Complications in patients with midlines compared to peripherally inserted central catheters for outpatient parenteral antimicrobial therapy

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Single-centre retrospective cohort of 1,169 patients receiving outpatient parenteral antimicrobial therapy.
Complication rates were 6.4 per 1,000 line-days for midlines versus 1.1 for PICCs.
Adjusted hazard ratio 3.60 (95% CI 1.66-7.81), indicating significantly higher complication risk with midlines.

Infect Control Hosp Epidemiol. 2026 Jul 17:1-3. doi: 10.1017/ice.2026.10512. Online ahead of print.

ABSTRACT

In this single-center, retrospective cohort study of 1169 patients requiring outpatient parenteral antimicrobial therapy, complications (i.e., bloodstream infections or venous thrombosis) occurred more frequently in patients with midlines (6.4 per 1,000 line-days) than peripherally inserted central catheters (1.1 per 1,000 line-days), adjusted hazard ratio 3.60 (95% confidence interval 1.66-7.81).

PMID:42464627 | DOI:10.1017/ice.2026.10512

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