Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Mol Aspects Med. 2022 Nov 10:101154. doi: 10.1016/j.mam.2022.101154. Online ahead of print.
ABSTRACT
Considerable evidence has established the importance of specific nutrients that have been found vital for the developing brain. We hypothesize that in a similar manner there should be nutrients vital to the aging brain and that based on aging’s distinct pathophysiology they should be different than those essential to development. Specific brain networks that govern cognition are particularly vulnerable to the aging process, resulting in what is referred to as ‘cognitive aging’. Common late-life disorders, however, such as Alzheimer’s disease also target these same brain networks. Studies have disambiguated cognitive aging from late-life disease by isolating regions and biological pathways within each network differentially linked to one or the other. This anatomical biology anchors a framework to identify nutrients and/or dietary bioactives relevant to cognitive aging whose utility is illustrated via a decades-long research program into how dietary bioactive flavanols benefit the brain. As we are living longer in cognitively more demanding lives, the framework’s ultimate goal is to generate specific dietary recommendations that will fortify our mind for its golden years.
PMID:36372583 | DOI:10.1016/j.mam.2022.101154
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Anatomical biology guides a search for nutrients for the aging brain
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Influence of human gut microbiome on the healthy and the neurodegenerative aging T Cells Trafficking into the Brain in Aging and Alzheimer's Disease Systemic inflammatory markers in ageing, Alzheimer's disease and other dementias Accelerated biological brain aging in major depressive disorder Brain aging patterns in a large and diverse cohort of 49,482 individuals Brain aging patterns in a large and diverse cohort of 49,482 individuals Brain aging patterns in a large and diverse cohort of 49,482 individuals Aging Brain from a Lifespan Perspective Cognitive and brain morphological deviations in middle-to-old aged autistic adults: A systematic review and meta-analysis Peripheral vascular dysfunction and the aging brain Modern neurophysiological techniques indexing normal or abnormal brain aging White matter brain-age in diverse forms of epilepsy and interictal psychosis The blood brain barrier dysfunction in healthy aging and dementia: why, how, what for? The blood brain barrier dysfunction in healthy aging and dementia: why, how, what for? A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders - a systematic review Distinct Longitudinal Brain White Matter Microstructure Changes and Associated Polygenic Risk of Common Psychiatric Disorders and Alzheimer's Disease in the UK Biobank National Institute on Aging's 50th anniversary: Advancing cognitive aging research and the cognitive health of older adults Photobiomodulation in the aging brain: a systematic review from animal models to humans Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects Cardiac aging: from hallmarks to therapeutic opportunities Trioxidized cysteine and aging: a molecular binomial that extends far beyond classical proteinopathic paradigms 4D dynamic spatial brain networks at rest linked to cognition show atypical variability and coupling in schizophrenia Associations between regional blood-brain barrier permeability, aging, and Alzheimer's disease biomarkers in cognitively normal older adults Establishing validated RT-qPCR workflow for the analysis of oligodendrocyte gene expression in the developing murine brain Glymphatic dysfunction as a driver of Alzheimer’s disease: Moving past the hype Brain age has limited utility as a biomarker for capturing fluid cognition in older individuals Brain age has limited utility as a biomarker for capturing fluid cognition in older individuals Tractometry of Human Visual White Matter Pathways in Health and Disease Tractometry of Human Visual White Matter Pathways in Health and Disease Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies Altered intra- and inter-network connectivity in autism spectrum disorder Dissociation of focal and large-scale inhibitory functions in the older adults: A multimodal MRI study Jingfang granules protects against intracerebral hemorrhage by inhibiting neuroinflammation and protecting blood-brain barrier damage Brief Aging Education Impacts Continuing Education Preferences and Behaviors of Mental Health Providers Brief Aging Education Impacts Continuing Education Preferences and Behaviors of Mental Health Providers Characterizing dog cognitive aging using spontaneous problem-solving measures: development of a battery of tests from the Dog Aging Project Characterizing dog cognitive aging using spontaneous problem-solving measures: development of a battery of tests from the Dog Aging Project Resting State Electrophysiological Profiles and Their Relationship with Cognitive Performance in Cognitively Unimpaired Older Adults: A Systematic Review Aging suppresses subthalamic neuronal activity in patients with Parkinson's disease Mendelian randomization evidence for the causal effect of mental well-being on healthy aging Beta-to-Theta Entropy Ratio of EEG in Aging, Frontotemporal Dementia, and Alzheimer's Dementia Gut microbiota-astrocyte axis: new insights into age-related cognitive decline NODDI in gray matter is a sensitive marker of aging and early AD changes Brain network localization of gray matter atrophy, neurocognitive and social cognitive dysfunction in schizophrenia Connecting the Dots: Gender, Sexuality, and Societal Influences on Cognitive Aging and Alzheimer's Disease How Diet and Lifestyle Can Fine-Tune Gut Microbiomes for Healthy Aging Efficacy of bumetanide in animal models of ischemic stroke: a systematic review and meta-analysis Relationship between falls, cognitive decline, and dementia in older adults: Insights from the Korean longitudinal study of aging, 2006-2020 The neuron-specific IIS/FOXO transcriptome in aged animals reveals regulatory mechanisms of cognitive aging Comparison of deep learning architectures for predicting amyloid positivity in Alzheimer's disease, mild cognitive impairment, and healthy aging, from T1-weighted brain structural MRI Immune gene regulation is associated with age and environmental adversity in a nonhuman primate Sex-Dependent Effects of Cardiometabolic Health and APOE4 on Brain Age: A Longitudinal Cohort Study P-glycoprotein activity in vivo in older adults: physiological, pathophysiological and pharmacokinetic interplay at the blood-brain barrier Acute Exercise Improves Large-Scale Brain Network Segregation in Healthy Older Adults Tau follows principal axes of functional and structural brain organization in Alzheimer's disease Low testosterone levels relate to poorer cognitive function in women in an APOE-ε4-dependant manner Low testosterone levels relate to poorer cognitive function in women in an APOE-ε4-dependant manner Connecto-informatics at the mesoscale: current advances in image processing and analysis for mapping the brain connectivity Connecto-informatics at the mesoscale: current advances in image processing and analysis for mapping the brain connectivity Enhancing Care for Older Adults and Dementia Patients with Large Language Models: Proceedings of the National Institute on Aging -Artificial Intelligence & Technology Collaboratory for Aging Research Symposium A second X chromosome improves cognition in aging male and female mice Nur77 improves ovarian function in reproductive aging mice by activating mitophagy and inhibiting apoptosis Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies Delineating the Heterogeneity of Alzheimer's Disease and Mild Cognitive Impairment Using Normative Models of the Dynamic Brain Functional Networks
Evidence Blueprint
Anatomical biology guides a search for nutrients for the aging brain
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Anatomical biology guides a search for nutrients for the aging brain
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
New directions for studying the aging social-cognitive brain Influence of human gut microbiome on the healthy and the neurodegenerative aging Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions Rhythmic musical activities may strengthen connectivity between brain networks associated with aging-related deficits in timing and executive functions Cerebellum and Aging: Update and Challenges T Cells Trafficking into the Brain in Aging and Alzheimer's Disease Strategies to dissect microglia-synaptic interactions during aging and in Alzheimer's disease Strategies to dissect microglia-synaptic interactions during aging and in Alzheimer's disease Systemic inflammatory markers in ageing, Alzheimer's disease and other dementias Does the liver facilitate aging-related cognitive impairment: Conversation between liver and brain during exercise? Accelerated biological brain aging in major depressive disorder Arterial Aging and Cerebrovascular Function: Impact of Aerobic Exercise Training in Older Adults Brain aging patterns in a large and diverse cohort of 49,482 individuals Brain aging patterns in a large and diverse cohort of 49,482 individuals Brain aging patterns in a large and diverse cohort of 49,482 individuals From theory to practice: translating the concept of cognitive resilience to novel therapeutic targets that maintain cognition in aging adults Aging Brain from a Lifespan Perspective Cognitive and brain morphological deviations in middle-to-old aged autistic adults: A systematic review and meta-analysis Peripheral vascular dysfunction and the aging brain Skin-brain axis in Alzheimer's disease - Pathologic, diagnostic, and therapeutic implications: A Hypothetical Review Modern neurophysiological techniques indexing normal or abnormal brain aging White matter brain-age in diverse forms of epilepsy and interictal psychosis The blood brain barrier dysfunction in healthy aging and dementia: why, how, what for? The blood brain barrier dysfunction in healthy aging and dementia: why, how, what for? The 'middle-aging' brain Organ aging signatures in the plasma proteome track health and disease Neuronal cell cycle reentry events in the aging brain are more prevalent in neurodegeneration and lead to cellular senescence Brain structure ages-A new biomarker for multi-disease classification Microglial Senescence and Activation in Healthy Aging and Alzheimer's Disease: Systematic Review and Neuropathological Scoring Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients Age-associated cortical similarity networks correlate with cell type-specific transcriptional signatures Quantitative Susceptibility Mapping of Brain Iron in Healthy Aging and Cognition Considering the response in addition to the challenge - a narrative review in appraisal of a motor reserve framework Exploring Timescale-Specific Functional Brain Networks and Their Associations with Aging and Cognitive Performance in a Healthy Cohort without Dementia A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders - a systematic review Distinct Longitudinal Brain White Matter Microstructure Changes and Associated Polygenic Risk of Common Psychiatric Disorders and Alzheimer's Disease in the UK Biobank The co-activation pattern between the DMN and other brain networks affects the cognition of older adults: evidence from naturalistic stimulation fMRI data National Institute on Aging's 50th anniversary: Advancing cognitive aging research and the cognitive health of older adults Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein Data-driven transcriptomics analysis identifies PCSK9 as a novel key regulator in liver aging Genetic and Clinical Correlates of AI-Based Brain Aging Patterns in Cognitively Unimpaired Individuals Atypical brain aging and its association with working memory performance in major depressive disorder Sonic Hedgehog Signalling Pathway Contributes in Age-Related Disorders and Alzheimer's Disease Lipid Droplets Accumulation in the Brain of HIV Transgenic Rat: Implication in the Accelerated Aging of HIV Infected Individuals Photobiomodulation in the aging brain: a systematic review from animal models to humans Frequency of cognitive "super-aging" in three Australian samples using different diagnostic criteria Apolipoprotein E2 Expression Alters Endosomal Pathways in a Mouse Model With Increased Brain Exosome Levels During Aging Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder Impact of NLRP3 Depletion on Aging-Related Metaflammation, Cognitive Function, and Social Behavior in Mice Immune proteins C1q and CD47 may contribute to aberrant microglia-mediated synapse loss in the aging monkey brain that is associated with cognitive impairment Cardiac aging: from hallmarks to therapeutic opportunities Region-specific and age-related differences in astrocytes in the human brain Intranasal GHK peptide enhances resilience to cognitive decline in aging mice Poor communication between ER and mitochondria: a signature of ALS/FTD? Cholinergic Neuromodulation in the Aging Brain - Implications for Neuropsychiatric Diseases: Commentary on "Neuromodulatory Systems in Aging and Disease" Special Issue Brain apolipoprotein E levels in mice challenged by a Western diet increase in an allele-dependent manner Berberine attenuates brain aging via stabilizing redox homeostasis and inflammation in an accelerated senescence model of Wistar rats Trioxidized cysteine and aging: a molecular binomial that extends far beyond classical proteinopathic paradigms Herpes simplex virus 2 serology is associated with thinner whole-brain cortex in community-dwelling older adults 4D dynamic spatial brain networks at rest linked to cognition show atypical variability and coupling in schizophrenia Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain Tomato and Lemon Extracts Synergistically Improve Cognitive Function by Increasing Brain-derived Neurotrophic Factor Levels in Aged Mice