Relationship Between Depression and Medication Adherence in Older Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis
Health Sci Rep. 2025 May 5;8(5):e70703. doi: 10.1002/hsr2.70703. eCollection 2025 May.
ABSTRACT
BACKGROUND: Depression and cardiovascular disease (CVD) by the end of 2030 will be among the major causes of disability worldwide. Meanwhile, medication adherence is an important factor in predicting clinical outcomes in patients with CVD. Further, lack of medication compliance is affected by depression. Thus, this study aimed to explore the relationship between depression and medication adherence among older patients with CVD.
MATERIALS AND METHODS: The search was done across eight databases of PubMed/MEDLINE, Google Scholar, Embase, Scopus, APA Psycinfo, CINAHL/ebsco, ProQuest, and Web of Science. For the selection of included studies, there were no constraints regarding publication language. All studies available in each of the databases were searched up to December 9, 2021. Risk of bias assessment was done based on the Joanna Briggs Institute scale. The final result was estimated using a random effects model. The data were analyzed by CMA 2 software.
RESULTS: Seven studies and 10,153 elderly suffering from CVD were identified. Most included studies had reported an inverse association between depression and medication adherence. There was a small effect between depression and medication adherence among these older patients (combined odds ratio 0.603, 95% confidence interval 0.252-1.442). Thus, having depression would reduce medication adherence by 40%.
CONCLUSION: Depression has a considerable effect on medication adherence among older patients with CVD. Thus, it is suggested that considering the importance of depression and lack of medication adherence in increasing the negative outcomes of this disease in these patients, primary studies be conducted in this regard to achieve conclusive results in subsequent systematic reviews and meta-analyses.
Ann Vasc Surg. 2025 May 5:S0890-5096(25)00315-2. doi: 10.1016/j.avsg.2025.04.121. Online ahead of print.ABSTRACTTHE BACKGROUND: North Wales Vascular Services were centralized to Glan Clwyd hospital in 2019...
Implement Sci Commun. 2025 May 7;6(1):55. doi: 10.1186/s43058-025-00744-7.ABSTRACTBACKGROUND: The global shortage of trained mental health workers disproportionately impacts mental health care access in low- and...
Addict Sci Clin Pract. 2025 May 8;20(1):39. doi: 10.1186/s13722-025-00564-z.ABSTRACTBACKGROUND: Opioid use disorder often co-occurs with other mental health and substance use disorders. Identifying clusters of...
Clin Epigenetics. 2025 May 7;17(1):78. doi: 10.1186/s13148-025-01880-6.ABSTRACTBACKGROUND: Epigenetic aging estimators commonly track chronological and biological aging, quantifying its accumulation (i.e., epigenetic age acceleration) or speed...
BMC Glob Public Health. 2025 May 7;3(1):41. doi: 10.1186/s44263-025-00163-9.ABSTRACTSexual violence on higher education campuses represents a global public health crisis that threatens students' safety, well-being,...
Pediatr Clin North Am. 2025 Jun;72(3):509-523. doi: 10.1016/j.pcl.2024.12.005. Epub 2025 Feb 5.ABSTRACTThis review article highlights the longitudinal impact of intimate partner violence (IPV) on children,...
