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Inhibition of Trpv4 rescues circuit and social deficits unmasked by acute inflammatory response in a Shank3 mouse model of Autism
🌐 90 Days
VR Related Evidence Matrix
- Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis
- Shank3 deficiency elicits autistic-like behaviors by activating p38alpha in hypothalamic AgRP neurons
- Adolescent Thalamocortical Inhibition Alters Prefrontal Excitation-Inhibition Balance
- Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease
- Dopamine control of social novelty preference is constrained by an interpeduncular-tegmentum circuit
- Inhibition of fatty acid amide hydrolase reverses aberrant prefrontal gamma oscillations in the sub-chronic PCP model for schizophrenia
- Human-derived fecal microbiota transplantation alleviates social deficits of the BTBR mouse model of autism through a potential mechanism involving vitamin B(6) metabolism
- Human-derived fecal microbiota transplantation alleviates social deficits of the BTBR mouse model of autism through a potential mechanism involving vitamin B(6) metabolism
- MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens
- Biochemical, Biomarker, and Behavioral Characterization of the GrnR493X Mouse Model of Frontotemporal Dementia
- Cannabidiol is a behavioral modulator in BTBR mouse model of idiopathic autism
- Topography and ensemble activity in auditory cortex of a mouse model of Fragile-X-Syndrome
- Delta opioid peptide [D-ala2, D-leu5]-Enkephalin's ability to enhance mitophagy via TRPV4 to relieve ischemia/reperfusion injury in brain microvascular endothelial cells
- Assessment of the excitation-inhibition ratio in the Fmr1 KO2 mouse using neuronal oscillation dynamics
- Increased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice
- Therapeutic effects of orexin-A in sepsis-associated encephalopathy in mice
- Inhibition of reactive oxygen species production accompanying alternatively activated microglia by risperidone in a mouse ketamine model of schizophrenia
- D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease
- Dysfunction of striatal parvalbumin interneurons drives motor stereotypies in Cntnap2-/- mouse model of autism spectrum disorders
- Benefits of bone marrow mesenchymal stem cells compared to their conditioned medium in valproic acid-induced autism in rats
- Soluble Epoxide Hydrolase Inhibition Reverses Cognitive Dysfunction in a Mouse Model of Metabolic Syndrome by Modulating Inflammation
- Choline chloride shows gender-dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide-induced rat model of autism
- Particulate matter (PM(10)) exacerbates on MK-801-induced schizophrenia-like behaviors through the inhibition of ERK-CREB-BDNF signaling pathway
- Targeting terminal pathway reduces brain complement activation, amyloid load and synapse loss, and improves cognition in a mouse model of dementia
- Validation of a computational biomechanical mouse brain model for rotational head acceleration
- Validation of a computational biomechanical mouse brain model for rotational head acceleration
- Validation of a computational biomechanical mouse brain model for rotational head acceleration
- Suppression of Cofilin function in the somatosensory cortex alters social contact behavior in the BTBR mouse inbred line
- Brain hypothyroidism silences the immune response of microglia in Alzheimer's disease animal model
- BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair
- Protocol for quantifying pyramidal neuron hyperexcitability in a mouse model of neurodevelopmental encephalopathy
- The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
- Offspring behavioral outcomes following maternal allergic asthma in the IL-4-deficient mouse
- Aflatoxin B(1) Exposure Exacerbates Chemokine Receptor Expression in the BTBR T(+) Itpr3(tf)/J Mouse Model, Unveiling Insights into Autism Spectrum Disorder: A Focus on Brain and Spleen
- Aflatoxin B(1) Exposure Exacerbates Chemokine Receptor Expression in the BTBR T(+) Itpr3(tf)/J Mouse Model, Unveiling Insights into Autism Spectrum Disorder: A Focus on Brain and Spleen
- Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation
- Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation
- Traumatic Brain Injury in Mice Generates Early-Stage Alzheimer's Disease Related Protein Pathology that Correlates with Neurobehavioral Deficits
- Colon impairments and inflammation driven by an altered gut microbiota leads to social behavior deficits rescued by hyaluronic acid and celecoxib
- Working memory and inhibitory control deficits in children with ADHD: an experimental evaluation of competing model predictions
- Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition
- Immunoregulatory role of the gut microbiota in inflammatory depression
- Patterns of spontaneous neural activity associated with social communication abilities among infants and toddlers showing signs of autism
- Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition
- Selective targeting and modulation of plaque associated microglia via systemic hydroxyl dendrimer administration in an Alzheimer's disease mouse model
- Adenosine mediates the amelioration of social novelty deficits during rhythmic light treatment of 16p11.2 deletion female mice
- Deficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice
- Tcf4 dysfunction alters dorsal and ventral cortical neurogenesis in Pitt-Hopkins syndrome mouse model showing sexual dimorphism
- Bioassay-guided isolation of anti-inflammatory and antinociceptive metabolites among three Moroccan Juniperus leaves extract supported with in vitro enzyme inhibitory assays
- Administration of Atosiban, an Oxytocin Receptor Antagonist, Ameliorates Autistic-like Behaviors in a Female Rat Model of Valproic Acid-induced Autism
- Resolving neuroinflammatory and social deficits in ASD model mice: Dexmedetomidine downregulates NF-kB/IL-6 pathway via a2AR
- Mechanism Explanation on Improved Cognitive Ability of D-Gal Inducing Aged Mice Model by Lactiplantibacillus plantarum MWFLp-182 via the Microbiota-Gut-Brain Axis
- A vasopressin circuit that modulates mouse social investigation and anxiety-like behavior in a sex-specific manner
- Juvenile peripheral LPS exposure overrides female resilience to prenatal VPA effects on adult sociability in mice
- Urolithin A Inhibits Anterior Basolateral Amygdala to Ventral Hippocampal CA1 Circuit to Ameliorate Amyloid-β-Impaired Social Ability
- Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo
- Developmental dopaminergic signaling modulates neural circuit formation and contributes to autism spectrum disorder (ASD)-related phenotypes
- Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition
- Mark4 ablation attenuates pathological phenotypes in a mouse model of tauopathy
- Model of negative affect induced by withdrawal from acute and chronic morphine administration in male mice
- Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice
- Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties
- Examination of associations between psychopathy and neural reinforcement sensitivity theory constructs
- Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation
Evidence Blueprint
Inhibition of Trpv4 rescues circuit and social deficits unmasked by acute inflammatory response in a Shank3 mouse model of Autism
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Inhibition of Trpv4 rescues circuit and social deficits unmasked by acute inflammatory response in a Shank3 mouse model of Autism
🌐 365 Days
VR Related Evidence Matrix
- The Shank3-InsG3680(+/+) mouse model of autism spectrum disorder displays auditory avoidance in a novel behavioral test
- Excitatory neurons in the lateral parabrachial nucleus mediate the interruptive effect of inflammatory pain on a sustained attention task
- Effects of extended-release 7-nitroindazole gel formulation treatment on the behavior of Shank3 mouse model of autism
- Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling
- Impaired synaptic function and hyperexcitability of the pyramidal neurons in the prefrontal cortex of autism-associated Shank3 mutant dogs
- Accelerated social representational drift in the nucleus accumbens in a model of autism
- Circuit-level theories for sensory dysfunction in autism: convergence across mouse models
- Serotonergic circuit dysregulation underlying autism-related phenotypes in BTBR mouse model of autism
- Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder
- Understanding the role of AMPA receptors in autism: insights from circuit and synapse dysfunction
- ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function
- Shank3 ameliorates neuronal injury after cerebral ischemia/reperfusion via inhibiting oxidative stress and inflammation
- Social circuits and their dysfunction in autism spectrum disorder
- EGR1 regulates SHANK3 transcription at different stages of brain development
- Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome
- Altered neural activity in the mesoaccumbens pathway underlies impaired social reward processing in Shank3 -deficient rats
- Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis
- Postsynaptic protein Shank3a deficiency synergizes with Alzheimer's disease neuropathology to impair cognitive performance in the 3xTg-AD murine model
- Postsynaptic protein Shank3a deficiency synergizes with Alzheimer's disease neuropathology to impair cognitive performance in the 3xTg-AD murine model
- Shank3 deficiency elicits autistic-like behaviors by activating p38alpha in hypothalamic AgRP neurons
- Spreading Depolarizations Contribute to the Acute Behavior Deficits Associated with a Mild Traumatic Brain Injury in Mice
- Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats
- Striatal Synaptic Changes and Behavior in Adult mouse Upon Prenatal Exposure to Valproic Acid
- Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism
- Tet2 acts in the lateral habenula to regulate social preference in mice
- A synbiotic formulation of Lactobacillus reuteri and inulin alleviates ASD-like behaviors in a mouse model: the mediating role of the gut-brain axis
- CSF1R-mediated myeloid cell depletion shifts the ratio of motor cortical excitatory to inhibitory neurons in a multiple system atrophy model
- Shank3 mutations enhance early neural responses to deviant tones in dogs
- Adolescent Thalamocortical Inhibition Alters Prefrontal Excitation-Inhibition Balance
- Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease
- Mouse models of human CNTNAP1-associated congenital hypomyelinating neuropathy and genetic restoration of murine neurological deficits
- Locus coeruleus integrity is linked to response inhibition deficits in Parkinson's disease and progressive supranuclear palsy
- Dopamine control of social novelty preference is constrained by an interpeduncular-tegmentum circuit
- Autistic traits in myotonic dystrophy type 1 due to MBNL inhibition and RNA mis-splicing
- Inhibition of fatty acid amide hydrolase reverses aberrant prefrontal gamma oscillations in the sub-chronic PCP model for schizophrenia
- Human-derived fecal microbiota transplantation alleviates social deficits of the BTBR mouse model of autism through a potential mechanism involving vitamin B(6) metabolism
- Human-derived fecal microbiota transplantation alleviates social deficits of the BTBR mouse model of autism through a potential mechanism involving vitamin B(6) metabolism
- From synapses to circuits: What mouse models have taught us about how autism spectrum disorder impacts hippocampal function
- Posterior cingulate cortex spontaneous activity associated with motor response inhibition in patients with obsessive-compulsive disorder: A resting-state fMRI study
- Faster Gastrointestinal Transit, Reduced Small Intestinal Smooth Muscle Tone and Dysmotility in the Nlgn3R451C Mouse Model of Autism
- Chronic psychosocial stress triggers microglial-/macrophage-induced inflammatory responses leading to neuronal dysfunction and depressive-related behavior
- A novel head-fixed assay for social touch in mice uncovers aversive responses in two autism models
- Shank3 Deficiency Results in a Reduction in GABAergic Postsynaptic Puncta in the Olfactory Brain Areas
- MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens
- Female mice prenatally exposed to valproic acid exhibit complex and prolonged social behavior deficits
- Biochemical, Biomarker, and Behavioral Characterization of the GrnR493X Mouse Model of Frontotemporal Dementia
- Inhibiting CSF1R alleviates cerebrovascular white matter disease and cognitive impairment
- Histone deacetylase 3 regulates microglial function through histone deacetylation
- Cannabidiol is a behavioral modulator in BTBR mouse model of idiopathic autism
- Cortex-restricted deletion of Foxp1 impairs barrel formation and induces aberrant tactile responses in a mouse model of autism
- A FOREBRAIN-HYPOTHALAMIC ER STRESS DRIVEN CIRCUIT MEDIATES HEPATIC STEATOSIS DURING OBESITY
- Topography and ensemble activity in auditory cortex of a mouse model of Fragile-X-Syndrome
- Delta opioid peptide [D-ala2, D-leu5]-Enkephalin's ability to enhance mitophagy via TRPV4 to relieve ischemia/reperfusion injury in brain microvascular endothelial cells
- The Relevance of Animal Models of Social Isolation and Social Motivation for Understanding Schizophrenia: Review and Future Directions
- Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11.2 Deletion Syndrome
- Establishment of heterozygous and homozygous SHANK3 knockout clonal pluripotent stem cells from the parental hESC line SA001 using CRISPR/Cas9
- Day-to-day spontaneous social behaviours is quantitatively and qualitatively affected in a 16p11.2 deletion mouse model
- Reversal of memory and autism-related phenotypes in Tsc2+/- mice via inhibition of Nlgn1
- The novel somatosensory nose-poke adapted paradigm (SNAP) is an effective tool to assess differences in tactile sensory preferences in autistic-like mice
- Assessment of the excitation-inhibition ratio in the Fmr1 KO2 mouse using neuronal oscillation dynamics
- Enteric glia promote visceral hypersensitivity during inflammation through intercellular signaling with gut nociceptors
- Independent and combined effects of astaxanthin and omega-3 on behavioral deficits and molecular changes in a prenatal valproic acid model of autism in rats
- 22q13.33 duplication involving SHANK3 gene: a boy and his mother with "persistent" language and speech sound disorder
- Polystyrene microplastics exposure aggravates acute liver injury by promoting Kupffer cell pyroptosis