Risk Factors for Scar Formation After Thyroidectomy and Advances in its Prevention and Treatment

Aesthetic Plast Surg. 2025 Apr 28. doi: 10.1007/s00266-025-04883-z. Online ahead of print.

ABSTRACT

An open thyroidectomy typically results in a “suicide” wound in the neck measuring approximately 4 to 6 cm in length. In the event that this wound develops into a hypertrophic scar, it can lead to significant psychological and quality-of-life challenges for the patient. The formation of proliferative scarring in surgical incisions is influenced by a multitude of risk factors, which can be broadly classified into intrinsic and extrinsic categories. Contemporary scar prevention and control strategies encompass a range of modalities, including postoperative rehabilitation physiotherapy, topical dressings, drug injections, laser therapy, combined therapy, and emerging therapeutic approaches. Among these, combined therapy has demonstrated superior efficacy in scar prevention and control. The objective of this article is to present a concise overview of the risk factors and interventions associated with proliferative scar formation following thyroid surgery. This is with a view to informing future research on the prevention of incisional scarring in thyroid surgery. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

PMID:40295371 | DOI:10.1007/s00266-025-04883-z