Evidence
J Pediatr Endocrinol Metab. 2023 Jul 10. doi: 10.1515/jpem-2022-0532. Online ahead of print.
ABSTRACT
OBJECTIVES: Metabolic syndrome (MetS) is a cluster of conditions linked to obesity that increases cardiovascular risk. We evaluated the frequency of clinical abnormalities associated with overweight and obesity in childhood, to determine whether a diagnosis of MetS is appropriate in this population.
METHODS: Cross-sectional study with 116 pubertal and prepubertal children with a mean age (SD) of 10.9 (2.5) years, with overweight and obesity. We defined MetS using the International Diabetes Federation criteria, regardless of the age.
RESULTS: 45 patients met the criteria, 20 had at least one metabolic abnormality in addition to a high waist circumference (WC), and seven with WC below percentile 90th, had at least one metabolic abnormality. The prepubertal had higher zBMI [3.1 (2.6-3.8) vs. 2.8 (2.4-3.3); p=0.037], less lean body mass (kg) [27.13 (7.3) vs. 34.13 (9.8); p=0.005] and a similar frequency of non-alcoholic fatty liver disease (NAFLD) compared to the pubertal [44.7 vs. 35.9; p=0.323]. Prepubertal with NAFLD had higher zBMI, lower HDL levels, higher TG/HDL ratios and higher fat percentages; while pubertal with NAFLD had higher WC/height, aspartate aminotransferase and oxaloacetic transaminase.
CONCLUSIONS: The diagnosis of MetS in childhood is not fundamental. Individualized management, focusing on the earliest age groups, in which we identified a more severe degree of obesity, should be done. We also recommend screening for NAFLD in all ages, due to the high prevalence observed.
PMID:37422722 | DOI:10.1515/jpem-2022-0532
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Metabolic risk factors in prepubertal and pubertal patients with overweight and obesity
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Controlled Study of Metabolic Syndrome Among Offspring of Parents With Bipolar Disorder
- The epigenetic mechanism of metabolic risk in bipolar disorder
- Research advances in understanding crosstalk between organs and pancreatic β-cell dysfunction
- Interaction of periodontal clinical indicators in metabolic syndrome and nonalcoholic fatty liver disease: Implications for preventive interventions
- Liraglutide in the management of obesity: real world data (Portugal)
- Association between non-alcoholic fatty liver disease and metabolic abnormalities in children with different weight statuses
- Cardiovascular risk reduction in type 2 diabetes: What the non-specialist needs to know about current guidelines
- Food addiction and the physical and mental health status of adults with overweight and obesity
- In-hospital outcomes in COVID-19 patients with non-alcoholic fatty liver disease by severity of obesity: Insights from national inpatient sample 2020
- Impact of Changes in Lifestyle and Psychological Factors on the Incidence of Metabolic Syndrome after the Great East Japan Earthquake: Follow-up of the Fukushima Health Management Survey
- Treatment adherence and nasogastric tube use in hospitalized youth with anorexia nervosa and premorbid overweight/obesity
- Association between postterm birth and adverse growth outcomes in children aged 3-6 years: A national retrospective cohort study
- Analyzing and evaluating the prevalence and metabolic profile of lean NAFLD compared to obese NAFLD: a systemic review and meta-analysis
- Childhood obesity's impact on cognition and brain connectivity worsens with low family income
- Cognitive impairment in patients with obesity and impaired carbohydrate metabolism (dysglycemia)
- Alanine aminotransferase as a risk marker for new-onset metabolic dysfunction-associated fatty liver disease
- Prevalence and diagnosis of polycystic ovary syndrome (PCOS) in adolescents - what's new in 2023? Systematic review
- Reduction of Antibiotic-Associated Conditions After Tympanostomy Tube Placement in Children
- Reduction of Antibiotic-Associated Conditions After Tympanostomy Tube Placement in Children
- Dementia and metabolic syndrome: a bibliometric analysis
- Role and mechanism of specialized pro-resolving mediators in obesity-associated insulin resistance
- Low circulating levels of neuregulin 4 as a potential biomarker associated with the severity and prognosis of obesity-related metabolic diseases: a systematic review
- Metabolic dysfunction-associated steatotic liver disease prevalence and risk factors in inflammatory bowel disease in tertiary center
- Effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease: Clinical implications
- Bariatric Surgery in Obesity: Metabolic Quality Analysis and Comparison of Surgical Options
- Cognitive ability, education, height and body mass index in relation to risk of schizophrenia and mortality following its diagnosis
- Camu-camu decreases hepatic steatosis and liver injury markers in overweight, hypertriglyceridemic individuals: A randomized crossover trial
- Causes, Consequences, and Preventive Strategies for Childhood Obesity: A Narrative Review
- Fecal virome transplantation: A promising strategy for the treatment of metabolic diseases
- Fecal virome transplantation: A promising strategy for the treatment of metabolic diseases
- Inadequate insurance coverage for overweight/obesity management
- Obesity: exploring its connection to brain function through genetic and genomic perspectives
- THE ROLE OF FGF19 IN METABOLIC REGULATION: INSIGHTS FROM PRECLINICAL MODELS TO CLINICAL TRIALS
- THE ROLE OF FGF19 IN METABOLIC REGULATION: INSIGHTS FROM PRECLINICAL MODELS TO CLINICAL TRIALS
- Multi-omics analysis reveals the impact of gut microbiota on antipsychotic-induced weight gain in schizophrenia
- Bariatric-Metabolic Surgery is the Most Effective Intervention in Reducing Food Addiction Symptoms: A Systematic Review and Meta-Analysis
- A review on cell-Free RNA Profiling: insights into metabolic diseases and predictive value for bariatric surgery outcomes
- Association of EEG and cognitive impairment in overweight and non-overweight patients with schizophrenia
- Validity of the Addiction-like Eating Behavior Scale among Patients with Compulsive Eating
- "A balancing act": parents' longitudinal perspectives of weight-related discussions with their children following obesity treatment
- Sesaminol alters phospholipid metabolism and alleviates obesity-induced NAFLD
- Reconsidering the role of depression and common psychiatric disorders as partners in the type 2 diabetes epidemic
- Metabolic Dysfunction-Associated Steatotic Liver Disease in Severe Obesity and Concordance Between Invasive (Biopsy) and Non-Invasive (OWLiver®) Diagnoses
- Effects of a New Group of Antidiabetic Drugs in Metabolic Diseases
- Household chaos and childhood obesity-related health outcomes
- Mental health and BMI in children and adolescents during one year in obesity treatment
- Association of whole blood copper, zinc, calcium, magnesium, and iron with non-alcoholic fatty liver disease in overweight and obese children
- Metabolic complications of psychotropic medications in psychiatric disorders: Emerging role of de novo lipogenesis and therapeutic consideration
- Fetal weight growth trajectories and childhood development: A population-based cohort study
- Obesity, Metabolic Syndrome, and Sugar-Sweetened Beverages (SSBs) in America: A Novel Bioethical Argument for a Radical Public Health Proposal
- Obesity management in the pediatric patient
- Metabolic syndrome in clinical psychiatric practice
- Approach to the Treatment of Children and Adolescents with Obesity
- The Cellular Genesis of Metabolic Syndrome and the Role of Anti-urate Drugs in Hyperuricemia Patients: A Systematic Review
- Self-Esteem Among U.S. African American and Latinx Adolescents With Depressive Symptoms and Overweight and/or Obesity
- Pre-pregnancy overweight or obesity moderates the association between prenatal maternal depressive symptoms and infant cord blood omega-3 levels
- Effects of Sesamin in Animal Models of Obesity-Associated Diseases: A Systematic Review and Meta-Analysis
- Autism Among Adults with Down Syndrome: Prevalence, Medicaid Usage, and Co-Occurring Conditions
- The impact of type 2 diabetes on polycystic ovary syndrome in patients undergoing sleeve gastrectomy
- Role of gut microbiota and immune cells in metabolic-associated fatty liver disease: clinical impact
- Gastric Bypass vs Diet and Cardiovascular Risk Factors: A Nonrandomized Controlled Trial
- Premodulator microbiome alterations associated with postmodulator growth outcomes in pediatric cystic fibrosis: Can we predict outcomes?
- Premodulator microbiome alterations associated with postmodulator growth outcomes in pediatric cystic fibrosis: Can we predict outcomes?
- Associations between maternal preconception and pregnancy adiposity and neuropsychiatric and behavioral outcomes in the offspring: A systematic review and meta-analysis
Evidence Blueprint
Metabolic risk factors in prepubertal and pubertal patients with overweight and obesity
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Metabolic risk factors in prepubertal and pubertal patients with overweight and obesity
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Spinal cord injury-induced metabolic impairment and steatohepatitis develops in non-obese rats and is exacerbated by premorbid obesity
- Incidence and predictors of metabolic syndrome onset in individuals with bipolar disorders: A longitudinal study from the FACE-BD cohort
- Increased risk of atypical antipsychotics-induced metabolic syndrome associated with MIF CATT >5/6 among females with chronic schizophrenia
- The advent of RNA-based therapeutics for metabolic syndrome and associated conditions: a comprehensive review of the literature
- Obesity in Children and Adolescents: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity
- Metabolic complications of obesity in children and adolescents
- Visceral and subcutaneous abdominal fat is associated with non-alcoholic fatty liver disease while augmenting Metabolic Syndrome's effect on non-alcoholic fatty liver disease: A cross-sectional study of NHANES 2017-2018
- Controlled Study of Metabolic Syndrome Among Offspring of Parents With Bipolar Disorder
- The epigenetic mechanism of metabolic risk in bipolar disorder
- The link between Alzheimer disease and metabolic syndrome: A mutual relationship and long rigorous investigation
- Nonalcoholic Fatty Liver Disease and Continuous Metabolic Syndrome in Adolescents with Overweight/Obesity
- Indian Academy of Pediatrics Revised Guidelines on Evaluation, Prevention and Management of Childhood Obesity
- Metabolic syndrome and its relation to antipsychotic polypharmacy in schizophrenia, schizoaffective and bipolar disorders
- Metabolic syndrome and its relation to antipsychotic polypharmacy in schizophrenia, schizoaffective and bipolar disorders
- Research advances in understanding crosstalk between organs and pancreatic β-cell dysfunction
- Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options (Review)
- Metabolic syndrome: a population-based study of prevalence and risk factors
- Brazilian evidence-based guideline for screening, diagnosis, treatment, and follow-up of metabolic dysfunction-associated steatotic liver disease (MASLD) in adult individuals with overweight or obesity: A joint position statement from the…
- Interaction of periodontal clinical indicators in metabolic syndrome and nonalcoholic fatty liver disease: Implications for preventive interventions
- Italian guidelines for the management of adult individuals with overweight and obesity and metabolic comorbidities that are resistant to behavioral treatment
- Association of metabolic syndrome components and NAFLD with quality of life: Insights from a cross-sectional study
- Increased prevalence of metabolic syndrome and non-alcoholic fatty liver disease in children with atopic dermatitis: A case-control study from northern India
- Cardiometabolic and Metabolic Profiles of Lean/Normal, Overweight and Obese Patients with Nonalcoholic Fatty Liver Disease
- Liraglutide in the management of obesity: real world data (Portugal)
- Risk factors associated with overweight and obesity in people with severe mental illness in South Asia: cross-sectional study in Bangladesh, India, and Pakistan
- Prevalence and risk factors for metabolic syndrome in schizophrenia, schizoaffective, and bipolar disorder
- Elevated thyroid stimulating hormone and metabolic syndrome risk in patients with first-episode and drug-naïve major depressive disorder: a large-scale cross-sectional study
- Phenotyping children and adolescents with obesity using behavioral, psychological, and familial data
- A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population
- Prevalence, inequality and associated factors of overweight/obesity among Bangladeshi adolescents aged 15-19 years
- Association between non-alcoholic fatty liver disease and metabolic abnormalities in children with different weight statuses
- Prevalence of metabolic syndrome and its associated factors in first-treatment drug-naive schizophrenia patients: A large-scale cross-sectional study
- Association of semaglutide with risk of suicidal ideation in a real-world cohort
- Familial co-aggregation and shared genetics of cardiometabolic disorders and traits: data from the multi-generational Lifelines Cohort Study
- Association of cytokines levels, psychopathology and cognition among CR-TRS patients with metabolic syndrome
- Metabolic disturbances are risk factors for readmission to psychiatric hospitals in non-smokers but not in smokers: results from a Swiss psychiatric cohort and in first-episode psychosis patients
- Maternal obesity induced metabolic disorders in offspring and myeloid reprogramming by epigenetic regulation
- Cardiovascular risk reduction in type 2 diabetes: What the non-specialist needs to know about current guidelines
- The newly proposed Metabolic Score for Visceral Fat is a reliable tool for identifying non-alcoholic fatty liver disease, requiring attention to age-specific effects in both sexes
- Association between BMI-based metabolic phenotypes and prevalence of intracranial atherosclerotic stenosis: a cross-sectional study
- Food addiction and the physical and mental health status of adults with overweight and obesity
- Low-Quality Carbohydrate Intake Is Associated With a Higher Prevalence of Metabolic Syndrome: The AWHS Study
- Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Comparative study of MAFLD as a predictor of metabolic disease treatment for NAFLD
- Metabolic effects of atypical antipsychotics: Molecular targets
- Shared and unique characteristics of metabolic syndrome in psychotic disorders: a review
- Mediation of the association between screen time and suicidality by overweight/obesity and perceived overweight: results from the youth risk behavior surveillance system of the United States
- Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome
- Metabolic Syndrome in people treated with Antipsychotics (RISKMet): A multimethod study protocol investigating genetic, behavioural, and environmental risk factors
- Determinants of central obesity in children and adolescents and associated complications in South Africa: a systematic review
- In-hospital outcomes in COVID-19 patients with non-alcoholic fatty liver disease by severity of obesity: Insights from national inpatient sample 2020
- Pro- and anti-inflammatory cytokines are the game-changers in childhood obesity-associated metabolic disorders (diabetes and non-alcoholic fatty liver diseases)
- Gender Differences in the Prevalence and Clinical Correlates of Metabolic Syndrome in First-Episode and Drug-Naïve Patients With Major Depressive Disorder
- Adipose triglyceride lipase gene expression in peripheral blood mononuclear cells of subjects with obesity and its association with insulin resistance, inflammation and lipid accumulation in liver
- Ginsenoside Rc: A potential intervention agent for metabolic syndrome
- Impact of Changes in Lifestyle and Psychological Factors on the Incidence of Metabolic Syndrome after the Great East Japan Earthquake: Follow-up of the Fukushima Health Management Survey
- Psychological symptoms and service utilization in prepubertal and pubertal transgender and gender-diverse patients
- Second-generation antipsychotics and metabolic syndrome: a role for mitochondria
- A population-based prospective study on obesity-related non-communicable diseases in northern Iran: rationale, study design, and baseline analysis
- A population-based prospective study on obesity-related non-communicable diseases in northern Iran: rationale, study design, and baseline analysis
- Prebiotics, Probiotics, and Synbiotics-A Research Hotspot for Pediatric Obesity
- Long term outcomes of metabolic/bariatric surgery in adults
- Treatment adherence and nasogastric tube use in hospitalized youth with anorexia nervosa and premorbid overweight/obesity
- Association between postterm birth and adverse growth outcomes in children aged 3-6 years: A national retrospective cohort study