Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Chem Sci. 2024 Jan 15;15(7):2509-2517. doi: 10.1039/d3sc06551k. eCollection 2024 Feb 14.
ABSTRACT
Patients with alcoholism and type 2 diabetes manifest altered metabolism, including elevated aldehyde levels and unusually low asparagine levels. We show that asparagine synthetase B (ASNS), the only human asparagine-forming enzyme, is inhibited by disease-relevant reactive aldehydes, including formaldehyde and acetaldehyde. Cellular studies show non-cytotoxic amounts of reactive aldehydes induce a decrease in asparagine levels. Biochemical analyses reveal inhibition results from reaction of the aldehydes with the catalytically important N-terminal cysteine of ASNS. The combined cellular and biochemical results suggest a possible mechanism underlying the low asparagine levels in alcoholism and diabetes. The results will stimulate research on the biological consequences of the reactions of aldehydes with nucleophilic residues.
PMID:38362406 | PMC:PMC10866355 | DOI:10.1039/d3sc06551k
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Asparagine reduces the risk of schizophrenia: a bidirectional two-sample mendelian randomization study of aspartate, asparagine and schizophrenia Asparagine reduces the risk of schizophrenia: a bidirectional two-sample mendelian randomization study of aspartate, asparagine and schizophrenia Norepinephrine Drives Sleep Fragmentation Activation of Asparagine Endopeptidase, Locus Coeruleus Degeneration and Hippocampal Amyloid-β42 Accumulation Exploiting pancreatic cancer metabolism: challenges and opportunities Inhibition of post-lanosterol biosynthesis by fentanyl: potential implications for Fetal Fentanyl Syndrome (FFS) Association Between Dipeptidyl Peptidase-4 Inhibitor Use and Cognitive Functions, Brain-Derived Neurotrophic Factor, and Pentraxin-3 Levels in Patients With Type 2 Diabetes Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation Asprosin aggravates nonalcoholic fatty liver disease via inflammation and lipid metabolic disturbance mediated by reactive oxygen species Effects of low fat diet on inflammatory parameters in individuals with obesity/overweight and non-alcoholic fatty liver disease: A cross-sectional study Aldehyde dehydrogenase 1 family: A potential molecule target for diseases Cell-cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calcium Fine-tuning amyloid precursor protein expression through non-sense mediated mRNA decay Fluid preservation in brain banking: a review On the (un)reliability of common behavioral and electrophysiological measures from the stop signal task: Measures of inhibition lack stability over time Liver Lipidomics Analysis Revealed the Protective mechanism of Zuogui Jiangtang Qinggan Formula in type 2 diabetes mellitus with non-alcoholic fatty liver disease Liver Lipidomics Analysis Revealed the Protective mechanism of Zuogui Jiangtang Qinggan Formula in type 2 diabetes mellitus with non-alcoholic fatty liver disease PPAR-γ agonists reactivate the ALDOC-NR2F1 axis to enhance sensitivity to temozolomide and suppress glioblastoma progression Inhibition of DAPK3 suppresses radiation-induced cellular senescence by activation of a PGC1alpha-dependent metabolism pathway in brain endothelial cells Falsely low glycosylated haemoglobin levels probably secondary to hypersplenism in a patient with diabetes mellitus Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease Effectiveness of rifaximin and probiotics for the correction of intestinal permeability in patients with metabolic-associated fatty liver disease in combination with type 2 diabetes mellitus Methoxsalen inhibits the acquisition of nicotine self-administration: attenuation by cotinine replacement in male rats Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection Connection between protein-tyrosine kinase inhibition and coping with oxidative stress in Bacillus subtilis Development of an alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell-derived liver organoids Development of an alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell-derived liver organoids Reversing valproic acid-induced autism-like behaviors through a combination of low-frequency repeated transcranial magnetic stimulation and superparamagnetic iron oxide nanoparticles Systemic inflammation, oxidative damage and neurocognition predict telomere length in a transdiagnostic sample stratified by global DNA methylation levels Zinc Deficiency Decreases Neurite Extension via CRMP2 Signal Pathway The Role of Oxidative Stress in Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Preclinical Studies Cobalt-based hybrid nanoparticles loaded with curcumin for ligand-enhanced synergistic nanocatalytic therapy/chemotherapy combined with calcium overload Effect of Zuogui Jiangtang Qinggan Formula on lipid metabolism in db/db mouse model of type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease Cellular adhesion molecules in drug-naive and previously medicated patients with schizophrenia-spectrum disorders LINC00894 inhibited neuron cellular apoptosis and regulated activating transcription factor 3 expression Study on the risk factors of postoperative wound complications in patients with ankle fracture Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of AB amyloidosis Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of AB amyloidosis Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function Vitamin D(3) exacerbates steatosis while calcipotriol inhibits inflammation in non-alcoholic fatty liver disease in Sod1 knockout mice: a comparative study of two forms of vitamin D Inhibition of reactive oxygen species production accompanying alternatively activated microglia by risperidone in a mouse ketamine model of schizophrenia What is the clinical significance of low serum amylase? Systematic review of the conditions associated with low serum amylase What is the clinical significance of low serum amylase? Systematic review of the conditions associated with low serum amylase Trimethylamine N-oxide ameliorates hepatic damage including reduction of hepatic bile acids and cholesterol in Fxr-null mice Causal effect of blood osteocalcin on the risk of Alzheimer's disease and the mediating role of energy metabolism The Role of Vitamin K in the Development of Neurodegenerative Diseases 5,7-dihydroxy-3',4',5'-trimethoxyflavone mitigates lead induced neurotoxicity in rats via its chelating, antioxidant, anti-inflammatory and monoaminergic properties Abnormal biochemical indicators of neonatal inherited metabolic disease in carriers Rare GPR37L1 variants reveal potential association between GPR37L1 and disorders of anxiety and migraine A positive feedback inhibition of isocitrate dehydrogenase 3b on paired-box gene 6 promotes Alzheimer-like pathology Cortical volume alterations in the limbic network in adolescents with high reactive aggression Cerebellum and Aging: Update and Challenges Inflammation and weight change related to neurocognitive and functional impairment in diabetes and psychiatric disorders Altered lipid homeostasis is associated with cerebellar neurodegeneration in SNX14 deficiency Insulin resistance may accelerate typical changes in heart function among type 1 diabetes patients, particularly in overweight patients: a preliminary study Insulin resistance may accelerate typical changes in heart function among type 1 diabetes patients, particularly in overweight patients: a preliminary study Altering plasma lipids and liver enzyme activities via hippocampal injections of hen Lysozyme amyloid aggregates in an Alzheimer's disease mouse model: Insights into the therapeutic role of Bis (Indolyl) phenylmethane The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation The interplay between diabetes and non-alcoholic fatty liver disease: a cross-sectional study from Pakistan The interplay between diabetes and non-alcoholic fatty liver disease: a cross-sectional study from Pakistan Long-term dynamics of serum alpha-MSH and alpha-MSH-binding immunoglobulins with a link to gut microbiota composition in patients with anorexia nervosa Cue-Reactive Phenomenology Mediates the Relationship Between Positive Schizotypy and Cue-Reactive Urge to Gamble in Poker-Machine Gamblers Combining Bayesian optimization and automation to simultaneously optimize reaction conditions and routes C-Reactive Protein Does Not Predict Future Depression Onset in Adolescents: Preliminary Findings from a Longitudinal Study C-Reactive Protein Does Not Predict Future Depression Onset in Adolescents: Preliminary Findings from a Longitudinal Study
Evidence Blueprint
Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Asparagine reduces the risk of schizophrenia: a bidirectional two-sample mendelian randomization study of aspartate, asparagine and schizophrenia Asparagine reduces the risk of schizophrenia: a bidirectional two-sample mendelian randomization study of aspartate, asparagine and schizophrenia A patent review on aldehyde dehydrogenase inhibitors: an overview of small molecule inhibitors from the last decade Norepinephrine Drives Sleep Fragmentation Activation of Asparagine Endopeptidase, Locus Coeruleus Degeneration and Hippocampal Amyloid-β42 Accumulation Discovery of Orally Available and Brain Penetrant AEP Inhibitors Impaired aldehyde detoxification exacerbates motor deficits in an alpha-synuclein mouse model of Parkinson's disease β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner Exploiting pancreatic cancer metabolism: challenges and opportunities Alpha-lipoic Acid Protects Against Chronic Alcohol Consumption-induced Cardiac Damage via the ALDH2-associated PINK/Parkin Pathway Inhibition of 26S proteasome activity by α-synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1 Terpenes based hydrophobic deep eutectic solvents for dispersive liquid-liquid microextraction of aliphatic aldehydes in drinking water and alcoholic beverages Additive-free selective oxidation of aromatic alcohols with molecular oxygen catalyzed by a mixed-valence polyoxovanadate-based metal-organic framework Inhibition of post-lanosterol biosynthesis by fentanyl: potential implications for Fetal Fentanyl Syndrome (FFS) Association Between Dipeptidyl Peptidase-4 Inhibitor Use and Cognitive Functions, Brain-Derived Neurotrophic Factor, and Pentraxin-3 Levels in Patients With Type 2 Diabetes Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems CD38 Inhibition Protects Fructose-Induced Toxicity in Primary Hepatocytes Circulating cell-free mitochondrial DNA levels and glucocorticoid sensitivity in a cohort of male veterans with and without combat-related PTSD Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer's disease-associated metabolites Elevated levels of alcohol dehydrogenase aggravate ethanol-evoked cardiac remodeling and contractile anomalies through FKBP5-yap-mediated regulation of ferroptosis and ER stress Role of liver parameters in diabetes mellitus - a narrative review Asprosin aggravates nonalcoholic fatty liver disease via inflammation and lipid metabolic disturbance mediated by reactive oxygen species Effects of flaxseed supplementation on weight loss, lipid profiles, glucose, and high-sensitivity C-reactive protein in patients with coronary artery disease: A systematic review and meta-analysis of randomized controlled trials Effects of low fat diet on inflammatory parameters in individuals with obesity/overweight and non-alcoholic fatty liver disease: A cross-sectional study Compromised very-low density lipoprotein induced polyunsaturated triglyceride accumulation in N-nitrosodiethylamine-induced hepatic steatosis Aldehyde dehydrogenase 1 family: A potential molecule target for diseases Gut microbiota dysbiosis contributes to α-synuclein-related pathology associated with C/EBPβ/AEP signaling activation in a mouse model of Parkinson's disease Cell-cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calcium Reactive oxygen species (ROS)-mediated oxidative stress in chronic liver diseases and its mitigation by medicinal plants Relationships of Brain Cholesterol and Cholesterol Biosynthetic Enzymes to Alzheimer's Pathology and Dementia in the CFAS Population-Derived Neuropathology Cohort Fine-tuning amyloid precursor protein expression through non-sense mediated mRNA decay Fluid preservation in brain banking: a review Temporal patterns of osteoclast formation and activity following withdrawal of RANKL inhibition Unpacking Psychological Vulnerabilities in Deaths of Despair On the (un)reliability of common behavioral and electrophysiological measures from the stop signal task: Measures of inhibition lack stability over time Risk factors for macro vascular disease in type 2 diabetes mellitus patients with non-alcoholic fatty liver disease Cellular and molecular effects of fipronil in lipid metabolism of HepG2 and its possible connection to non-alcoholic fatty liver disease LRP10 and α-synuclein transmission in Lewy body diseases Genetic inhibition of angiopoietin-like protein-3, lipids, and cardiometabolic risk Tmem178 negatively regulates IL-1β production through inhibition of the NLRP3 inflammasome Liver Lipidomics Analysis Revealed the Protective mechanism of Zuogui Jiangtang Qinggan Formula in type 2 diabetes mellitus with non-alcoholic fatty liver disease Liver Lipidomics Analysis Revealed the Protective mechanism of Zuogui Jiangtang Qinggan Formula in type 2 diabetes mellitus with non-alcoholic fatty liver disease Diabetes-related posttraumatic stress symptoms (PTSS) in adolescents and young adults with type 1 diabetes: A pilot study Multi-monoubiquitination controls VASP-mediated actin dynamics Energy Metabolism in Residents in the Low- and Moderate Altitude Regions of Central Asia with MAFLD and Type 2 Diabetes Mellitus Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis STUDY OF THE PROCESSES OF LIPID PEROXIDATION, THE STATE OF THE ANTIOXIDANT SYSTEM IN PATIENTS WITH POLYTRAUMA AND ALCOHOL ANAMNESIS The effect of circulating iron on barrier integrity of primary human endothelial cells Role of NRF2 and reactive aldehydes in acute cellular rejection in liver transplant recipients Elucidating the role of intrinsic adenosine A1 receptors in acute alcoholism using human induced pluripotent stem cell-derived hepatocytes Perilipin2 inhibits the replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions A gain of function mutation in AKT1 increases hexokinase 2 and diminishes oxidative stress in meningioma Lactate levels in the brain and blood of schizophrenia patients: A systematic review and meta-analysis Fermented Protaetia brevitarsis Larvae Ameliorates Chronic Ethanol-Induced Hepatotoxicity in Mice via AMPK and TLR-4/TGF-β1 Pathways PPAR-γ agonists reactivate the ALDOC-NR2F1 axis to enhance sensitivity to temozolomide and suppress glioblastoma progression Disulfiram: A novel repurposed drug for cancer therapy Inhibition of DAPK3 suppresses radiation-induced cellular senescence by activation of a PGC1alpha-dependent metabolism pathway in brain endothelial cells Knockout of Tmlhe in mice is not associated with autism spectrum disorder phenotypes or motor dysfunction despite low carnitine levels Analytical refractory period distribution for a class of time-variant biochemical systems with second-order reactions A CDAHFD-induced mouse model mimicking human NASH in the metabolism of hepatic phosphatidylcholines and acyl carnitines Falsely low glycosylated haemoglobin levels probably secondary to hypersplenism in a patient with diabetes mellitus New Highly Selective BACE1 Inhibitors and Their Effects on Dendritic Spine Density In Vivo Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease