Evidence
J Chin Med Assoc. 2024 Apr 24. doi: 10.1097/JCMA.0000000000001100. Online ahead of print.
ABSTRACT
BACKGROUND: Current evidence of volume changes in hippocampal subdivisions in schizophrenia remains inconsistent, and few studies have investigated the relationship between regional hippocampal volumes and symptom remission.
METHODS: In this cross-sectional study, we recruited 31 patients with schizophrenia and 31 healthy controls (HCs). Symptomatic remission in schizophrenia was determined according to Remission in Schizophrenia Working Group criteria. The volumes of hippocampal longitudinal subregions and transverse subfields were measured using manual and automatic techniques, respectively. Between-group regional hippocampal volume differences were analyzed using multivariate analysis of covariance followed by univariate analysis of covariance.
RESULTS: Compared with the HCs, the patients with schizophrenia had smaller bilateral heads and tails along the longitudinal axis; they also had reduced volumes of the bilateral CA1, CA3, CA4, GC-ML-DG, molecular layer, tail, left subiculum, left HATA, and right parasubiculum along the transverse axis in the hippocampus (all corrected p < 0.05). Furthermore, compared with the HCs and patients with remitted schizophrenia, the patients with non-remitted schizophrenia had smaller bilateral hippocampal tail subfields (corrected p < 0.05).
CONCLUSION: Our results indicated that the pathophysiology and symptomatic remission of schizophrenia are related to changes in the volumes of hippocampal subdivisions. These volume changes might be clinically relevant as biomarkers for schizophrenia identification and treatment.
PMID:38656303 | DOI:10.1097/JCMA.0000000000001100
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Hippocampal subfields in remitted schizophrenia
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- The associations of peripheral interleukin alterations and hippocampal subfield volume deficits in schizophrenia
- Longitudinal study on hippocampal subfields and glucose metabolism in early psychosis
- Hippocampal, thalamic, and amygdala subfield morphology in major depressive disorder: an ultra-high resolution MRI study at 7-Tesla
- Lower plasma tumor necrosis factor-alpha is associated with symptomatic remission in patients with schizophrenia
- Lower plasma tumor necrosis factor-alpha is associated with symptomatic remission in patients with schizophrenia
- Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort
- Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort
- Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort
- An uncommon neuroradiological finding of hippocampal malrotation in childhood onset schizophrenia and 22q11.2 Deletion Syndrome: a case report and a brief review of the literature
- Evaluation of inflammatory markers obtained from complete blood count in different stages of schizophrenia
- Evaluation of inflammatory markers obtained from complete blood count in different stages of schizophrenia
- Evaluation of inflammatory markers obtained from complete blood count in different stages of schizophrenia
- Association of sarcopenia with regional brain atrophy and white matter lesions in a general older population: the Hisayama Study
- The association between symptomatic remission and social support in community-dwelling schizophrenia patients during COVID-19
- The association between symptomatic remission and social support in community-dwelling schizophrenia patients during COVID-19
- Targeting the Manifestations of Subclinical and Overt Hypothyroidism Within the Hippocampus
- Remission in schizophrenia spectrum disorders: A randomized trial of amisulpride, aripiprazole and olanzapine
- Identification of novel genetic loci associated with major depressive disorder and the hippocampus in a European population using the condFDR method
- Publisher Correction: Longitudinal study on hippocampal subfields and glucose metabolism in early psychosis
- Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia
- Hippocampus and amygdala volumes are reduced in patients with schizoaffective disorder
- Hippocampus and amygdala volumes are reduced in patients with schizoaffective disorder
- Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adults
- Adjustment of Regional Cortical Thickness Measures for Global Cortical Thickness Obscures Deficits Across the Schizophrenia Spectrum: A Cautionary Note about Normative Modeling of Brain Imaging Data
- Hippocampal Availability of the α7 Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis
- Hippocampal Availability of the α7 Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis
- Hippocampal Availability of the alpha7 Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis
- Genetic determinants of coping, resilience and self-esteem in schizophrenia suggest a primary role for social factors and hippocampal neurogenesis
- Reduced hippocampal volume unmasks distinct impacts of cumulative adverse childhood events (ACEs) on psychotic-like experiences in late childhood and early adolescence
- Topological abnormalities of the morphometric similarity network of the cerebral cortex in schizophrenia
- The Impact of Childhood Trauma on the Negative Symptoms of Schizophrenia
- Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
- Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
- Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
- Trustworthiness judgments and pupil-size in individuals with schizophrenia
- Hippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis Risk
- Developing Topics
- Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training
- Assessment of socio-demographic characteristics and social status of patients with negative symptoms in schizophrenia at different stages of the disease
- Sex-specific effects of subchronic NMDA receptor antagonist MK-801 treatment on hippocampal gamma oscillations
- Sex-specific effects of subchronic NMDA receptor antagonist MK-801 treatment on hippocampal gamma oscillations
- Minor physical anomalies in schizophrenia and first-degree relatives in comparison to healthy controls: A systematic review and meta-analysis
- Dysfunction of thalamocortical circuits in early-onset schizophrenia
- Distinct Patterns of Brain Atrophy in amnestic Mild Cognitive Impairment and Motoric Cognitive Risk Syndromes
- Frontal brain volume correlates of impaired executive function in schizophrenia
- Frontal brain volume correlates of impaired executive function in schizophrenia
- Depressive symptoms during the transition to adolescence: Left hippocampal volume as a marker of social context sensitivity
- Treatment Outcomes for Asian Americans Diagnosed with Schizophrenia Spectrum Disorder
- Beyond the Hippocampus: Amygdala and Memory Functioning in Older Adults
- Clinical, cognitive, and functional characteristics of recent-onset psychosis with autistic features: A 2-year longitudinal study
- Increased and sex-differentiated medial prefrontal cortex activation during the MATRICS Consensus Cognitive Battery in schizophrenia: A fNIRS study
- Increased and sex-differentiated medial prefrontal cortex activation during the MATRICS Consensus Cognitive Battery in schizophrenia: A fNIRS study
- The relationship between adult hippocampal neurogenesis and cognitive impairment in Alzheimer's disease
- Location-based differences in cognition and functional capacity: Consistent levels of impairment in participants with schizophrenia compared to healthy controls
- Correlations between Immunoinflammatory Factor Levels and Cognitive Functions and Brain Structural Magnetic Resonance Imaging Features among Patients with Primary Schizophrenia
- Heavy metal concentrations and clinical symptoms in patients diagnosed with schizophrenia related to cigarette smoking
- Characterization and modulation of voltage-gated potassium channels in human lymphocytes in schizophrenia
- Identification of schizophrenia by applying interpretable radiomics modeling with structural magnetic resonance imaging of the cerebellum
- Association between reduced plasma BDNF concentration and MMSE scores in both chronic schizophrenia and mild cognitive impairment
- Neuroretinal Alterations in Schizophrenia and Bipolar Disorder: An Updated Meta-analysis
- Non-linear development of brain morphometry in child and adolescent offspring of individuals with bipolar disorder or schizophrenia
- Machine learning classification of functional neurological disorder using structural brain MRI features
- Deciphering language disturbances in schizophrenia: A study using fine-tuned language models
- Evaluation of systemic immune inflammation index and neutrophil-to-lymphocyte ratio in schizophrenia, bipolar disorder and depression
Evidence Blueprint
Hippocampal subfields in remitted schizophrenia
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Hippocampal subfields in remitted schizophrenia
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- The associations of peripheral interleukin alterations and hippocampal subfield volume deficits in schizophrenia
- Smaller anterior hippocampal subfields in the early stage of psychosis
- Machine learning classifiers and associations of cognitive performance with hippocampal subfields in amnestic mild cognitive impairment
- Longitudinal study on hippocampal subfields and glucose metabolism in early psychosis
- Effects of healthy aging and mnemonic strategies on verbal memory performance across the adult lifespan: Mediating role of posterior hippocampus
- Hippocampal, thalamic, and amygdala subfield morphology in major depressive disorder: an ultra-high resolution MRI study at 7-Tesla
- Differential longitudinal changes of hippocampal subfields in patients with anorexia nervosa
- Volume of the Dentate Gyrus/CA4 Hippocampal subfield mediates the interplay between sleep quality and depressive symptoms
- Medial positioning of the hippocampus and hippocampal fissure volume in developmental topographical disorientation
- Volumetric analysis of hippocampal subregions and subfields in left and right semantic dementia
- Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases
- Lower plasma tumor necrosis factor-alpha is associated with symptomatic remission in patients with schizophrenia
- Lower plasma tumor necrosis factor-alpha is associated with symptomatic remission in patients with schizophrenia
- Less is more: Smaller hippocampal subfield volumes predict greater improvements in posttraumatic stress disorder symptoms over 2 years
- Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort
- Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort
- Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort
- Hippocampal subfield volumes predict treatment response to oral ketamine in people with suicidality
- Longitudinal hippocampal subfield development associated with psychotic experiences in young people
- Memory Impairment in Amyloidβ-status Alzheimer's disease is associated with a reduction in CA1 and dentate gyrus volume: in vivo MRI at 7T
- Limbic brain subregions associated with mental health symptoms in youth with and without prenatal alcohol exposure
- An uncommon neuroradiological finding of hippocampal malrotation in childhood onset schizophrenia and 22q11.2 Deletion Syndrome: a case report and a brief review of the literature
- Relation of hippocampal volume and SGK1 gene expression to treatment remission in major depression is moderated by childhood maltreatment: A CAN-BIND-1 report
- Relationship between hippocampal subfield volumes and cognitive decline in healthy subjects
- Cerebro-cerebellar gray matter abnormalities associated with cognitive impairment in patients with recent-onset and chronic schizophrenia
- Biomarkers of neurodegeneration in schizophrenia: systematic review and meta-analysis
- Hippocampal subfield associations with memory depend on stimulus modality and retrieval mode
- Cannabis Dependence is Associated with Reduced Hippocampal Subregion Volumes Independently of Sex: Findings from an ENIGMA Addiction Working Group Multi-Country Study
- Evaluation of inflammatory markers obtained from complete blood count in different stages of schizophrenia
- Evaluation of inflammatory markers obtained from complete blood count in different stages of schizophrenia
- Evaluation of inflammatory markers obtained from complete blood count in different stages of schizophrenia
- TDP-43 Is Associated with Subiculum and Cornu Ammonis 1 Hippocampal Subfield Atrophy in Primary Age-Related Tauopathy
- Association of sarcopenia with regional brain atrophy and white matter lesions in a general older population: the Hisayama Study
- The association between symptomatic remission and social support in community-dwelling schizophrenia patients during COVID-19
- The association between symptomatic remission and social support in community-dwelling schizophrenia patients during COVID-19
- Hippocampal volume changes across developmental periods in female migraineurs
- Targeting the Manifestations of Subclinical and Overt Hypothyroidism Within the Hippocampus
- Sex-Specific Association of Body Mass Index with Hippocampal Subfield Volume and Cognitive Function in Non-Demented Chinese Older Adults
- Hippocampal subfield volumes in treatment resistant depression and serial ketamine treatment
- Striatum and globus pallidus structural abnormalities in schizophrenia: A retrospective study of the different stages of the disease
- Distinct Volume Alterations of Thalamic Nuclei Across the Schizophrenia Spectrum
- Functional connectivity changes of the hippocampal subregions in anti-N-methyl-D-aspartate receptor encephalitis
- Remission in schizophrenia spectrum disorders: A randomized trial of amisulpride, aripiprazole and olanzapine
- Identification of novel genetic loci associated with major depressive disorder and the hippocampus in a European population using the condFDR method
- Hemispheric asymmetries in hippocampal volume related to memory in left and right temporal variants of frontotemporal degeneration
- Structural Neuroimaging of Hippocampus and Amygdala Subregions in Posttraumatic Stress Disorder: A Scoping Review
- Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study
- The altered volume of striatum: A neuroimaging marker of treatment in first-episode and drug-naive schizophrenia
- Publisher Correction: Longitudinal study on hippocampal subfields and glucose metabolism in early psychosis
- Effects of web-based adapted physical activity on hippocampal plasticity, cardiorespiratory fitness, symptoms, and cardiometabolic markers in patients with schizophrenia: a randomized, controlled study
- Atherosclerosis and Hippocampal Volumes in Older Adults: The Role of Age and Blood Pressure
- Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia
- Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia
- Hippocampus and amygdala volumes are reduced in patients with schizoaffective disorder
- Hippocampus and amygdala volumes are reduced in patients with schizoaffective disorder
- Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adults
- Enlarged pituitary gland volume: a possible state rather than trait marker of psychotic disorders
- Videogame training increases clinical well-being, attention and hippocampal-prefrontal functional connectivity in patients with schizophrenia
- Comparison of Quantitative Hippocampal Volumes and Structured Scoring Scales in Predicting Alzheimer Disease Diagnosis
- Hippocampal volume loss in individuals with a history of non-fatal opioid overdose
- Adjustment of Regional Cortical Thickness Measures for Global Cortical Thickness Obscures Deficits Across the Schizophrenia Spectrum: A Cautionary Note about Normative Modeling of Brain Imaging Data
- Symptomatic remission and recovery in major psychosis: Is there a role for BDNF? A secondary analysis of the LABSP cohort data
- Hypothalamic Subunit Volumes in Schizophrenia and Bipolar Spectrum Disorders
- Trauma-related intrusive memories and anterior hippocampus structural covariance: an ecological momentary assessment study in posttraumatic stress disorder