS homeostasis. EVs could be one of the best candidates to operate as nanosized biological platforms for analysing multidimensional bioactive cargos, which are protected during systemic circulation of EVs. Having a window into the molecular level processes that are happening in the CNS could open a new avenue in CNS research. This raises a particular point of interest: can CNS-derived EVs in blood serve as circulating biomarkers that reflect the pathological status of neurological diseases? L1 cell adhesion molecule (L1CAM) is a widely reported biomarker to identify CNS-derived EVs in peripheral blood. However, it has been demonstrated that L1CAM is also expressed outside the CNS. Given that principal data related to neurodegenerative diseases, such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease and Alzheimer’s disease were obtained using L1CAM-positive EVs, efforts to overcome present challenges related to its specificity are required. In this sense, other surface biomarkers for CNS-derived EVs, such as glutamate aspartate transporter (GLAST) and myelin oligodendrocyte glycoprotein (MOG), among others, have started to be used. Establishing a panel of EV biomarkers to analyse CNS-derived EVs in blood could increase the specificity and sensitivity necessary for these types of studies. This review covers the main evidence related to CNS-derived EVs in cerebrospinal fluid and blood samples of patients with neurological diseases, focusing on the reported biomarkers and the technical possibilities for their isolation. EVs are emerging as a mirror of brain physiopathology, reflecting both localized and systemic changes. Therefore, when the technical hindrances for EV research and clinical applications are overcome, novel disease-specific panels of EV biomarkers would be discovered to facilitate transformation from traditional medicine to personalized medicine.

PMID:38898538 | DOI:10.1186/s40035-024-00418-9

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Mohammad-Amin Nasiri, Seyedeh Azam Sajadi, Zahra Farsi and Marzie Heidarieh
Psychological distress among healthcare professionals in Mbarara, following the 2022 Ebola Virus Disease outbreak in Uganda: a mixed methods study 25 June 2024
The 2022 Ebola Virus Disease (EVD) outbreak occurred at a time when Uganda was still battling the social and psychological challenges of the COVID-19 pandemic; placing health care professionals (HCPs) at a muc...
Joan Abaatyo, Godfrey Zari Rukundo, Margaret Twine, Dan Lutasingwa, Alain Favina, Novatus Nyemara and Rosemary Ricciardelli

Maternal Mental Health Awareness Week
This Maternal Mental Health Awareness Week, we’re highlighting our mental health leaflets for patients and their families.
www.rcpsych.ac.uk
‘Discrimination against people with severe mental illness is cutting lives short’
The President of the Royal College of Psychiatrists, Dr Lade Smith CBE, warns that prejudice against people with severe mental illness prevents them from seeking help and cuts lives short.
www.rcpsych.ac.uk
King Charles III retains patronage of Royal College of Psychiatrists
The Royal College of Psychiatrists is thrilled to announce His Majesty The King has retained his patronage of the College.
www.rcpsych.ac.uk

Capacity to Consent to Treatment of Substance Use Disorders at Ontario's Consent and Capacity Board: A Review of Past Reported Decisions 14 June 2024
The Canadian Journal of Psychiatry, Ahead of Print. Capacity to consent to treatment of substance use disorders at Ontario's Consent and Capacity Board: A review of past reported decisionsPlain Language Summary TitleAn Ontario review of legal cases which have considered patients' ability to consent to substance use treatmentsPlain Language SummaryIn general, prescribers must consider whether […]
Tanya S. Hauck
Effect of Bright Light Therapy on Perinatal Depression: A Systematic Review and Meta-Analysis: Effet de la luminothérapie sur la dépression périnatale: une revue systématique et une méta-analyse 12 June 2024
The Canadian Journal of Psychiatry, Ahead of Print. ObjectiveThis study represents the inaugural attempt to systematically review and analyse the efficacy of bright light therapy on depression among women experiencing major depressive disorder or depressive symptoms during the perinatal period, encompassing its efficacy on depression scores, remission rates, and response rates.MethodsWe searched 10 databases for […]
Yujia Chen
Commentary on the Canadian Network for Mood and Anxiety Treatments 2023 Clinical Guidelines for Management of Major Depressive Disorder in Adults – Capturing the State of the Art 10 June 2024
The Canadian Journal of Psychiatry, Ahead of Print.
Katherine Beck

Integrating exercise into depression care 17 June 2024
Send us a Text Message.On this episode of the CMAJ Podcast, Dr. Blair Bigham and Dr. Mojola Omole discuss the evidence supporting exercise as an effective treatment option for mild to moderate depression. They explore how exercise might be used effectively and the challenges involved in implementing it for patients.Dr. Nicholas Fabiano, a second-year psychiatry […]
Canadian Medical Association Journal
Responding to rising measles rates in Canada 3 June 2024
Send us a Text Message.On this episode of the CMAJ Podcast, Dr. Blair Bigham and Dr. Mojola Omole tackle an unexpected yet urgent topic: the resurgence of measles. With rising cases globally and in Canada, they discuss the implications and necessary actions for healthcare professionals.Dr. Sarah Wilson, a public health physician at Public Health Ontario, […]
Canadian Medical Association Journal
Constructive conversations on CanMEDS revisions 20 May 2024
Send us a Text Message.On this episode of the CMAJ Podcast, Dr. Blair Bigham and Dr. Mojola Omole discuss the heated debate over proposed updates to the CanMEDS framework. The controversy ignited when an interim report placed principles of equity, social justice, and anti-racism at the heart of the framework, rather than medical expertise.Dr. Kannin […]
Canadian Medical Association Journal

Bioethical implications of cosmetic psychiatry: Distributive justice versus utilitarianism 21 June 2024
Australasian Psychiatry, Ahead of Print.
Michael James Weightman
Bloom’s taxonomy—Can evidence-based teaching improve junior medical officers’ knowledge of the mental health and guardianship acts? 15 June 2024
Australasian Psychiatry, Ahead of Print. ObjectiveTo determine whether a brief educational intervention for Junior Medical Officers (JMOs), using teaching methods aimed at achieving higher outcomes on Bloom’s Taxonomy, significantly improved participant confidence and knowledge in decision making about restrictive care.MethodJMOs received a teaching session on restrictive medical and mental health care. Groups were randomly assigned […]
Trent Koessler
Any psychiatric assessment of a drowsy patient must be preliminary 15 June 2024
Australasian Psychiatry, Ahead of Print.
Mathew Coleman

Caregiver burden and its sociodemographic determinants in family caregivers of patients with schizophrenia attending a psychiatric tertiary hospital in South Africa 21 June 2024
Background: Chronic mental illnesses such as schizophrenia affect patients’ functioning, making caregiving necessary although burdensome.Aim: This study aimed to determine caregiver burden and its sociodemographic determinants in family caregivers of patients with schizophrenia attending a Psychiatric Outpatient Department (POD).Setting: Tertiary hospital in Northern Pretoria, South Africa.Methods: In this cross-sectional study conducted over 3 months, 300 consecutive family caregivers who […]
Chioma O. Onyia
The effects of inpatient suicide on nurses at Weskoppies Hospital: A qualitative study 21 May 2024
Background: Inpatient suicide is a serious adverse event in psychiatric wards. Suicide can cause severe trauma to both patients and health professionals, who may develop maladaptation with poor coping skills. Healthcare practitioners are the second victims and historically, this concept has been overlooked. The psychological effects and lack of support have not been sufficiently explored.Aim: The emotional […]
Nomthandazo Zola
Clinical profile of children and adolescents with autism spectrum disorder in Durban, South Africa 14 May 2024
Background: There are often delays in accessing care and diagnosing autism spectrum disorders (ASDs), with little data from Southern Africa on the clinical profile of affected children and adolescents.Aim: To describe the socio-demographic and clinical variables of children and adolescents with ASD attending psychiatric services at two state hospitals in eThekwini Municipality, KwaZulu-Natal province, South Africa.Setting: Two state […]
Manisharani Gangai

Standards for randomized controlled trials of efficacy of psychological treatments 10 May 2024
World Psychiatry, Volume 23, Issue 2, Page 286-287, June 2024.
David C. Mohr
The future of dynamic networks in research and clinical practice 10 May 2024
World Psychiatry, Volume 23, Issue 2, Page 288-289, June 2024.
Laura F. Bringmann
Algorithm‐based modular psychotherapy vs. cognitive‐behavioral therapy for patients with depression, psychiatric comorbidities and early trauma: a proof‐of‐concept randomized controlled trial 10 May 2024
World Psychiatry, Volume 23, Issue 2, Page 257-266, June 2024.
Elisabeth Schramm, Moritz Elsaesser, Carolin Jenkner, Martin Hautzinger, Sabine C. Herpertz

Placebo effects in randomized trials of pharmacological and neurostimulation interventions for mental disorders: An umbrella review 24 June 2024
Molecular Psychiatry, Published online: 24 June 2024; doi:10.1038/s41380-024-02638-xPlacebo effects in randomized trials of pharmacological and neurostimulation interventions for mental disorders: An umbrella review
Nathan T. M. Huneke
Comment on: Antidepressants act by directly binding to TRKB neurotrophin receptors 22 June 2024
Molecular Psychiatry, Published online: 22 June 2024; doi:10.1038/s41380-024-02615-4Comment on: Antidepressants act by directly binding to TRKB neurotrophin receptors
Philip W. Gold
Association of fluvoxamine with mortality and symptom resolution among inpatients with COVID-19 21 June 2024
Molecular Psychiatry, Published online: 21 June 2024; doi:10.1038/s41380-024-02635-0Association of fluvoxamine with mortality and symptom resolution among inpatients with COVID-19
Guangting Zeng

Eyes on glutamate in angiogenesis and barrier formation
In this issue of , Biswas et al. demonstrate the roles of glutamatergic neuronal activity in the regulation of angiogenesis and retinal vascular endothelial barrier maturation using three different knockout mouse models. Their findings shed light on how aberrant glutamatergic activity can impact neural vascular function and barrier integrity.In this issue of , Biswas et al. demonstrate […]
Fuse mitochondria to win peer competition
In this issue of , Kochan et al. report that enhanced mitochondrial fusion is essential for the heightened synaptic plasticity in adult-born neurons during the critical period, thus supporting their competition with neurons of similar age for survival.In this issue of , Kochan et al. report that enhanced mitochondrial fusion is essential for the heightened synaptic plasticity […]
Tracking defensive states with prefrontal dynorphin-expressing neurons
The dynamic suppression of threat-related behavior as a function of environmental constraint is critical for survival in mammals, yet the neurobiological underpinnings remain largely unknown. In this issue of , Wang et al. identified prefrontal dynorphin-expressing neurons as key elements for tracking threat-related behavioral states and regulating fear suppression.The dynamic suppression of threat-related behavior as a […]

Prevalence and patterns of methamphetamine use and mental health disparity in the United States 26 June 2024
Nature Mental Health, Published online: 26 June 2024; doi:10.1038/s44220-024-00282-6Investigating the influence of using methamphetamine on the rate of admissions for mental health disorders, this study finds that concurrent methamphetamine use increased mental health-related hospital admissions 10.5-fold. Increased prevalence was also found for men, non-Hispanic Black people, middle-aged adults, and people living in the South.
Diensn G. Xing
Understanding the maternal brain in the context of the mental load of motherhood 25 June 2024
Nature Mental Health, Published online: 25 June 2024; doi:10.1038/s44220-024-00268-4This Review discusses the key factors that comprise the mental load of motherhood and the need to provide support for a healthy transition to motherhood.
Bridget L. Callaghan
Gamma oscillations of visual cortex underlying emotion and cognition deficits associated with suicide attempt in major depressive disorder 21 June 2024
Nature Mental Health, Published online: 21 June 2024; doi:10.1038/s44220-024-00269-3The authors investigate neural oscillations, measured by magnetoencephalography, in response to emotionally valenced stimuli as a potential biomarker characterizing individuals with major depressive disorder who had previously made a suicide attempt.
Zhongpeng Dai

Altered blood parameters in “major depression” patients receiving repetitive transcranial magnetic stimulation (rTMS) therapy: a randomized case-control study 25 June 2024
Translational Psychiatry, Published online: 25 June 2024; doi:10.1038/s41398-024-02942-8Altered blood parameters in “major depression” patients receiving repetitive transcranial magnetic stimulation (rTMS) therapy: a randomized case-control study
Beyza Nur Ozkan
Correction: Differential posttraumatic stress disorder symptom cluster response to stellate ganglion block: secondary analysis of a randomized controlled trial 25 June 2024
Translational Psychiatry, Published online: 25 June 2024; doi:10.1038/s41398-024-02983-zCorrection: Differential posttraumatic stress disorder symptom cluster response to stellate ganglion block: secondary analysis of a randomized controlled trial
Shannon M. Blakey
Development of a differential treatment selection model for depression on consolidated and transformed clinical trial datasets 21 June 2024
Translational Psychiatry, Published online: 21 June 2024; doi:10.1038/s41398-024-02970-4Development of a differential treatment selection model for depression on consolidated and transformed clinical trial datasets
Kelly Perlman

WFP News Section 21 May 2024
Oxytocin-Augmented Modular-Based Group Intervention for Loneliness: A Proof-Of-Concept Randomized Controlled Trial 16 May 2024
AbstractIntroduction: Loneliness poses a significant health problem and existing psychological interventions have shown only limited positive effects on loneliness. Based on preliminary evidence for impaired oxytocin signaling in trait-like loneliness, the current proof-of-concept study used a randomized, double-blind, placebo-controlled design to probe intranasal oxytocin (OT) as an adjunct to a short-term modular-based group intervention for […]
Efficacy of an Internet- and Mobile-Based Intervention for Subclinical Anxiety and Depression (ICare Prevent) with Two Guidance Formats: Results from a Three-Armed Randomized Controlled Trial 30 April 2024
AbstractIntroduction: Limited research exists on intervention efficacy for comorbid subclinical anxiety and depressive disorders, despite their common co-occurrence. Internet- and mobile-based interventions (IMIs) are promising to reach individuals facing subclinical symptoms. Objective: This study aimed to evaluate the efficacy of a transdiagnostic and self-tailored IMI in reducing subclinical anxiety and depressive symptom severity with either […]

First-ever seizure and eligibility for commercial motor vehicle driving 26 June 2024
BackgroundAfter a first-ever seizure, 6 months of seizure freedom is usually required before returning to driving a private motor vehicle, after which the annual risk of seizure recurrence has fallen to ≤20%. Stricter criteria apply for commercial driver’s licence (CDL) holders, and a longer period of seizure freedom sufficient for the annual risk of recurrence […]
Lawn, N., Lee, J., Dunne, J.
Most SOD1 mutations are pathogenic, and their identification can lead to early access to treatment 26 June 2024
IntroductionALS is a neurodegenerative disease affecting motor neurons, leading to progressive loss of bulbar and limb motor function, respiratory insufficiency and death in a median of 3 years.1About 10% to 20% of ALS are familial (fALS), meaning that at least one other member of the family is affected by the disease. In these families, a […]
De La Cruz, E., Esselin, F., Polge, A., Mouzat, K., Guissart, C.
Visuospatial dysfunction predicts dementia-first phenoconversion in isolated REM sleep behaviour disorder 26 June 2024
ObjectiveWhile isolated rapid eye movement sleep behaviour disorder (iRBD) is known as a prodrome of α-synucleinopathies, the prediction for its future phenoconversion to parkinsonism-first or dementia-first subtype remains a challenge. This study aimed to investigate whether visuospatial dysfunction predicts dementia-first phenoconversion in iRBD.MethodsPatients with iRBD and control subjects were enrolled in this prospective cohort study. […]
Wang, J., Huang, B., Zhou, L., Tang, S., Feng, H., Chan, J. W. Y., Chau, S. W. H., Zhang, J., Li, S. X., Mok, V., Wing, Y. K., Liu, Y.

Mendelian randomization: causal inference leveraging genetic data 19 April 2024
Mendelian randomization (MR) leverages genetic information to examine the causal relationship between phenotypes allowing for the presence of unmeasured confounders. MR has been widely applied to unresolved questions in epidemiology, making use of summary statistics from genome-wide association studies on an increasing number of human traits. However, an understanding of essential concepts is necessary for […]
Chen, Lane G.
Interventions targeting social determinants of mental disorders and the Sustainable Development Goals: a systematic review of reviews 25 March 2024
Globally, mental disorders account for almost 20% of disease burden and there is growing evidence that mental disorders are socially determined. Tackling the United Nations Sustainable Development Goals (UN SDGs), which address social determinants of mental disorders, may be an effective way to reduce the global burden of mental disorders. We conducted a systematic review […]
Oswald, Tassia Kate
Do metacognitive therapies for schizophrenia-spectrum disorders work? A meta-analytic investigation 21 March 2024
Recent reviews and meta-analyses of metacognitive therapy for schizophrenia-spectrum disorder (SSD) have included uncontrolled studies, single-session interventions, and/or analyses limited to a single form of metacognitive therapy. We sought to evaluate the efficacy of metacognitive therapies more broadly based on controlled trials (CT) of sustained treatments. We conducted a pre-registered meta-analysis of controlled trials that […]
Melville, Grace

Call for action to address premature mortality due to physical illness in individuals with severe mental disorders 25 June 2024
Acta Psychiatrica Scandinavica, EarlyView.
Laurent Boyer, Pierre‐Michel Llorca, Guillaume Fond
Antidepressant‐associated diagnostic change from major depressive to bipolar disorder 25 June 2024
Acta Psychiatrica Scandinavica, EarlyView.
Leonardo Tondo, Alessandro Miola, Marco Pinna, Martina Contu, Ross J. Baldessarini
The conversation about family planning and desire for children in mental healthcare: Patients' perspective versus Professionals' perspective in a mixed methods study 25 June 2024
Acta Psychiatrica Scandinavica, EarlyView.
Noralie N. Schonewille, Monique J. M. van den Eijnden, Ruveyda Sahin, Nini H. Jonkman, Anne A. M. W. van Kempen, Maria G. van Pampus, Fedde Scheele, Odile A. van den Heuvel, Birit F. P. Broekman

Wondrous transformations: A maverick physician, the science of hormones, and the birth of the transgender revolution By Alison Li University of North Carolina Press. 2023.pp. 258. $30.00 (cloth). ISBN‐13: 978‐1‐4696‐7485‐8 26 June 2024
Journal of the History of the Behavioral Sciences, Volume 60, Issue 3, Summer 2024.
Beans Velocci
Pharmacotherapy of Weight‐loss and Obesity with a Focus on GLP 1‐Receptor Agonists 26 June 2024
The Journal of Clinical Pharmacology, EarlyView.
Merle Myerson, Rodis D. Paparodis
Developmental trajectories of child and adolescent emotional problems: associations with early adult alcohol use behaviors 26 June 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Tong Chen, Olakunle A. Oginni, Laurie J. Hannigan, Thalia C. Eley, Jennifer L. Maggs, Ashley N. Linden‐Carmichael, Jenae M. Neiderhiser

A role for Shugoshin in human cilia?
We have recently described a novel role for the conserved centromeric/kinetochore protein and cohesin protector, Shugoshin, in cilia of C. elegans. Worms are unusual in that the sole Shugoshin protein ( SGO-1 ) is dispensable for chromosome segregation but required for cilia function in fully differentiated sensory neurons. Depletion of sgo-1 leads to an array […]
sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity.
Expression of human tau in C. elegans neurons causes progressive, age-associated loss of motor coordination, selective neurodegeneration, and shortened lifespan. Loss of function (LOF) mutations in the conserved gene sut-2 protects against progressive motor uncoordination and neurodegeneration in models of tauopathy. To determine whether sut-2 LOF also protects against shortened lifespan of tau transgenic C. […]
Evidence Based Clinical Analytics Supporting the Genetic Addiction Risk Severity (GARS) Assessment to Early Identify Probands in Preaddiction.
No abstract supplied.

Addressing the Youth Mental Health Epidemic
A Model for Providing Psychological Support to Healthcare Leaders and Teams in Times of Crisis
Pre-pandemic, the healthcare workforce was already at risk for higher burnout than the general population and, in some roles (e.g., physicians, nurses), at higher risk for clinical distress and suicide. Studies of healthcare workforce well-being during and after past pandemics reflect that distress can persist after a pandemic subsides, if adequate support within the workplace […]
Assessment of Brief Online Approaches for Teaching Neuroscience in Psychiatry
The goal of this study was to assess an online collection of brief educational resources (videos, case studies, articles) for teaching a broad range of concepts relating to neuroscience in psychiatry.A national sample of 52 psychiatrists enrolled in the study. Forty (77%) completed an assessment before and after having access to the educational resources for […]

Vitamin B12 Supplementation in Psychiatric Practice
Vitamin B (B12, cobalamin) deficiency has been associated with neuropsychiatric symptoms, suggesting a role for B12 supplementation both as a treatment for psychiatric symptoms due to B12 deficiency and as an augmentation strategy for pharmacological treatments of psychiatric disorders. This critical review discusses the major causes of B12 deficiency, the range of psychiatric and non-psychiatric […]
Dignity in Medicine: Definition, Assessment and Therapy
Over the last 20 years, dignity and dignity-conserving care have become the center of investigation, in many areas of medicine, including palliative care, oncology, neurology, geriatrics, and psychiatry. We summarized peer-reviewed literature and examined the definition, conceptualization of dignity, potential problems, and suggested interventions.We performed a review utilizing several databases, including the most relevant studies […]
Metaverse in Mental Health: The Beginning of a Long History
We review the first pilot studies applying metaverse-related technologies in psychiatric patients and discuss the rationale for using this complex federation of technologies to treat mental diseases. Concerning previous virtual-reality applications in medical care, metaverse technologies provide the unique opportunity to define, control, and shape virtual scenarios shared by multi-users to exploit the “synchronized brains” […]

Editorial Board
The efficacy of psychotherapy for social anxiety disorder, a systematic review and meta-analysis
Largest meta-analysis about psychotherapy for SAD (66 studies with 98 comparisons).Psychotherapy is an effective treatment for SAD ( = 0.88, NNT = 3.8).Moderate to large effect sizes across all treatment types and formats.Self-help treatments can increase psychotherapy scalability in low-resource settings. Given the growth in research examining the effects of psychotherapy on social anxiety disorder […]
Metacognitive therapy versus exposure and response prevention for obsessive-compulsive disorder – A non-inferiority randomized controlled trial
Exposure with response prevention (ERP) is the first-line treatment for obsessive-compulsive disorder (OCD). However, refusals, dropouts and the required high time and logistic effort constitute barriers to the use of ERP. In a non-inferiority randomized controlled trial, we compared metacognitive therapy (MCT) to exposure with response prevention (ERP) as treatments for OCD.74 outpatients received 12 […]

The association between early regulatory problems and adult peer relationship quality is mediated by the brain's allostatic‐interoceptive system 26 June 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Saša Zorjan, Dieter Wolke, Nicole Baumann, Christian Sorg, Satja Mulej Bratec
Later (“evening”) circadian preference is associated with poorer executive, academic, and attentional functioning in adolescents with and without ADHD 21 June 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Stephen P. Becker, Aleah Brown, Joshua M. Langberg, Dean W. Beebe
Socio‐demographic variation in diagnosis of and prescribing for common mental illnesses among children and young people during the COVID‐19 pandemic: time series analysis of primary care electronic health records 15 June 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Louise Jane Hussey, Evan Kontopantelis, Pearl L. H. Mok, Darren M. Ashcroft, Matthew J. Carr, Shruti Garg, Carolyn A. Chew‐Graham, Nav Kapur, Karina Lovell, Roger T. Webb

Enhancing the well-being and resiliency of primary care providers 25 June 2024
The International Journal of Psychiatry in Medicine, Volume 59, Issue 4, Page 411-414, July 2024.
Harold G. Koenig
COVID-19 and mental health treatment in primary care: Impacts of a global pandemic on a psychopharmacological collaborative care management program 22 June 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. ObjectiveThe COVID-19 pandemic has had a profound impact on individuals with mental health (MH) disorders and on the delivery of MH services. Studies examining treatment models which did not require substantial changes to the delivery of services during pandemic restrictions, such as collaborative care management […]
Zachary D Zuschlag
Calcium and vitamin D supplements and burnout of anesthesiologists: National cross-sectional study from China 21 June 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. ObjectiveJob burnout among anesthesiologists has been consistently high. This study evaluated the association of calcium and vitamin D supplementation with burnout among Chinese anesthesiologists.MethodA cross-sectional online survey was conducted during April and May 2023. Burnout was evaluated using the Maslach Burnout Inventory, which assesses emotional […]
Fu Zhang

Risk of major mental disorders in the offspring of parents with migraine 22 June 2024
Migraine has been associated with mental disorders, however whether parental migraine is associated with an increased risk of major mental disorders (MMDs) in offspring has not been investigated. We aimed to e...
Dian-Jeng Li, Shih-Jen Tsai, Tzeng-Ji Chen, Chih-Sung Liang and Mu-Hong Chen
Children with ADHD and EEG abnormalities at baseline assessment, risk of epileptic seizures and maintenance on methylphenidate three years later 21 June 2024
This study aimed to assess the incidence of EEG abnormalities (EEG-ab) in children diagnosed with ADHD, investigate the risk of epileptic seizures (SZ) and maintenance on methylphenidate (MPH) over a three-yea...
Dobrinko Socanski, Geir Ogrim and Nezla Duric
Treating depression in patients with borderline personality disorder: clinical clues on the use of antidepressants 30 May 2024
Personality disorders (PD) are described as enduring patterns of markedly deviant and pervasive inner experiences and behaviors, with onset in adolescence, which lead to severe distress or impairment. Patients...
Carmine Tomasetti, G. Autullo, A. Ballerini, A. de Bartolomeis, B. Dell’Osso, A. Fiorentini, F. Tonioni, V. Villari and D. De Berardis

Blighted phenomena: Learning to work with the dark. 8 April 2024
Blighted phenomena are understood as derivatives of dark, lonely, injured experiences—those that are often difficult to put into words. These phenomena can manifest in innumerable configurations in patients’ presentations and in the specificity of their developmental struggles and language. The present article aims to describe ways of working with the darkness of blighted experience, through […]
Intimate partner violence: Narratives of attachment relationships and linguistic analysis of emotional schemas through a quali-quantitative approach. 18 January 2024
Intimate partner violence (IPV) is a concerning, widespread issue with serious health, social, and financial consequences. Previous studies highlighted the role of insecure attachment patterns in predicting IPV victimization. This study investigates attachment classifications among women survivors of IPV referred to antiviolence centers, as determined by the Adult Attachment Interview and compare them with a […]
Review of Reading French Psychoanalysis. 25 December 2023
Reviews the book, Reading French Psychoanalysis edited by Dana Birksted-Breen, Sara Flanders, and Alain Gibeault (2010). In this essay, the author discusses eight reviews of Reading French Psychoanalysis. The reviews considered are Cheshire (2010) in the British Journal of Psychotherapy, Forde (2010) in the Revista de Psicoanálisis, Glassgold (2014) in the Psychoanalytic Quarterly, Lefer (2011) […]

Development and validation of the Gender Identity and Expression Microaggressions in Therapy Scale (GIEMTS). 18 April 2024
Developing affirming interventions for transgender and nonbinary (TNB) therapy clients requires understanding their experiences with microaggressions in psychotherapy, yet no self-report measure of anti-TNB microaggressions in this context exists. Moreover, few studies have tested the associations between anti-TNB microaggressions and therapy processes. To better address the burden of unmet mental health care needs among TNB […]
The evolution of feedback: Toward a multicultural orientation. 18 April 2024
There have been great strides in psychology regarding diversity, equity, inclusion, and multicultural competence, but a need remains to translate these values into actionable practices in psychotherapy. While the case has been made that measurement-based care is an evidence-based intervention that improves outcomes and reduces dropouts (de Jong et al., 2021) and recently that it […]
Beyond the dyad: Broadening the APA supervision guidelines to include group supervision. 28 March 2024
Group supervision is an extensively used format across many training agencies, yet it has been largely disregarded in theory and research within the supervision literature. In fact, the Guidelines for Clinical Supervision in Health Service Psychology (American Psychological Association, 2015a) mentions group supervision only one time, despite the fact that supervision within a group context […]

A Community Data Sharing Resource: The LDbase Data Repository 29 May 2024
Journal of Learning Disabilities, Ahead of Print. The purpose of this invited paper is to show the learning disabilities field what LDbase is, why it’s important for the field, what it offers the field, and examples of how you can leverage LDbase in your own work.
Sara A. Hart
Teaching Constant Rate-of-Change Problem-Solving to Secondary Students With or at Risk of Learning Disabilities 21 May 2024
Journal of Learning Disabilities, Ahead of Print. Rate of change (i.e., slope) is a critical mathematics concept for success in everyday life, academics, and professional careers. Students with or at risk of learning disabilities struggle with solving rate-of-change problems, especially word problems. Interventions that incorporate representations and problem-solving strategies are effective for improving the word […]
Kaitlin Bundock
Concept-Focused and Procedure-Focused Instruction on the Algebra Performance of Grade 9 Students With and Without Mathematics Difficulty 18 May 2024
Journal of Learning Disabilities, Ahead of Print. Developing both conceptual and procedural knowledge is important for students’ mathematics competence. This study examined whether Grade 9 general education mathematics teachers’ self-reported use of concept-focused instruction (CFI) and procedure-focused instruction (PFI) were associated differently with ninth graders’ algebra achievement after 2.5 years, depending on students’ mathematics difficulty […]
Jihyun Lee

Consumer decisions in virtual commerce: Predict good help-timing based on cognitive load. 10 June 2024
The retail sector is steadily moving toward virtual commerce (v-commerce), and the process has recently gained momentum. With the latest developments in headset technology and the rise of artificial intelligence, virtual shopping has become relevant for an increasing number of products. In this article, we present a study that combines consumer behavior research, eye tracking, […]
Correction to “Magnitude effects in preference reversals” by Lu and Nieznański (2021). 10 June 2024
Reports an error in "Magnitude effects in preference reversals" by Yong Lu and Marek Nieznański (Journal of Neuroscience, Psychology, and Economics, 2021[Sep], Vol 14[3], 149-184). In the article, the authors analyzed the data by applying an inappropriate statistical methodology, the Kruskal–Wallis analysis of variance by ranks, for mixed-subjects comparisons (i.e., one sample group of 57 […]
Fast and wrong: An eye-tracking exploration on how low “cognitive reflection” people analyze and choose commercial packages with multidimensional prices. 10 June 2024
Based on the literature on individual differences in cognitive processes, we analyzed gaze behavior during a purchase decision context to understand if the levels of cognitive reflection affect the type of price-information processing and, in turn, the quality of choice. The participants were presented with two websites selling the same commercial package and asked to […]

EJIHPE, Vol. 14, Pages 1902-1912: Psychometric Properties of the Chinese Version of the Core Symptom Index: A Study among Chinese Parents of Children with Autistic Spectrum Disorders 26 June 2024
(1) Background: Parents of children with autism spectrum disorders often experience psychological distress, which can affect the quality of childcare they provide. It is crucial to screen for psychiatric symptoms among these parents. The core symptom index (CSI) is a widely recognized tool used to assess general symptoms, including depression, anxiety, and somatic issues. It […]
Yu Chang
EJIHPE, Vol. 14, Pages 1890-1901: Development and Preliminary Validation of a Scale to Measure Perceived Therapist’s Knowledge about Gender Identity Diversity among Trans and Non-Binary Individuals in Puerto Rico 25 June 2024
This study aimed to describe the development of the Perceived Therapist’s Knowledge about Gender Identity Diversity Scale and to preliminarily validate this scale by describing its psychometric properties. This research instrument was constructed based on the existing literature and recommendations for instrument development. Initially, a 36-item scale was devised to assess perceived openness and knowledge […]
Caleb Esteban
EJIHPE, Vol. 14, Pages 1868-1880: Online Games and Cognitive Distortions: A Comparative Analysis in Students with and without Disabilities 24 June 2024
Online games have experienced significant growth in recent years, with gaming becoming a popular form of entertainment for people of all ages. However, their impact on cognition, especially among vulnerable groups such as students with disabilities, is a topic that requires deeper exploration. The objectives of this study are twofold: firstly, to understand the typology […]
Raquel Suriá-Martínez

Analysis of the impact of legal circumstances on schizophrenia and bipolar disorder hospitalizations in Portugal: a nationwide study 25 June 2024
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Manuel Gonçalves-Pinho Ana Machado Marta Queirós João Pedro Ribeiro Pedro Martins Lia Fernandes Alberto Freitas a CINTESIS@RISE, Department of Clinical Neurosciences and Mental Health, Faculty of Medicine, University of Porto (FMUP), Porto, Portugalb Department of Psychiatry and Mental Health, Unidade Local de Saúde Tâmega e Sousa, Penafiel, Portugalc Unidade de Internamento de Psiquiatria Forense, Unidade Local de Saúde Santo António, Porto, Portugald Psychiatry Service, Unidade Local de Saúde São João, Porto, Portugale CINTESIS@RISE, Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine University of Porto (FMUP), Porto, Portugal
Relationships between adverse childhood experiences, attachment, resilience, psychological distress and trauma among forensic mental health populations 12 June 2024
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Katie Finch Daniel Lawrence Marc O. Williams Andrew R. Thompson Christopher Hartwright a School of Psychology, Cardiff University, UKb Priory Group, Priory Healthcare, Monmouthshire, UKc Department of Applied Psychology, Cardiff Metropolitan University, UK
Unlocking a taboo topic: the sexuality of institutionalized men within a forensic psychiatric facility 29 May 2024
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Frédérique Fortin Jo-Annie Spearson Goulet Mathieu Goyette Ashley J. Lemieux a Department of Sexology, Université du Québec à Montréal, Canadab Research Center, Institut national de psychiatrie légale Philippe-Pinel, Montreal, Canadac Department of Psychiatry and Addiction, Université de Montréal, Canada

The CRPD and mental health law reform in Scotland
Scotland's mental health and capacity legislation and its implementation is underpinned by European Convention on Human Rights (ECHR) informed principles, and such legislation and its implementation has remained largely ECHR compliant. It is designed to protect individuals' autonomy from inappropriate and disproportionate nonconsensual intrusions but its scope is largely limited to this. However, since the […]
Effects of entrapment, anger, psychological flexibility, and self-compassion on the ward climate and reactive aggression in forensic psychiatric hospital patients
This study aimed to investigate the double mediation effect of entrapment and anger, as well as the moderated mediation effect of psychological flexibility and self-compassion on the relationship between the forensic psychiatric hospital ward climate and reactive aggression perceived by patients. A self-reporting method was used to measure ward climate, entrapment, anger, reactive aggression, psychological […]
The violence profile of male mentally disordered offenders in a high secure unit in Turkiye
Our knowledge of the severity and reoffending is limited for mentally disordered offenders, and studies generally evaluate without separation between different diagnostic groups. It was aimed to determine the general profile of mentally disordered offenders who are inpatients in a high secure psychiatry unit from Turkiye and to evaluate the factors associated with violence profiles […]

Changing environments to promote safety in libraries
The purpose of this article is to investigate how changes in the environment of a library affect the safety conditions of both visitors and staff. Using principles of Crime Prevention Through Environmental Design, crime and incidents of public disturbance from 2017 to 2020 from libraries in Stockholm, Sweden, are analyzed and later mapped using 3D […]
Revisiting the tautology problem in rational choice theory: What it is and how to move forward theoretically and empirically
Criminological rational choice theory is blighted by tautology—that if a crime occurs, then by definition the benefits must exceed the costs. The current analysis details the nature of this tautology as well as its theoretical and philosophical implications concerning the circumstances under which offenders make rational (thoughtful and reflective) or irrational (habitual, intuitive, or instinctual) […]
Experiences of fatherhood in prison: A thematic analysis of differences between fathers in a family approach programme and a comparison group
Various programmes have been implemented in prisons to strengthen parental involvement and parent–child relationships during imprisonment. In-depth insights into such programmes are limited. This qualitative study compared the experiences of two groups of imprisoned fathers in the Netherlands: fathers who participated in a family approach programme ( = 10) and fathers in a comparison group ( = 29). Based […]

“I just thought maybe this is [the] way of doing things”: Exploring lesbian-, gay-, and bisexual-specific intimate partner violence in Norway. 23 May 2024
Objective: Intimate partner violence (IPV) in lesbian, gay, and bisexual (LGB) relationships seems to be at least as high as in heterosexual relationships. However, there are uncertainties regarding how IPV is more specifically experienced in LGB relationships. We explore how LGB individuals exposed to IPV make sense of the potentially more specific ways in which […]
When childhood states become adult traits: Trait anxiety and anger as mediators linking childhood maltreatment to marital outcomes in midlife adults. 23 May 2024
Objective: Childhood maltreatment has been consistently linked to problematic marriages. The pathways, however, linking childhood maltreatment to marital problems over time remain understudied. The present study examined trait anger and trait anxiety as possible mediators linking childhood maltreatment to marital quality, support, and strain over a 9 year period. It was expected that both trait […]
Profiles of service-engaged intimate partner violence survivors: Considerations for service delivery and continuation. 16 May 2024
Objective: This study examined factors considered to influence service engagement among intimate partner violence (IPV) survivors. Specifically, it (a) investigated patterns of cultural beliefs, stigma related to attitudes about seeking formal help, and IPV experiences among service-engaged survivors and (b) explored their association with sociodemographic characteristics. Method: Mixture modeling was conducted using the Testing and […]

Classifying national drinking patterns in Europe between 2000 and 2019: A clustering approach using comparable exposure data 25 June 2024
Addiction, EarlyView.
Daniela Correia, Jakob Manthey, Maria Neufeld, Carina Ferreira‐Borges, Aleksandra Olsen, Kevin Shield, Jürgen Rehm
Predictability of buprenorphine‐naloxone treatment retention: A multi‐site analysis combining electronic health records and machine learning 24 June 2024
Addiction, EarlyView.
Fateme Nateghi Haredasht, Sajjad Fouladvand, Steven Tate, Min Min Chan, Joannas Jie Lin Yeow, Kira Griffiths, Ivan Lopez, Jeremiah W. Bertz, Adam S. Miner, Tina Hernandez‐Boussard, Chwen‐Yuen Angie Chen, Huiqiong Deng, Keith Humphreys, Anna Lembke, L. Alexander Vance, Jonathan H. Chen
Young adults with a history of substance use disorder experienced more negative mental health, social and economic outcomes during the COVID‐19 pandemic period 24 June 2024
Addiction, EarlyView.
Max A. Halvorson, Margaret R. Kuklinski, Jennifer A. Bailey, Justin D. Caouette, Katarina Guttmannova, Isaac C. Rhew, Sabrina Oesterle

Selective outcome reporting in trials of behavioural health interventions in health psychology and behavioural medicine journals: a review 26 June 2024
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Karen Matvienko-Sikar Jen O'Shea Stephen Kennedy Siobhan D. Thomas Kerry Avery Molly Byrne Sheena McHugh Daryl B. O’ Connor Ian J. Saldanha Valerie Smith Elaine Toomey Kerry Dwan Jamie J. Kirkham a School of Public Health, University College Cork, Cork, Irelandb School of Applied Psychology, University College Cork, Cork, Irelandc College of Medicine, University College Cork, Cork, Irelandd Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, UKe School of Psychology, University of Galway, Galway, Irelandf School of Psychology, University of Leeds, Leeds, UKg Center for Clinical Trials and Evidence Synthesis, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USAh School of Nursing, Midwifery, and Health Systems, University College Dublin, Dublin, Irelandi School of Nursing & Midwifery, University College Galway, Galway, Irelandj Liverpool School of Tropical Medicine, Liverpool, UKk Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
Does socioeconomic position moderate the associations between the content and delivery features of digital behaviour change interventions for smoking cessation and intervention effectiveness? A systematic review and meta-analysis 19 June 2024
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Corinna Leppin Tosan Okpako Jamie Brown Claire Garnett Olga Perski a Department of Behavioural Science and Health, University College London, London, UKb School of Psychological Science, University of Bristol, Bristol, UKc Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, CA, USAd Faculty of Social Sciences, Tampere University, Tampere, Finland
App-based interventions to improve cancer outcomes rely on informational support from professionals: a systematic review 17 May 2024
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Karoline Villinger Corina Berli Urte Scholz a Department of Psychology, University of Zurich, Zurich, Switzerlandb Institute of Psychology, University of Bern, Bern, Switzerland

Editorial: International perspectives in public mental health 5 June 2024
Editorial: International perspectives in public mental health
Neil Quinn
Mental Health First Aid™ for Deaf communities: responses to a lack of national Deaf mental health service provision 17 May 2024
For over 15 years, Mental Health First Aid™ (MHFA) has successfully been delivered in Wales, United Kingdom, with growing interest in the MHFA programme and increasing course attendees. Trainers, aware of the need for support, know the importance of MHFA being accessible for different communities and learner groups. MHFA has always focused on increasing mental […]
Julia Terry
Prevalence of cosmetic surgery and its relationship with psychosocial status: a population based study in Sulaymaniyah, Iraq 16 May 2024
This study aims to investigate the prevalence of cosmetic surgery and its relationship with the level of mental health and socioeconomic variables in Sulaymaniyah city in Iraq. This descriptive-analytical and cross-sectional study was conducted on 941 subjects who were selected using multistage sampling method. Data were collected using a checklist as well as a questionnaire. […]
Farman Zahir Abdullah

A history of mental illness among women in the Straits Settlements in the nineteenth century 15 June 2024
History of Psychiatry, Ahead of Print. The Straits Settlements, a collective colony under the administration of British Malaya, was a very unhealthy area in the early years of the nineteenth century. One of the most common sicknesses was mental illness, which could not be cured by medicines. The number of women suffering from mental illness […]
Haszira Muhamad Yusof
Social issues relating to Vladimir Bekhterev’s concept of reflexology: a hitherto underestimated aspect of his work 12 June 2024
History of Psychiatry, Ahead of Print. This article investigates the diversity of social and political assertions in the work of Vladimir M Bekhterev. Its findings reveal that he drew social and political conclusions based on his doctrine of reflexology. Moreover, he propagated the use of statistical investigations by scientific and governmental institutions to estimate the […]
Birk Engmann
Phrenitis and the pathology of the mind in western medical thought (fifth century BCE to twentieth century cE) 11 June 2024
History of Psychiatry, Ahead of Print. Phrenitis is ubiquitous in ancient medicine and philosophy. Galen mentions the disease innumerable times, Patristic authors take it as a favourite allegory of human flaws, and no ancient doctor fails to diagnose it and attempt its cure. Yet the nature of this once famous disease has not been properly […]
Chiara Thumiger

Examining mental health correlates of hate-motivated behaviour in Scotland: An investigation of victims, perpetrators and victim-perpetrators 25 June 2024
International Journal of Social Psychiatry, Ahead of Print. Background:Hate-motivated behaviour (HMB) ranges from microaggressions to criminal acts and is a public health concern with wide-ranging consequences.Aims:The current study aimed to examine the mental health correlates of HMB perpetration, victimisation and co-occurring victimisation/perpetration.Methods:Participants (n = 447) completed an online cross-sectional survey assessing demographic factors, HMB (perpetration and victimisation), […]
Kirsten Russell
High levels of anxiety and depression in women farmers from Ecuador: A cross-section study in Coastal and Highlands regions 25 June 2024
International Journal of Social Psychiatry, Ahead of Print. Background:Previous studies have shown that women farmers are particularly vulnerable to mental health disorders such as depression and anxiety.Aims:This study aimed to investigate the prevalence of anxiety and depression in women farmers from Ecuador Coastal and Highlands regions.Method:General Anxiety Disorder‑7 (GAD‑7) and Patient Health Questionnaire‑9 (PHQ‑9) were […]
Aline Siteneski
Mental health and the ballot box: A correlational analysis of Google searches for mental health and national election periods in the United States and the United Kingdom from 2008 to 2020 25 June 2024
International Journal of Social Psychiatry, Ahead of Print. Background:In electoral contexts, mental health topics have recently attracted sociopolitical relevance, influenced by policy developments, election-related psychopathology and popular discourse about individual candidates. Yet, whether this reflects generalised trends or is contingent on election-specific and contextual factors remains difficult to ascertain.Aims:This study sought to examine correlations between […]
Alexander J. Smith

Exposure to violence and attitudes toward war and peace in Ukraine. 24 June 2024
The purpose of this study is to advance our understanding of how exposure to war-related violence can affect civilians’ willingness to support peace negotiations. We surveyed 1,812 people in three eastern cities of war-torn Ukraine to examine how different forms of loss during war influenced people’s support for peace agreements and how the mechanisms of […]
Indonesians remember East Timor: Exploring East Timor integration and separation from Indonesia and Indonesia’s past transgressions. 24 June 2024
At the end of 1975, Indonesia invaded East Timor and declared it as one of Indonesia’s provinces. However, East Timor eventually became an independent country in 2002. During Indonesia’s occupation, it was estimated that between 100,000 and 200,000 East Timorese were killed. The present study aims to explore the Indonesian people’s collective memories about East […]
Liberal legitimacy in global politics: Navigating toleration and cooperation. 24 June 2024
Reviews the book, International Toleration: A Theory by Pietro Maffettone (2020). features a thorough investigation into the liberal principle of legitimacy, scrutinizing its adaptability across diverse political domains—from the domestic realm of liberal democratic societies to the broader context of an international society of liberal peoples. The author focuses on philosophical underpinnings, domain-specific distinctions, and […]

Coronavirus pandemic dreams in China: A qualitative research on the effect of the Wuhan lockdown on dream contents. 15 April 2024
This study investigated the “coronavirus pandemic dream” phenomenon in Chinese including residing in Wuhan city based on the continuity hypothesis, which states that dream contents reflect waking life. We analyzed the effects of lockdown due to coronavirus disease-2019 (COVID-19) on dream reported from Chinese university students and workers residing in inside and outside of Hubei […]
Dreaming about the pandemic: A thematic content analysis of COVID-19-related dreams during the outbreak in Portugal. 4 April 2024
The COVID-19 pandemic has affected the mental health of people around the world, altering sleep patterns and dream experiences. Since dream content is associated with waking-life experiences, one would expect pandemic-related concerns to pervade dreams. Building upon previous research efforts, this study aims to contribute to the ongoing debate on dream function and to address […]
Prolonged changes in the perception of dreaming behaviors resulting from the COVID-19 pandemic. 18 March 2024
Reports of changes in dreaming behaviors emerged immediately after the onset of the COVID-19 pandemic. However, it is unclear if these changes persisted long term, after initial lockdowns were lifted and people became accustomed to pandemic life. The current study measured dreaming behaviors known to have changed immediately after the pandemic onset and other behaviors […]

AI Helps Predict Dementia Using Speech Patterns 26 June 2024
(MedPage Today) -- Voice recordings helped predict which patients with mild cognitive impairment developed Alzheimer's dementia in 6 years. Combined with basic demographic information, speech patterns recorded in neuropsychological exams achieved...
Oral Ketamine for Depression; ADHD Video Game Cleared; Narcolepsy Drug OK'd for Kids 26 June 2024
(MedPage Today) -- A phase II study showed that twice-weekly oral ketamine tablets led to significantly greater reductions in Montgomery-Åsberg Depression Rating Scale (MADRS) scores compared with placebo after 13 weeks in adults with treatment...
Nationwide Coffee Recall; Aspirin Misuse Common; Gena Rowlands' Alzheimer's Disease 26 June 2024
(MedPage Today) -- Note that some links may require registration or subscription. Snapchill recalled all of its canned coffee products distributed nationwide through coffee roasters and retailers due to potential botulinum toxin contamination...

Alzheimer's Disease Blood Biomarkers Identified in New Feinstein Institutes Study 26 June 2024
... Psychiatry suggest the potential development of a blood test to help identify the risk of psychosis from the disease. By 2060, it's estimated that ...
RE104: A Novel, Fast-Acting Psychedelic for Postpartum Depression - Psychiatric Times 26 June 2024
Am J Psychiatry. 2004;161(9):1548-57. 18. FDA approves first treatment for post-partum depression. US Food and Drug Administration. News ...
Q&A: SAGE test catches cognitive impairment early in a 'critical time' - Healio 26 June 2024
... psychiatry at The Ohio State University Wexner Medical Center, said in a press release. PC0624Scharre_Graphic_01_WEB Data derived from: Scharre D ...

World Drug Day report highlights spike in drug use, increased trafficking 26 June 2024
The UN agency tackling crime and drug abuse (UNODC) released its annual World Drug Report on Wednesday warning that there are now nearly 300 million users globally, alongside an increase in trafficking.
Over three million preventable deaths per year due to alcohol and drug use 25 June 2024
Over three million deaths per year were attributable to alcohol consumption and drug use, a new report from the World Health Organization (WHO) found. Of these deaths, 2.6 million were attributable to alcohol consumption, accounting for nearly five per cent of all deaths, with the highest numbers in the WHO European Region and African Region.
Half the world now following doctors’ orders on cutting trans fats: WHO 24 June 2024
A total of 53 countries had best practice policies in place for tackling industrial trans fats in food as of last year, vastly improving the food environment for 3.7 billion people, or 46 per cent of the world’s population, according to a milestone report published by the UN World Health Organization on Monday.

Strengthening HIV testing services in francophone countries from West and Central Africa and the Indian Ocean sub-region 25 June 2024
Meeting of Francophone countries from West and Central Africa and the Indian Ocean sub-region to strengthen HIV testing services and integration. It aims to support the identification of solutions to address existing testing gaps and to strengthen testing and linkage services.
who.int
Six partners on a global journey to celebrate excellence in public health 20 June 2024
Chronology of how six global health awards, established by the founders through the Executive Board and administered by WHO, have been recognizing outstanding contributions to public health throughout decades.
who.int
Health in All Policies: Advancing Multisectoral Collaboration for Health Equity 19 June 2024
Join the WHO Global Knowledge Network for Health Equity and the Global Network for Health in All Policies for a webinar exploring Health in All Policies (HiAP) and its potential for advancing equity across various sectors.
who.int

Regional Director's statement during the press briefing on emergencies in the Eastern ... 26 June 2024
When we held our first press briefing on health emergencies after I took office about four months ago, I could not have foreseen the escalation of violence in our Region. The situation has grown more relentless and unforgiving, while life-saving aid remains out of reach for too many whose lives depend on it. In Gaza, […]
WHO concerned about escalating health crisis in West Bank 15 June 2024
15 June 2024, Jerusalem/Cairo/Geneva WHO remains concerned about the escalating health crisis in the occupied Palestinian territory, including the West Bank, where attacks on health infrastructure and increased restrictions on movement are obstructing access to health care. A spike in violence in the West Bank, including East Jerusalem, since the war in Gaza started has […]
World Elder Abuse Awareness Day 2024: ensuring older people’s safety in emergencies 12 June 2024
15 June 2024, Cairo, Egypt – On World Elder Abuse Awareness Day 2024, the spotlight is on older people in emergencies. Older people often face mobility issues, chronic health conditions or social isolation –some of the factors that can hinder their ability to access aid, evacuate safely or receive timely medical care and support services. […]

Only severe Injuries are effectively reduced by muscles' injury prevention protocols in football players: A systematic review [version 1; peer review: awaiting peer review] 26 June 2024
Background Muscle injuries are the most frequent in football and may lead to the end of a player’s career. Many studies have evaluated the effectiveness of prevention programs for all injury types. Few studies have evaluated the effects of exercise on muscle injuries. Methods A documentary search was conducted in October 2022 from three databases: […]
Rihab Moncer
Impact on postoperative complications of combined prehabilitation targeting co-existing smoking, malnutrition, obesity, alcohol drinking, and physical inactivity: a systematic review and meta-analysis of randomised trials [version 1; peer review: awaiting peer review] 26 June 2024
Background This study aimed to compare the effect on postoperative complications of prehabilitation targeting predefined co-existing risky lifestyle factors with usual preoperative routines in surgical patients. Methods This systematic review followed the PRISMA 2020 guideline and the protocol (CRD42022282611). Five databases were searched from inception to November 7, 2022 for randomised controlled trials on prehabilitation […]
Line N Lydom
Determinants of Household Resilience to Food Insecurity for Comparison: the Case of Chencha District, Southern Ethiopia [version 1; peer review: awaiting peer review] 26 June 2024
Background Food insecurity is a historical global human challenge, but has yet remained a burning development agenda. The capacity to withstand and recover from food insecurity shocks and stresses refereed as resilience, which is determined by a strand of factors. This paper deals with measuring and; identifying major determinants of household resilience to food insecurity […]
Desta Dereje

GALENOS in the BMJ 9 June 2024
Today the British Medical Journal shared their perspective on GALENOS.
galenos.org.uk
Welcoming the New Chair and Vice-Chair of GLEAB 16 May 2024
We are delighted to welcome a brand new Chair and Vice Chair of the GLEAB.
galenos.org.uk
In Memory Of Lea Milligan 30 April 2024
Lea Milligan, CEO of MQ Mental Health Research and a founding member of the GALENOS leadership team passed away unexpectedly on the 15th of April following a sudden illness.
galenos.org.uk

Death certification reform and the introduction of medical examiners 25 June 2024
Information about changes to the death certification process in England and Wales from 9 September 2024.
HM Government
Receiving the new medical certificate of cause of death (MCCD) 25 June 2024
How to get the new MCCD if your organisation uses the current MCCD.
HM Government
New MCCD: check that your organisation is on the distribution list 24 June 2024
Current list of organisations that will receive the new medical certificate of cause of death (MCCD), which must be used from 9 September 2024.
HM Government

Artificial Intelligence (AI): The Future of Data 20 May 2024
With the public release of large language models like Chat GPT putting Artificial Intelligence (AI) firmly on our radar, the...
stevemilne
Measuring wellbeing and going ‘Beyond GDP’ 9 May 2024
A new ONS publication out today, aims to give an holistic view on how society is doing, beyond purely economic measures. Here, Tim Vizard explores what we have done so far on Beyond GDP and outlines our next steps on this important work.
samcollin
Understanding the new income statistics for local areas: Different measures for better insights 30 April 2024
The ONS has been busy producing faster, more detailed statistics using new data sources. Providing clearer insights at the local level is an important aspect of this work. Ainslie Woods explains how our local income statistics compare and why they offer a complementary picture of local areas.
croydl

How can we get malaria control back on track? 26 June 2024
Malaria remains a significant global health burden. The World Health Organization’s 2023 malaria report estimates that the number of cases worldwide increased by five million between 2021 and 2022, reaching 249 million.3 Although annual malaria deaths steadily declined between 2000 and 2019, they reached 608 000 in 2022, roughly 32 000 more than pre-pandemic levels. […]
Amal A El-Moamly
Doctors vote for BMA to oppose four year medical degrees and apprenticeships 26 June 2024
BMA representatives have firmly rejected proposals for medical apprenticeships and four year undergraduate medical degrees.The association’s annual representative meeting in Belfast overwhelmingly passed a motion on 25 June declaring that it “abhors attempts to dilute the quality of medical standards in the UK.” It urged the BMA to continue to oppose “scope creep from professions […]
Gareth Iacobucci
SGLT-2 inhibitors, GLP-1 receptor agonists, and DPP-4 inhibitors and risk of hyperkalemia among people with type 2 diabetes in clinical practice: population based cohort study 26 June 2024
AbstractObjectivesTo evaluate the comparative effectiveness of sodium-glucose cotransporter-2 (SGLT-2) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and dipeptidyl peptidase-4 (DPP-4) inhibitors in preventing hyperkalemia in people with type 2 diabetes in routine clinical practice.DesignPopulation based cohort study with active-comparator, new user design.SettingClaims data from Medicare and two large commercial insurance databases in the United States from […]
Edouard L Fu, Deborah J Wexler, Sara J Cromer, Katsiaryna Bykov, Julie M Paik, Elisabetta Patorno

5-mm Margin Excision Evaluated in Small Melanoma In Situ 26 June 2024
Researchers evaluated outcomes for 351 melanoma in situ lesions in 294 patients in a retrospective study. Medscape Medical News
Most Cancer Patients Don't Receive Recommended Anemia Care 26 June 2024
Studies show low rates of adherence to guidelines calling for evaluating and treating anemia among patients with cancer. Medscape Medical News
Which Surgeries Drive the Most Opioid Prescriptions in Youth 26 June 2024
New research pinpointed the top three surgeries driving highest opioid prescriptions in teens and adolescents, highlighting the need for alternate pain management. Medscape Medical News

Federal Experts Talk Bird Flu ‘What Ifs’ in WebMD Live Event 16 May 2024
WebMD brought together experts from four federal agencies to talk prevention, monitoring, and what the “what ifs” of bird flu might look like.
What’s Next in Health Care for Older Adults: Questions and Answers With John Whyte, MD 16 May 2024
As WebMD’s chief medical officer, John Whyte, MD, is in a unique position to see both the current state of medical care for America’s older adults and the way things are trending for the future. We asked him to share his insight on a few topics, along with a bit of advice.
Get the Care You Need in a COVID-19 World 16 May 2024
What to expect at the doctor’s office, hospitals, and long-term care facilities, the future of telemedicine, and how to get the best care during COVID-19.

Deaths in police custody 26 June 2024
To date there have been 1897 deaths in police custody or otherwise following contact with the police in England & Wales since 1990 Below is a breakdown of deaths in police custody or following other forms of contact with the police, as well as vehicular pursuits and road traffic incidents (RTIs) since 1990, by calendar […]
Inquest
Deaths in prison 25 June 2024
In this country we do not give a death sentence, but for everyone who has taken their life in prison that is exactly what they got - Mark Saunders, whose son Dean died in HMP & YOI Chelmsford in 2016 Below is a breakdown of deaths in prison in England and Wales by calendar year […]
Inquest
Alison Henley: family speak out after long delays to inquest into self-inflicted death in Derbyshire 24 June 2024
24 June 2024
Inquest

Central nervous system-derived extracellular vesicles: the next generation of neural circulating biomarkers?

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Shared symptomatology between atopic dermatitis, ADHD and autism spectrum disorder: a protocol for a systematic scoping review

Psychosocial Impact of Penile Cancer: An Unmet Need

Generative artificial intelligence in ophthalmology: current innovations, future applications and challenges

Kaempferol Inhibits Cervical Cancer Cells by Inducing Apoptosis and Autophagy via Inactivation of the PI3K/AKT/mTOR Signaling Pathway

Paediatric sleep diagnostics in the 21st century: the era of “sleep-omics”?

Transforming Cardiovascular Care With Artificial Intelligence: From Discovery to Practice: JACC State-of-the-Art Review

The FDA and the Cardiovascular Community

Adapting the Cornell assessment of pediatric delirium for Swedish context: translation, cultural validation and inter-rater reliability

Dexmedetomidine in paediatric anaesthesia: a call for action?

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