Hist Psychiatry. 2025 Apr 28:957154X251318489. doi: 10.1177/0957154X251318489. Online ahead of print.
ABSTRACT
This paper provides an overview of psychedelic research at the Mayo Clinic in the 1950s and 1960s, focusing on methods, objectives, findings, and ethical practices. We highlight instances where researchers prioritized scientific progress over the autonomy, safety, and equitable treatment of research subjects, and discuss this history in the context of ongoing challenges with informed consent and equity in contemporary psychedelic research.
PMID:40293719 | DOI:10.1177/0957154X251318489
AI-Assisted Evidence Search
Share Evidence Blueprint
Search Google Scholar
RAISR4D Evidence Matrix
Jacqueline Anne Potter:… Peter Westwell, Mary Cunningham,… The use and misuse of power in… Gender-informed and place-based… About Psychiatryai.com Christopher Brazil: Prevention… Reporting and Representation of… Linda Sitch: Prevention of… Sheila Edwards: Prevention of… Lorraine Parker: Prevention of… Exploring the relationship… Game Design, Effectiveness, and… Political economy of adolescent… Evaluation of a participatory… Redefining and solving the… Personality assessment inventory… Cannabis and psychopathology:… Uncovering Genetic Risk Beyond… Validity and Reliability Study… Distinct Convergent Brain… Distinct Convergent Brain… Participants' Experience of… Risk and Protective Factors… Women's experiences of… The mediating role of adult… The role of the brain-bone axis… A cross-sectional study of… Identifying Alcohol Use Disorder… Characterization and Evaluation… Raymond Mills: Prevention of… Depression and Anxiety Among… Health leaders' perspectives and… Feasibility and acceptability of… Acceptability, feasibility, and… Neighborhood disorder and… Stepping Stones and Creating… A systematic narrative review of… Transgender and nonbinary young… Discussing end-of-life care for… Linking inclusive school… Melatonin supplementation: new… The Role of Women's Empowerment… Violence experience among… Examination of Patient and… Global burden and trend of… Investigating Protective and… Trauma systems: a global comparison Suicidal ideation, attempted… Factors that affect clinical… Unique and overlapping… The antidepressant effects of… The Applications of Large… Acceptability and Usability of a… AI-driven early diagnosis of… Comparison and cutoff values of… Legal gender recognition and the… Mental health literacy: a… Changes in the prevalence of… Psychometric Properties of… Experiences and Perceptions of… Childhood maltreatment and… Iris Carter: Prevention of… Updates on digital mental health… Predicting happiness in the… Positive Emotion Dysregulation… Machine Learning Multimodal… Study protocol for a randomized… The association between hot days… Research Participant Interest in… Research on Turkish and U.S.… Psychological first aid for… Joint and distinct neural… Social Safety and Health… Redlining, reinvestment, and… Quantitative Evidence for… "And I don't know how I can… PSYCHOLOGICAL FEATURES OF THE… Prevalence of anxiety disorders… Climate change, resource… Differentiating pure cognitive… Multi-sector determinants of… Performance of the 2021… The Challenges of Decolonising… Oral health and oral health… Screening and Response for… Stigmatizing attitudes and… Neurodevelopmental Disorders in… Mental health homicide inquiries… The Prevalence and Incidence of… Individual placement and… Effective connectivity… Six-year trajectories of core… Factors influencing the… Antipsychotic Acute-Phase… Association of gender-based… Transcriptomic and epigenomic… LONG-TERM DEVELOPMENT OF 12- AND… Patient Perspectives on a Rapid… Negative Affect Circuit Subtypes… Sexual Trauma, Suicide, and… Reflective mindfulness and… Power and possibility: an… Lessons learned from the… "No peace in my heart":… Shadows of trauma: an umbrella… Peripheral tissue BDNF… Chronic fatigue syndrome,… Sexual Violence Among a State… Compliance with mandatory… COVID-19 isolation and recovery… Medicaid reimbursement for… Developing a brief online… Professionals' and Families'… A Social-Ecological Model to… Trends and Disparities in… Mental Wellbeing and its… Workplace Bullying and Coping… 16 weeks of moderate intensity… Juvenile Delinquency in Kashmir:… Effects of cognitive combined… Using Social Media to Recruit a… Digital interventions in mental… Maternal Cardiometabolic Risk… Adverse childhood experiences… Exploring the association… The psychometric properties of… Difficult Airway Management: An… Standardizing Advanced Training… A Computational Approach to… PREVALENCE AND SOCIO-DEMOGRAPHIC… Black and Minoritized Women's… A cash transfer plus gender… Media Discourse, Influence, and… Cerebrovascular Pathology and… The effect of anti-CD20 on… The effect of anti-CD20 on… Violence Against Administrators:… Lifetime prevalence of psychotic… Harms to children from men's… Effect of person-centered… Interventions to Foster Mental… Mediating role of coping… Fiscal Impact of Expanded… Toward an understanding of… Autistic Traits Are Associated… War impact on mental health and… Medicaid Costs and Outcomes for… Clustering analysis of risk… Relationships among cortical… BDNF mediates the heart-brain… The impact of social… Evaluating the effectiveness of… The reliability of medical… Fremanezumab for the Treatment… Validation of the… Community-based interventions… Associations of childhood… "Maladaptive Stress-Coping… The Mediating Role of Authentic… Maternal Disability and… Attributes that influence… Assessing a Digital Tool to… Psychosocial stress in families… Predicting Agitation Events in… Suicide risk assessment and… Readdressing the Ongoing… Psychological traits associated… The development and validation… Access to justice for Ethiopian… Racial and Ethnic Disparities in… Construction of a novel five… Gut microbiota variations in… Female sex workers' perceptions,… Cerebral blood flow increases in… Introduction to the "Japanese… A Rent Subsidy and Identity… Medical preparedness for… Demographic variation in… What's in a Shame? Rethinking… Lessons from a Community-Based… Design of a public health… Associations of Collegiate… Feasibility and usability of… Virtual Versus In-Person… Heart Rate Variability… Early Experience With Postmortem… The Effect of Environmental… Varenicline for Youth Nicotine… Varenicline for Youth Nicotine… Prevalence and Impact of Sexual… A Predictive Nomogram for… A retrospective cross-sectional… Psychoanalysis, criminology and… Association of whole-body and… Benzodiazepines use and… Different behavior of NK cells… Cerebrospinal Fluid Biomarkers… One-year outcomes in sepsis: a… Unraveling the stigma: a… Mental Health, Psychological… Impact of Medical Comorbidities… Effects of exercise-cognitive… Clinical characteristics and… Clinical characteristics and… Protein-truncating variants and… A Qualitative Study Exploring… A Qualitative Study Exploring… The behavioral health needs of… Bullying victimization and… Desire to Die Communication… "They're Lacking Purpose. It's a… Resistance and resilience to… Mental health and… Classroom Debate as a… Distinct gray matter and… Duration of untreated or… Orthorexia in… Relationships between nurses'… Epidemiology and predictors of… "Stuck Due to COVID": Applying… Nurse-Led Mental Health… Detection Bias in EHR-Based… Detection Bias in EHR-Based… Parenting Training Plus… Why administration of lethal…