Substance Use Disorder Outcomes and Treatment by Autism Status in Medicaid Enrollees With Substance Use Disorder

AI Summary

Substantial and increasing prevalence of substance use disorders among autistic people, representing an unaddressed public health challenge.
Autistic enrollees with SUD have higher overdose, hospitalisation, and certain polysubstance use risks than matched neurotypical SUD patients.
Autistic people with SUD use fewer SUD services than neurotypical counterparts, highlighting need for integrated, autism-tailored, evidence-based SUD interventions.

Autism Res. 2026 Jul 16:e70291. doi: 10.1002/aur.70291. Online ahead of print.

ABSTRACT

The prevalence of substance use disorders (SUD) among autistic people is substantial and growing. This unaddressed public health challenge is particularly important given the lack of knowledge about SUD service needs among people on the spectrum. This paper presents the first national-level study of SUD-related clinical outcomes and service use among US-based autistic Medicaid enrollees with SUD (N = 50,487) compared to matched neurotypical enrollees with SUD (N = 151,461). The analyses reveal that overdose, hospitalizations, and some polysubstance use risks are elevated among autistic people with SUD compared to neurotypical SUD patients. Analyses also suggest that autistic people with SUD use fewer SUD services compared to their neurotypical counterparts. Results highlight the need for integrative, evidence-based autism-tailored SUD service solutions.

PMID:42464513 | DOI:10.1002/aur.70291

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