Evidence
Contemp Clin Trials. 2024 Jan 16:107445. doi: 10.1016/j.cct.2024.107445. Online ahead of print.
ABSTRACT
BACKGROUND: Obsessive compulsive disorder (OCD) is effectively treated with exposure and response prevention (ERP), yet very few veterans receive ERP for OCD within the Veterans Health Administration (VHA). Veterans are a clinically complex population, and no prior research has evaluated the effectiveness of ERP in veterans with OCD or comorbid OCD and posttraumatic stress disorder (PTSD). Given the limited accessibility of ERP-trained providers within VHA, assessment of video telehealth (VTH) delivery of ERP is warranted.
METHODS: A sample of 160 veterans with OCD (80 diagnosed with comorbid PTSD) will be randomly assigned to receive up to 16 sessions of ERP or a stress management training control delivered via VTH. Assessments will occur at baseline, posttreatment, and 6-month follow-up. The primary outcome will evaluate the impact of ERP on participants’ functioning, and secondary outcomes will include quality of life and OCD symptoms. At posttreatment, qualitative interviews with veterans, clinicians, and administrators will explore barriers and facilitators to treatment delivery, and the implementation potential of ERP.
CONCLUSIONS: Results will provide direction for the treatment of OCD and comorbid PTSD in veterans, as well as guidance for future implementation efforts for ERP within VHA.
CLINICALTRIALS: gov Identifier:NCT05240924.
PMID:38237674 | DOI:10.1016/j.cct.2024.107445
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
A protocol for a randomized controlled trial of exposure and response prevention for veterans with obsessive compulsive disorder
🌐 90 Days
VR Related Evidence Matrix
- A Randomized Controlled Trial of OC-Go for Childhood Obsessive-Compulsive Disorder: Augmenting Homework Compliance in Exposure With Response Prevention Treatment
- Effectiveness of One Videoconference-Based Exposure and Response Prevention Session at Home in Adjunction to Inpatient Treatment in Persons With Obsessive-Compulsive Disorder: Nonrandomized Study
- A network analysis of mechanisms of change during exposures over the course of intensive OCD treatment
- Patient adherence as a predictor of acute and long-term outcomes in concentrated exposure treatment for difficult-to-treat obsessive-compulsive disorder
- Patient adherence as a predictor of acute and long-term outcomes in concentrated exposure treatment for difficult-to-treat obsessive-compulsive disorder
- Feeling more confident to encounter negative emotions: The mediating role of distress tolerance on the relationship between self-efficacy and outcomes of exposure and response prevention for OCD
- ØCD: protocol for the development and evaluation of a cognitive-behavioral prevention program for obsessive-compulsive disorder
- Intensive exposure treatment for obsessive compulsive disorder in old age.
- Rates of diagnosis and service utilization in veterans with hoarding disorder
- Examining veterans' preferences for how to deliver couples-based treatments for posttraumatic stress disorder: Home-based telehealth or in-person?
- Family accommodation in obsessive-compulsive disorder: an updated systematic review and meta-analysis
- Association of Posttraumatic Stress Disorder and Race on Readmissions After Stroke
- Cognitive processing therapy (CPT) versus individual drug counseling (IDC) for PTSD for veterans with opioid use disorder maintained on buprenorphine
- Posttraumatic Stress Disorder Is Associated With Elevated Risk of Incident Stroke and Transient Ischemic Attack in Women Veterans
- Differences in the phenotypic expression of posttraumatic stress disorder symptoms in US military veterans with and without clinical insomnia
- Does mental contamination mediate the association between childhood trauma and obsessive-compulsive symptoms in adults?
- Impact of PTSD treatment on postconcussive symptoms in veterans: A comparison of sertraline, prolonged exposure, and their combination
- Ketamine-enhanced prolonged exposure therapy in veterans with PTSD: A randomized controlled trial protocol
- Obsessive compulsive disorder: overview of the condition and its nursing management
- Design of a randomized clinical trial of brief couple therapy for PTSD augmented with intranasal oxytocin
- The effectiveness and acceptability of the Bergen 4-day treatment for adolescents with OCD: a replication and extension
- Pain and Post-traumatic Stress Disorder Symptoms: Dyadic Relationships Between Canadian Armed Forces Members/Veterans with Chronic Pain and their Offspring
- Impact of three variants of prolonged exposure therapy on comorbid diagnoses in patients with childhood abuse-related PTSD
- A Network Analysis Study to Evaluate Obsessive-Compulsive Beliefs/Dimensions and Personality Beliefs in Patients with Obsessive-Compulsive Disorder (OCD): A Cross-Sectional Study in Two Common OCD Subtypes
- The Relationship between Childhood Trauma Experiences and Psychotic Vulnerability in Obsessive Compulsive Disorder: An Italian Cross-Sectional Study
- The mediating role of posttraumatic stress disorder symptoms in pain cognitions among Veterans with chronic pain
- Association of rs11081062 polymorphism of DLGAP1 gene and levels of SLC1A1 protein with obsessive-compulsive disorder
- Advances in DTI studies for diagnoses and treatment of obsessive-compulsive disorder
- Massed written exposure therapy delivered to veterans with posttraumatic stress symptoms on an acute inpatient mental health unit
- A pilot study of stellate ganglion block paired with exposure therapy: Feasibility and acceptability in combat veterans with posttraumatic stress disorder
- Obesity in Latinx and White U.S. military veterans: Mental health, psychosocial burden, non-suicidal self-injury and suicidal behavior
- The Role of Mental Health Conditions in Early Detection and Treatment of Veterans With Alzheimer's Dementia
- Cognitive-behavioural conjoint therapy versus prolonged exposure for PTSD in military service members and veterans: results and lessons from a randomized controlled trial
- Sensory over-responsivity and orbitofrontal cortex connectivity in obsessive-compulsive disorder
- Lower odds of successful community discharge after medical hospitalization for Veterans with schizophrenia: A retrospective cohort study of national data
- Posttraumatic cognitions about the self are associated with depression symptoms in veterans endorsing a history of assaultive military sexual trauma
- Restore and Rebuild (R&R): a protocol for a phase 2, randomised control trial to compare R&R as a treatment for moral injury-related mental health difficulties in UK military veterans to treatment as usual
- An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
- An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
- The epidemiology of obsessive-compulsive disorder in the Kingdom of Saudi Arabia: Data from the Saudi National Mental Health Survey
- Emotion regulation and heart rate variability may identify the optimal posttraumatic stress disorder treatment: analyses from a randomized controlled trial
- Neurological soft signs as trait markers of a subset of patients with obsessive-compulsive disorder with low insight and altered cognitive abilities
- A Preliminary Analysis of Psychiatric Service Dog Placements and Sleep Patterns of Partners of Veterans With PTSD
- Identifying candidate mechanisms of comorbidity in disordered eating and posttraumatic stress disorder symptoms among U.S. veterans: A network analytic approach
- Temporal dynamics of autonomic nervous system responses under cognitive-emotional workload in obsessive-compulsive disorder
- Ethnoracial Disparities in Perinatal Outcomes among Women Veterans
- Altered Error Monitoring and Decreased Flanker Task Accuracy in Pediatric Obsessive-Compulsive Disorder
- Characterizing 1991 Gulf War women veterans from the Boston Biorepository and Integrative Network for Gulf War Illness: demographics, exposures, neuroimaging and cognitive outcomes
- Obsessive-Compulsive Disorder as an Epiphenomenon of Comorbid Bipolar Disorder? An Updated Systematic Review
- Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive-compulsive disorder
- Investigating Retrospective and Prospective Metamemory Judgments During Episodic Memory in Patients With Obsessive-Compulsive Disorders
- Internet-Delivered Exposure and Response Prevention for Pediatric Tourette Syndrome: 12-Month Follow-Up of a Randomized Clinical Trial
- An examination of the potential core symptoms of posttraumatic stress disorder: What is integral after removing general psychopathology & distress?
- Forebrain EAAT3 overexpression increases susceptibility to amphetamine-induced repetitive behaviors
- Contingency management for substance use disorders in the U.S. Veterans Health Administration: 2018-2022
- Selective alterations of endocannabinoid system genes expression in obsessive compulsive disorder
- Effectiveness of online group cognitive-behavior therapy for adolescents with obsessive-compulsive disorder: a pilot study
- Resting-state functional connectivity of amygdala subregions predicts treatment outcome for cognitive behavioral therapy in obsessive-compulsive disorder at a 4-month follow-up
- Determinants of Exposure Therapy Implementation in Clinical Practice for the Treatment of Anxiety, OCD, and PTSD: A Systematic Review
- 'Autism is the Arena and OCD is the Lion': Autistic adults' experiences of co-occurring obsessive-compulsive disorder and repetitive restricted behaviours and interests
- Reduced pre-attentive threat versus nonthreat signal discrimination in clinically healthy military personnel with recurrent combat exposure history: A preliminary event-related potential (ERP) study
- Associations between somatomotor-putamen resting state connectivity and obsessive-compulsive symptoms vary as a function of stress during early adolescence: Data from the ABCD Study
- Comparing effectiveness of residential versus intensive virtual treatment for veterans with posttraumatic stress disorder
- Gender differences in PTSD severity and pain outcomes: Baseline results from the LAMP trial
Evidence Blueprint
A protocol for a randomized controlled trial of exposure and response prevention for veterans with obsessive compulsive disorder
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
A protocol for a randomized controlled trial of exposure and response prevention for veterans with obsessive compulsive disorder
🌐 365 Days
VR Related Evidence Matrix
- Exposure and response prevention versus stress management training for adults and adolescents with obsessive compulsive disorder: A randomized clinical trial
- A Randomized Controlled Trial of OC-Go for Childhood Obsessive-Compulsive Disorder: Augmenting Homework Compliance in Exposure With Response Prevention Treatment
- A 28-Year-Old Man with Obsessive-Compulsive Disorder, Post-Traumatic Stress Disorder, and Dissociative Identity Disorder Responding to Aripiprazole Augmentation of Clomipramine Combined with Psychoeducation and Exposure and Response Prevention
- Assessment of Comorbid Obsessive-Compulsive Disorder and Posttraumatic Stress Disorder
- Effectiveness of One Videoconference-Based Exposure and Response Prevention Session at Home in Adjunction to Inpatient Treatment in Persons With Obsessive-Compulsive Disorder: Nonrandomized Study
- The role of between-session homework in cognitive-behavioral therapy for comorbid obsessive-compulsive disorder and autism: A case vignette
- Personalized exposure and experience sampling method feedback versus exposure as usual for obsessive-compulsive disorder: a study protocol for a randomized controlled trial
- A network analysis of mechanisms of change during exposures over the course of intensive OCD treatment
- Patient adherence as a predictor of acute and long-term outcomes in concentrated exposure treatment for difficult-to-treat obsessive-compulsive disorder
- Patient adherence as a predictor of acute and long-term outcomes in concentrated exposure treatment for difficult-to-treat obsessive-compulsive disorder
- A targeted strategic peer support intervention to increase adherence to video teletherapy exposure and response prevention treatment for obsessive-compulsive disorder: a retrospective observational analysis
- Feeling more confident to encounter negative emotions: The mediating role of distress tolerance on the relationship between self-efficacy and outcomes of exposure and response prevention for OCD
- Intentional Self-Harm Among US Veterans With Traumatic Brain Injury or Posttraumatic Stress Disorder: Retrospective Cohort Study From 2008 to 2017
- Closing the Gap for Children with OCD: A Staged-Care Model of Cognitive Behavioural Therapy with Exposure and Response Prevention
- Engagement in posttraumatic stress disorder treatment for veterans who experienced military sexual trauma and are diagnosed with serious mental illness
- Different Psychological Processes in Traditional and ACT-Enhanced ERP for Obsessive-Compulsive Disorder
- ØCD: protocol for the development and evaluation of a cognitive-behavioral prevention program for obsessive-compulsive disorder
- Intensive exposure treatment for obsessive compulsive disorder in old age.
- Obsessive-Compulsive Disorder in Children and Adolescents
- Mixed results for exposure and response prevention therapy in mixed reality for patients with contamination-related obsessive-compulsive disorder: A randomized controlled pilot study
- Brazilian research consortium on obsessive-compulsive spectrum disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part II: Cognitive-Behavior Therapy treatment
- Effectiveness of Neuropsychoeducation, Intrinsic Motivation, and Metaphoric Content Integrated with Cognitive Behavioral Therapy in the Treatment of Obsessive-Compulsive Disorder: A Pilot Study
- Written exposure therapy for veterans with co-occurring substance use disorders and PTSD: Study design of a randomized clinical trial
- Rates of diagnosis and service utilization in veterans with hoarding disorder
- Examining the Veterans Health Administration whole health model of care within the context of posttraumatic stress disorder
- A Case Series of Continuous Theta Burst Stimulation Treatment for the Supplementary Motor Area Twice a Day in Patients with Obsessive-Compulsive Disorder: A Real World TMS Registry Study in Japan
- Online versus in-person delivery of cognitive behaviour therapy for obsessive compulsive disorder: An examination of effectiveness
- Examining veterans' preferences for how to deliver couples-based treatments for posttraumatic stress disorder: Home-based telehealth or in-person?
- Obsessive-Compulsive Symptoms and Daily Experiences of Posttraumatic Stress and Mental Contamination Following Sexual Trauma
- Family accommodation in obsessive-compulsive disorder: an updated systematic review and meta-analysis
- Which veterans with PTSD are most likely to report being told of their diagnosis?
- Clinical features in co-occuring obsessive-compulsive disorder and bipolar disorder: A systematic review and meta-analysis
- Remission and Relapse Across Three Years in Pediatric Obsessive Compulsive Disorder Following Evidence-Based Treatments
- Perspectives of VA healthcare from rural women veterans not enrolled in or using VA healthcare
- Obsessive-compulsive disorder in youth and young adults with depression: Clinical characteristics of comorbid presentations
- The clinical presentation of major depressive disorder in youth with co-occurring obsessive-compulsive disorder
- A Case Study of a Woman with Obsessions Related to COVID-19
- Clinical case report: considerable improvement of severe and difficult-to-treat obsessive-compulsive disorder with comorbid depression under treatment with esketamine and concomitant psychotherapy
- A Meta-Analysis of Transcranial Magnetic Stimulation in Obsessive Compulsive Disorder
- Association of Posttraumatic Stress Disorder and Race on Readmissions After Stroke
- Lurasidone as add-on to fluoxetine in obsessive-compulsive disorder with comorbid restrictive anorexia: a case report
- Olfactory Reference Syndrome: Its Relationship to Comorbidity of Social Anxiety Disorder and Obsessive-Compulsive Disorder
- Obsessive-compulsive disorder following severe traumatic brain injury
- Improving suicide prevention for women veterans: Recommendations from VHA suicide prevention coordinators
- Esketamine Augmentation in Treatment-Resistant Obsessive-Compulsive Disorder: A Retrospective Chart Review
- Clinical Advances in Treatment Strategies for Obsessive-compulsive Disorder in Adults
- Course and clinical correlates of obsessive-compulsive disorder with or without comorbid personality disorder
- Palliative care in the older adult Veteran
- Clinical Effectiveness of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Adult Obsessive-Compulsive Disorder (OCD) Treatment: A Systematic Review
- Episodic obsessive-compulsive disorder and bipolar spectrum disorder: new evidence from a large Italian OCD sample
- Cognitive processing therapy (CPT) versus individual drug counseling (IDC) for PTSD for veterans with opioid use disorder maintained on buprenorphine
- Obsessive-compulsive disorder symptoms and intrusive thoughts in the postpartum period: Associations with trauma exposure and PTSD symptoms
- Posttraumatic Stress Disorder Is Associated With Elevated Risk of Incident Stroke and Transient Ischemic Attack in Women Veterans
- The effect of obstructive sleep apnea severity on PTSD symptoms during the course of esketamine treatment: a retrospective clinical study
- Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans
- A pilot randomized controlled trial of online written exposure therapy delivered by peer coaches to veterans with posttraumatic stress disorder
- The effect of a reduction in irrational beliefs on Posttraumatic Stress Disorder (PTSD), depression, and anxiety symptoms in a group treatment for post-9/11 Veterans
- What's control got to do with it? A systematic review of control beliefs in obsessive-compulsive disorder
- Differences in the phenotypic expression of posttraumatic stress disorder symptoms in US military veterans with and without clinical insomnia
- Normal congruency sequence effects in psychopathology: A behavioral and electrophysiological examination using a confound-minimized design
- Does mental contamination mediate the association between childhood trauma and obsessive-compulsive symptoms in adults?
- Temperament Traits in Pediatric Obsessive-Compulsive Disorder in Relation to Tourette Syndrome and Attention-Deficit Hyperactivity Disorder
- Care Retention Among Veterans with Serious Mental Illness who were once lost-to-Veterans Health Administration care
- Impact of PTSD treatment on postconcussive symptoms in veterans: A comparison of sertraline, prolonged exposure, and their combination