Category: Psychosis

Psychedelic Med (New Rochelle). 2026 Nov 12:28314425261505140. doi: 10.1177/28314425261505140. Online ahead of print.ABSTRACTBACKGROUND: In 1984, early clinical researcher Daniel Freedman noted that the clinical effects...

J Cereb Blood Flow Metab. 2026 Nov 12:271678X261508659. doi: 10.1177/0271678X261508659. Online ahead of print.ABSTRACTBACKGROUND: Quantitative dynamic PET imaging requires metabolite-corrected arterial input functions, traditionally obtained...

Acta Neuropsychiatr. 2026 Nov 13;38:e62. doi: 10.1017/neu.2026.10105.ABSTRACTOBJECTIVES: We previously trained and tested a machine learning model to predict incident type 2 diabetes (T2D) in patients...

Psychiatr Serv. 2026 Nov 13:appips20260147. doi: 10.1176/appi.ps.20260147. Online ahead of print.ABSTRACTOBJECTIVE: Online screening may facilitate help-seeking behavior among individuals at risk for psychosis, although adolescents...

Psychiatr Serv. 2026 Nov 13:appips20260546. doi: 10.1176/appi.ps.20260546. Online ahead of print.ABSTRACTRecent developments at the NIH raise concerns that the agency is narrowing its definition of...

BMC Psychol. 2026 Sep 15;14(1):1641. doi: 10.1186/s40359-026-05528-9.ABSTRACTBACKGROUND: Moyamoya disease (MMD) is a rare, chronic occlusive cerebrovascular disorder. A small number of patients may present with...

Psychiatry Res. 2026 Nov 10;367:117579. doi: 10.1016/j.psychres.2026.117579. Online ahead of print.ABSTRACTIt is unknown whether gut microbial composition causally influences mental illness. Using genetic variants as...

Asian J Psychiatr. 2026 Nov 6;126:105205. doi: 10.1016/j.ajp.2026.105205. Online ahead of print.NO ABSTRACTPMID:43019781 | DOI:10.1016/j.ajp.2026.105205

J Affect Disord. 2026 Nov 4:122690. doi: 10.1016/j.jad.2026.122690. Online ahead of print.ABSTRACTBACKGROUND: Traumatic childhood events have been associated with poorer adult mental health. We examined...

Alzheimers Dement (N Y). 2026 Nov 2;12(4):e70332. doi: 10.1002/trc2.70332. eCollection 2026 Oct-Dec.ABSTRACTINTRODUCTION: ORM-12741 is a potent and selective alpha-2C adrenoceptor antagonist. The primary objective of...

Cureus. 2026 Oct 31;18(10):e118869. doi: 10.7759/cureus.118869. eCollection 2026 Oct.ABSTRACTRapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia in which the normal muscle atonia...

Trials. 2026 Aug 5;27(1):641. doi: 10.1186/s13063-026-09861-7.ABSTRACTBACKGROUND: Schizophrenia, bipolar depression and major depressive disorders collectively affect over 10 million people across the European Union and are...

Aust N Z J Psychiatry. 2026 Nov 1:48674261502669. doi: 10.1177/00048674261502669. Online ahead of print.ABSTRACTAlthough debate remains about gender differences in the experience of bipolar disorder,...

Health Expect. 2026 Dec;29(6):e70944. doi: 10.1111/hex.70944.ABSTRACTKnowledge derived from personal experience of mental health service use, by way of individuals with lived and living experience, is...

Front Immunol. 2026 Oct 16;17:1936750. doi: 10.3389/fimmu.2026.1936750. eCollection 2026.ABSTRACTImmune involvement in psychosis is well supported, although most of the evidence comes from studies of negative...

Front Psychiatry. 2026 Oct 16;17:1813256. doi: 10.3389/fpsyt.2026.1813256. eCollection 2026.ABSTRACTINTRODUCTION: Research on resilience in clinical recovery following first-episode schizophrenia (FES) remains limited, and few longitudinal studies...

BMC Psychiatry. 2026 Aug 3;26(1):849. doi: 10.1186/s12888-026-08486-z.ABSTRACTOBJECTIVE: Previous studies have shown that elevated homocysteine (Hcy) levels are associated with cognitive deficits in first-episode and drug-naive...

NPJ Digit Med. 2026 Oct 30;9(1):827. doi: 10.1038/s41746-026-03435-2.ABSTRACTDigital mental health technologies hold promise, yet their integration into routine care remains challenging. This study reports findings...

Transl Psychiatry. 2026 Aug 3;16(1):598. doi: 10.1038/s41398-026-04329-3.ABSTRACTComputational analysis of speech enables precise, objective measurements of a behavioral signal closely linked to manic episodes. In a...

Rev Colomb Psiquiatr (Engl Ed). 2026 Jul-Sep;55(3):184-195. doi: 10.1016/j.rcpeng.2026.10.001.ABSTRACTINTRODUCTION: Previous studies have suggested that the neurovascular structure of the retina is affected in schizophrenia spectrum...

Schizophr Res. 2026 Oct 29;298:312-320. doi: 10.1016/j.schres.2026.10.016. Online ahead of print.ABSTRACTBACKGROUND & HYPOTHESIS: Dysfunctional predictive processing (PP), specifically the aberrant weighting of priors, is a...

Clin Psychopharmacol Neurosci. 2026 Nov 30;24(4):885-889. doi: 10.9758/cpn.26.1449. Epub 2026 Oct 4.ABSTRACTContinuous subcutaneous foslevodopa/foscarbidopa infusion (CSFLI) is an emerging treatment for advanced Parkinson's disease (PD)....

Clin Psychopharmacol Neurosci. 2026 Nov 30;24(4):864-879. doi: 10.9758/cpn.26.1490. Epub 2026 Aug 28.ABSTRACTOBJECTIVE: The Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) provides expert consensus-based pharmacotherapy...

Clin Psychopharmacol Neurosci. 2026 Nov 30;24(4):844-853. doi: 10.9758/cpn.26.1429. Epub 2026 May 13.ABSTRACTOBJECTIVE: Immune dysregulation has been increasingly implicated in the pathophysiology of schizophrenia, although findings...

Clin Psychopharmacol Neurosci. 2026 Nov 30;24(4):759-766. doi: 10.9758/cpn.25.1389. Epub 2026 Apr 6.ABSTRACTOBJECTIVE: This study aimed to investigate the association between the human telomerase reverse transcriptase...

Clin Psychopharmacol Neurosci. 2026 Nov 30;24(4):692-700. doi: 10.9758/cpn.26.1406. Epub 2026 Sep 2.ABSTRACTXanomeline-trospium (Cobenfy) is a novel treatment for schizophrenia that exerts its therapeutic benefit through...

J Med Case Rep. 2026 Jul 31;20(1):660. doi: 10.1186/s13256-026-06432-x.ABSTRACTBACKGROUND: Epilepsy affects over 50 million people worldwide, and approximately 30% of cases are treatment-resistant. Neuromodulatory therapies...

Trials. 2026 Aug 1;27(1):633. doi: 10.1186/s13063-026-09871-5.ABSTRACTBACKGROUND: Clinically diagnosed anxiety and depressive disorders are widely recognized as the most common mental health issues in India, affecting...

Transl Psychiatry. 2026 Jul 31;16(1):588. doi: 10.1038/s41398-026-04312-y.ABSTRACTExcitation/inhibition (E/I) balance is crucial for maintaining healthy brain function and can be disrupted in various neurological and psychiatric...

bioRxiv [Preprint]. 2026 Oct 6:2026.10.05.756754. doi: 10.64898/2026.10.05.756754.ABSTRACTBACKGROUND: Auditory verbal hallucinations (AVH) are among the most disabling symptoms of schizophrenia, yet the network-level mechanisms linking auditory...

Aust N Z J Psychiatry. 2026 Oct 24:48674261497851. doi: 10.1177/00048674261497851. Online ahead of print.ABSTRACTPhysical health assessment and investigations are important considerations during the first episode...

Eur Neuropsychopharmacol. 2026 Oct 24;114:113897. doi: 10.1016/j.euroneuro.2026.113897. Online ahead of print.NO ABSTRACTPMID:42925810 | DOI:10.1016/j.euroneuro.2026.113897

J Psychiatr Res. 2026 Oct 19;204:249-257. doi: 10.1016/j.jpsychires.2026.10.021. Online ahead of print.ABSTRACTBACKGROUND: Mobile app-based interventions for first-episode psychosis (FEP) can extend care, yet heterogenous engagement...

Gen Hosp Psychiatry. 2026 Oct 21;103:196-203. doi: 10.1016/j.genhosppsych.2026.10.003. Online ahead of print.ABSTRACTOBJECTIVE: Psychiatric disorders have been implicated in a bidirectional association with inflammation. Current methods...

Australas Psychiatry. 2026 Oct 23:10398562261502228. doi: 10.1177/10398562261502228. Online ahead of print.ABSTRACTAimTo compare demographic characteristics, diagnostic patterns, and discharge outcomes between an Aotearoa (Ngā Taiohi) and...

Nervenarzt. 2026 Oct 22. doi: 10.1007/s00115-026-02023-9. Online ahead of print.ABSTRACTEarly detection of psychotic disorders is complicated by nonspecific symptoms, heterogeneous trajectories and the limited ability...

J Cardiothorac Vasc Anesth. 2026 Sep 15:S1053-0770(26)00875-X. doi: 10.1053/j.jvca.2026.08.167. Online ahead of print.ABSTRACTOBJECTIVES: To determine whether postoperative mechanical ventilation duration is associated with the risk...

Biol Psychiatry. 2026 Oct 23:S0006-3223(26)01614-8. doi: 10.1016/j.biopsych.2026.09.029. Online ahead of print.ABSTRACTBACKGROUND: Individuals at clinical high risk for psychosis (CHR) present with heterogeneous combinations of positive,...

J Affect Disord. 2026 Oct 23:122660. doi: 10.1016/j.jad.2026.122660. Online ahead of print.ABSTRACTBACKGROUND: Scalable, accurate and efficient monitoring tools are urgently needed to support psychiatric assessment...

Schizophr Res. 2026 Oct 23;298:275-284. doi: 10.1016/j.schres.2026.09.043. Online ahead of print.ABSTRACTSchizophrenia spectrum disorders (SSD) have been linked to immune dysregulation and altered intestinal barrier function,...

Schizophr Res. 2026 Oct 23;298:268-274. doi: 10.1016/j.schres.2026.10.005. Online ahead of print.ABSTRACTRacial disparities in emergency department (ED) use among patients with schizophrenia may reflect differences in...

Psychiatry Res. 2026 Oct 16;367:117532. doi: 10.1016/j.psychres.2026.117532. Online ahead of print.ABSTRACTBACKGROUND: Anhedonia and verbal memory impairments are transdiagnostic features of psychopathology, contributing to poorer clinical...

NPJ Acoust. 2026;2(1):39. doi: 10.1038/s44384-026-00076-3. Epub 2026 Oct 20.ABSTRACTFunctional abnormalities of the globus pallidus interna (GPi) are linked to psychosis severity and treatment response in...

BMC Psychol. 2026 Jul 23;14(1):1534. doi: 10.1186/s40359-026-05128-7.ABSTRACTBACKGROUND: Peer support for older adolescents and young adults has become increasingly available as a formal mental health service....

BMC Psychiatry. 2026 Jul 23;26(1):812. doi: 10.1186/s12888-026-08440-z.ABSTRACTBACKGROUND: Major Depressive Disorder with psychotic features (MDD-Psy) represents a severe clinical subtype with distinct psychopathology, yet its underlying...

Discov Ment Health. 2026 Jul 25;6(1):208. doi: 10.1007/s44192-026-00548-8.ABSTRACTBACKGROUND: Considerable evidence exists to support family carers' positive impact on the recovery of young adults with psychotic...

J Am Acad Child Adolesc Psychiatry. 2026 Oct 20:S0890-8567(26)02198-2. doi: 10.1016/j.jaac.2026.10.015. Online ahead of print.NO ABSTRACTPMID:42901236 | DOI:10.1016/j.jaac.2026.10.015

Br J Psychiatry. 2026 Oct 20:1-10. doi: 10.1192/bjp.2026.10798. Online ahead of print.ABSTRACTBACKGROUND: Although commonly accepted depressive subtypes reflect phenotypic differences, there has been minimal progress...

Int J Law Psychiatry. 2026 Oct 20;110:102290. doi: 10.1016/j.ijlp.2026.102290. Online ahead of print.ABSTRACTMandatory Treatment Orders (MTOs) are used in Singapore to manage offenders whose culpability...

West J Emerg Med. 2026 Jul 28;27(5):1180-1188. doi: 10.5811/westjem.58307.ABSTRACTINTRODUCTION: Frequent emergency department (ED) users, particularly those with high rates of use, often experience complex social...

Int J Behav Med. 2026 Oct 19. doi: 10.1007/s12529-026-10498-8. Online ahead of print.ABSTRACTBACKGROUND: Poor cardiovascular health (CVH) remains a leading cause of early mortality among...

J Clin Epidemiol. 2026 Oct 19:112569. doi: 10.1016/j.jclinepi.2026.112569. Online ahead of print.ABSTRACTBACKGROUND: Umbrella reviews (URs) are frequently used to provide high-level syntheses of evidence to...

Neuropsychologia. 2026 Oct 19:109612. doi: 10.1016/j.neuropsychologia.2026.109612. Online ahead of print.ABSTRACTLanguage disorganisation is a core feature of schizophrenia with significant functional consequences. However, its neurophysiological substrates...

Schizophr Res. 2026 Oct 19;298:229-236. doi: 10.1016/j.schres.2026.10.010. Online ahead of print.ABSTRACTFollowing the development of widely accessible large language model-based chatbot systems, concerns have emerged that...

Schizophr Res. 2026 Oct 19;298:216-228. doi: 10.1016/j.schres.2026.10.002. Online ahead of print.ABSTRACTBACKGROUND: Schizophrenia is a complex psychiatric disorder resulting from the dynamic interaction between genetic vulnerability...

Ir J Psychol Med. 2026 Oct 19:1-6. doi: 10.1017/ipm.2026.10240. Online ahead of print.ABSTRACTOBJECTIVES: To describe the demographic, clinical, and treatment characteristics of individuals admitted with...

BJPsych Open. 2026 Oct 19;12(6):e268. doi: 10.1192/bjo.2026.12132.ABSTRACTLithium is a first-line maintenance treatment for bipolar disorder yet delays in diagnosis and lithium initiation remain common. This...

Int J Clin Health Psychol. 2026 Jul-Sep;26(3):100726. doi: 10.1016/j.ijchp.2026.100726. Epub 2026 Oct 7.ABSTRACTPsychosis has been likened to dream-like mentation permeating waking, with hallucinatory experiences, flawed...

Adv Urol. 2026 Oct 17;2026:1858698. doi: 10.1155/aiu/1858698. eCollection 2026.ABSTRACTUrinary tract infections (UTIs) remain among the most common bacterial infections worldwide, affecting millions every year. While...

Nurs Open. 2026 Oct;13(10):e70948. doi: 10.1002/nop2.70948.ABSTRACTBACKGROUND: Intensive Care Unit (ICU) nurses frequently care for patients with mental illness, yet many report feeling insufficiently prepared to...

Eur Arch Psychiatry Clin Neurosci. 2026 Oct 17. doi: 10.1007/s00406-026-02408-6. Online ahead of print.ABSTRACTNegative symptoms such as amotivation begin to emerge in the at-risk mental...

Int J Mol Sci. 2026 Oct 7;27(19):8909. doi: 10.3390/ijms27198909.ABSTRACTClozapine (Clo) is the most effective antipsychotic for treatment-resistant schizophrenia (TRS), yet the mechanisms underlying its unique...

Int J Mol Sci. 2026 Sep 29;27(19):8710. doi: 10.3390/ijms27198710.ABSTRACTPost-traumatic stress disorder (PTSD) is associated with immune and autonomic disturbances, but molecular programs linking PTSD-related blood...

Biology (Basel). 2026 Sep 26;15(19):1714. doi: 10.3390/biology15191714.ABSTRACTPsychosis involves striatal circuit dysfunction, but the regional molecular and cellular changes remain unclear. We re-analyzed 215 postmortem RNA-seq...

J Clin Med. 2026 Oct 1;15(19):7628. doi: 10.3390/jcm15197628.ABSTRACTBackground: Electroconvulsive therapy (ECT) is used as an augmentation strategy in treatment-resistant schizophrenia, but real-world data on individualized...

J Clin Med. 2026 Sep 28;15(19):7542. doi: 10.3390/jcm15197542.ABSTRACTBackground/Objectives: Schizophrenia pathophysiology has been linked to immune dysregulation, but the role of interleukin-33 (IL-33) during acute psychotic...

J Clin Med. 2026 Sep 23;15(19):7403. doi: 10.3390/jcm15197403.ABSTRACTDelusion of pregnancy (DoP) is a rare psychopathological symptom characterised by the fixed, delusional conviction of being pregnant...

NPJ Aging. 2026 Oct 15;12(1):144. doi: 10.1038/s41514-026-00546-8.ABSTRACTPopulation-based studies on the relation between polygenic longevity scores (PGLSs) and specific brain regions on magnetic resonance imaging (MRI)...

Handb Clin Neurol. 2026;219:205-221. doi: 10.1016/B978-0-443-19043-8.00024-4.ABSTRACTSchizophrenia is a severe psychiatric disorder characterized by abnormalities of thought, behavior, cognition, and affect. Risk factors for schizophrenia include...

J Affect Disord. 2026 Oct 15:122641. doi: 10.1016/j.jad.2026.122641. Online ahead of print.ABSTRACTBACKGROUND: Negative affect and psychotic-like experiences (PLEs) reinforce each other in daily life, but...

Lancet. 2026 Oct 17;408(10564):1552-1553. doi: 10.1016/S0140-6736(26)01423-6.NO ABSTRACTPMID:42880303 | DOI:10.1016/S0140-6736(26)01423-6

Psychiatry Res. 2026 Oct 9;367:117503. doi: 10.1016/j.psychres.2026.117503. Online ahead of print.ABSTRACTTo date, there have been only a few scientific studies about characteristics of homeless patients...

Qual Health Res. 2026 Oct 15:10497323261481767. doi: 10.1177/10497323261481767. Online ahead of print.ABSTRACTThe diagnosis of a psychotic disorder in youth often leads to high costs, emotional...

Prim Care Companion CNS Disord. 2026 Oct 15;28(5):26cr04300. doi: 10.4088/PCC.26cr04300.NO ABSTRACTPMID:42879684 | DOI:10.4088/PCC.26cr04300

Psychopathology. 2026 Oct 15:1. doi: 10.1159/psp/aelag014. Online ahead of print.ABSTRACTSchizophrenia spectrum disorders, autism spectrum disorder, and psychopathy may resemble one another at the behavioural surface....

Brain. 2026 Oct 15:awag359. doi: 10.1093/brain/awag359. Online ahead of print.ABSTRACTNegative symptoms in schizophrenia severely impair function and quality of life, yet respond poorly to current...

Addiction. 2026 Oct 11. doi: 10.1111/add.70601. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Over the past decade, there has been increased lifetime use of illicit and...

Schizophr Bull Open. 2026 Sep 16;7(1):sgag038. doi: 10.1093/schizbullopen/sgag038. eCollection 2026.ABSTRACTBACKGROUND AND HYPOTHESIS: Hallucination-like experiences (HLE) are increasingly conceptualized as existing on a continuum ranging from...

Cureus. 2026 Sep 10;18(9):e116065. doi: 10.7759/cureus.116065. eCollection 2026 Sep.ABSTRACTVery late‑onset schizophrenia‑like psychosis (VLOSLP) presents diagnostic complexity due to the broad range of medical, neurological, and...

J Coll Physicians Surg Pak. 2026 Oct;36(10):1362-1365. doi: 10.29271/jcpsp.2026.10.1362.ABSTRACTThis descriptive, quantitative cross-sectional survey aimed to determine the prevalence and explore different demographic characteristics of body...

J ECT. 2026 Oct 9. doi: 10.1097/YCT.0000000000001344. Online ahead of print.NO ABSTRACTPMID:42850704 | DOI:10.1097/YCT.0000000000001344

BMC Psychiatry. 2026 Sep 17;26(1):766. doi: 10.1186/s12888-026-08633-6.ABSTRACTBACKGROUND: Severe mental illness, such as psychosis, significantly affects many areas of life. Involving patients in their care may...

Mol Psychiatry. 2026 Oct 8. doi: 10.1038/s41380-026-03925-5. Online ahead of print.ABSTRACTExisting findings of creativity and mental health associations are inconsistent, partly due to heterogeneous assessment...

Transl Psychiatry. 2026 Sep 19;16(1):539. doi: 10.1038/s41398-026-04457-w.ABSTRACTBACKGROUND: Brain abnormalities related to childhood adversity (CA) have been reported across clinical presentations in psychotic disorder (PD) and...

medRxiv [Preprint]. 2026 Aug 10:2026.08.04.26359703. doi: 10.64898/2026.08.04.26359703.ABSTRACTHistoric epidemiological studies have long observed a paradoxical resistance to solid tumors in cohorts with severe psychiatric conditions, such...

bioRxiv [Preprint]. 2026 Aug 16:2026.08.10.743999. doi: 10.64898/2026.08.10.743999.ABSTRACTSerotonergic psychedelics (SP) are increasingly used in clinical research and naturalistic settings, but their psychotic-like side effects, including persisting...

Br J Clin Psychol. 2026 Oct 6. doi: 10.1111/bjc.70102. Online ahead of print.ABSTRACTOBJECTIVES: This study aimed to examine the underlying dynamics between theory of mind...

Br J Clin Psychol. 2026 Oct 6. doi: 10.1111/bjc.70102. Online ahead of print.ABSTRACTOBJECTIVES: This study aimed to examine the underlying dynamics between theory of mind...

Health Sci Rep. 2026 Oct 5;9(10):e73325. doi: 10.1002/hsr2.73325. eCollection 2026 Oct.ABSTRACTBACKGROUND AND AIMS: Significant apprehension has been triggered concerning various behavioral modalities in humans, including...

Health Sci Rep. 2026 Oct 5;9(10):e73325. doi: 10.1002/hsr2.73325. eCollection 2026 Oct.ABSTRACTBACKGROUND AND AIMS: Significant apprehension has been triggered concerning various behavioral modalities in humans, including...

Health Sci Rep. 2026 Oct 5;9(10):e73341. doi: 10.1002/hsr2.73341. eCollection 2026 Oct.ABSTRACTBACKGROUND AND AIMS: TikTok addiction has been linked to depression and anxiety, yet mechanisms underlying...

Health Sci Rep. 2026 Oct 5;9(10):e73341. doi: 10.1002/hsr2.73341. eCollection 2026 Oct.ABSTRACTBACKGROUND AND AIMS: TikTok addiction has been linked to depression and anxiety, yet mechanisms underlying...

Int J Dermatol. 2026 Oct 5. doi: 10.1111/ijd.70721. Online ahead of print.NO ABSTRACTPMID:42834507 | DOI:10.1111/ijd.70721

Int J Dermatol. 2026 Oct 5. doi: 10.1111/ijd.70721. Online ahead of print.NO ABSTRACTPMID:42834507 | DOI:10.1111/ijd.70721

J Gen Intern Med. 2026 Oct 5. doi: 10.1007/s11606-026-10843-3. Online ahead of print.ABSTRACTBACKGROUND: Surveys suggest mental health conditions are more common among physicians than the...

J Gen Intern Med. 2026 Oct 5. doi: 10.1007/s11606-026-10843-3. Online ahead of print.ABSTRACTBACKGROUND: Surveys suggest mental health conditions are more common among physicians than the...

Br J Pharmacol. 2026 Oct 5. doi: 10.1111/bph.70697. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: Clinical observations suggest that acute inflammatory states transiently modulate psychotic symptoms....

Br J Pharmacol. 2026 Oct 5. doi: 10.1111/bph.70697. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: Clinical observations suggest that acute inflammatory states transiently modulate psychotic symptoms....

Biol Psychiatry Cogn Neurosci Neuroimaging. 2026 Oct;11(10):1201-1203. doi: 10.1016/j.bpsc.2026.08.008.NO ABSTRACTPMID:42833769 | DOI:10.1016/j.bpsc.2026.08.008

Front Public Health. 2026 Sep 17;14:1878232. doi: 10.3389/fpubh.2026.1878232. eCollection 2026.ABSTRACTINTRODUCTION: The COVID-19 pandemic substantially affected people who use drugs (PWUD) with comorbid psychiatric disorders. Lockdowns,...