RAISR4D Suicide

Antidepressants for Child and Adolescent Depression: Evidence, Controversies, and Clinical Implications

21/05/2026

AI Summary

Antidepressants show generally limited efficacy in children and adolescents, producing only modest symptom reduction according to evidence-based research.
They should not be the sole treatment; expert commentary urges caution when prescribing and highlights need for broader therapeutic strategies.
Effective care requires comprehensive, personalised plans emphasising psychotherapy, family support, stabilising mood, suicide prevention and close clinical monitoring.

Curr Neuropharmacol. 2026 May 15. doi: 10.2174/011570159X425926260409110804. Online ahead of print.

ABSTRACT

The question of whether antidepressant medications are effective in treating depression among children and adolescents has long been a subject of intense discussion. Evidence-based medical research indicates that the efficacy of antidepressants in this age group is generally limited, with only a modest impact on alleviating depressive symptoms. This finding is supported by the editorial note published in the magazine that featured the article, which highlights the need for caution when prescribing these medications. Many comments from experts and practitioners also echo this sentiment, emphasizing that antidepressants should not be the sole focus of treatment. In clinical practice, stabilizing mood, preventing suicide, and preventing mood swings are equally crucial components in the treatment of depression in children and adolescents. These aspects often require a multifaceted approach, including psychotherapy, family support, and close monitoring by healthcare professionals. Given the complexity of pediatric and adolescent depression, a compre-hensive and personalized treatment plan is essential to ensure the best possible outcomes for young patients.

PMID:42163670 | DOI:10.2174/011570159X425926260409110804

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