Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
J Drug Target. 2024 Aug 12:1-25. doi: 10.1080/1061186X.2024.2391913. Online ahead of print.
ABSTRACT
Nanotechnology has significantly impacted human life, particularly in overcoming the limitations associated with neurodegenerative diseases (NDs). Various nanostructures and vehicle systems, such as polymer nanoparticles, carbon nanotubes (CNTs), nanoliposomes, nano-micelles, lipid nanoparticles, lactoferrin, polybutylcyanoacrylate, and poly lactic-co-glycolic acid, have been shown to enhance drug efficacy, reduce side effects, and improve pharmacokinetics. NDs affect millions worldwide and are challenging to treat due to the blood-brain barrier (BBB), which hinders drug delivery to the central nervous system (CNS). Research suggests that natural ingredients can be formulated into nanoparticles, offering a promising approach for ND treatment. This review examines the advantages and disadvantages of herbal-based nanoformulations, highlighting their potential effectiveness when used alone or in combination with other medications. Herbal nanoparticles provide benefits over synthetic ones due to their biocompatibility, reduced toxicity, and potential for synergistic effects. The study’s findings can be applied to develop more efficient drug delivery systems, improving the treatment of NDs by enhancing drug penetration across the BBB and targeting affected CNS areas more precisely.
PMID:39133517 | DOI:10.1080/1061186X.2024.2391913
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Herbal Nanoparticles: A targeted approach for Neurodegenerative disorder Treatment
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Tau- and α-synuclein-targeted gold nanoparticles: applications, opportunities, and future outlooks in the diagnosis and therapy of neurodegenerative diseases Application of quality by design in optimization of nanoformulations: Principle, perspectives and practices Small Scale, Big Impact: Nanotechnology-Enhanced Drug Delivery for Brain Diseases Small Particles, Big Potential: Polymeric Nanoparticles for Drug Delivery in Parkinson's Disease Revolutionizing Neurotherapeutics: Nanocarriers Unveiling the Potential of Phytochemicals in Alzheimer's Disease Revolutionizing Neurotherapeutics: Nanocarriers Unveiling the Potential of Phytochemicals in Alzheimer's Disease Nanoparticles crossing blood-brain barrier need specific design for normal, neurodegenerative or cancerous brain conditions Nanocarrier drug delivery system: promising platform for targeted depression therapy Cannabidiol and Neurodegeneration: From Molecular Mechanisms to Clinical Benefits Cannabidiol and Neurodegeneration: From Molecular Mechanisms to Clinical Benefits Microfluidics-enabled mesenchymal stem cell derived Neuron like cell membrane coated nanoparticles inhibit inflammation and apoptosis for Parkinson's Disease Bohemian Rhapsody of Future Drug Delivery Systems: Rational Changes Necessary for the Next Revolution Neurodevelopmental changes in Drosophila melanogaster are restored by treatment with lutein-loaded nanoparticles: Positive modulation of neurochemical and behavioral parameters Neurodevelopmental changes in Drosophila melanogaster are restored by treatment with lutein-loaded nanoparticles: Positive modulation of neurochemical and behavioral parameters Physiological Microenvironment Dependent Self-Cross-Linking of Multifunctional Nanohybrid for Prolonged Antibacterial Therapy via Synergistic Chemodynamic-Photothermal-Biological Processes Amino Acid Transporters in Neurological Disorders and Neuroprotective Effects of Cysteine Derivatives Predicting blood-brain barrier permeability of molecules with a large language model and machine learning Strategies for enhanced gene delivery to the central nervous system Strategies for enhanced gene delivery to the central nervous system Improving the Biocompatibility and Functionality of Neural Interface Devices with Silica Nanoparticles Nanomaterials that Aid in the Diagnosis and Treatment of Alzheimer's Disease, Resolving Blood-Brain Barrier Crossing Ability Softening the tumor matrix through cholesterol depletion breaks the physical barrier for enhanced antitumor therapy Lipid Nanoparticle-Mediated Delivery of CRISPR-Cas9 Against Rubicon Ameliorates NAFLD by Modulating CD36 Along with Glycerophospholipid Metabolism Natural Product-Inspired Dopamine Receptor Ligands Current Findings and Potential Mechanisms of KarXT (Xanomeline-Trospium) in Schizophrenia Treatment Drug repurposing for neurodegenerative diseases Targeting chronic liver diseases: Molecular markers, drug delivery strategies and future perspectives Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier Protocol for delivering proteins, peptides, and shRNAs via the intrathecal route in the experimental allergic encephalomyelitis mouse model Therapeutic resurgence of 6-diazo-5-oxo-l-norleucine (DON) through tissue-targeted prodrugs Advances in medical polyesters for vascular tissue engineering Camouflaging nanoreactor traverse the blood-brain barrier to catalyze redox cascade for synergistic therapy of glioblastoma Camouflaging nanoreactor traverse the blood-brain barrier to catalyze redox cascade for synergistic therapy of glioblastoma Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening Unique Properties of Synaptosomes and Prospects for Their Use for the Treatment of Alzheimer's Disease Gut-brain axis: A cutting-edge approach to target neurological disorders and potential synbiotic application Gut-brain axis: A cutting-edge approach to target neurological disorders and potential synbiotic application Silica nanoparticles induce liver lipid metabolism disorder via ACSL4-mediated ferroptosis New insights into sodium phenylbutyrate as a pharmacotherapeutic option for neurological disorders Glucocorticoids-based prodrug design: Current strategies and research progress Drug Evaluation of Parkinson's Disease Patient-Derived Midbrain Organoids Using Mesoporous Au Nanodot-Patterned 3D Concave Electrode Contribution of CNS and extra-CNS infections to neurodegeneration: a narrative review Preclinical systemic pharmacokinetics, dose-proportionality, and CNS distribution of the ATM inhibitor WSD0628, a novel radiosensitizer for the treatment of brain tumors Exosome for mRNA delivery: strategies and therapeutic applications Exploring the gut-brain Axis: Potential therapeutic impact of Psychobiotics on mental health The blood brain barrier dysfunction in healthy aging and dementia: why, how, what for? The blood brain barrier dysfunction in healthy aging and dementia: why, how, what for? Optimisation of pharmacotherapy in psychiatry through therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests: focus on antipsychotics Resmetirom's Approval: Highlighting the Need for Comprehensive Approaches in NASH Therapeutics Understanding the Potential of CBD for Health Benefits: an Overview The distribution of neurotransmitters in the brain circuitry: mesolimbic pathway and addiction P-glycoprotein activity in vivo in older adults: physiological, pathophysiological and pharmacokinetic interplay at the blood-brain barrier Dissolving microarray patches for transdermal delivery of risperidone for schizophrenia management Nanocellulose extraction from acai bagasse through mixed acid hydrolysis and oxidative techniques Causal relationship between PCSK9 inhibitor and common neurodegenerative diseases: A drug target Mendelian randomization study A Visual Approach for Inducing Dolichoectasia in Mice to Model Large Vessel-Mediated Cerebrovascular Dysfunction A Visual Approach for Inducing Dolichoectasia in Mice to Model Large Vessel-Mediated Cerebrovascular Dysfunction Research progress on astrocyte-derived extracellular vesicles in the pathogenesis and treatment of neurodegenerative diseases Global trends and hotspots in research on acupuncture for neurodegenerative diseases over the last decade: a bibliometric and visualization analysis Laser-activated perfluorocarbon nanodroplets for intracerebral delivery and imaging via blood-brain barrier opening and contrast-enhanced imaging The effects of simvastatin-loaded nanoliposomes on human multilineage liver fibrosis microtissue Curcumin and nano-curcumin applications in psychiatric disorders From Gut Microbiomes to Infectious Pathogens: Neurological Disease Game Changers
Evidence Blueprint
Herbal Nanoparticles: A targeted approach for Neurodegenerative disorder Treatment
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Herbal Nanoparticles: A targeted approach for Neurodegenerative disorder Treatment
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Tau- and α-synuclein-targeted gold nanoparticles: applications, opportunities, and future outlooks in the diagnosis and therapy of neurodegenerative diseases Application of quality by design in optimization of nanoformulations: Principle, perspectives and practices Small Scale, Big Impact: Nanotechnology-Enhanced Drug Delivery for Brain Diseases Small Particles, Big Potential: Polymeric Nanoparticles for Drug Delivery in Parkinson's Disease Exploring the potential of quercetin in Alzheimer's Disease: Pharmacodynamics, Pharmacokinetics, and Nanodelivery systems Optimization of Lurasidone HCl-Loaded PLGA Nanoparticles for Intramuscular Delivery: Enhanced Bioavailability, Reduced Dosing Frequency, Pharmacokinetics, and Therapeutic Outcomes Revolutionizing Neurotherapeutics: Nanocarriers Unveiling the Potential of Phytochemicals in Alzheimer's Disease Revolutionizing Neurotherapeutics: Nanocarriers Unveiling the Potential of Phytochemicals in Alzheimer's Disease Machine learning assisted-nanomedicine using magnetic nanoparticles for central nervous system diseases Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review Cell-mediated nanoparticle delivery systems: towards precision nanomedicine Receptor Ligand-Free Mesoporous Silica Nanoparticles: A Streamlined Strategy for Targeted Drug Delivery across the Blood-Brain Barrier Regulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles Metabolic dysfunction-associated steatohepatitis treated by poly(ethylene glycol)-block-poly(cysteine) block copolymer-based self-assembling antioxidant nanoparticles Nanopharmacology as a new approach to treat neuroinflammatory disorders New retinoblastoma (RB) drug delivery approaches: anti-tumor effect of atrial natriuretic peptide (ANP)-conjugated hyaluronic-acid-coated gold nanoparticles for intraocular treatment of chemoresistant RB Blood-brain barrier disruption in dementia: Nano-solutions as new treatment options Aurothioglucose encapsulated nanoparticles fostered neuroprotection in streptozotocin-induced Alzheimer's disease Modeling the Drug delivery Lifecycle of PLG Nanoparticles Using Intravital Microscopy Microgel Encapsulated Nanoparticles for Intra-articular Disulfiram Delivery to Treat Osteoarthritis Flash nanoprecipitation allows easy fabrication of pH-responsive acetalated dextran nanoparticles for intracellular release of payloads Magnetic hybrid nanovesicles for the precise diagnosis and treatment of central nervous system disorders Nanoparticles crossing blood-brain barrier need specific design for normal, neurodegenerative or cancerous brain conditions Diabetes: a review of its pathophysiology, and advanced methods of mitigation Comparison of the protective effects of CS/TPP and CS/HPMCP nanoparticles containing berberine in ethanol-induced hepatotoxicity in rat Nanocarrier drug delivery system: promising platform for targeted depression therapy Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer's disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology and amyloidogenesis Antimicrobial effect of hydro-alcoholic extract of apple with and without zinc oxide nanoparticles on Streptococcus Mutans Cannabidiol and Neurodegeneration: From Molecular Mechanisms to Clinical Benefits Cannabidiol and Neurodegeneration: From Molecular Mechanisms to Clinical Benefits Magnetic separation, sunlight-driven photocatalytic activity, and antibacterial studies of Sm-doped Co0.33Mg0.33Ni0.33Fe2O4 nanoparticles Intranasal Delivery of Curcumin Nanoparticles Improves Neuroinflammation and Neurological Deficits in Mice with Intracerebral Hemorrhage Microfluidics-enabled mesenchymal stem cell derived Neuron like cell membrane coated nanoparticles inhibit inflammation and apoptosis for Parkinson's Disease Protection by Nano-Encapsulated Bacoside A and Bacopaside I in Seizure Alleviation and Improvement in Sleep- In Vitro and In Vivo Evidences Bohemian Rhapsody of Future Drug Delivery Systems: Rational Changes Necessary for the Next Revolution An overview of in vitro and in vivo techniques for characterization of intranasal protein and peptide formulations for brain targeting Neurodevelopmental changes in Drosophila melanogaster are restored by treatment with lutein-loaded nanoparticles: Positive modulation of neurochemical and behavioral parameters Neurodevelopmental changes in Drosophila melanogaster are restored by treatment with lutein-loaded nanoparticles: Positive modulation of neurochemical and behavioral parameters Physiological Microenvironment Dependent Self-Cross-Linking of Multifunctional Nanohybrid for Prolonged Antibacterial Therapy via Synergistic Chemodynamic-Photothermal-Biological Processes Co-encapsulated astaxanthin and kaempferol nanoparticles: fabrication, characterization, and their potential synergistic effects on treating non-alcoholic fatty liver disease Amino Acid Transporters in Neurological Disorders and Neuroprotective Effects of Cysteine Derivatives Selective and Controlled Release Responsive Nanoparticles with Adsorption-Pairing Synergy for Anthocyanin Extraction Magnetically actuated pandanus fruit-like nanorobots for enhanced pH-stimulated drug release and targeted biofilm elimination in wound healing pH-responsive targeted nanoparticles release ERK-inhibitor in the hypoxic zone and sensitize free gemcitabine in mutant K-Ras-addicted pancreatic cancer cells and mouse model Effects of selenium nanoparticles produced by Lactobacillus acidophilus HN23 on lipid deposition in WRL68 cells Green synthesis of carbon nanotubes functionalized with iron nanoparticles and coffee husk biomass for efficient removal of losartan and diclofenac: Adsorption kinetics and ANN modeling studies Predicting blood-brain barrier permeability of molecules with a large language model and machine learning Strategies for enhanced gene delivery to the central nervous system Strategies for enhanced gene delivery to the central nervous system Poly(vinyl chloride)/Nanocarbon Composites for Advanced Potentiometric Membrane Sensor Design Relevance of alcoholic solvents in the growth of ZnO nanoparticles and ZnO hierarchical nanorod structures on their optical and opto-electrical properties Improving the Biocompatibility and Functionality of Neural Interface Devices with Silica Nanoparticles Focused Ultrasound as a Novel Non-Invasive Method for the Delivery of Gold Nanoparticles to Retinal Ganglion Cells Nanomaterials that Aid in the Diagnosis and Treatment of Alzheimer's Disease, Resolving Blood-Brain Barrier Crossing Ability Design, Development, Evaluation, and In Vivo Performance of Buccal Films Embedded with Paliperidone-Loaded Nanostructured Lipid Carriers Antioxidants and mitochondrial/lysosomal protective agents reverse toxicity induced by titanium dioxide nanoparticles on human lymphocytes Multimodal neuro-nanotechnology: Challenging the existing paradigm in glioblastoma therapy Prediction of blood-brain barrier penetrating peptides based on data augmentation with Augur Softening the tumor matrix through cholesterol depletion breaks the physical barrier for enhanced antitumor therapy Drug Delivery Angle for Various Atherosclerosis and Aneurysm Percentages of the Carotid Artery Targeting NLRP3 inflammasome for neurodegenerative disorders Lipid Nanoparticle-Mediated Delivery of CRISPR-Cas9 Against Rubicon Ameliorates NAFLD by Modulating CD36 Along with Glycerophospholipid Metabolism A Dual-Responsive Morphologically-Adaptable Nanoplatform for Targeted Delivery of Activatable Photosensitizers in Precision Photodynamic Therapy Natural Product-Inspired Dopamine Receptor Ligands