Role of the Cerebellum in Bipolar Disorder: A Systematic Literature Review
Evidence
Cureus. 2024 Mar 12;16(3):e56044. doi: 10.7759/cureus.56044. eCollection 2024 Mar.
ABSTRACT
The aim of this systematic literature review was to investigate the role of the cerebellum in the affective symptoms observed in patients with bipolar disorder. The present systematic literature review included clinical studies conducted from 2013-2023 among adult populations with bipolar I and II disorders, along with their specifiers. With regard to cerebellar pathology, it was found that those with bipolar disorder performed worse than their healthy counterparts in their ability to comprehend the mental states of others and in identifying negative mental states. Additionally, individuals with bipolar disorder had reduced gray matter loss in regions such as lobules I-IX, crus I, and crus II, different functional activation patterns of the thalamus, striatum, and hippocampus on functional magnetic resonance imaging (fMRI), and increased cortical thickness. Cerebro-cerebellar functional connectivities were altered in patients with bipolar disorder. The effects of lamotrigine and lithium on cerebellar volume and abnormalities are also discussed in this paper. The present systematic literature review illustrates the emerging involvement of the cerebellum in bipolar disorder and its affective symptoms and paves the way for future research and a better understanding of bipolar disorder.
Schizophr Res. 2024 Jul 12;271:9-18. doi: 10.1016/j.schres.2024.06.047. Online ahead of print.ABSTRACTSchizophrenia is a serious mental disorder, and monitoring remission is a widely used measure of...
Schizophr Res. 2024 Jul 12;271:19-27. doi: 10.1016/j.schres.2024.07.025. Online ahead of print.ABSTRACTA substantial body of evidence implicates dysfunction in N-methyl-d-aspartate receptors (NMDARs) in the pathophysiology of...
Psychiatry Res. 2024 Jul 5;339:116072. doi: 10.1016/j.psychres.2024.116072. Online ahead of print.ABSTRACTBACKGROUND: Psychotic-like experiences (PLEs) are subtle, subclinical perturbations of perceptions and thoughts and are common...
Schizophr Res. 2024 Jul 12;270:486-493. doi: 10.1016/j.schres.2024.06.042. Online ahead of print.ABSTRACTBACKGROUND: Formal Thought Disorder (FTD) is a recognised psychiatric symptom, yet its characterisation remains debated....
Cell Rep. 2024 Jul 11;43(7):114505. doi: 10.1016/j.celrep.2024.114505. Online ahead of print.ABSTRACTIncreasing global concerns about psychoactive substance addiction and psychotic disorders highlight the need for comprehensive...
J Clin Med. 2024 Jun 30;13(13):3873. doi: 10.3390/jcm13133873.ABSTRACTBackground/Objectives: Primary Familial Brain Calcification is a rare neurodegenerative disorder of adulthood characterized by calcium deposition in the...
This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Cookie settingsACCEPT
Privacy & Cookies Policy
Privacy Overview
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.