Evidence
Sci Adv. 2023 Dec 15;9(50):eadi7632. doi: 10.1126/sciadv.adi7632. Epub 2023 Dec 13.
ABSTRACT
In comparison to other species, the human brain exhibits one of the highest energy demands relative to body metabolism. It remains unclear whether this heightened energy demand uniformly supports an enlarged brain or if specific signaling mechanisms necessitate greater energy. We hypothesized that the regional distribution of energy demands will reveal signaling strategies that have contributed to human cognitive development. We measured the energy distribution within the brain functional connectome using multimodal brain imaging and found that signaling pathways in evolutionarily expanded regions have up to 67% higher energetic costs than those in sensory-motor regions. Additionally, histology, transcriptomic data, and molecular imaging independently reveal an up-regulation of signaling at G-protein-coupled receptors in energy-demanding regions. Our findings indicate that neuromodulator activity is predominantly involved in cognitive functions, such as reading or memory processing. This study suggests that an up-regulation of neuromodulator activity, alongside increased brain size, is a crucial aspect of human brain evolution.
PMID:38091393 | DOI:10.1126/sciadv.adi7632
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
An energy costly architecture of neuromodulators for human brain evolution and cognition
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Physiological strategies of acute thermal conditions of Rhamdia voulezi collected in the Iguaçu river watershed, Paraná, Brazil: biochemical markers of metabolic and oxidative stress
- Using a comprehensive atlas and predictive models to reveal the complexity and evolution of brain-active regulatory elements
- A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity
- Comparative neuroimaging of sex differences in human and mouse brain anatomy
- Stochastic neuro-fuzzy system implemented in memristor crossbar arrays
- Species -shared and -unique gyral peaks on human and macaque brains
- Spotl:ght: Illuminating Engineering
- Alzheimer's disease rewires gene coexpression networks coupling different brain regions
- Detailed mapping of the complex fiber structure and white matter pathways of the chimpanzee brain
- Cholinergic neurotransmission controls orexigenic endocannabinoid signaling in the gut in diet-induced obesity
- The emerging role of glucagon-like peptide-1 in binge eating
- The emerging role of glucagon-like peptide-1 in binge eating
- Cardinality-constrained plan-quality and delivery-time optimization method for proton therapy
- Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood
- Discovering the gene-brain-behavior link in autism via generative machine learning
- Building Bridges between Energy Net Zero Technology, Policy and Finance: Interdisciplinary Networking Reception
- Medium-Chain Triglycerides (MCTs) for the Symptomatic Treatment of Dementia-Related Diseases: A Systematic Review
- Regulation of the mouse ventral tegmental area by melanin-concentrating hormone
- Regulation of the mouse ventral tegmental area by melanin-concentrating hormone
- The Challenge of Emissions - ZERO Institute keynote invited talk from Breakthrough Energy's Dr Eric Toone
- The Challenge of Emissions - ZERO Institute keynote invited talk from Breakthrough Energy's Dr Eric Toone
- The Challenge of Emissions - ZERO Institute keynote invited talk from Breakthrough Energy's Dr Eric Toone
- Longitudinal Biochemical and Behavioral Alterations in a Gyrencephalic Model of Blast-Related Mild Traumatic Brain Injury
- Extracellular ATP is a homeostatic messenger that mediates cell‒cell communication in physiological processes and psychiatric diseases
- Extracellular ATP is a homeostatic messenger that mediates cell‒cell communication in physiological processes and psychiatric diseases
- Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data
- Fusion of memristor and digital compute-in-memory processing for energy-efficient edge computing
- Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data
- The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation
- ADNP dysregulates methylation and mitochondrial gene expression in the cerebellum of a Helsmoortel-Van der Aa syndrome autopsy case
- Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit
- Developmental dopaminergic signaling modulates neural circuit formation and contributes to autism spectrum disorder (ASD)-related phenotypes
- Seasonality in regional brain glucose metabolism
- Energy landscape analysis of brain network dynamics in Alzheimer's disease
- Ratiometric Afterglow Luminescent Imaging of Matrix Metalloproteinase-2 Activity via an Energy Diversion Process
- Characterization of reduced astrocyte creatine kinase levels in Alzheimer's disease
- Connectome reorganization associated with temporal lobe pathology and its surgical resection
- Case for supporting astrocyte energetics in glucose transporter 1 deficiency syndrome
- Progress in The Research of Lactate Metabolism Disruption And Astrocyte-Neuron Lactate Shuttle Impairment in Schizophrenia: A Comprehensive Review
- Termination of convulsion seizures by destabilizing and perturbing seizure memory engrams
- Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data
- Research progress in mitochondrial quality control in schizophrenia
- Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2
- Peripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment
- HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis
- The genetic architecture of multimodal human brain age
- CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans
- Interpretable prediction of brain activity during conversations from multimodal behavioral signals
- The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells
- Brain-Derived Neurotrophic Factor as a Potential Mediator of the Beneficial Effects of Myo-Inositol Supplementation during Suckling in the Offspring of Gestational-Calorie-Restricted Rats
- Brain hypothyroidism silences the immune response of microglia in Alzheimer's disease animal model
- Emerging Theories of Allostatic-Interoceptive Overload in Neurodegeneration
- Neural mechanism of non-adaptive cognitive emotion regulation in patients with non-suicidal self-injury
- Sustainable Sea of Internet of Things: Wind Energy Harvesting System for Unmanned Surface Vehicles
- Light affects the prefrontal cortex via intrinsically photosensitive retinal ganglion cells
- Post-retrieval stress impairs subsequent memory depending on hippocampal memory trace reinstatement during reactivation
- Altered structural connectivity and functional brain dynamics in individuals with heavy alcohol use elucidated via network control theory
- Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics
- Sensitive interventions to catalyse China’s net-zero transition in energy and transport
- Theory of centralized aerobic-anaerobic energy balance compensation and non-pharmaceutical treatment methods of arterial hypertension
- Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics
- Howard Covington on AI & Climate Change - Adrian Fernando Memorial Lecture
- Energy expenditure during nutritional rehabilitation: a scoping review to investigate hypermetabolism in individuals with anorexia nervosa
- Emerging Vanadium-Doped Cobalt Chloride Carbonate Hydroxide for Flexible Electrochromic Micro-Supercapacitor: Charged-State Prediction from RGB Input by ANN Model
Evidence Blueprint
An energy costly architecture of neuromodulators for human brain evolution and cognition
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
An energy costly architecture of neuromodulators for human brain evolution and cognition
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Brain energy metabolism is optimized to minimize the cost of enzyme synthesis and transport
- Frontal-temporal regional differences in brain energy metabolism and mitochondrial function using 31P MRS in older adults
- Human-specific features and developmental dynamics of the brain N-glycome
- Oxford University to lead tidal energy project for carbon emission reduction and energy security
- In vivo mapping of pharmacologically induced functional reorganization onto the human brain's neurotransmitter landscape
- Electro-metabolic signaling
- LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
- Mechanistic multiscale modelling of energy metabolism in human astrocytes reveals the impact of morphology changes in Alzheimer's Disease
- Balance-energy of resting state network in obsessive-compulsive disorder
- The metabolic overdrive hypothesis: hyperglycolysis and glutaminolysis in bipolar mania
- Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
- Physiological strategies of acute thermal conditions of Rhamdia voulezi collected in the Iguaçu river watershed, Paraná, Brazil: biochemical markers of metabolic and oxidative stress
- Energy as a Social and Commercial Determinant of Health: A Qualitative Study of Australian Policy
- Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer's Disease
- TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain
- Energy metabolism of the immune system : Consequences in chronic inflammation
- Short-term energy drink consumption influences plasma glucose, apolipoprotein B, body mass index and pulse rate among students
- Genomic loci influence patterns of structural covariance in the human brain
- Using a comprehensive atlas and predictive models to reveal the complexity and evolution of brain-active regulatory elements
- ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis
- A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity
- Ketone bodies mediate alterations in brain energy metabolism and biomarkers of Alzheimer's disease
- New energy vehicle battery recycling strategy considering carbon emotion from a closed-loop supply chain perspective
- Comparative neuroimaging of sex differences in human and mouse brain anatomy
- Lactate levels in the brain and blood of schizophrenia patients: A systematic review and meta-analysis
- Stochastic neuro-fuzzy system implemented in memristor crossbar arrays
- TDP-43 impairs sleep in Drosophila through Ataxin-2-dependent metabolic disturbance
- Wind and solar power could significantly exceed Britain’s energy needs
- Subject-specific maximum entropy model of resting state fMRI shows diagnostically distinct patterns of energy state distributions
- Daylight quality: high-transmittance glass versus low transmittance glass - effects on daylight quality, health, comfort and energy consumption
- Possible roles of deep cortical neurons and oligodendrocytes in the neural basis of human sociality
- Synthesis of [11C]BIIB104, an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic-Acid-Positive Allosteric Modulator, and Evaluation of the Bio-Distribution in Non-Human Primate Brains Using Positron Emission Tomography
- Species -shared and -unique gyral peaks on human and macaque brains
- The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPARα/γ activity
- Spotl:ght: Illuminating Engineering
- Alzheimer's disease rewires gene coexpression networks coupling different brain regions
- Using energy psychology to remediate emotional wounds rooted in childhood trauma: preliminary clinical guidelines
- Relation of connectome topology to brain volume across 103 mammalian species
- Detailed mapping of the complex fiber structure and white matter pathways of the chimpanzee brain
- OBESITY AND GUT-BRAIN AXIS
- Cholinergic neurotransmission controls orexigenic endocannabinoid signaling in the gut in diet-induced obesity
- Functional connectome through the human life span
- The emerging role of glucagon-like peptide-1 in binge eating
- The emerging role of glucagon-like peptide-1 in binge eating
- Cardinality-constrained plan-quality and delivery-time optimization method for proton therapy
- Spexin and nesfatin-1-expressing neurons in the male human claustrum
- High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling
- Abnormal energy metabolism in ALS: a key player?
- Experts call for new economic modelling to meet energy transition ambition
- Brain energetics and glucose transport in metabolic diseases: role in neurodegeneration
- How the Brain Becomes the Mind: Can Thermodynamics Explain the Emergence and Nature of Emotions?
- Aberrant brain dynamics of large-scale functional networks across schizophrenia and mood disorder
- Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood
- Discovering the gene-brain-behavior link in autism via generative machine learning
- Hedonic eating, obesity, and addiction result from increased neuropeptide Y in the nucleus accumbens during human brain evolution
- Energy Metabolism in Residents in the Low- and Moderate Altitude Regions of Central Asia with MAFLD and Type 2 Diabetes Mellitus
- Building Bridges between Energy Net Zero Technology, Policy and Finance: Interdisciplinary Networking Reception
- Medium-Chain Triglycerides (MCTs) for the Symptomatic Treatment of Dementia-Related Diseases: A Systematic Review
- Paraventricular thalamic MC3R circuits link energy homeostasis with anxiety-related behavior
- Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury
- Regulation of the mouse ventral tegmental area by melanin-concentrating hormone
- Regulation of the mouse ventral tegmental area by melanin-concentrating hormone
- Impact of cannabis use on brain metabolism using 31P and 1H magnetic resonance spectroscopy
- The Challenge of Emissions - ZERO Institute keynote invited talk from Breakthrough Energy's Dr Eric Toone