Evidence
Brain. 2023 Sep 4:awad199. doi: 10.1093/brain/awad199. Online ahead of print.
ABSTRACT
Tumour heterogeneity is increasingly recognized as a major obstacle to therapeutic success across neuro-oncology. Gliomas are characterized by distinct combinations of genetic and epigenetic alterations, resulting in complex interactions across multiple molecular pathways. Predicting disease evolution and prescribing individually optimal treatment requires statistical models complex enough to capture the intricate (epi)genetic structure underpinning oncogenesis. Here, we formalize this task as the inference of distinct patterns of connectivity within hierarchical latent representations of genetic networks. Evaluating multi-institutional clinical, genetic and outcome data from 4023 glioma patients over 14 years, across 12 countries, we employ Bayesian generative stochastic block modelling to reveal a hierarchical network structure of tumour genetics spanning molecularly confirmed glioblastoma, IDH-wildtype; oligodendroglioma, IDH-mutant and 1p/19q codeleted; and astrocytoma, IDH-mutant. Our findings illuminate the complex dependence between features across the genetic landscape of brain tumours and show that generative network models reveal distinct signatures of survival with better prognostic fidelity than current gold standard diagnostic categories.
PMID:37665980 | DOI:10.1093/brain/awad199
Add to Google Keep
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Brain tumour genetic network signatures of survival
🌐 90 Days
VR Related Evidence Matrix
- Glioma
- Functional Neural Networks for High-Dimensional Genetic Data Analysis
- Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation
- Robust and replicable functional brain signatures of 22q11.2 deletion syndrome and associated psychosis: a deep neural network-based multi-cohort study
- Multi-hierarchy Network Configuration Can Predict Brain States and Performance
- End-to-End Multi-task Learning Architecture for Brain Tumor Analysis with Uncertainty Estimation in MRI Images
- Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure
- Exploring genetic testing requests, genetic alterations and clinical associations in a cohort of children with autism spectrum disorder
- Topological state-space estimation of functional human brain networks
- Identifying latent genetic interactions in genome-wide association studies using multiple traits
- Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence
- iPSC-derived models for anorexia nervosa research
- Zmiz1 is a novel regulator of brain development associated with autism and intellectual disability
- Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile
- Genetic-based patient stratification in Alzheimer's disease
- Identifying temporal pathways using biomarkers in the presence of latent non-Gaussian components
- The genetic architecture of multimodal human brain age
- Identification of moderate effect size genes in autism spectrum disorder through a novel gene pairing approach
- Convergent and divergent genes expression profiles associated with brain-wide functional connectome dysfunction in deficit and non-deficit schizophrenia
- Metabolic models predict fotemustine and the combination of eflornithine/rifamycin and adapalene/cannabidiol for the treatment of gliomas
- Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants
- Neuroprotective effects of niclosamide on disease progression via inflammatory pathways modulation in SOD1-G93A and FUS-associated amyotrophic lateral sclerosis models
- Identifying latent genetic interactions in genome-wide association studies using multiple traits
- Developmental Genetic and Molecular Analysis of Drosophila Central Complex Lineages
- Prominent genetic variants and epigenetic changes in post-traumatic stress disorder among combat veterans
- Enhancing neural encoding models for naturalistic perception with a multi-level integration of deep neural networks and cortical networks
- The brain-heart axis: Integrative analysis of the shared genetic etiology between neuropsychiatric disorders and cardiovascular disease
- Association of whole-person eigen-polygenic risk scores with Alzheimer's disease
- Association of whole-person eigen-polygenic risk scores with Alzheimer's disease
- Dissecting Parkinson's disease with long-read RNA-sequencing
- Dissecting the genetic and causal relationship between sleep-related traits and common brain disorders
- Best practice guidelines on genetic diagnostics of facioscapulohumeral muscular dystrophy: Update of the 2012 guidelines
- Molecular signatures of attention networks
- Macaque Brainnetome Atlas: A multifaceted brain map with parcellation, connection, and histology
- Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome
- Exploring the interconnected between type 2 diabetes mellitus and nonalcoholic fatty liver disease: Genetic correlation and Mendelian randomization analysis
- Using rare genetic mutations to revisit structural brain asymmetry
- An update on susceptibility-weighted imaging in brain gliomas
- Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts
- Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts
- Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts
- Genetic Determinants of Vascular Dementia
- Dissecting the genetic overlap between severe mental disorders and markers of cellular aging: Identification of pleiotropic genes and druggable targets
- Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy
- Gastroesophageal reflux disease with 6 neurodegenerative and psychiatric disorders: Genetic correlations, causality, and potential molecular mechanisms
- Shared Genetic Determinants of Schizophrenia and Autism Spectrum Disorder Implicate Opposite Risk Patterns: A Genome-Wide Analysis of Common Variants
- Detecting differential transcript usage in complex diseases with SPIT
- Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches
- Aberrant single-subject morphological brain networks in first-episode, treatment-naive adolescents with major depressive disorder
- Methylome-wide and meQTL analysis helps to distinguish treatment response from non-response and pathogenesis markers in schizophrenia
- Delineating Transdiagnostic Subtypes in Neurodevelopmental Disorders via Contrastive Graph Machine Learning of Brain Connectivity Patterns
- A prognostic neural epigenetic signature in high-grade glioma
- Genomic Insights into Dementia: Precision Medicine and the Impact of Gene-Environment Interaction
- Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis
- Modeling refined differences of cortical folding patterns via spatial, morphological, and temporal fusion representations
- Mendelian randomization: causal inference leveraging genetic data
- Mendelian randomization: causal inference leveraging genetic data
- Management of patients with diffuse intrinsic pontine glioma in Australia and New Zealand: Australian and New Zealand Children's Haematology/Oncology Group position statement
- A comprehensive histomolecular characterization of meningioangiomatosis: Further evidence for a precursor neoplastic lesion
- Genetic variants for head size share genes and pathways with cancer
- Genetic variants for head size share genes and pathways with cancer
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
Evidence Blueprint
Brain tumour genetic network signatures of survival
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Brain tumour genetic network signatures of survival
🌐 365 Days
VR Related Evidence Matrix
- Glioma
- Shared genetic architecture between mental health and the brain functional connectome in the UK Biobank
- Abnormal higher-order network interactions in Parkinson's disease visual hallucinations
- A Novel Type of IDH Wild-type Glioma Characterized by Gliomatosis Cerebri-like Growth Pattern, TERT Promoter Mutation, and Distinct Epigenetic Profile
- Functional Neural Networks for High-Dimensional Genetic Data Analysis
- Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas
- Assessing network degeneration and phenotypic heterogeneity in genetic frontotemporal lobar degeneration by decoding FDG-PET
- A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes
- Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture
- Neuromuscular disease genetics in underrepresented populations: increasing data diversity
- Comprehensive exploration of multi-modal and multi-branch imaging markers for autism diagnosis and interpretation: insights from an advanced deep learning model
- Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation
- Robust and replicable functional brain signatures of 22q11.2 deletion syndrome and associated psychosis: a deep neural network-based multi-cohort study
- Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy
- Deregulation of the Glymphatic System in Alzheimer's Disease: Genetic and Non-Genetic Factors
- Identification and discovery of imaging genetic patterns using fusion self-expressive network in major depressive disorder
- Pediatric brain tumors
- Multi-hierarchy Network Configuration Can Predict Brain States and Performance
- End-to-End Multi-task Learning Architecture for Brain Tumor Analysis with Uncertainty Estimation in MRI Images
- Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes
- Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure
- Genome-wide DNA methylation risk scores for schizophrenia derived from blood and brain tissues further explain the genetic risk in patients stratified by polygenic risk scores for schizophrenia and bipolar disorder
- Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation
- Exploring genetic testing requests, genetic alterations and clinical associations in a cohort of children with autism spectrum disorder
- Primary brain tumours in adults
- SCN1A-deficient excitatory neuronal networks display mutation-specific phenotypes
- Topological state-space estimation of functional human brain networks
- Identifying latent genetic interactions in genome-wide association studies using multiple traits
- Concurrent gliomas in patients with multiple sclerosis
- Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence
- Novel data-driven subtypes and stages of brain atrophy in the ALS-FTD spectrum
- Genomic loci influence patterns of structural covariance in the human brain
- Genetic factors linked to aberrant neural activity of individuals with substance use disorder phenotypes: A systematic review and meta-analysis of EEG studies
- iPSC-derived models for anorexia nervosa research
- White and gray matter alterations in bipolar I and bipolar II disorder subtypes compared with healthy controls - exploring associations with disease course and polygenic risk
- Integrated molecular analysis reveals hypermethylation and overexpression of HOX genes to be poor prognosticators in IDH mutant glioma
- Drug addiction and treatment: An epigenetic perspective
- Genetic heterogeneity within a consanguineous family involving TTPA and SETX genes
- Zmiz1 is a novel regulator of brain development associated with autism and intellectual disability
- Lysosomal polygenic risk is associated with the severity of neuropathology in Lewy body disease
- Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile
- Genetic-based patient stratification in Alzheimer's disease
- Explaining Deep Learning-Based Representations of Resting State Functional Connectivity Data: Focusing on Interpreting Nonlinear Patterns in Autism Spectrum Disorder
- Gender effects on autism spectrum disorder: a multi-site resting-state functional magnetic resonance imaging study of transcriptome-neuroimaging
- ICA-based Individualized Differential Structure Similarity Networks for Predicting Symptom Scores in Adolescents with Major Depressive Disorder
- Identifying temporal pathways using biomarkers in the presence of latent non-Gaussian components
- Unlocking the epigenetic symphony: histone acetylation's impact on neurobehavioral change in neurodegenerative disorders
- GBA-associated Parkinson's disease in Hungary: clinical features and genetic insights
- Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
- The genetic architecture of multimodal human brain age
- Identification of moderate effect size genes in autism spectrum disorder through a novel gene pairing approach
- Convergent and divergent genes expression profiles associated with brain-wide functional connectome dysfunction in deficit and non-deficit schizophrenia
- Investigating trait variability of gene co-expression network architecture in brain by controlling for genomic risk of schizophrenia
- Metabolic models predict fotemustine and the combination of eflornithine/rifamycin and adapalene/cannabidiol for the treatment of gliomas
- Clinicopathological correlates in frontotemporal lobar degeneration: motor neuron disease spectrum
- Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants
- Neuroprotective effects of niclosamide on disease progression via inflammatory pathways modulation in SOD1-G93A and FUS-associated amyotrophic lateral sclerosis models
- Endophenotype trait domains for advancing gene discovery in autism spectrum disorder
- High-density electroencephalographic functional networks in genetic generalized epilepsy: Preserved whole-brain topology hides local reorganization
- UNVEILING THE COMPLEX ROLE OF NF-ΚB IN ALZHEIMER'S DISEASE: INSIGHTS INTO BRAIN INFLAMMATION AND POTENTIAL THERAPEUTIC TARGETS
- Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology
- Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits
- Genetic and Clinical Correlates of AI-Based Brain Aging Patterns in Cognitively Unimpaired Individuals
- Disentangling differing relationships between internalizing disorders and alcohol use