RAISR4D Violence

Leveraging nanoparticle protein corona to advance plasma proteome profiling

16/06/2026

AI Summary

Nanoparticle protein coronas enrich low-abundance plasma proteins, markedly increasing proteome coverage and revealing previously inaccessible biomarkers.
Technical challenges include variability, nanoparticle property-driven bias, and the need for standardised protocols to ensure reproducibility and quantitative accuracy.
Future work should prioritise proteoform-level characterisation and integration with causal inference frameworks to translate corona-enriched discoveries into clinical biomarkers.

Nat Commun. 2026 Jun 15;17(1):5291. doi: 10.1038/s41467-026-74426-w.

ABSTRACT

The blood plasma proteome is a rich reservoir of potential biomarkers, yet its analysis is hindered by a protein concentration dynamic range exceeding ten orders of magnitude. Traditional fractionation and enrichment methods often present limitations in detecting rare proteins masked by the presence of abundant proteins. A promising frontier technology has emerged to overcome such limitations: leveraging nanoparticle protein coronas to enrich low-abundance plasma proteins and unveil previously inaccessible layers of the proteome. This Perspective highlights the capabilities of the protein corona technology in enhancing proteome coverage, addresses its current limitations and outlines future directions in proteoform analysis and causal inference.

PMID:42297805 | DOI:10.1038/s41467-026-74426-w

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