Quantifying plasticity: a network-based framework linking structure to dynamical regimes

AI Summary

Plasticity operationalised as the ratio of system size to connectivity strength, with size setting state space and connectivity tuning dynamical regime.
An optimal plasticity at intermediate connectivity coincides with criticality; yields a normalised effective plasticity measure enabling cross-system comparison and prediction of adaptive capacity.
Plasticity acts as structural tuning parameter driving criticality, forecasting functional regime shifts in psychopathology and offering a unified framework for ecology, economics and social systems.

Neurosci Biobehav Rev. 2026 May 19:106765. doi: 10.1016/j.neubiorev.2026.106765. Online ahead of print.

ABSTRACT

Plasticity is a fundamental property of complex systems, such as the brain or an organism. Yet it typically remains a descriptive concept inferred retrospectively from observed outcomes, such as modifications in activity or morphology. Here, the network-based operationalization of plasticity is further formalized as the ratio between system size and connectivity strength among system elements. Within this framework, system size determines the dimensionality of the accessible state space, while connectivity strength tunes the system’s regime. Therefore, a system’s plasticity is defined as the capacity for change within the constraints imposed by its current structure, rather than as structural modifications that modulate the level of plasticity. An optimal range of plasticity — balancing capacity for change and capacity to maintain coherence — emerges at intermediate connectivity strength. Notably, this balance coincides with the critical regime, which provides a theoretically motivated benchmark that enables a normalized unit of measure, termed effective plasticity, and comparisons of adaptive efficacy across diverse systems. Plasticity is thus transformed into a predictive tool that quantifies a system’s capacity for change before it occurs. Its validity is supported across disciplines and, in particular, by evidence from psychopathology where it anticipates transitions between mental states. At a mechanistic level, plasticity acts as a structural tuning parameter for criticality, reframing their relationship as causal, with plasticity driving criticality rather than merely accompanying it. Furthermore, this network-based operationalization explains how larger systems can more robustly maintain critical dynamics. Crucially, the proposed perspective distinguishes functional regime shifts from thermodynamic phase changes, identifying plasticity as the system-level property that shapes and constrains the dynamic repertoire. This framework is applicable across domains, including ecology, economics, and social systems, and may foster cross-disciplinary integration within complexity science.

PMID:42162679 | DOI:10.1016/j.neubiorev.2026.106765

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