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Illuminating the complex interplay of risk factors for depression symptoms within a large-scale US longitudinal cohort

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Large-scale US longitudinal cohort reveals multifactorial risk architecture for depressive symptoms.
Interactions among social, biological and environmental risk factors substantially influence symptom trajectories.
Findings support integrated, targeted prevention and intervention strategies accounting for risk interplay.

Soc Psychiatry Psychiatr Epidemiol. 2026 May 5. doi: 10.1007/s00127-026-03098-0. Online ahead of print.

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PMID:42084756 | DOI:10.1007/s00127-026-03098-0

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