Evidence
Ageing Res Rev. 2024 Mar 19:102278. doi: 10.1016/j.arr.2024.102278. Online ahead of print.
ABSTRACT
Vascular dementia (VaD) is the second most common type of dementia. VaD is synonymous with ageing, and its symptoms place a significant burden on the health and wellbeing of older people. Despite the identification of a substantial number of risk factors for VaD, the pathological mechanisms underpinning this disease remain to be fully elucidated. Consequently, a biogerontological imperative exists to highlight the modifiable lifestyle factors which can mitigate against the risk of developing VaD. This review will critically examine some of the factors which have been revealed to modulate VaD risk. The survey commences by providing an overview of the putative mechanisms which are associated with the pathobiology of VaD. Next, the factors which influence the risk of developing VaD are examined. Finally, emerging treatment avenues including epigenetics, the gut microbiome, and pro-longevity pharmaceuticals are discussed. By drawing this key evidence together, it is our hope that it can be used to inform future experimental investigations in this field.
PMID:38513772 | DOI:10.1016/j.arr.2024.102278
Add to Google Keep
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Vascular Dementia: From Pathobiology to Emerging Perspectives
🌐 90 Days
VR Related Evidence Matrix
- Genetic Determinants of Vascular Dementia
- Comorbidities in patients with vascular dementia and Alzheimer's disease with Neuropsychiatric symptoms
- Executive Dysfunction in Patients Undergoing Chronic Haemodialysis Treatment: A Possible Symptom of Vascular Dementia
- Genetic Susceptibility Variants of Vascular Dementia among Asians: A Systematic Review and Meta-Analysis
- Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer's disease and experimental chronic cerebral hypoperfusion
- Postural control characteristics in Alzheimer's disease, dementia with Lewy bodies, and vascular dementia
- Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer's disease and vascular dementia
- Types of memory, dementia, Alzheimer's disease, and their various pathological cascades as targets for potential pharmacological drugs
- Bioinformatic Identification of Signaling Pathways and Hub Genes in Vascular Dementia
- Motoric cognitive risk syndrome as a predictor of adverse health outcomes: A systematic review and meta-analysis
- Air pollution, APOE genotype and risk of dementia among individuals with cardiovascular diseases: A population-based longitudinal study
- The efficacy of dyadic interventions for community-dwelling people with dementia and their caregivers: a systematic review and meta-analysis
- Cognitive and neuroscientific perspectives of healthy ageing
- Experimental laboratory models as tools for understanding modifiable dementia risk
- Potentially modifiable risk factors for dementia in six low-income and middle-income countries: A multinational, population-based survey
- Cross-sectional associations between neighborhood characteristics, cognition and dementia risk factor burden in middle-aged and older Australians
- Mechanisms of pain in aging and age-related conditions: focus on caregivers
- Binary Nano-inhalant Formulation of Icariin Enhances Cognitive Function in Vascular Dementia via BDNF/TrkB Signaling and Anti-inflammatory Effects
- 20-year depressive symptoms, dementia, and structural neuropathology in older women
- SuperAgers and Centenarians, Dynamics of Healthy Ageing with Cognitive Resilience
- Prediction of dementia based on older adults' sleep disturbances using machine learning
- Microvascular burden and long-term risk of stroke and dementia in type 2 diabetes mellitus
- Promoting Healthy Aging to Reduce the Risk of Dementia: A Public Health Imperative
- Utility of learning ratio scores from the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word List Memory Test in distinguishing patterns of cognitive decline in veterans referred for neuropsychological evaluation
- Blood-based Biomarkers of Cerebral Small Vessel Disease
- Psilocybin for dementia prevention? The potential role of psilocybin to alter mechanisms associated with major depression and neurodegenerative diseases
- Interaction effect of race-ethnicity and dementia on COVID-19 diagnosis among a national US older adult sample
- What influences life expectancy in people with dementia? Social support as an emerging protective factor
- Alzheimer's Drugs APPlication for Down syndrome?
- Lifestyle and incident dementia: A COSMIC individual participant data meta‐analysis
- Predicting cognitive function and dementia risk in patients with hypertension
- Causal relationship between dietary salt intake and dementia risk: Mendelian randomization study
- Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology
- Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology
- Delirium is more common and associated with worse outcomes in Parkinson's disease compared to older adult controls: results of two prospective longitudinal cohort studies
- Effectiveness of cognitive stimulation therapy (CST) for mild to moderate dementia: A systematic literature review and meta-analysis of randomised control trials using the original CST protocol
- Unraveling the Dual Role of ADAM10: Bridging the Gap between Cancer and Alzheimer's Disease
- Similarities and differences in the prevalence and risk factors of suicidal behavior between caregivers and people with dementia: a systematic review
- White matter brain age as a biomarker of cerebrovascular burden in the ageing brain
- Associations of sleep disorders with all-cause MCI/dementia and different types of dementia - clinical evidence, potential pathomechanisms and treatment options: A narrative review
- Screening for dementia and associated factors in older adults from low socioeconomic communities in iLembe, KwaZulu-Natal
- New horizons in the diagnosis and management of Alzheimer's Disease in older adults
- Bidirectional relationship between late-onset epilepsy (LOE) and dementia: A systematic review and meta-analysis of cohort studies
- Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease
- Stroke in the Time of Circadian Medicine
- Prevention of Vascular Contributions to Cognitive Impairment and Dementia: The Role of Physical Activity and Exercise
- Developmental priming of early cerebrovascular ageing: Implications across a lifetime
- Exploring causal mechanisms of psychosis risk
- Exploring causal mechanisms of psychosis risk
- Sonic Hedgehog Signalling Pathway Contributes in Age-Related Disorders and Alzheimer's Disease
- Sex matters in the association between cardiovascular health and incident dementia: evidence from real world data
- Understanding age-related pathologic changes in TDP-43 functions and their consequence on RNA splicing and signalling in health and disease
- Risk factors for faster aging in the brain revealed in new study
- Alzheimer's Disease Prevention and Treatment Based on Population-Based Approaches
- "I know now that it's something that you can do something about": Deductive thematic analysis of experiences at an arts-based dementia risk reduction exhibit
- Therapeutic potential of mesenchymal stem cells for cerebral small vessel disease
- Therapeutic potential of mesenchymal stem cells for cerebral small vessel disease
- Personality nuances and risk of dementia: Evidence from two longitudinal studies
- Effects of rhythm-control and rate-control strategies on cognitive function and dementia in atrial fibrillation: a systematic review and meta-analysis
- Dementia, dementia's risk factors and premorbid brain structure are concentrated in disadvantaged areas: National register and birth-cohort geographic analyses
- Association of Rest-Activity Rhythm and Risk of Developing Dementia or Mild Cognitive Impairment in the Middle-Aged and Older Population: Prospective Cohort Study
- The burden of neurological conditions in north Africa and the Middle East, 1990-2019: a systematic analysis of the Global Burden of Disease Study 2019
- Subclinical vascular composites predict clinical cardiovascular disease, stroke, and dementia: The Multi-Ethnic Study of Atherosclerosis (MESA)
- Potential Convergence of Olfactory Dysfunction in Parkinson's Disease and COVID-19: The Role of Neuroinflammation
Evidence Blueprint
Vascular Dementia: From Pathobiology to Emerging Perspectives
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Vascular Dementia: From Pathobiology to Emerging Perspectives
🌐 365 Days
VR Related Evidence Matrix
- Genetic Determinants of Vascular Dementia
- Comorbidities in patients with vascular dementia and Alzheimer's disease with Neuropsychiatric symptoms
- Executive Dysfunction in Patients Undergoing Chronic Haemodialysis Treatment: A Possible Symptom of Vascular Dementia
- Oligodendrocytes play a critical role in white matter damage of vascular dementia
- Deep learning applications in vascular dementia using neuroimaging
- Genetic Susceptibility Variants of Vascular Dementia among Asians: A Systematic Review and Meta-Analysis
- Associations between antipsychotics exposure and dementia risk: A prospective cohort study of 415,100 participants
- Cerebrovascular Hemodynamics in Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Transcranial Doppler Studies
- Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer's disease and experimental chronic cerebral hypoperfusion
- Postural control characteristics in Alzheimer's disease, dementia with Lewy bodies, and vascular dementia
- Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer's disease and vascular dementia
- Vitamin A Deficiency from Maternal Gestation May Contribute to Autistic-like Behaviors and Gastrointestinal Dysfunction in Rats Through the Disrupted Purine and Tryptophan Metabolism
- Integration of metabolomics and network pharmacology technology to explain the effect mechanisms of Danggui Buxue decoction in vascular dementia
- Types of memory, dementia, Alzheimer's disease, and their various pathological cascades as targets for potential pharmacological drugs
- Xinshubao tablet rescues cognitive dysfunction in a mouse model of vascular dementia: Involvement of neurogenesis and neuroinflammation
- Montelukast Ameliorates 2K1C-Hypertension Induced Endothelial Dysfunction and Associated Vascular Dementia
- Vascular Cognitive Impairment - Past, Present, and Future Challenges
- Profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin D3 treatment in the mice model of vascular dementia
- Bioinformatic Identification of Signaling Pathways and Hub Genes in Vascular Dementia
- Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia
- Multimorbidity, cognitive phenotypes, and Alzheimer's disease plasma biomarkers in older adults: A population-based study
- Motoric cognitive risk syndrome as a predictor of adverse health outcomes: A systematic review and meta-analysis
- Air pollution, APOE genotype and risk of dementia among individuals with cardiovascular diseases: A population-based longitudinal study
- The efficacy of dyadic interventions for community-dwelling people with dementia and their caregivers: a systematic review and meta-analysis
- Association between pre-dementia psychiatric diagnoses and all-cause dementia is independent from polygenic dementia risks in the UK Biobank
- Cognitive and neuroscientific perspectives of healthy ageing
- Experimental laboratory models as tools for understanding modifiable dementia risk
- Psychedelics for Alzheimer's Disease-Related Dementia: Unveiling Therapeutic Possibilities and Pathways
- A Comprehensive Review of Modifiable Cardiovascular Risk Factors and Genetic Influences in Dementia Prevention
- Current perspectives on prevention of vascular cognitive impairment and promotion of vascular brain health
- Potentially modifiable risk factors for dementia in six low-income and middle-income countries: A multinational, population-based survey
- Dementia prevention and individual and socioeconomic barriers: Avoiding "lifestyle" stigma
- Cross-sectional associations between neighborhood characteristics, cognition and dementia risk factor burden in middle-aged and older Australians
- Impact of sleep duration and sleep disturbances on the incidence of dementia and Alzheimer's disease: A 10-year follow-up study
- Mechanisms of pain in aging and age-related conditions: focus on caregivers
- Binary Nano-inhalant Formulation of Icariin Enhances Cognitive Function in Vascular Dementia via BDNF/TrkB Signaling and Anti-inflammatory Effects
- Dementia, osteoporosis and fragility fractures: intricate epidemiological relationships, plausible biological connections, and twisted clinical practices
- Mild Cognitive Impairment Progression and Alzheimer's Disease Risk: A Comprehensive Analysis of 3553 Cases over 203 Months
- Dysregulation of Ion Channels and Transporters and Blood-Brain Barrier Dysfunction in Alzheimer's Disease and Vascular Dementia
- Dysregulation of Ion Channels and Transporters and Blood-Brain Barrier Dysfunction in Alzheimer's Disease and Vascular Dementia
- 20-year depressive symptoms, dementia, and structural neuropathology in older women
- SuperAgers and Centenarians, Dynamics of Healthy Ageing with Cognitive Resilience
- Insights into the Pathological Basis of Dementia from Population Based Neuropathology Studies
- Prediction of dementia based on older adults' sleep disturbances using machine learning
- Increasing awareness for dementia risk reduction through a public awareness campaign in Denmark: A pre-post study
- Microvascular burden and long-term risk of stroke and dementia in type 2 diabetes mellitus
- Single nuclei transcriptomics in diabetic mice reveals altered brain hippocampal endothelial cell function, permeability, and behavior
- Promoting Healthy Aging to Reduce the Risk of Dementia: A Public Health Imperative
- Utility of learning ratio scores from the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word List Memory Test in distinguishing patterns of cognitive decline in veterans referred for neuropsychological evaluation
- Blood-based Biomarkers of Cerebral Small Vessel Disease
- Potential blindness from nutritional xerophthalmia in autistic patients
- Psilocybin for dementia prevention? The potential role of psilocybin to alter mechanisms associated with major depression and neurodegenerative diseases
- GLP-1/Sigma/RAGE Receptors: An evolving picture of Alzheimer's Disease pathology and treatment
- Navigating the Dementia Landscape: Biomarkers and Emerging Therapies
- Identification of high likelihood of dementia in population-based surveys using unsupervised clustering: a longitudinal analysis
- Interaction effect of race-ethnicity and dementia on COVID-19 diagnosis among a national US older adult sample
- Lower mortality risk in APOE4 carriers with normal cognitive ageing
- Age at cardiovascular disease onset, dementia risk, and the role of lifestyle factors
- Understanding the mechanisms of disease modifying effects of aerobic exercise in people with Alzheimer's disease
- What influences life expectancy in people with dementia? Social support as an emerging protective factor
- Alzheimer's Drugs APPlication for Down syndrome?
- Lifestyle and incident dementia: A COSMIC individual participant data meta‐analysis
- Predicting cognitive function and dementia risk in patients with hypertension
- Causal relationship between dietary salt intake and dementia risk: Mendelian randomization study