Evidence
J Neurooncol. 2023 May 26. doi: 10.1007/s11060-023-04341-3. Online ahead of print.
ABSTRACT
BACKGROUND: Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited advances in finding new treatments for GBM. In this study, we investigated molecular differences between patients with extremely short (≤ 9 months, Short term survivors, STS) and long survival (≥ 36 months, Long term survivors, LTS).
METHODS: Patients were selected from an in-house cohort (GLIOTRAIN-cohort), using defined inclusion criteria (Karnofsky score > 70; age < 70 years old; Stupp protocol as first line treatment, IDH wild type), and a multi-omic analysis of LTS and STS GBM samples was performed.
RESULTS: Transcriptomic analysis of tumour samples identified cilium gene signatures as enriched in LTS. Moreover, Immunohistochemical analysis confirmed the presence of cilia in the tumours of LTS. Notably, reverse phase protein array analysis (RPPA) demonstrated increased phosphorylated GAB1 (Y627), SRC (Y527), BCL2 (S70) and RAF (S338) protein expression in STS compared to LTS. Next, we identified 25 unique master regulators (MR) and 13 transcription factors (TFs) belonging to ontologies of integrin signalling and cell cycle to be upregulated in STS.
CONCLUSION: Overall, comparison of STS and LTS GBM patients, identifies novel biomarkers and potential actionable therapeutic targets for the management of GBM.
PMID:37237151 | DOI:10.1007/s11060-023-04341-3
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Comparative analysis of deeply phenotyped GBM cohorts of ‘short-term’ and ‘long-term’ survivors
🌐 90 Days
VR Related Evidence Matrix
- Regorafenib and glioblastoma: a literature review of preclinical studies, molecular mechanisms and clinical effectiveness
- Regorafenib and glioblastoma: a literature review of preclinical studies, molecular mechanisms and clinical effectiveness
- The impact of cancer patient pathway on timing of radiotherapy and survival: a cohort study in glioblastoma patients
- Post-intensive care syndrome and health-related quality of life in long-term survivors of cardiac arrest: a prospective cohort study
- Impact of frailty on survival glioblastoma, IDH-wildtype patients
- Mental health sequelae in survivors of cardiogenic shock complicating myocardial infarction. A population-based cohort study
- Mental health sequelae in survivors of cardiogenic shock complicating myocardial infarction. A population-based cohort study
- Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial
- Impact of Delirium Onset and Duration on Mortality in Patients With Cancer Admitted to the ICU
- Long-Term Outcomes in Patients With Spontaneous Cerebellar Hemorrhage: An International Cohort Study
- The Roles of AGTRAP, ALKBH3, DIVERSIN, NEDD8 and RRM1 in Glioblastoma Pathophysiology and Prognosis
- PPAR-γ agonists reactivate the ALDOC-NR2F1 axis to enhance sensitivity to temozolomide and suppress glioblastoma progression
- The influence of advanced maternal age on congenital malformations, short- and long-term outcomes in offspring of nulligravida: a Korean National Cohort Study over 15 years
- Long-Term Blood Pressure Reductions Following Catheter-Based Renal Denervation: A Systematic Review and Meta-Analysis
- Factors Influencing Recovery From Pediatric Stroke Based on Discussions From a UK-Based Online Stroke Community: Qualitative Thematic Study
- Age-stratified comorbid and pharmacologic analysis of patients with glioblastoma
- Age-stratified comorbid and pharmacologic analysis of patients with glioblastoma
- Outcomes of Decompressive Surgery for Patients With Severe Cerebral Venous Thrombosis: DECOMPRESS2 Observational Study
- Autophagy-related CMTM6 promotes glioblastoma progression by activating Wnt/b-catenin pathway and acts as an onco-immunological biomarker
- Mental Health Support Is an Unmet Need for Long-Term Burn Survivors: A Web-Based Survey
- Serum Albumin and Post-Stroke Outcomes: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis
- Presence and utility of electrocardiographic abnormalities in long-term childhood cancer survivors
- Efficacy and suitability of adding short-term psychodynamic psychotherapy (STPP) to pharmacotherapy in patients with depressive disorders: a systematic review
- Effects of two different social exclusion paradigms on ambiguous facial emotion recognition
- Personality traits as predictors of recovery among patients with substance use disorder
- Status epilepticus in patients with brain tumors and metastases: A multicenter cohort study of 208 patients and literature review
- Immune cell infiltration and inflammatory landscape in primary brain tumours
- CAR T-cell therapy induces a high rate of prolonged remission in relapsed primary CNS lymphoma: Real-life results of the LOC network
- Comparison of children and adults in deep brain stimulation for Tourette Syndrome: a large-scale multicenter study of 102 cases with long-term follow-up
- Tracts in the limbic system show microstructural alterations post COVID-19 recovery
- Tracts in the limbic system show microstructural alterations post COVID-19 recovery
- Congenital myasthenic syndromes in adults: clinical features, diagnosis and long-term prognosis
- Long-term (11 Years) Results of Laparoscopic Gastric Bypass: Changes in Weight, Blood Levels of Sugar and Lipids, and Late Adverse Effects : Laparoscopic Gastric Bypass Results
- The mitochondria-related gene risk mode revealed p66Shc as a prognostic mitochondria-related gene of glioblastoma
- The mitochondria-related gene risk mode revealed p66Shc as a prognostic mitochondria-related gene of glioblastoma
- Hypothalamic sex-specific metabolic shift by canagliflozin during aging
- Impact of COVID-19 on posttraumatic stress disorder in ICU survivors: a prospective observational comparative cohort study
- PRMT6-mediated transcriptional activation of ythdf2 promotes glioblastoma migration, invasion, and emt via the wnt-b-catenin pathway
- Lift Yourself Up: The Short-Term Associations Between Strength Training and Mood States and the Longer Term Development of Physical Capital and "Grit" Among People Recovering From Substance Use Disorders
- Occupational Therapy in Psychiatric Short-Term Hospitalization Units: Scoping Review
- Nausea and vomiting in pregnancy
- Laser interstitial thermal therapy in neurosurgery: a single-surgeon experience of 313 patients
- The Prevalence of Post-traumatic Stress Disorder as Part of Post-ICU Syndrome among Israeli ICU Survivors
- A 3-Year Study Investigating the Utility of PROMIS-29 for Long-Term Follow-Up in Adult Spinal Deformity
- Isocitrate Dehydrogenase 1/2 Wildtype Adult Astrocytoma with WHO Grade 2/3 Histological Features: Molecular Re-Classification, Prognostic Factors, Clinical Outcomes
- Rural-urban differences in use of health services before and after dementia diagnosis: a retrospective cohort study
- Association between life's essential 8 and frailty status among cancer survivors in the United States: a cross-sectional analysis
- Association between life's essential 8 and frailty status among cancer survivors in the United States: a cross-sectional analysis
- Impact of Long-COVID in children: a large cohort study
- Overtime: Long-Term Betting Trajectories Among Highly-Involved and Less-Involved Online Sports Bettors
- Clinical and healthcare use outcomes after cessation of long term opioid treatment due to prescriber workforce exit: quasi-experimental difference-in-differences study
- Clinical and healthcare use outcomes after cessation of long term opioid treatment due to prescriber workforce exit: quasi-experimental difference-in-differences study
- Neuropsychiatric symptoms associated with the COVID-19 and its potential nervous system infection mechanism: the role of imaging in the study
- Opportunistic screening for long-term muscle wasting in critically ill patients: insights from an acute pancreatitis cohort
- Predictors of long-term mortality in older patients with hip fractures managed by hemiarthroplasty: a 10-year study based on a population registry in Saxony, Germany
- Efficacy of resilience-related psychological interventions in patients with long-term diseases: A meta-analysis of randomised controlled trials
- Long-term persistence of the risk of agranulocytosis with clozapine compared with other antipsychotics: a nationwide cohort and case-control study in Finland
- Long-term persistence of the risk of agranulocytosis with clozapine compared with other antipsychotics: a nationwide cohort and case-control study in Finland
- Machine learning identifies risk factors associated with long-term opioid use in fibromyalgia patients newly initiated on an opioid
- Lithium versus anticonvulsants and the risk of physical disorders - Results from a comprehensive long-term nation-wide population-based study emulating a target trial
- Dementia Development during Long-Term Follow-Up after Surgical Aortic Valve Replacement with a Biological Prosthesis in a Geriatric Population
- Development of a brief bedside tool to screen women sexual assault survivors for risk of persistent posttraumatic stress six months after sexual assault
- Indirect functional connectivity does not predict overall survival in glioblastoma
- Gestational age at birth and type 1 diabetes in childhood and young adulthood: a nationwide register study in Finland, Norway and Sweden
Evidence Blueprint
Comparative analysis of deeply phenotyped GBM cohorts of ‘short-term’ and ‘long-term’ survivors
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Comparative analysis of deeply phenotyped GBM cohorts of ‘short-term’ and ‘long-term’ survivors
🌐 365 Days
VR Related Evidence Matrix
- Clinicopathological and molecular landscape of 5-year IDH-wild-type glioblastoma survivors: A multicentric retrospective study
- MGMT methylation pattern of long-term and short-term survivors of glioblastoma reveals CpGs of the enhancer region to be of high prognostic value
- Regorafenib and glioblastoma: a literature review of preclinical studies, molecular mechanisms and clinical effectiveness
- Regorafenib and glioblastoma: a literature review of preclinical studies, molecular mechanisms and clinical effectiveness
- Long-term survival with IDH wildtype glioblastoma: first results from the ETERNITY Brain Tumor Funders' Collaborative Consortium (EORTC 1419)
- Radio-chemotherapy feasibility for biopsy-only unresectable IDH wild-type glioblastomas (BO-GBM)
- Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma
- Outcome assessment of intraoperative radiotherapy for brain metastases: results of a prospective observational study with comparative matched-pair analysis
- EXPRESS: Long-term outcomes, residual symptoms and quality of life in COVID-19 hospitalized patients: a 12-month longitudinal study
- Multifocal and multicentric glioblastoma: Imaging signature, molecular characterization, patterns of spread, and treatment
- The impact of cancer patient pathway on timing of radiotherapy and survival: a cohort study in glioblastoma patients
- Eliciting calcium transients with UV nanosecond laser stimulation in adult patient-derived glioblastoma brain cancer cells in vitro
- Undetected pseudoprogressions in the CeTeG/NOA-09 trial: hints from postprogression survival and MRI analyses
- Post-intensive care syndrome and health-related quality of life in long-term survivors of cardiac arrest: a prospective cohort study
- Impact of frailty on survival glioblastoma, IDH-wildtype patients
- Identification of health-related quality of life profiles among long-term survivors of primary central nervous system tumors
- Sexual Problems as Late Effects: Awareness and Information Needs Among 1870 Long-term Norwegian Childhood, Adolescent, and Young Adult Cancer Survivors (The NOR-CAYACS Study)
- Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells
- Evidence for Overlapping Visual Processing Difficulties in Adult ADHD and Visual Stress
- Mental health sequelae in survivors of cardiogenic shock complicating myocardial infarction. A population-based cohort study
- Mental health sequelae in survivors of cardiogenic shock complicating myocardial infarction. A population-based cohort study
- Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial
- Granulocyte colony-stimulating factor plus pentoxifylline increases short-term survival in patients with severe alcoholic hepatitis: a network meta-analysis
- Prognostic Value of BRAF Mutation in Glioblastoma
- Chemotherapy reduces long-term quality of life in recurrence-free colon cancer survivors (LaTE study)-a nationwide inverse probability of treatment-weighted registry-based cohort study and survey
- Outcomes and treatment algorithm in glioblastoma patients 80 years and older
- Impact of Delirium Onset and Duration on Mortality in Patients With Cancer Admitted to the ICU
- Long-Term Outcomes in Patients With Spontaneous Cerebellar Hemorrhage: An International Cohort Study
- Long-term mortality after self-inflicted burns
- Associations of sleep disorders with all-cause and cause-specific mortality in cancer survivors: a cross-sectional analysis of the NHANES 2005-2016
- The patient's perspective on radiation for rectal cancer: Initial expectations versus actual experience
- The Roles of AGTRAP, ALKBH3, DIVERSIN, NEDD8 and RRM1 in Glioblastoma Pathophysiology and Prognosis
- Short-term and long-term phenotypic stability of actigraphic sleep metrics involving repeated sleep loss and recovery
- Chronic deep brain stimulation of the human nucleus accumbens region disrupts the stability of inter-temporal preferences
- A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs
- Long-term follow-up of brain regional changes and the association with cognitive impairment in quarantined COVID-19 survivors
- Effectiveness of Exercise, Cognitive Behavioral Therapy, and Pharmacotherapy on Improving Sleep in Adults with Chronic Insomnia: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
- Gene signatures associated with prognosis and chemotherapy resistance in glioblastoma treated with temozolomide
- Treatment benefit in patients aged 80 years or older with biopsy-proven and non-resected glioblastoma is dependent on MGMT promoter methylation status
- Long-term neurocognitive function and quality of life after multimodal therapy in adult glioma patients: a prospective long-term follow-up
- Long term outcomes of hyperbaric oxygen therapy in post covid condition: longitudinal follow-up of a randomized controlled trial
- PPAR-γ agonists reactivate the ALDOC-NR2F1 axis to enhance sensitivity to temozolomide and suppress glioblastoma progression
- SOMATIC DEFICIENT MISMATCH REPAIR ASSESSED BY IMMUNOHISTOCHEMISTRY AND CLINICAL FEATURES IN BRAZILIAN GLIOBLASTOMA PATIENTS
- Biomolecules to Biomarkers? U87MG Marker Evaluation on the Path towards Glioblastoma Multiforme Pathogenesis
- Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology: A risk-benefit analysis
- Long-Term Quality of Life After Out-of-Hospital Cardiac Arrest
- Long-term headache after spontaneous intracerebral haemorrhage
- Tumor size, treatment patterns, and survival in neuro-oncology patients before and during the COVID-19 pandemic
- Invadopodia associated Thrombospondin-1 contributes to a post-therapy pro-invasive response in glioblastoma cells
- Health Care Access Barriers and Self-Reported Health Among Adolescent and Young Adult Cancer Survivors
- Cardiac and mortality outcome differences between methadone, buprenorphine and naltrexone prescriptions in patients with an opioid use disorder
- The influence of advanced maternal age on congenital malformations, short- and long-term outcomes in offspring of nulligravida: a Korean National Cohort Study over 15 years
- Short-term neonatal and long-term neurodevelopmental outcome of children born term low birth weight
- Chronic stress accelerates glioblastoma progression via DRD2/ERK/β-catenin axis and Dopamine/ERK/TH positive feedback loop
- Neuroprotectant Activity of Novel Water-Soluble Synthetic Neurosteroids on Organophosphate Intoxication and Status Epilepticus-induced Long-term Neurological Dysfunction, Neurodegeneration and Neuroinflammation
- Fatigue after spontaneous intracerebral haemorrhage: prevalence and associated factors
- Improved prognostic stratification of patients with isocitrate dehydrogenase-mutant astrocytoma
- Long-Term Blood Pressure Reductions Following Catheter-Based Renal Denervation: A Systematic Review and Meta-Analysis
- Longer-term organ abnormalities confirmed in some post-hospitalised COVID patients
- Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production
- Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production
- The genomic alterations in glioblastoma influence the levels of CSF metabolites
- Cognitive functions in COVID-19 survivors, approaches strategies, and impact on health systems: a qualitative systematic review
- Long-term Neuropsychiatric Developmental Defects after Neonatal Organophosphate Exposure: Mitigation by Synthetic Neurosteroids