Category: Delirium

Opinion & Special Articles: Mobile Stroke Treatment Unit: A Distinctive Learning Experience in Neurology Residency

Neurology. 2026 Dec 22;107(12):e218833. doi: 10.1212/WNL.0000000000218833. Epub 2026 Nov 12.ABSTRACTThe mobile stroke treatment unit (MSTU) elective offers a novel immersive experience that exposes neurology trainees...

Delirium

Cerebral Amyloid Angiopathy in Alzheimer Disease Continuum: Prevalence and Clinical Relevance in a Biomarker-Defined Memory Clinic Cohort

Neurology. 2026 Dec 8;107(11):e218738. doi: 10.1212/WNL.0000000000218738. Epub 2026 Nov 12.ABSTRACTBACKGROUND AND OBJECTIVES: Cerebral amyloid angiopathy (CAA) frequently co-occurs with Alzheimer disease (AD), yet the prevalence...

Delirium

Poly(N-isopropylacrylamide)-Grafted Hyaluronic Acid Semi-Gels for Localized Mitochondrial Transplantation in Spinal Cord Injuries

ACS Appl Bio Mater. 2026 Nov 12. doi: 10.1021/acsabm.6c01366. Online ahead of print.ABSTRACTMitochondrial transplantation (MT) represents a promising strategy for treating conditions associated with mitochondrial...

Delirium

TMEM184 proteins are Ca2+ uptake transporters in lysosomes

Science. 2026 Nov 12;394(6825):eaeh3996. doi: 10.1126/science.aeh3996. Epub 2026 Nov 12.ABSTRACTLysosomal Ca2+ release from acidic stores is critical for lysosomal function, yet the molecular identity of...

Delirium

The sideshow

Science. 2026 Nov 12;394(6825):712-715. doi: 10.1126/science.aeo0622. Epub 2026 Nov 12.ABSTRACTHow an unpopular hypothesis linking Alzheimer's disease to the loss of crucial neurons made a comeback.PMID:43019413...

Delirium

Novel gene therapy lets drug dampen brain cell activity, reducing seizures

Science. 2026 Nov 12;394(6825):706-707. doi: 10.1126/science.aeo0640. Epub 2026 Nov 12.ABSTRACTIn first clinical result using "chemogenetic" strategy, a team in China treated three patients to control...

Delirium

The effects of dual task training to improve self-efficacy, functional performance, and quality of life in individuals with Parkinson’s disease: A study protocol

PLoS One. 2026 Nov 12;21(11):e0362454. doi: 10.1371/journal.pone.0362454. eCollection 2026.ABSTRACTINTRODUCTION: Dual tasking is impaired in Parkinson's disease (PD) and adversely impacts activities of daily living and...

Delirium

Successful treatment of multidrug-resistant Candida auris ventriculitis with Intraventricular Caspofungin: first report from Türkiye

J Infect Dev Ctries. 2026 Oct 31;20(10):1566-1570. doi: 10.3855/jidc.22209.ABSTRACTINTRODUCTION: Candida auris is an emerging multidrug-resistant fungus with limited therapeutic options. Central nervous system (CNS) infections...

Delirium

Hearing loss drives region-specific amyloid accumulation along the auditory pathway in female 5xFAD mice

Sci Rep. 2026 Jul 29;16:34914. doi: 10.1038/s41598-026-64191-7. eCollection 2026.ABSTRACTHearing loss is a major modifiable risk factor for Alzheimer's disease (AD), but how auditory deprivation engages...

Delirium

Peripheral DNA methylation of candidate Alzheimer’s disease risk genes and its associations with cognition, brain volume and amyloid-beta burden

Sci Rep. 2026 Aug 3;16:35889. doi: 10.1038/s41598-026-64935-5. eCollection 2026.ABSTRACTAlzheimer's disease (AD) is a growing major public health issue, affecting millions of people worldwide. Genome-wide association...

Delirium

Full-compartmental modeling of [(18)F]FDG PET suggests divergent brain metabolism trajectories from healthy aging to early Alzheimer disease

Sci Rep. 2026 Aug 13;16:35963. doi: 10.1038/s41598-026-64573-x. eCollection 2026.ABSTRACTWithin the Alzheimer disease (AD) spectrum, metabolic alterations occur in addition to proteinopathies. While hypometabolism is frequently...

Delirium

Deep learning mitigates batch effects in Raman spectroscopy

Sci Rep. 2026 Oct 26;16:34019. doi: 10.1038/s41598-026-62086-1. eCollection 2026.ABSTRACTRaman spectroscopy is widely used for its ability to provide rich molecular-level information from biological samples. However,...

Delirium

Association of Accelerated Biological Age in Midlife with Cardiovascular Events, Dementia, and All-Cause Mortality in the Framingham Offspring Study

Sci Rep. 2026 Aug 10;16:37418. doi: 10.1038/s41598-026-64591-9. eCollection 2026.ABSTRACTAccelerated biological age (ABA) better capture the aging process than chronological age (CA) and has been linked...

Delirium

Functional characterization and pharmacochaperone rescue of a novel SLC6A1 variant associated with developmental epileptic encephalopathies

Sci Rep. 2026 Oct 7;16:33835. doi: 10.1038/s41598-026-72601-z. eCollection 2026.ABSTRACTMutations in SLC6A1, encoding the γ-aminobutyric acid (GABA) transporter 1 (GAT-1), are associated with a spectrum of...

Delirium

The hidden burden of structural variants in neurodegenerative and neuromuscular disorders

Sci Rep. 2026 Sep 11;16:36122. doi: 10.1038/s41598-026-69714-w. eCollection 2026.ABSTRACTNeurodegenerative and neuromuscular disorders are genetically heterogeneous, and many patients remain without a genetic diagnosis after multiple...

Delirium

12/11/2026

Multiple Sclerosis Relapses Are Associated With EBV-Specific T-Cell Expansion Amid Broad Immune Activation

Neurol Neuroimmunol Neuroinflamm. 2027 Jan;14(1):e200645. doi: 10.1212/NXI.0000000000200645. Epub 2026 Nov 11.ABSTRACTBACKGROUND AND OBJECTIVES: Epstein-Barr virus (EBV) infection is strongly implicated in multiple sclerosis (MS), yet...

Delirium

12/11/2026

Semantic Processing in Unresponsive Patients With Acute Brain Injury

Neurology. 2026 Dec 8;107(11):e218680. doi: 10.1212/WNL.0000000000218680. Epub 2026 Nov 11.ABSTRACTBACKGROUND AND OBJECTIVES: Early prognostication after acute brain injury (ABI) is challenging because behavioral responsiveness may...

Delirium

12/11/2026

Evaluation of Submandibular Gland Biopsies With Real-Time Quaking-Induced Conversion in Clinical Parkinson Disease

Neurology. 2026 Dec 8;107(11):e218704. doi: 10.1212/WNL.0000000000218704. Epub 2026 Nov 11.ABSTRACTBACKGROUND AND OBJECTIVES: The definite diagnosis of Parkinson disease (PD) is usually made by the detection...

Delirium

Severity-Based Triage for Direct Transportation to Nearest Comprehensive Stroke Center: A Systematic Review and Meta-Analysis

Neurology. 2026 Dec 8;107(11):e218473. doi: 10.1212/WNL.0000000000218473. Epub 2026 Nov 10.ABSTRACTBACKGROUND AND OBJECTIVES: The efficacy of endovascular thrombectomy (EVT) for acute ischemic stroke due to large...

Delirium

Association of Prethrombectomy Hemorrhagic Infarction on MRI With Further Transformation and Functional Outcomes: A Multicenter Study

Neurology. 2026 Dec 8;107(11):e218742. doi: 10.1212/WNL.0000000000218742. Epub 2026 Nov 10.ABSTRACTBACKGROUND AND OBJECTIVES: Mechanical thrombectomy (MT) is the standard of care for acute ischemic stroke from...

Delirium

Performance of Diagnostic Criteria for Autoimmune Encephalitis in Patients With Suspected Rapidly Progressive Dementia

Neurology. 2026 Dec 8;107(11):e218783. doi: 10.1212/WNL.0000000000218783. Epub 2026 Nov 10.ABSTRACTBACKGROUND AND OBJECTIVES: The Graus criteria for possible autoimmune encephalitis (AE) are increasingly used to identify...

Delirium

Personality Correlates of Functional Status in Patients With Early-Stage Behavioral Variant Frontotemporal Dementia

Neurology. 2026 Dec 22;107(12):e218820. doi: 10.1212/WNL.0000000000218820. Epub 2026 Nov 10.ABSTRACTBACKGROUND AND OBJECTIVES: Functional impairment emerges early in behavioral variant frontotemporal dementia (bvFTD), significantly disrupting independence...

Delirium

Increased Need for High Levels of Care in Patients with Delirium Superimposed on Dementia and Risk of Malnutrition

J Nutr Gerontol Geriatr. 2026 Nov 10:1-14. doi: 10.1080/21551197.2026.2759953. Online ahead of print.ABSTRACTWe examined the impact of a malnutrition risk (Malnutrition Universal Screening Tool (MUST)...

Delirium

Comparative cytokine profiling in cerebrospinal fluid and serum of dogs with meningoencephalitis of unknown origin

J Vet Intern Med. 2026 Nov 2;40(6):aalag248. doi: 10.1093/jvimsj/aalag248.ABSTRACTBACKGROUND: Meningoencephalitis of unknown origin (MUO) is a common inflammatory central nervous system (CNS) disease in dogs...

Delirium

Study protocol for a non-randomized trial of community participation support for people with Acquired Brain Injury who have ceased driving in Japan

PLoS One. 2026 Nov 10;21(11):e0362487. doi: 10.1371/journal.pone.0362487. eCollection 2026.ABSTRACTINTRODUCTION: Driving cessation after acquired brain injury (ABI) represents a major life transition that can restrict community...

Delirium

Targeted urine metabolomics for enhanced diagnosis of hypoxic-ischemic encephalopathy in newborns: A pilot study

PLoS One. 2026 Nov 10;21(11):e0361619. doi: 10.1371/journal.pone.0361619. eCollection 2026.ABSTRACTWhile therapeutic hypothermia (cooling treatment) is successful in preventing hypoxic ischemic encephalopathy (HIE), current diagnosis is limited...

Delirium

Variable presentation of neonatal alloimmune thrombocytopenia diagnosed by platelet crossmatch studies: a case series

J Trop Pediatr. 2026 Oct 9;72(6):fmag077. doi: 10.1093/tropej/fmag077.ABSTRACTAlloimmune thrombocytopenia is a significant cause of severe thrombocytopenia and intracranial bleeding in neonates, resulting from the transfer...

Delirium

Thoracic Epidural Blood Patch for Cerebrospinal Fluid Leak After Posterior Spinal Fusion in Adolescent Idiopathic Scoliosis: Report of 2 Cases

JBJS Case Connect. 2026 Oct 9;16(4). doi: 10.2106/JBJS.CC.26.00209. eCollection 2026 Oct 1.ABSTRACTCASE: Postoperative cerebrospinal fluid (CSF) leak following posterior spinal fusion (PSF) for adolescent idiopathic...

Delirium

Effects of Remote Ischemic Conditioning on Cerebral Blood Flow Regulation in Atherosclerosis: A Randomized Trial

Ann N Y Acad Sci. 2026 Nov;1565(1):e70449. doi: 10.1111/nyas.70449.ABSTRACTImpaired dynamic cerebral autoregulation (dCA) contributes to cerebral perfusion instability in patients with cerebrovascular atherosclerosis. Remote ischemic...

Delirium

Tubuloreticular Inclusions in Kidney Tissues of Patients With Lupus Nephritis: An Ultrastructural Biomarker of Type I Interferon-Driven Disease Activity

Am J Nephrol. 2026 Oct 15:ablag021. doi: 10.1159/ajn/ablag021. Online ahead of print.ABSTRACTINTRODUCTION: Tubuloreticular inclusions (TRIs) in kidney tissues associate with type I interferon (IFN-I) pathway...

Delirium

Highly Emissive NIR-II Unimolecular Micelles via a Core-Cap Synthetic Strategy for Deep-Tissue Imaging and Image-Guided Surgery

ACS Nano. 2026 Nov 10;20(44):29951-29962. doi: 10.1021/acsnano.6c13533.ABSTRACTHigh-performance fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window holds promise for deep-tissue optical diagnostics. However, simultaneously...

Delirium

A Hyaluronic Acid-Stabilized Zinc-Loaded Probiotic Mitigates Nanoplastic Toxicity across the Microbiota-Gut-Brain Axis

ACS Nano. 2026 Nov 10;20(44):30216-30232. doi: 10.1021/acsnano.6c15315.ABSTRACTNanoplastics are emerging stressors that perturb host physiology across the gut-immune-brain continuum, yet scalable interventions remain limited. Here, we...

Delirium

Chirality-Functionalized Covalent Organic Frameworks for Enantioselective Neuroprotection with Restored Neuroactive Signaling in Alzheimer’s Disease

ACS Nano. 2026 Nov 10;20(44):29550-29563. doi: 10.1021/acsnano.6c08616.ABSTRACTAlzheimer's disease (AD) is driven by amyloid-β (Aβ) accumulation and a cascade of interconnected neurotoxic events, including oxidative stress,...

Delirium

Effects of Supplementation With Genistein on the Progression of Cognitive Decline in Patients With Mild Cognitive Impairment Due to Alzheimer Disease: Protocol for a Randomized Controlled Trial

JMIR Res Protoc. 2026 Nov 9;15:e98087. doi: 10.2196/98087.ABSTRACTBACKGROUND: Mild cognitive impairment (MCI) may represent a prodromal stage of Alzheimer disease, but interventions to delay progression...

Delirium

Sex Differences in Blood Pressure Dynamics and Outcomes After Endovascular Thrombectomy

Neurology. 2026 Dec 8;107(11):e218703. doi: 10.1212/WNL.0000000000218703. Epub 2026 Nov 9.ABSTRACTBACKGROUND AND OBJECTIVES: Optimal blood pressure (BP) management after endovascular thrombectomy (EVT) for acute ischemic stroke...

Delirium

Pearls & Oy-sters: Anti-GABAA Receptor Encephalitis Presenting as Fulminant Hemicerebellitis in a 5-Year-Old Girl

Neurology. 2026 Dec 8;107(11):e218778. doi: 10.1212/WNL.0000000000218778. Epub 2026 Nov 9.ABSTRACTA previously healthy 5-year-old girl presented with several days of fever/malaise followed by acute neurologic decline....

Delirium

Gait and Dementia Risk in Older Adults

Neurology. 2026 Dec 8;107(11):e218776. doi: 10.1212/WNL.0000000000218776. Epub 2026 Nov 9.NO ABSTRACTPMID:43002717 | DOI:10.1212/WNL.0000000000218776

Delirium

09/11/2026

Post-resuscitation care 2025: neurological prognosis of post-cardiac arrest brain injury

Orv Hetil. 2026 Nov 8;167(45):1799-1809. doi: 10.1556/650.2026.33659. Print 2026 Nov 8.ABSTRACTPost-cardiac arrest brain injury represents a central component of the post-resuscitation syndrome, driven not only...

Delirium

09/11/2026

Clinical Characteristics, Etiologies, and Outcomes of Adults Presenting With Altered Mental Status to the Emergency Department: A Retrospective Cohort Study

Cureus. 2026 Oct 8;18(10):e117634. doi: 10.7759/cureus.117634. eCollection 2026 Oct.ABSTRACTBackground Altered mental status (AMS) is a common emergency presentation with diverse neurological, infectious, metabolic, toxicological, and...

Delirium

09/11/2026

Pregnancy-Induced Hypertension Complicated by Posterior Reversible Encephalopathy Syndrome: A Case Series of Two Patients

Clin Case Rep. 2026 Nov 6;14(11):e73800. doi: 10.1002/ccr3.73800. eCollection 2026 Nov.ABSTRACTPosterior reversible encephalopathy syndrome (PRES) is a rare but potentially life-threatening neurological complication associated with...

Delirium

Prevalence and Profile of Undiagnosed Dementia in Brazil: A 5-Year Nationally Representative Analysis From the ELSI-Brazil

Neurology. 2026 Dec 8;107(11):e218735. doi: 10.1212/WNL.0000000000218735. Epub 2026 Nov 6.ABSTRACTBACKGROUND AND OBJECTIVES: Dementia underdiagnosis is a major barrier to public health strategies, particularly in low-...

Delirium

CD8(+) T cells induce RIPK1-regulated brain endothelial cell death in cerebral malaria

Sci Adv. 2026 Nov 6;12(45):eaej4381. doi: 10.1126/sciadv.aej4381. Epub 2026 Nov 6.ABSTRACTCerebral malaria (CM) is a potentially lethal complication of Plasmodium falciparum infection characterized by blood-brain...

Delirium

Myeloid cells run amok in injured brains

Sci Immunol. 2026 Nov 6;11(125):eaen3917. doi: 10.1126/sciimmunol.aen3917. Epub 2026 Nov 6.ABSTRACTAberrant, cranial bone marrow-derived myelopoiesis drives neuroinflammation in chronic traumatic brain injury.PMID:42993811 | DOI:10.1126/sciimmunol.aen3917

Delirium

Chemoproteomics Discovery of a Central Nervous System-Penetrant Covalent Inhibitor of PIKfyve

ACS Chem Biol. 2026 Nov 6. doi: 10.1021/acschembio.6c00795. Online ahead of print.ABSTRACTPIKfyve is a lipid kinase involved in regulating protein clearance mechanisms and is a...

Delirium

Stroke disability burden and rehabilitation service-capacity proxies in China, 1990-2023: A population-based analysis using GBD 2023 and national service statistics

PLoS One. 2026 Nov 6;21(11):e0361758. doi: 10.1371/journal.pone.0361758. eCollection 2026.ABSTRACTChina's stroke burden is increasingly shaped by survival with disability, population ageing, and demand for rehabilitation and...

Delirium

Electroencephalography-based machine learning models for hyperacute detection of large vessel occlusion stroke

Eur Stroke J. 2026 Nov 2;11(11):aakag134. doi: 10.1093/esj/aakag134.ABSTRACTINTRODUCTION: Electroencephalography (EEG) has shown potential as a prehospital triage instrument for anterior circulation large vessel occlusion (LVO-a)...

Delirium

Blood serotonin, ionized magnesium, cardiac troponin I, N-terminal pro-brain natriuretic peptide concentrations, and mitral valve billowing in horses with mitral valve regurgitation

J Vet Intern Med. 2026 Nov 2;40(6):aalag280. doi: 10.1093/jvimsj/aalag280.ABSTRACTBACKGROUND: Serotonin, ionized magnesium (iMg), cardiac biomarkers, and mitral valve prolapse are extensively investigated in humans and...

Delirium

Exploratory cluster analysis of noninvasive vascular measures reveals heterogeneous vascular profiles after stroke

PLoS One. 2026 Nov 6;21(11):e0362305. doi: 10.1371/journal.pone.0362305. eCollection 2026.ABSTRACTVascular dysfunction is prevalent after stroke and contributes to elevated cardiovascular risk; however, the extent to which...

Delirium

Rethinking hypertension in the brain: from blood pressure control to temporal blood pressure stability-a scoping review

Blood Press. 2026 Dec;35(1):2754674. doi: 10.1080/08037051.2026.2754674. Epub 2026 Nov 6.ABSTRACTBACKGROUND: Temporal blood pressure variability (BPV) may contribute to cerebrovascular injury beyond mean blood pressure (BP),...

Delirium

Pharmacological cGAS-STING pathway inhibition on neuroinflammation in animal models of traumatic brain injury: A systematic review and meta-analysis protocol

PLoS One. 2026 Nov 6;21(11):e0362397. doi: 10.1371/journal.pone.0362397. eCollection 2026.ABSTRACTBACKGROUND: Traumatic brain injury (TBI) is a major cause of mortality and long-term neurological disability worldwide. Secondary...

Delirium

Effectiveness of dose-matched immersive virtual reality-stationary cycling combined with neurological physiotherapy versus neurological physiotherapy alone in individuals with chronic stroke (CIVIS): A single-blind, randomized crossover trial protocol

PLoS One. 2026 Nov 6;21(11):e0362132. doi: 10.1371/journal.pone.0362132. eCollection 2026.ABSTRACTBACKGROUND: Stroke is a leading cause of long-term disability worldwide and frequently results in persistent motor and...

Delirium

Visual outcomes and headache in intracranial hypertension following cerebral venous sinus thrombosis: A retrospective cohort study

PLoS One. 2026 Nov 6;21(11):e0362200. doi: 10.1371/journal.pone.0362200. eCollection 2026.ABSTRACTIntracranial hypertension is a frequent complication of cerebral venous sinus thrombosis (CVT), posing a risk for permanent...

Delirium

Systemic Immune-Inflammation Index is Associated With Tumor Size and Preoperative Cerebrovascular Events in Left Atrial Myxoma

Echocardiography. 2026 Nov;43(11):e70672. doi: 10.1111/echo.70672.ABSTRACTBACKGROUND: Cardiac myxomas are benign tumors associated with potentially serious cerebrovascular complications. The systemic immune-inflammation index (SII) is a readily available...

Delirium

Donation After Circulatory Versus Brain Death Among Adult Trauma Donors: A Retrospective Multicenter Study

Clin Transplant. 2026 Nov;40(11):e70740. doi: 10.1111/ctr.70740.ABSTRACTBACKGROUND: Donation after circulatory death (DCD) is an increasingly important source of organs and tissues, yet differences between DCD and...

Delirium

Cause, Situation, and Impact of Nonaccidental Falls in Persons with Idiopathic Parkinson’s Disease – A Hospital-based Patient-Perceived Observational Study

Indian J Public Health. 2026 Jul 1;70(3):485-488. doi: 10.4103/ijph.ijph_1740_21. Epub 2026 Sep 10.ABSTRACTClinical characteristics, drug responsiveness, and natural history of Parkinson's disease are different in...

Delirium

Association of LATE-NC With Neuropathologic Lesions and Cognitive Abilities: A Population-Based Autopsy Study

Neurology. 2026 Dec 8;107(11):e218694. doi: 10.1212/WNL.0000000000218694. Epub 2026 Nov 5.ABSTRACTBACKGROUND AND OBJECTIVES: Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is a common finding in aging...

Delirium

Knowledge and application of the ABCDEF bundle in a pediatric intensive care unit: a cross-sectional study

Rev Paul Pediatr. 2026 Nov 2;44:e2026069. doi: 10.1590/1984-0462/2026/44/2026069. eCollection 2026.ABSTRACTOBJECTIVE: To describe healthcare professionals' knowledge and use of the ABCDEF bundle in the Pediatric Intensive...

Delirium

NT-proBNP levels and arrhythmias in adolescents with chronic upper gastrointestinal diseases

Rev Paul Pediatr. 2026 Nov 2;44:e2026053. doi: 10.1590/1984-0462/2026/44/2026053. eCollection 2026.ABSTRACTOBJECTIVE: To assess plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in adolescents with chronic upper gastrointestinal...

Delirium

Analysis of hospitalizations and deaths due to stroke in different regions of Brazil before and during the COVID-19 pandemic

Cien Saude Colet. 2026 Oct 30;31(10):e11252024. doi: 10.1590/1413-812320263110.11252024. eCollection 2026.ABSTRACTStroke, the second leading cause of death globally and a significant source of disability, has been...

Delirium

Tuberculous meningoencephalitis in a heart transplant recipient: a case report

Einstein (Sao Paulo). 2026 Nov 2;24:eRC2463. doi: 10.31744/einstein_journal/2026RC2463. eCollection 2026.ABSTRACTA 33-year-old woman who had undergone heart transplantation two years earlier for post-COVID-19 myocarditis was admitted...

Delirium

05/11/2026

Intravenous Thrombolysis for Acute Ischemic Stroke – New Directions

N Engl J Med. 2026 Nov 5;395(18):1841-1847. doi: 10.1056/NEJMra2519017.ABSTRACTIn the past 5 years, substantial changes have been made in the use of intravenous thrombolysis (IVT)...

Delirium

Dextromethorphan as a Potentially Safer Treatment for Agitation Associated With Dementia Due to Alzheimer’s Disease

J Psychosoc Nurs Ment Health Serv. 2026 Nov;64(11):6-8. doi: 10.3928/02793695-20260921-01. Epub 2026 Nov 1.ABSTRACTAgitation associated with dementia due to Alzheimer's disease can present safety issues...

Delirium

Spreading depolarization drives distant connectivity changes in the focally injured cortex

PLoS One. 2026 Nov 3;21(11):e0362090. doi: 10.1371/journal.pone.0362090. eCollection 2026.ABSTRACTCortical spreading depolarization (SD), a slow-propagating wave of transient cellular depolarization, reliably occurs after acute brain injury...

Delirium

Resource allocation under uncertainty and equity constraints in Parkinson’s disease care: An econometrically grounded machine learning framework

PLoS One. 2026 Nov 3;21(11):e0360944. doi: 10.1371/journal.pone.0360944. eCollection 2026.ABSTRACTOBJECTIVE: To apply an integrated causal-inference and welfare-optimization framework to Iranian Parkinson's disease (PD) inpatient insurance claims,...

Delirium

Unveiling the neuroinflammatory potential of aspartame in Alzheimer’s disease: A comprehensive network toxicology and experimental validation approach

PLoS One. 2026 Nov 3;21(11):e0361766. doi: 10.1371/journal.pone.0361766. eCollection 2026.ABSTRACTAspartame, a widely used artificial sweetener, has raised significant concerns regarding its safety, especially in light of...

Delirium

Rigorous nested cross-validation and external generalization-gap analysis of a machine-learning classifier for U-251 glioblastoma cytotoxicity

PLoS One. 2026 Nov 3;21(11):e0361912. doi: 10.1371/journal.pone.0361912. eCollection 2026.ABSTRACTGlioblastoma remains difficult to treat, and drug-repositioning strategies require efficient methods to evaluate chemical libraries. Here, we...

Delirium

Microfluidic Profiling of an Immune Cell-Associated Extracellular Vesicle Signature for Active Tuberculosis Diagnosis and Treatment Monitoring

J Extracell Vesicles. 2026 Nov;15(11):e70395. doi: 10.1002/jev2.70395.ABSTRACTRapid and accurate diagnosis of active tuberculosis (ATB) remains challenging, particularly in paucibacillary cases, where conventional pathogen detection often...

Delirium

Readability of Artificial-Intelligence-Generated Responses to Patient Questions About Hearing Loss and Dementia

Noise Health. 2026 Sep-Oct 01;28(134):1360-1367. doi: 10.4103/nah.nah_159_26. Epub 2026 Oct 31.ABSTRACTOBJECTIVE: This study examines the readability of artificial intelligence (AI)-generated responses to public queries regarding...

Delirium

Effects of Noise Reduction Combined with AI-Based Nursing System on Postoperative Sleep Quality and Delirium Incidence in Older Patients with Severe Glioma

Noise Health. 2026 Sep-Oct 01;28(134):1266-1274. doi: 10.4103/nah.nah_82_26. Epub 2026 Oct 31.ABSTRACTOBJECTIVE: To explore the effect of noise reduction combined with the artificial intelligence (AI)-based nursing...

Delirium

Effects of Plan-Do-Check-Act Cycle Nursing Combined with Noise Management on Sleep and Clinical Outcomes in Children with Mycoplasma pneumoniae Pneumonia Complicated by Encephalitis

Noise Health. 2026 Sep-Oct 01;28(134):1230-1240. doi: 10.4103/nah.nah_113_26. Epub 2026 Oct 31.ABSTRACTOBJECTIVE: This study aimed to examine the effects of Plan-Do-Check-Act (PDCA) cycle nursing combined with...

Delirium

03/11/2026

Germline Genetic Variants and Epilepsy Surgery Response: Individual Participant Pooled Analysis of 272 Patients

Neurology. 2026 Nov 24;107(10):e218687. doi: 10.1212/WNL.0000000000218687. Epub 2026 Nov 2.ABSTRACTBACKGROUND AND OBJECTIVES: Genetic testing is increasingly used in presurgical evaluation, but the yield of resection...

Delirium

03/11/2026

Plasma P-Tau217 and NfL Longitudinal Changes Across Neurodegenerative Diseases: Impact of alpha-Synuclein in Alzheimer Disease

Neurology. 2026 Nov 24;107(10):e218685. doi: 10.1212/WNL.0000000000218685. Epub 2026 Nov 2.ABSTRACTBACKGROUND AND OBJECTIVES: Plasma phospho-tau217 (p-tau 217) is a validated biomarker of Alzheimer disease (AD), and...

Delirium

03/11/2026

Pearls & Oy-sters: The Price of Patency: Intractable Headache Subsequent to Fourth Ventricular Recanalization

Neurology. 2026 Dec 8;107(11):e218710. doi: 10.1212/WNL.0000000000218710. Epub 2026 Nov 2.ABSTRACTFourth ventricular hemorrhage is a devastating subtype of hemorrhagic stroke that can be primary or secondary...

Delirium

Effects of Dual-Task Training With and Without Backward Walking on Balance, Functional Mobility, and Participation in Ambulatory Children With Spastic Diplegic Cerebral Palsy: A Randomized Controlled Trial

Physiother Res Int. 2027 Jan;32(1):e70371. doi: 10.1002/pri.70371.ABSTRACTBACKGROUND AND PURPOSE: Children with cerebral palsy (CP) commonly have impairments in balance, functional mobility, and participation. Whether adding...

Delirium

Targeting RIPK1-NF-κB crosstalk: A novel perspective on necroptosis in Alzheimer’s Disease

Mol Biol Rep. 2026 Nov 1;53(1):1874. doi: 10.1007/s11033-026-13067-0.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative condition characterised by gradual neuronal degradation, resulting in cognitive decline and...

Delirium

Effects of Permissive Hypercapnia Versus Normocapnia on Cerebral Oxygenation and Postoperative Outcomes in Adult Surgical Patients: A Systematic Review and Meta-Analysis

Anesthesiol Res Pract. 2026 Oct 31;2026:3569464. doi: 10.1155/anrp/3569464. eCollection 2026.ABSTRACTBACKGROUND: Evidence suggests that intraoperative cerebral hypoxia is the main contributor of postoperative neurological complications, particularly...

Delirium

The “Invisible Killer” of Neurodegeneration: Mitochondrial Dysfunction in Neurodegenerative Disorders, Mechanisms, Emerging Pathways and Therapeutic Strategies

J Inflamm Res. 2026 Oct 27;19:653025. doi: 10.2147/JIR.S653025. eCollection 2026.ABSTRACTNeurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), multiple sclerosis (MS),...

Delirium

Listeria monocytogenes Sepsis With Meningitis Complicating Biologic Immunosuppression in a Patient With Haemophagocytic Lymphohistiocytosis Secondary to Adult-Onset Still’s Disease: A Case Report

Cureus. 2026 Oct 1;18(10):e117297. doi: 10.7759/cureus.117297. eCollection 2026 Oct.ABSTRACTAdult-onset Still's disease (AOSD) and haemophagocytic lymphohistiocytosis (HLH) are treated with potent immunosuppression, including high-dose corticosteroids and...

Delirium

Effect of Preoperative Intranasal Dexmedetomidine on Postoperative Myocardial Injury in Patients Undergoing Coronary Artery Bypass Grafting

Drug Des Devel Ther. 2026 Oct 27;20:644667. doi: 10.2147/DDDT.S644667. eCollection 2026.ABSTRACTPURPOSE: To evaluate the effects of preoperative intranasal dexmedetomidine on postoperative myocardial injury biomarkers in...

Delirium

Biomaterial-Enabled Delivery Strategies to Overcome Treatment Resistance in Medulloblastoma

Int J Nanomedicine. 2026 Oct 27;21:640704. doi: 10.2147/IJN.S640704. eCollection 2026.ABSTRACTMultimodal therapy has improved survival in medulloblastoma (MB), yet recurrence, neuraxis dissemination, and treatment-related late effects...

Delirium

Code-Free Automated Machine-Learning (AutoML) Classification of Curated MRI Images Labeled for Rare Neurological Diseases: An Image-Level Proof-of-Concept Study

Cureus. 2026 Oct 1;18(10):e117321. doi: 10.7759/cureus.117321. eCollection 2026 Oct.ABSTRACTRare neurological disorders present substantial diagnostic and research challenges because their low prevalence limits clinical exposure and...

Delirium

Severe Rhabdomyolysis With Minimal Muscular Symptoms After Long-Term Rosuvastatin Use: A Case Report and Brief Literature Review

Cureus. 2026 Oct 1;18(10):e117283. doi: 10.7759/cureus.117283. eCollection 2026 Oct.ABSTRACTSevere rhabdomyolysis may present with limited muscular symptoms despite substantial biochemical injury. We describe a case of...

Delirium

Beyond Blood-Brain Barrier Crossing in Reperfusion-Era Ischemic Stroke: Interface-Matched Active-Entity Delivery and Translational Product Design

Int J Nanomedicine. 2026 Oct 27;21:650851. doi: 10.2147/IJN.S650851. eCollection 2026.ABSTRACTReperfusion therapy has transformed acute ischemic stroke care, yet large-vessel recanalization does not ensure capillary reperfusion,...

Delirium

Probable Hypophysitis Recognized More Than Two Years After Pembrolizumab Discontinuation

Cureus. 2026 Sep 30;18(9):e117267. doi: 10.7759/cureus.117267. eCollection 2026 Sep.ABSTRACTImmune checkpoint inhibitor-associated hypophysitis is an uncommon but clinically important endocrine immune-related adverse event. We report a...

Delirium

Diffusion-weighted imaging reversal after reperfusion therapy in acute ischemic stroke: associations with white matter hyperintensities and cerebral microbleeds

Neurol Res Pract. 2026 Oct 29;8(1):90. doi: 10.1186/s42466-026-00545-w.ABSTRACTBACKGROUND: White matter hyperintensities (WMH) and cerebral microbleeds (CMBs) are common MRI markers of chronic small-vessel brain injury...

Delirium

Improving outcomes in the management of acute external laryngotracheal trauma

Eur Arch Otorhinolaryngol. 2026 Oct 31. doi: 10.1007/s00405-026-10783-y. Online ahead of print.ABSTRACTAIMS AND OBJECTIVES: To highlight the presentation, management, and functional outcomes of subjects with...

Delirium

In vivo frataxin expression of a triplex purified minicircle

Gene Ther. 2026 Oct 31. doi: 10.1038/s41434-026-00653-x. Online ahead of print.ABSTRACTFriedreich's ataxia (FRDA) is a progressive neurodegenerative disorder caused by (GAA•TTC)n repeat expansions in the...

Delirium

Neurodevelopmental outcomes of infants evaluated for but not treated with therapeutic hypothermia: a prospective cohort study

Pediatr Res. 2026 Oct 31. doi: 10.1038/s41390-026-05615-y. Online ahead of print.ABSTRACTBACKGROUND: Therapeutic hypothermia (TH) is the standard of care for moderate to severe neonatal encephalopathy...

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Corrigendum to “Paeonol alleviates oxidative stress and brain injury in hypoxic-ischemic encephalopathy by activating the PI3K/Akt/Nrf2 signaling pathway” [Eur. J. Pharmacol. 1037 (2026) 179403]

Eur J Pharmacol. 2026 Oct 31:179486. doi: 10.1016/j.ejphar.2026.179486. Online ahead of print.NO ABSTRACTPMID:42966659 | DOI:10.1016/j.ejphar.2026.179486

Delirium

When In-Person Interpretation Matters: Perspectives From ICUs and Acute Inpatient Care Settings

Am J Crit Care. 2026 Nov 1;35(6):432-444. doi: 10.4037/ajcc2026387.ABSTRACTBACKGROUND: Clinicians often care for multilingual patients and generally prefer in-person rather than remote interpretation. However, little...

Delirium

Postoperative Delirium in the ICU: Not One Syndrome, but Many?

Anaesth Crit Care Pain Med. 2026 Oct 31:101972. doi: 10.1016/j.accpm.2026.101972. Online ahead of print.NO ABSTRACTPMID:42966560 | DOI:10.1016/j.accpm.2026.101972

Delirium

Brain Regions Involved in Object-Location Memory in Healthy Adults: A Systematic Review and Activation Likelihood Estimation Meta-Analysis of Task-Based fMRI

Neurosci Biobehav Rev. 2026 Oct 31:107068. doi: 10.1016/j.neubiorev.2026.107068. Online ahead of print.ABSTRACTThe ability to remember where objects are located is a fundamental cognitive function particularly...

Delirium

Dendrobium officinale extract ameliorates Alzheimer’s disease by modulating PI3K-AKT-mTOR pathway and autophagy-related processes: An integrated study combining feature-based molecular networking, network pharmacology and multi-omics

J Ethnopharmacol. 2026 Oct 31:122588. doi: 10.1016/j.jep.2026.122588. Online ahead of print.ABSTRACTETHNOPHARMACOLOGICAL RELEVANCE: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder with limited effective treatments. Dendrobium...

Delirium

Potential Involvement of TLR4/MyD88 Signaling in the Neuroprotective Effects of NBP in DEACMP

Brain Res Bull. 2026 Oct 31:112190. doi: 10.1016/j.brainresbull.2026.112190. Online ahead of print.ABSTRACTDelayed encephalopathy after carbon monoxide poisoning (DEACMP) is a major neurological complication following acute...

Delirium