Neural Bases of Affect-Based Impulsivity: A Decision Neuroscience Account

Comput Psychiatr. 2026 Apr 22;10(1):85-103. doi: 10.5334/cpsy.159. eCollection 2026.

ABSTRACT

Affect-based impulsivity describes the tendency to behave impulsively while experiencing negative or positive affective states. In the context of psychiatric disorders, the consequences of affect-based impulsivity can be dire, including suicidal behavior and harmful substance use. Here, we provide a narrative review and articulate a decision neuroscience account of affect-based impulsivity. We focus specifically on how negative emotions alter the balance of Pavlovian and goal-directed decision systems. We consider how negative affect influences whether to act, what actions to consider, which action to select, and how vigorously to engage in a selected action. Further, we describe the neural and neuroendocrine bases of these computations. We propose that modulation of norepinephrine and glucocorticoids during negative affective states enhances the pursuit of rewards by reducing goal-directed computations and increasing appetitive Pavlovian computations.

PMID:42040507 | PMC:PMC13109919 | DOI:10.5334/cpsy.159