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Lithium: challenges of being king

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Lithium is the only true mood stabiliser, effectively treating and preventing both mania and depression.
Its use has declined in practice despite clear anti-suicidal and neuroprotective properties.
The authors call for wider clinical recognition and greater use of lithium in mood disorder management.

Br J Psychiatry. 2026 May 5:1-4. doi: 10.1192/bjp.2026.10655. Online ahead of print.

ABSTRACT

Lithium is the only true mood stabiliser as it is able to both treat and prevent mania and depression. In practice, its popularity has declined despite discovering it has anti-suicidal and neuroprotective properties. Here, we argue for recognition of its benefits and advocate for its clinical use more widely.

PMID:42083011 | DOI:10.1192/bjp.2026.10655

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