Quality of life and psychological wellbeing of adults with anaphylaxis: a mixed method systematic review

Qual Life Res. 2026 Jun 6;35(7):183. doi: 10.1007/s11136-026-04266-0.

ABSTRACT

PURPOSE: To review the current evidence on quality of life (QOL) and psychological wellbeing of adults with anaphylaxis.

METHODS: A mixed method systematic review was conducted. The comprehensive search used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Nine databases (MEDLINE, EBSCOhost, Embase, CINAHL Complete, Joanna Briggs Institute [JBI], Nursing and Allied Health ProQuest, PsycINFO, Cochrane Library and Google Scholar) were searched for literature published between January 2011 and October 2024. The Mixed Methods Appraisal Tool was used to assess methodological quality. Data from included studies were analysed using convergent mixed methods design. The protocol was prospectively registered (PROSPERO 2024 CRD42024583368).

RESULTS: A total of 11 papers (10 studies) met the inclusion criteria. Most studies reported that anaphylaxis has a negative impact on adults’ psychological wellbeing, with many experiencing high levels of stress, anxiety, and/or depression. Women reported worse mental health than men. QOL was also affected, as most participants reported daily limitations, and many expressed reduced enjoyment in social activities. Impaired QOL was attributed to fear and emotional burden arising from previous episodes of anaphylaxis, contributing to avoidant behaviours and social withdrawal in an attempt to reduce the risk of future anaphylaxis events.

CONCLUSION: Anaphylaxis affects adults’ psychological wellbeing and QOL. This review highlighted that clinicians may consider routine assessment of QOL and psychological wellbeing to not only provide adequate support but to identify patients who may require additional support as they learn to balance daily living with anaphylaxis.

PMID:42250067 | DOI:10.1007/s11136-026-04266-0