Psychiatry RAISR4D

PI3K/Akt/mTOR signaling pathway: The major signal transduction involved in the anticancer effects of resveratrol

07/05/2026

AI Summary

Resveratrol modulates the PI3K/Akt/mTOR pathway, which controls cell survival, proliferation, metabolism and motility.
Dysregulation of PI3K/Akt/mTOR is prevalent across most cancers, identifying the pathway as a prime therapeutic target.
Targeting key nodes of the pathway, resveratrol suppresses tumourigenesis and supports its potential utilisation in oncological treatment.

Pathol Res Pract. 2026 Apr 25;283:156491. doi: 10.1016/j.prp.2026.156491. Online ahead of print.

ABSTRACT

Resveratrol, a naturally occurring polyphenolic compound found in grapes, blueberries, raspberries, and peanuts, has high potential to treat several pathological diseases, including cancer. Its anticancer efficacy is due to the regulation of multiple genes and pathways. Of these, the PI3K/Akt/mTOR pathway is particularly significant since it regulates cell survival, proliferation, metabolism, and motility. Dysregulation of this pathway is a feature of the majority of cancers and is therefore a therapeutic target candidate. This review integrates evidence for the regulatory action of resveratrol on the PI3K/Akt/mTOR pathway, revealing its mechanism in inhibiting tumorigenesis. Evidence demonstrates significant impacts in suppressing tumorigenesis by targeting key nodes of this pathway, providing strong justification for the potential utilization of resveratrol in oncological treatment.

PMID:42092228 | DOI:10.1016/j.prp.2026.156491

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