Evidence
Sci Rep. 2023 Aug 25;13(1):13946. doi: 10.1038/s41598-023-40971-3.
ABSTRACT
Oxycodone is one of the most widely prescribed and misused opioid painkillers in the United States. Evidence suggests that biological sex and hormonal status can impact drug reward in humans and rodents, but the extent to which these factors can influence the rewarding effects of oxycodone is unclear. The purpose of this study was to utilize place conditioning to determine the effects of sex and female hormonal status on the expression of oxycodone conditioned reward in rats. Gonadally intact adult Sprague-Dawley male and female rats were used to test: (1) whether both sexes express conditioned reward to oxycodone at similar doses, (2) the impact of conditioning session length on oxycodone conditioned reward expression in both sexes, and (3) the influence of female estrous cycle stage on oxycodone conditioned reward expression. Both sexes expressed conditioned reward at the same doses of oxycodone. Increasing the length of conditioning sessions did not reveal an effect of sex and resulted in lower magnitude conditioned reward expression. Importantly however, female stage of estrous cycle significantly influenced oxycodone conditioned reward expression. These results suggest that female hormonal status can impact the rewarding effects of opioids and thus have important implications for prescription opioid treatment practices.
PMID:37626154 | DOI:10.1038/s41598-023-40971-3
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Estrous cycle dependent expression of oxycodone conditioned reward in rats
🌐 90 Days
VR Related Evidence Matrix
- Increased anxiolytic effect in aged female rats and increased motoric behavior in aged male rats to acute alcohol administration: Comparison to younger animals
- The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents
- Social-Single Prolonged Stress affects contextual fear conditioning in male and female Wistar rats: Molecular insights in the amygdala
- Microglial knockdown does not affect acute withdrawal but delays analgesic tolerance from oxycodone in male and female C57BL/6J mice
- Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea
- Adolescents rats engage the orbitofrontal-striatal pathway differently than adults during impulsive actions
- Adolescent alcohol binge drinking and withdrawal: behavioural, brain GFAP-positive astrocytes and acute methamphetamine effects in adult female rats
- Exploring the potential use of melatonin as a modulator of tramadol-induced rewarding effects in rats
- Use of Quantitative Electroencephalography to Inform Age- and Sex-Related Differences in NMDA Receptor Function Following MK-801 Administration
- The Effects of Fingolimod (FTY720) on Leukocyte Subset Circulation cannot be Behaviourally Conditioned in Rats
- Circuit-wide gene network analysis reveals sex-specific roles for phosphodiesterase 1b in cocaine addiction
- Sex-dependent alterations of inflammatory factors, oxidative stress, and histopathology of the brain-gut axis in a VPA-induced autistic-like model of rats
- Sex-dependent effects of acute stress in adolescence or adulthood on appetitive motivation
- Sex-dependent effects of acute stress in adolescence or adulthood on appetitive motivation
- Sex-dependent alterations of inflammatory factors, oxidative stress, and histopathology of the brain-gut axis in a VPA-induced autistic-like model of rats
- Acute stress yields a sex-dependent facilitation of signaled active avoidance in rats
- Towards understanding sex differences in autism spectrum disorders
- Sex differences in body temperature and neural power spectra in response to repeated restraint stress
- Rosiglitazone Promotes Microglial Distribution via Activation of PPARγ and CD36 in the ICH Rat Model
- The role of melatonin deficiency induced by pinealectomy on motor activity and anxiety responses in young adult, middle-aged and old rats
- Perturbations in Risk/Reward Decision Making and Frontal Cortical Catecholamine Regulation Induced by Mild Traumatic Brain Injury
- Sodium Bicarbonate Decreases Alcohol Consumption in Mice
- Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns
- Transcriptomic effects of paternal cocaine-seeking on the reward circuitry of male offspring
- Reward contingency gates selective cholinergic suppression of amygdala neurons
- The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain
- Brain antioxidant status and gene expressions of nicotinic and dopamine receptors are improved by black seed oil administration in cigarette smoke or nicotine vapour-exposed rats
- Crocin (bioactive compound of Crocus sativus L.) potently restores REM sleep deprivation-induced manic- and obsessive-compulsive-like behaviors in female rats
- Organization of spontaneous spatial behaviors under dark conditions is unaffected in adult male and female long-Evans rats after moderate prenatal alcohol exposure
- Early-life exposure to sex hormones promotes voluntary ethanol intake in adulthood. A vulnerability factor to drug addiction
- Sex Dimorphism in Pain Threshold and Neuroinflammatory Response: The Protective Effect of Female Sexual Hormones on Behavior and Seizures in an Allergic Rhinitis Model
- Age and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol
- Oxyresveratrol-b-cyclodextrin mitigates streptozotocin-induced Alzheimer's model cognitive impairment, histone deacetylase activity in rats: in silico & in vivo studies
- Serotonin signaling in hippocampus during initial cocaine abstinence drives persistent drug seeking
- Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants
- Short-Term Opioid Treatment of Acute Locomotor Pain in Older Adults: Comparison of Effectiveness and Safety between Tramadol and Oxycodone: A Randomized Trial
- Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model
- Optogenetic inhibition of rat anterior cingulate cortex impairs the ability to initiate and stay on task
- Neuroimaging of opioid effects in humans across conditions of acute administration, chronic pain therapy, and opioid use disorder
- Subjective feelings associated with expectations and rewards during risky decision-making in impulse control disorder
- Subjective feelings associated with expectations and rewards during risky decision-making in impulse control disorder
- Lesion of NPY Receptor-expressing Neurons in Perifornical Lateral Hypothalamus Attenuates Glucoprivic Feeding
- Effects of carbamazepine on BDNF expression in trigeminal ganglia and serum in rats with trigeminal neuralgia
- Benefits of bone marrow mesenchymal stem cells compared to their conditioned medium in valproic acid-induced autism in rats
- Adrenarche-accompanied rise of adrenal sex steroid precursors prevents NAFLD in Young Female rats by converting into active androgens and inactivating hepatic Srebf1 signaling
- Beneficial Effects of Dietary Flaxseed on Non-Alcoholic Fatty Liver Disease
- Dual-step pharmacological intervention for traumatic-like memories: implications from D-cycloserine and cannabidiol or clonidine in male and female rats
- Quantifying the Lymphatic Transport of Model Therapeutics from the Brain in Rats
- N-oleoyl alanine attenuates nicotine reward and spontaneous nicotine withdrawal in mice
- Treadmill exercise training inhibits morphine CPP by reversing morphine effects on GABA neurotransmission in D2-MSNs of the accumbens-pallidal pathway in male mice
- Treadmill exercise training inhibits morphine CPP by reversing morphine effects on GABA neurotransmission in D2-MSNs of the accumbens-pallidal pathway in male mice
- Extracellular matrix abnormalities in the hippocampus of subjects with substance use disorder
- Psilocybin restrains activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms
- Psilocybin restrains activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms
- A large-scale c-Fos brain mapping study on extinction of cocaine-primed reinstatement
- The impact of policing and homelessness on violence experienced by women who sell sex in London: a modelling study
- TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury
- Ghrelin decreases sensitivity to negative feedback and increases prediction-error related caudate activity in humans, a randomized controlled trial
- Sex differences in heart rate variability measures that predict alcohol drinking in rats
- GABAergic interneurons in the hippocampal CA1 mediate contextual fear generalization in PTSD rats
- Assessment of the Antinociceptive, Respiratory-Depressant, and Reinforcing Effects of the Low pKa Fluorinated Fentanyl Analogs, FF3 and NFEPP
- A novel paradigm for observational learning in rats
- Altered reward processing following sucrose bingeing in male and female mice
- The impact of high-fat diet consumption and inulin fiber supplementation on anxiety-related behaviors and liver oxidative status in female Wistar rats
Evidence Blueprint
Estrous cycle dependent expression of oxycodone conditioned reward in rats
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Estrous cycle dependent expression of oxycodone conditioned reward in rats
🌐 365 Days
VR Related Evidence Matrix
- An ethogram analysis of cutaneous thermal pain sensitivity and oxycodone reward-related behaviors in rats
- Role of sex hormones in the effects of sleep deprivation on methamphetamine reward memory
- The Effects of Sleep Restriction During Abstinence on Oxycodone Seeking: Sex-Dependent Moderating Effects of Behavioral and Hypothalamic-Pituitary-Adrenal Axis-Related Phenotypes
- Sex difference in the effect of environmental enrichment on food restriction-induced persistence of cocaine conditioned place preference and mechanistic underpinnings
- Interactions between estradiol and ERK, but not mTOR, signaling is necessary for enhanced cocaine-induced conditioned place preference in female rats
- Strain and sex-related behavioral variability of oxycodone dependence in rats
- Attenuation of morphine conditioned place preference and reinstatement by vitamin D
- Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury
- Environmental Enrichment during Abstinence Reduces Oxycodone Seeking and c-Fos Expression in a Subpopulation of Medial Prefrontal Cortex Neurons
- Impact of OPRM1 (mu-opioid receptor gene) A112G polymorphism on dual oxycodone and cocaine self-administration behavior in a mouse model
- Female rats are more responsive than are males to the protective effects of voluntary physical activity against the behavioral consequences of inescapable stress
- Low Current Intensity Plus an Ineffective Dose of Morphine Affect Conditioning Place Preference Through Different Pathways in the Lateral Habenula
- Outcome devaluation by sensory-specific satiety alters Pavlovian-conditioned behavior in male and female rats
- Sex- and age-specific effects on the development of addiction and compulsive-like drinking in rats
- Increased anxiolytic effect in aged female rats and increased motoric behavior in aged male rats to acute alcohol administration: Comparison to younger animals
- Varenicline but not cotinine increased the value of a visual stimulus reinforcer in rats: No evidence for synergy of the two compounds
- Sex differences in carbamazepine effects in a rat model of trigeminal neuropathic pain
- Effects of adolescent methylphenidate administration on methamphetamine conditioned place preference in an animal model of attention-deficit/hyperactivity disorder: Examination of potential sex differences
- Poor inhibitory control predicts sex-specific vulnerability to nicotine rewarding properties in mice
- The enteric metabolite, propionic acid, impairs social behavior and increases anxiety in a rodent ASD model: Examining sex differences and the influence of the estrous cycle
- The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents
- Ceftriaxone alters the gut microbiome composition and reduces alcohol intake in male and female Sprague-Dawley rats
- Sex and hormonal status influence the anxiolytic-like effect of oxytocin in mice
- Differential effects of acute and prolonged morphine withdrawal on motivational and goal-directed control over reward-seeking behavior
- Social Interaction in Adolescent Rats with Neonatal Ethanol Exposure: Impact of Sex and CE-123, a Selective Dopamine Reuptake Inhibitor
- Unpredictable, intermittent access to sucrose or water promotes increased reward pursuit in rats
- Validation of Wistar-Kyoto rats kept in solitary housing as an animal model for depression using voxel-based morphometry
- Social-Single Prolonged Stress affects contextual fear conditioning in male and female Wistar rats: Molecular insights in the amygdala
- An Analysis of Oxycodone and Hydrocodone Distribution Trends in Delaware, Maryland, and Virginia Between 2006 and 2014
- Microglial knockdown does not affect acute withdrawal but delays analgesic tolerance from oxycodone in male and female C57BL/6J mice
- Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea
- Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation
- Adolescents rats engage the orbitofrontal-striatal pathway differently than adults during impulsive actions
- tRNA epitranscriptomic alterations associated with opioid-induced reward-seeking and long-term opioid withdrawal in male mice
- Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making
- Inhibition of dopamine neurons prevents incentive value encoding of a reward cue: With revelations from deep phenotyping
- Adolescent alcohol binge drinking and withdrawal: behavioural, brain GFAP-positive astrocytes and acute methamphetamine effects in adult female rats
- Somatic and anxiety-like behaviors in male and female rats during withdrawal from the non-selective cannabinoid agonist WIN 55,212-2
- Effects of music on cognitive behavioral impairments in both sex of adult rats exposed prenatally to valproic acid
- Exploring the potential use of melatonin as a modulator of tramadol-induced rewarding effects in rats
- Contingent administration of typical and biased kappa opioid agonists reduces cocaine and oxycodone choice in a drug vs. food choice procedure in male rhesus monkeys
- Use of Quantitative Electroencephalography to Inform Age- and Sex-Related Differences in NMDA Receptor Function Following MK-801 Administration
- Early and transitory hypoactivity and olfactory alterations after chronic atrazine exposure in female Sprague-Dawley rats
- Phasic dopamine signals are reduced in the spontaneously hypertensive rat and increased by methylphenidate
- How sucrose preference is gained and lost: An in-depth analysis of drinking behavior during the sucrose preference test in mice
- Aromatase inhibition and electroconvulsive seizures in adolescent rats: antidepressant and long-term cognitive sex differences
- Estradiol administration increases anxiety-like behavior following chronic escalating morphine administration in hormone-replaced ovariectomized female rats
- The role of lateral habenula NMDA receptors in tramadol-induced conditioning
- Sex Differences in Organophosphate Model of Benzodiazepine-Refractory Status Epilepticus and Neuronal Damage
- Myricetin suppresses traumatic brain injury-induced inflammatory response via EGFR/AKT/STAT pathway
- Dysregulation of Amino Acid Transporters in a Rat Model of TLR7-Mediated Maternal Immune Activation
- Calcitonin receptor signaling in nucleus accumbens D1R- and D2R-expressing medium spiny neurons bidirectionally alters opioid taking in male rats
- Electronic Cigarette Vape Exposure Exacerbates Post-Ischemic Outcomes in Female but Not in Male Rats
- The Effects of Fingolimod (FTY720) on Leukocyte Subset Circulation cannot be Behaviourally Conditioned in Rats
- Abnormal neurophysiological sensitivity to rewards in depression is moderated by sex and age in middle adulthood
- Sex influences the effects of social status on socioemotional behavior and serotonin neurochemistry in rhesus monkeys
- Circuit-wide gene network analysis reveals sex-specific roles for phosphodiesterase 1b in cocaine addiction
- The genetics of a "femaleness/maleness" score in cardiometabolic traits in the UK biobank
- Adolescent restraint stress enhances adult nicotine reinforcement in male and female rats
- Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: a systematic review
- Sex-dependent alterations of inflammatory factors, oxidative stress, and histopathology of the brain-gut axis in a VPA-induced autistic-like model of rats
- Sex-dependent effects of acute stress in adolescence or adulthood on appetitive motivation
- Sex-dependent effects of acute stress in adolescence or adulthood on appetitive motivation
- Sex-dependent alterations of inflammatory factors, oxidative stress, and histopathology of the brain-gut axis in a VPA-induced autistic-like model of rats