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Beyond Enthusiasm: Ayahuasca and the Future of Depression Research

AI Summary
  • Prioritise rigorous, placebo-controlled clinical trials to establish ayahuasca's antidepressant efficacy beyond anecdote.
  • Investigate biological and psychological mechanisms, standardise dosing, and account for set and setting influences on outcomes.
  • Address safety, adverse effects, long-term outcomes, ethical concerns, cultural context, and regulatory frameworks for clinical implementation.
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Braz J Psychiatry. 2026 Jul 7. doi: 10.47626/1516-4446-2026-5035. Online ahead of print.

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PMID:42413001 | DOI:10.47626/1516-4446-2026-5035

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