Response to Li et al., “Comment on Nie et al. (2026) ‘Suicidality Reports in Acne Patients Treated with Isotretinoin and Concomitant Antidepressants: A Descriptive Analysis of FDA Adverse Event Reporting System Data'”
AI Summary
Defends original descriptive analysis and clarifies methodological choices addressing Li et al.'s criticisms about case selection and signal interpretation.
Emphasises inherent FAERS limitations, including underreporting, missing denominators, and inability to establish causality from spontaneous reports.
Recommends cautious interpretation, continued pharmacovigilance, and careful clinical assessment when isotretinoin is prescribed with antidepressants.
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