Major depressive episode symptoms and help-seeking behavior: A network analysis in a nationally representative cohort

Psychiatry Res. 2026 Apr 18;361:117179. doi: 10.1016/j.psychres.2026.117179. Online ahead of print.

ABSTRACT

BACKGROUND: Major depressive episode remains largely untreated, and identifying symptom-level predictors of help-seeking is a clinical priority. This study uses network analysis to examine these predictors in a longitudinal nationally representative cohort.

METHODS: The population consisted of individuals who had experienced a major depressive episode in the year prior to the interview and who had not sought care during that period. We estimated a symptom network including DSM-IV major depressive episode criteria at baseline (Wave 1), depressive symptoms at three years, and help-seeking behavior at three years (Wave 2). Bridge centrality indices were computed to identify key symptoms linking depressive symptoms to help-seeking behavior. Sensitivity analyses tested robustness to adjustment for symptom burden, episode duration, and functional impairment.

RESULTS: Among the 1900 individuals with major depressive episode at Wave 1, 16.4% (312) sought help three years later, with 81.1% (256) consulting a healthcare professional and 78.8% (244) receiving a prescription. Three symptoms at follow-up were significantly linked to help-seeking: fatigue, insomnia, and suicidal ideation. Suicidal ideation at baseline was indirectly linked to help-seeking through its persistence at three-year follow-up. Sensitivity analyses confirmed that the three key symptoms remained significantly associated with help-seeking after adjustment for symptom count, episode duration, and functional impairment.

CONCLUSION: Fatigue, insomnia, and suicidal ideation represent key predictors of help-seeking in individuals with untreated major depressive episode. The persistence of suicidal ideation underscores the importance of its systematic assessment in clinical practice. These findings support the development of symptom-anchored interventions to facilitate earlier engagement with care.

PMID:42025610 | DOI:10.1016/j.psychres.2026.117179