Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Cell Rep. 2024 Jun 22;43(7):114386. doi: 10.1016/j.celrep.2024.114386. Online ahead of print.
ABSTRACT
The dentate gyrus plays a key role in the discrimination of memories by segregating and storing similar episodes. Whether hilar mossy cells, which constitute a major excitatory principal cell type in the mammalian hippocampus, contribute to this decorrelation function has remained largely unclear. Using two-photon calcium imaging of head-fixed mice performing a spatial virtual reality task, we show that mossy cell populations robustly discriminate between familiar and novel environments. The degree of discrimination depends on the extent of visual cue differences between contexts. A context decoder revealed that successful environmental classification is explained mainly by activity difference scores of mossy cells. By decoding mouse position, we reveal that in addition to place cells, the coordinated activity among active mossy cells markedly contributes to the encoding of space. Thus, by decorrelating context information according to the degree of environmental differences, mossy cell populations support pattern separation processes within the dentate gyrus.
PMID:38909362 | DOI:10.1016/j.celrep.2024.114386
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Context and space coding in mossy cell population activity
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity Dominant activities of fear engram cells in the dorsal dentate gyrus underlie fear generalization in mice Dominant activities of fear engram cells in the dorsal dentate gyrus underlie fear generalization in mice Degraded tactile coding in the Cntnap2 mouse model of autism Lineage specification in glioblastoma is regulated by METTL7B Dorsoventral heterogeneity of synaptic connectivity in hippocampal CA3 pyramidal neurons Activity of ventral hippocampal parvalbumin interneurons during anxiety Molecular cascade reveals sequential milestones underlying hippocampal neural stem cell development into an adult state Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration Regulation of stress-induced sleep perturbations by dorsal raphe VGLUT3 neurons in male mice Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity Gestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice Distinct action signals by subregions in nucleus accumbens during STOP-change performance Effects of context changes on memory reactivation Effects of context changes on memory reactivation Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity Incorporating simulated spatial context information improves the effectiveness of contrastive learning models A neural-mast cell axis regulates skin microcirculation in diabetes Movement-related increases in subthalamic activity optimize locomotion Evaluation of altered cell-cell communication between glia and neurons in the hippocampus of 3xTg-AD mice at two time points Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics Determinantal point process attention over grid cell code supports out of distribution generalization Germ Cell Nuclear Factor: from reproductive to craniofacial development Dentate Gyrus Morphogenesis is Regulated by an Autism Risk Gene Trio Function in Granule Cells Huntington's disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids Preconfigured architecture of the developing mouse brain Preconfigured architecture of the developing mouse brain Cell-cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calcium Hippocampal astrocytes induce sex-dimorphic effects on memory Hippocampal astrocytes induce sex-dimorphic effects on memory Myeloid derived suppressor cells and macrophages in regulation of immune response in cancer and tumor progression Innate immune memory after brain injury drives inflammatory cardiac dysfunction Innate immune memory after brain injury drives inflammatory cardiac dysfunction LINC00894 inhibited neuron cellular apoptosis and regulated activating transcription factor 3 expression Decoding frontotemporal and cell-type-specific vulnerabilities to neuropsychiatric disorders and psychoactive drugs Cell-type-specific loops linked to RNA polymerase II elongation in human neural differentiation Using Organoids to Model Sex Differences in the Human Brain Modulation of structural and functional plasticity in the hippocampus across the murine estrous cycle Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics Adult-born granule cells modulate CA2 network activity during retrieval of developmental memories of the mother Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number The neuron mixer and its impact on human brain dynamics Anti-PD-1 cancer immunotherapy induces central nervous system immune-related adverse events by microglia activation Single cell RNA sequencing reveals immunomodulatory mechanism of stem cell factor and granulocyte colony-stimulating factor treatment in the brains of aged APP/PS1 mice Immune signature and therapeutic approach of natural killer cell in chronic liver disease and hepatocellular carcinoma Loss of dysbindin-1 in excitatory neurons in mice impacts NMDAR-dependent behaviors, neuronal morphology and synaptic transmission in the ventral hippocampus Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test Single-Cell Data Analysis Reveals Critical Hepatic Cells Subpopulations in the Progression of Non-alcoholic Fatty Liver Disease to Non-Alcoholic Steatohepatitis Breast Tumor Cell Survival and Morphology in a Brain-like Extracellular Matrix Depends on Matrix Composition and Mechanical Properties Trauma in neonatal acute brain slices alters calcium and network dynamics and causes calpain-mediated cell death Trauma in neonatal acute brain slices alters calcium and network dynamics and causes calpain-mediated cell death ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma Single cell transcriptome analysis identified a unique neutrophil type associated with Alzheimer's disease A novel paradigm for measuring prediction abilities in a rat model using a speech-sound discrimination task Task and stimulus coding in the multiple-demand network Parvalbumin interneuron mGlu5 receptors govern sex differences in prefrontal cortex physiology and binge drinking Parvalbumin interneuron mGlu5 receptors govern sex differences in prefrontal cortex physiology and binge drinking Perspectives in collective cell migration - moving forward T cell activation and lowered T regulatory cell numbers are key processes in severe major depressive disorder: Effects of recurrence of illness and adverse childhood experiences
Evidence Blueprint
Context and space coding in mossy cell population activity
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Context and space coding in mossy cell population activity
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Altered Hippocampal Activation in Seizure-Prone CACNA2D2 Knock-out Mice Dopamine D2 receptors in hilar mossy cells regulate excitatory transmission and hippocampal function A neural code for time and space in the human brain Adaptive spike threshold dynamics associated with sparse spiking of hilar mossy cells are captured by a simple model Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity Comparative anatomy of the dentate mossy cells in non-human primates: their spatial distributions and axonal projections compared with mouse mossy cells Engram reactivation mimics cellular signatures of fear Dominant activities of fear engram cells in the dorsal dentate gyrus underlie fear generalization in mice Dominant activities of fear engram cells in the dorsal dentate gyrus underlie fear generalization in mice Intrinsic and synaptic contributions to repetitive spiking in dentate granule cells Single-cell RNA sequencing uncovers the cell type-dependent transcriptomic changes in the retrosplenial cortex after peripheral nerve injury Environmental interventions reduced repetitive behavior in a mouse model: Physiology and Behavior Degraded tactile coding in the Cntnap2 mouse model of autism Lineage specification in glioblastoma is regulated by METTL7B Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice Dorsoventral heterogeneity of synaptic connectivity in hippocampal CA3 pyramidal neurons Activity of ventral hippocampal parvalbumin interneurons during anxiety Molecular cascade reveals sequential milestones underlying hippocampal neural stem cell development into an adult state Working memory features are embedded in hippocampal place fields Single-cell long-read sequencing in human cerebral organoids uncovers cell-type-specific and autism-associated exons Feedforward and disinhibitory circuits differentially control activity of cortical somatostatin interneurons during behavioral state transitions NMDAR-mediated activation of pannexin1 channels contributes to the detonator properties of hippocampal mossy fiber synapses NMDAR-mediated activation of pannexin1 channels contributes to the detonator properties of hippocampal mossy fiber synapses Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics ΔFosB is part of a homeostatic mechanism that protects the epileptic brain from further deterioration Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport Impaired oxysterol-liver X receptor signaling underlies aberrant cortical neurogenesis in a stem cell model of neurodevelopmental disorder Theta phase-entrainment of single cell spiking in rat somatosensory barrel cortex and secondary visual cortex is enhanced during multisensory discrimination behavior An axon-T cell feedback loop enhances inflammation and axon degeneration Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration Nucleus accumbens local circuit for cue-dependent aversive learning Spermatogenesis: a paradigm of stem cell regulation Regulation of stress-induced sleep perturbations by dorsal raphe VGLUT3 neurons in male mice Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease models A pilot study examining the impact of lithium treatment and responsiveness on mnemonic discrimination in bipolar disorder Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer's disease mice Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers Srcap haploinsufficiency induced autistic-like behaviors in mice through disruption of Satb2 expression Gestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice Visual experience induces 4-8 Hz synchrony between V1 and higher-order visual areas Mitf is a Schwann cell sensor of axonal integrity that drives nerve repair A developmental critical period for ocular dominance plasticity of binocular neurons in mouse superior colliculus Distinct action signals by subregions in nucleus accumbens during STOP-change performance Sex-biased single cell genetic landscape in mice with autism spectrum disorder Minute-scale periodicity of neuronal firing in the human entorhinal cortex Perinatal loss of galactosylceramidase in both oligodendrocytes and microglia is crucial for the pathogenesis of Krabbe disease in mice Perinatal loss of galactosylceramidase in both oligodendrocytes and microglia is crucial for the pathogenesis of Krabbe disease in mice Infernape uncovers cell type-specific and spatially resolved alternative polyadenylation in the brain Prefrontal neuronal ensembles link prior knowledge with novel actions during flexible action selection Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis Selective vulnerability of the ventral hippocampus-prelimbic cortex axis parvalbumin interneuron network underlies learning deficits of fragile X mice Ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward-seeking behavior Effects of context changes on memory reactivation Effects of context changes on memory reactivation Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory network ESCRT-I protein UBAP1 controls ventricular expansion and cortical neurogenesis via modulating adherens junctions of radial glial cells Paroxysmal dystonia results from the loss of RIM4 in Purkinje cells Incorporating simulated spatial context information improves the effectiveness of contrastive learning models Exploration biases forelimb reaching strategies A neural-mast cell axis regulates skin microcirculation in diabetes