Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Chemistry. 2022 Nov 20. doi: 10.1002/chem.202202735. Online ahead of print.
ABSTRACT
Precise manipulating both the morphology and chiroptical signals of supramolecular assemblies will help to better understand the natural biological self-assembly mechanism. Herein, two simple L/D-phenylalanine based derivatives (L/DPFM) are designed and their solvent-dependent morphology evolutions are illustrated. It is found that by increasing the content of H2O in the ethanol aqueous solutions, LPFM can self-assemble into right-handed nanofibers, flat fibrous structures and inversed left-handed nanofibers, respectively. The assemblies in ethanol and H2O exhibit opposite conformations and circular dichroism (CD) signals even though they are constructed from the same molecules. Thus, the morphology-dependent cell adhesion and proliferation behaviors are further characterized. Left-handed nanofibers are found to be more favorable for the cell adhesion compared with right-handed nanostructures. The quantitative AFM analysis showed that L929 cell adhesion force on left-handed LPFM fibers is much higher than that on structures with inversed handedness. Besides, the value of cell Young’s modulus is lower for left-handed nanofibrous films, which indicates better flexibility. The difference in cell-substrate interactions may lead to different effect on cell behaviors.
PMID:36404280 | DOI:10.1002/chem.202202735
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Assembly of Helical Nanostructures: Solvent-Induced Morphology Transition and the Effect on Cell Adhesion
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Hemichannels contribute to mitochondrial Ca2+ and morphology alterations evoked by ethanol in astrocytes Click-chemistry mediated synthesis of OTBN-1,2,3-Triazole derivatives exhibiting STK33 inhibition with diverse anti-cancer activities Breast Tumor Cell Survival and Morphology in a Brain-like Extracellular Matrix Depends on Matrix Composition and Mechanical Properties Stimuli-Responsive Chiral Cellulose Nanocrystals Based Self-Assemblies for Security Measures to Prevent Counterfeiting: A Review Photoinduced Transition-MetalExternal Photosensitizer Free Benzylic Fluorination of Unactivated Alkylarenes Brain Morphology Normative modelling platform for abnormality and Centile estimation: Brain MoNoCle Fabrication of porous poly(L-lactide-co-ε-caprolactone) micropowder for microbubble effect and ultrasound-mediated drug delivery Global systematical and comprehensive overview of mountainous flood risk under climate change and human activities In Silico Chemical Experiments in the Age of AI: From Quantum Chemistry to Machine Learning and Back MCA Parallel Anatomic Scanning MR Imaging-Guided Recanalization of a Chronic Occluded MCA by Endovascular Treatment MCA Parallel Anatomic Scanning MR Imaging-Guided Recanalization of a Chronic Occluded MCA by Endovascular Treatment AlphaFold2 structures guide prospective ligand discovery Nanocellulose extraction from acai bagasse through mixed acid hydrolysis and oxidative techniques Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport Bioinspired Colorimetric Double Inverse Opal Photonic Crystal Indicators for Ethanol Concentration Sensing in Fermentation Engineering Preconception ethanol exposure changes anxiety, depressive and checking-like behavior and alter the expression levels of MAO-B in male offspring Chronic Alcohol Exposure Alters the Levels and Assembly of the Actin Cytoskeleton and Microtubules in the Adult Mouse Hippocampus Evaluation of artificial intelligence-assisted morphological analysis for platelet count estimation Disrupting glioblastoma networks with tumor treating fields (TTFields) in in vitro models Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression Improves Mitophagy in Alzheimer's Disease Models Crystal Composition Transformer: Self-Learning Neural Language Model for Generative and Tinkering Design of Materials Calcium channel signalling at neuronal endoplasmic reticulum-plasma membrane junctions Calcium channel signalling at neuronal endoplasmic reticulum-plasma membrane junctions PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton, modulating emotional behavior The disease-causing tau V337M mutation induces tau hypophosphorylation and perturbs axon morphology pathways The Rational Design of Atomically Dispersed Catalysts via Spin Manipulation Mobility capillary electrophoresis-native mass spectrometry reveals the dynamic conformational equilibrium of calmodulin and its complexes Sex differences in intestinal morphology and increase in diencephalic neuropeptide Y gene expression in female but not male Pekin ducks exposed to chronic heat stress Kainate receptor channel opening and gating mechanism Thinking Three-Dimensionally: A Self- and Externally-Controlled Approach to Screening for Drug-Drug-Drug Interactions Among High-Risk Populations Thinking Three-Dimensionally: A Self- and Externally-Controlled Approach to Screening for Drug-Drug-Drug Interactions Among High-Risk Populations Moderate India Pale Ale beer consumption promotes antigenotoxic and non-mutagenic effects in ex vivo and in vivo mice models Local modulation of dopaminergic action signals during goal-directed learning Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene Generative Artificial Intelligence for Designing Multi-Scale Hydrogen Fuel Cell Catalyst Layer Nanostructures Diagnostics Accuracy of Magnetic Resonance Imaging in Detection of Atherosclerotic Plaque Characteristics in Carotid Arteries Compared to Histology: A Systematic Review The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons Effects of self- and experimenter-administered cocaine on subsequent ethanol drinking in rhesus monkeys Evaluation of tribological and biological properties of Ti6Al4V coated with Si3N4/ND nanoparticles for orthopedic applications: a comprehensive analysis Digital in-line holographic microscopy for label-free identification and tracking of biological cells Morphological patterns and spatial probability maps of the inferior frontal sulcus in the human brain Morphological patterns and spatial probability maps of the inferior frontal sulcus in the human brain Nobiletin Protects Against Alcoholic Liver Disease in Mice via the BMAL1-AKT-Lipogenesis Pathway Imbalanced mitochondrial dynamics contributes to the pathogenesis of X-linked adrenoleukodystrophy OpenChemIE: An Information Extraction Toolkit for Chemistry Literature A comparative anatomical network analysis of the human and chimpanzee brains Synaptic Mechanisms of Ethanol Tolerance and Neuroplasticity: Insights from Invertebrate Models Radiomics analysis of ultrasound images to discriminate between benign and malignant adnexal masses with solid ultrasound morphology Emulation and evaluation of tumor cell combined chemotherapy in isotropic/anisotropic collagen fiber microenvironments Emulation and evaluation of tumor cell combined chemotherapy in isotropic/anisotropic collagen fiber microenvironments The mitochondria-related gene risk mode revealed p66Shc as a prognostic mitochondria-related gene of glioblastoma The mitochondria-related gene risk mode revealed p66Shc as a prognostic mitochondria-related gene of glioblastoma Embryonic alcohol exposure alters cholinergic neurotransmission and memory in adult zebrafish GABA-edited MEGA-PRESS at 3 T: Does a measured macromolecule background improve linear combination modeling? Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number A theoretical study of the oxidation of benzene by manganese oxide clusters: formation of quinone intermediates Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice A high-performance organic lithium salt-doped OFET with the optical radical effect for photoelectric pulse synaptic simulation and neuromorphic memory learning The morphology strikes back The laminar position, morphology, and gene expression profiles of cortical astrocytes are influenced by time of birth from ventricular/subventricular progenitors Accelerating Molecular Docking using Machine Learning Methods Revolutionizing Playing with Skeleton Atoms: Molecular Editing Surgery in Medicinal Chemistry Alcohol- and Low-Iron Induced Changes in Antioxidant and Energy Metabolism Associated with Protein Lys Acetylation
Evidence Blueprint
Assembly of Helical Nanostructures: Solvent-Induced Morphology Transition and the Effect on Cell Adhesion
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Assembly of Helical Nanostructures: Solvent-Induced Morphology Transition and the Effect on Cell Adhesion
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Suicide Gene Delivery by Morphology-Adaptable Enantiomeric Peptide Assemblies for Combined Ovarian Cancer Therapy Berberis integerrima bioactive molecules loaded in chitosan-based electrospun nanofibers for soybean oil oxidative protection Epileptic activity triggers rapid ROCK1-dependent astrocyte morphology changes Atomic Scale Structure of Self-assembled Lipidated Peptide Nanomaterials δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions Toolkits for detailed and high-throughput interrogation of synapses in C. elegans Crowding alters F-actin secondary structure and hydration Hemichannels contribute to mitochondrial Ca2+ and morphology alterations evoked by ethanol in astrocytes Species -shared and -unique gyral peaks on human and macaque brains Abnormal microglial density and morphology in the brain of cyclooxygenase 2 knockin mice Morphological and electrophysiological characterization of a novel displaced astrocyte in the mouse retina Click-chemistry mediated synthesis of OTBN-1,2,3-Triazole derivatives exhibiting STK33 inhibition with diverse anti-cancer activities Imaging Amyloid-β Membrane Interactions: Ion-Channel Pores and Lipid-Bilayer Permeability in Alzheimer's Disease Multimeric structure of a subfamily III haloalkane dehalogenase-like enzyme solved by combination of cryo-EM and X-ray crystallography Breast Tumor Cell Survival and Morphology in a Brain-like Extracellular Matrix Depends on Matrix Composition and Mechanical Properties Stimuli-Responsive Chiral Cellulose Nanocrystals Based Self-Assemblies for Security Measures to Prevent Counterfeiting: A Review Accelerating Computation of Acidity Constants and Redox Potentials for Aqueous Organic Redox Flow Batteries by Machine Learning Potential-Based Molecular Dynamics Relevance of alcoholic solvents in the growth of ZnO nanoparticles and ZnO hierarchical nanorod structures on their optical and opto-electrical properties Elevated levels of alcohol dehydrogenase aggravate ethanol-evoked cardiac remodeling and contractile anomalies through FKBP5-yap-mediated regulation of ferroptosis and ER stress BCFtools/liftover: an accurate and comprehensive tool to convert genetic variants across genome assemblies Photoinduced Transition-MetalExternal Photosensitizer Free Benzylic Fluorination of Unactivated Alkylarenes Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study Brain Morphology Normative modelling platform for abnormality and Centile estimation: Brain MoNoCle Photo-thermal Cooperative Carbonylation of Ethanol with CO2 on Cu2O-SrTiCuO3-x Fabrication of porous poly(L-lactide-co-ε-caprolactone) micropowder for microbubble effect and ultrasound-mediated drug delivery Emotion recognition in EEG signals using deep learning methods: A review Quantitative assessment of mitochondrial morphology relevant for studies on cellular health and environmental toxicity Alcohol Promotes Lipogenesis in Sebocytes-Implications for Acne Nuclear morphology is shaped by loop-extrusion programs Pyrazoline Derivatives as Promising MAO-A Targeting Antidepressants: An Update HydrogelFinder: A Foundation Model for Efficient Self-Assembling Peptide Discovery Guided by Non-Peptidal Small Molecules Hyperspectral Mapping of Human Primary and Stem Cells at Cell-Matrix Interfaces Alcohol induces hepatocytes necroptosis through the LC3/RIPK1/RIPK3 pathway Sake yeast symbiosis with lactic acid bacteria and alcoholic fermentation Co-encapsulated astaxanthin and kaempferol nanoparticles: fabrication, characterization, and their potential synergistic effects on treating non-alcoholic fatty liver disease Synthesis and self-assembly behaviors of α-galactosyl ceramide (1,2)-polysaccharide analogue Reduction of alcohol-induced mitochondrial damage with ginsenoside Rg1 studied by atomic force microscopy Ethanol causes non-communicable disease through activation of NLRP3 inflammasome: a review on mechanism of action and potential interventions Dual color miniscope imaging of microvessels and neuronal activity in the hippocampus CA1 region of freely moving mice following alcohol administration Biochemical approaches to assess the impact of post-translational modifications on pathogenic tau conformations using recombinant protein Pharmacokinetic Analysis of Ethanol in a Human Study: New Modification of Mathematic Model Alcohol-induced Conformational Changes and Thermodynamic Signatures in the Binding of Polyphenols to Proline-rich Salivary Proteins Ethanol-Induced Hepatic Ferroptosis Is Mediated by PERK-Dependent MAMs Formation: Preventive Role of Quercetin Regulation of Presynaptic Release Machinery by Cell Adhesion Molecules Global systematical and comprehensive overview of mountainous flood risk under climate change and human activities The impact of chemical fixation on the microanatomy of mouse organotypic hippocampal slices Higher-order thalamocortical circuits are specified by embryonic cortical progenitor types in the mouse brain Everyday home radon exposure is associated with altered structural brain morphology in youths Interaction between fatty acid oxidation and ethanol metabolism in liver Toward individualized connectomes of brain morphology In Silico Chemical Experiments in the Age of AI: From Quantum Chemistry to Machine Learning and Back MCA Parallel Anatomic Scanning MR Imaging-Guided Recanalization of a Chronic Occluded MCA by Endovascular Treatment MCA Parallel Anatomic Scanning MR Imaging-Guided Recanalization of a Chronic Occluded MCA by Endovascular Treatment Bitter taste function-related genes are implicated in the behavioral association between taste preference and ethanol preference in male mice AlphaFold2 structures guide prospective ligand discovery The Drosophila homolog of APP promotes Dscam expression to drive axon terminal growth, revealing interaction between Down syndrome genes Three-dimensional visualization and analysis of dendritic spines in human brain tissue Nanocellulose extraction from acai bagasse through mixed acid hydrolysis and oxidative techniques Saline as solvent and ethanol-based purification process for the extraction of proteins and isoflavones from wet okara cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice Molecular Docking, Synthesis, and Characterization of Furanyl-pyrazolyl acetamide and 2,4-thiazolidinyl-furan-3-carboxamide Derivatives as Neuroinflammatory Protective Agents Effect of RpoS on the survival, induction, resuscitation, morphology, and gene expression of viable but non-culturable Salmonella Enteritidis in powdered infant formula Imp is expressed in INPs and newborn neurons where it regulates neuropil targeting in the central complex Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation