Cross-Species Framework for Emotional Well-Being and Brain Aging: Lessons From Behavioral Neuroscience
JAMA Psychiatry. 2025 May 7. doi: 10.1001/jamapsychiatry.2025.0581. Online ahead of print.
ABSTRACT
IMPORTANCE: Emotional well-being (EWB) is an emerging therapeutic target for managing and preventing symptoms associated with Alzheimer disease and related dementias (ADRD). However, more research is needed to establish causal inferences between brain changes, EWB, and behavioral changes observed in typical aging and ADRD.
OBSERVATIONS: This article presents a framework for using a cross-species behavioral neuroscience approach to study EWB and brain aging, adopting a well-established biobehavioral model that highlights the reciprocal roles of brain changes, EWB, and ADRD symptoms. First, the challenges and opportunities in this field are reviewed. Then, a practical solution to improve comparability between animal and human studies is proposed.
CONCLUSIONS AND RELEVANCE: The goal is to draw comprehensive parallels and distinctions that could enhance the understanding of the mechanisms linking brain aging, EWB, and ADRD symptomatic disturbances across different species.
Ann Vasc Surg. 2025 May 5:S0890-5096(25)00315-2. doi: 10.1016/j.avsg.2025.04.121. Online ahead of print.ABSTRACTTHE BACKGROUND: North Wales Vascular Services were centralized to Glan Clwyd hospital in 2019...
Implement Sci Commun. 2025 May 7;6(1):55. doi: 10.1186/s43058-025-00744-7.ABSTRACTBACKGROUND: The global shortage of trained mental health workers disproportionately impacts mental health care access in low- and...
Addict Sci Clin Pract. 2025 May 8;20(1):39. doi: 10.1186/s13722-025-00564-z.ABSTRACTBACKGROUND: Opioid use disorder often co-occurs with other mental health and substance use disorders. Identifying clusters of...
Clin Epigenetics. 2025 May 7;17(1):78. doi: 10.1186/s13148-025-01880-6.ABSTRACTBACKGROUND: Epigenetic aging estimators commonly track chronological and biological aging, quantifying its accumulation (i.e., epigenetic age acceleration) or speed...
BMC Glob Public Health. 2025 May 7;3(1):41. doi: 10.1186/s44263-025-00163-9.ABSTRACTSexual violence on higher education campuses represents a global public health crisis that threatens students' safety, well-being,...
Pediatr Clin North Am. 2025 Jun;72(3):509-523. doi: 10.1016/j.pcl.2024.12.005. Epub 2025 Feb 5.ABSTRACTThis review article highlights the longitudinal impact of intimate partner violence (IPV) on children,...
