Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Chemistry. 2022 Nov 20. doi: 10.1002/chem.202202735. Online ahead of print.
ABSTRACT
Precise manipulating both the morphology and chiroptical signals of supramolecular assemblies will help to better understand the natural biological self-assembly mechanism. Herein, two simple L/D-phenylalanine based derivatives (L/DPFM) are designed and their solvent-dependent morphology evolutions are illustrated. It is found that by increasing the content of H2O in the ethanol aqueous solutions, LPFM can self-assemble into right-handed nanofibers, flat fibrous structures and inversed left-handed nanofibers, respectively. The assemblies in ethanol and H2O exhibit opposite conformations and circular dichroism (CD) signals even though they are constructed from the same molecules. Thus, the morphology-dependent cell adhesion and proliferation behaviors are further characterized. Left-handed nanofibers are found to be more favorable for the cell adhesion compared with right-handed nanostructures. The quantitative AFM analysis showed that L929 cell adhesion force on left-handed LPFM fibers is much higher than that on structures with inversed handedness. Besides, the value of cell Young’s modulus is lower for left-handed nanofibrous films, which indicates better flexibility. The difference in cell-substrate interactions may lead to different effect on cell behaviors.
PMID:36404280 | DOI:10.1002/chem.202202735
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Assembly of Helical Nanostructures: Solvent-Induced Morphology Transition and the Effect on Cell Adhesion
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Berberis integerrima bioactive molecules loaded in chitosan-based electrospun nanofibers for soybean oil oxidative protection Bioinspired Colorimetric Double Inverse Opal Photonic Crystal Indicators for Ethanol Concentration Sensing in Fermentation Engineering HydrogelFinder: A Foundation Model for Efficient Self-Assembling Peptide Discovery Guided by Non-Peptidal Small Molecules Ethanol-Induced Hepatic Ferroptosis Is Mediated by PERK-Dependent MAMs Formation: Preventive Role of Quercetin Imaging Amyloid-β Membrane Interactions: Ion-Channel Pores and Lipid-Bilayer Permeability in Alzheimer's Disease Species -shared and -unique gyral peaks on human and macaque brains Morphological and electrophysiological characterization of a novel displaced astrocyte in the mouse retina Click-chemistry mediated synthesis of OTBN-1,2,3-Triazole derivatives exhibiting STK33 inhibition with diverse anti-cancer activities Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria Accelerating Computation of Acidity Constants and Redox Potentials for Aqueous Organic Redox Flow Batteries by Machine Learning Potential-Based Molecular Dynamics Indicaxanthin prevents eryptosis induced by cigarette smoke extract by interfering with active Fas-mediated signaling Direct Extraction and Determination of Free Nicotine in Cigarette Smoke Fabrication of porous poly(L-lactide-co-ε-caprolactone) micropowder for microbubble effect and ultrasound-mediated drug delivery Optimization of peptide synthesis time and sustainability using novel eco-friendly binary solvent systems with induction heating on an automated peptide synthesizer cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice Brain-specific serine/threonine-protein kinase 1 is a substrate of protein kinase C epsilon involved in sex-specific ethanol and anxiety phenotypes Steven Starks, M.D., M.B.A., Assumes Office of APA Assembly Speaker Engineering fibronectin-templated multi-component fibrillar extracellular matrices to modulate tissue-specific cell response Engineering fibronectin-templated multi-component fibrillar extracellular matrices to modulate tissue-specific cell response Prevention of amyloid b fibril deposition on the synaptic membrane in the precuneus by ganglioside nanocluster-targeting inhibitors PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton, modulating emotional behavior miR-92a-3p regulates ethanol-induced apoptosis in H9c2 cardiomyocytes Global systematical and comprehensive overview of mountainous flood risk under climate change and human activities Nobiletin Protects Against Alcoholic Liver Disease in Mice via the BMAL1-AKT-Lipogenesis Pathway Higher-order thalamocortical circuits are specified by embryonic cortical progenitor types in the mouse brain Everyday home radon exposure is associated with altered structural brain morphology in youths Psilocybin reduces alcohol self-administration via selective left nucleus accumbens activation in rats AlphaFold2 structures guide prospective ligand discovery In Silico Chemical Experiments in the Age of AI: From Quantum Chemistry to Machine Learning and Back Interaction between fatty acid oxidation and ethanol metabolism in liver Nanocellulose extraction from acai bagasse through mixed acid hydrolysis and oxidative techniques Molecular Docking, Synthesis, and Characterization of Furanyl-pyrazolyl acetamide and 2,4-thiazolidinyl-furan-3-carboxamide Derivatives as Neuroinflammatory Protective Agents Effects of self- and experimenter-administered cocaine on subsequent ethanol drinking in rhesus monkeys Mobility capillary electrophoresis-native mass spectrometry reveals the dynamic conformational equilibrium of calmodulin and its complexes Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury Naphthoquinones and anthraquinones: Exploring their impact on acetylcholinesterase enzyme activity Atomic Force Microscopy beyond Topography: Chemical Sensing of 2D Material Surfaces through Adhesion Measurements The CB1 negative allosteric modulator PSNCBAM-1 reduces ethanol self-administration via a nonspecific hypophagic effect PAH deficient pathology in humanized c.1066-11G>A phenylketonuria mice Novel microbial synthesis of titania nanoparticles using probiotic Bacillus coagulans and its role in enhancing the microhardness of glass ionomer restorative materials Clinical predictors of Alzheimer's disease-like brain atrophy in individuals with memory complaints Expanding TheCellVision.org: A Central Repository for Visualizing and Mining High-Content Cell Imaging Projects Aurothioglucose encapsulated nanoparticles fostered neuroprotection in streptozotocin-induced Alzheimer's disease Left Ventricular Segmentation, Warping, and Myocardial Registration for Automated Strain Measurement Mimicking chronic alcohol effects through a controlled and sustained ethanol release device New insights into patterns of integration in the femur and pelvis among catarrhines Asymmetric Additions Empowered by OrganoCatalysts, Metal Catalysts, and Deep Natural Eutectic Solvents (NADES) Flexible Conformally Bioadhesive MXene Hydrogel Electronics for Machine Learning-Facilitated Human-Interactive Sensing Preconception ethanol exposure changes anxiety, depressive and checking-like behavior and alter the expression levels of MAO-B in male offspring Enhanced gelling property and freeze-thaw stability of potato, tapioca, and corn starches modified by mild heating in aqueous ethanol solution Theta phase-entrainment of single cell spiking in rat somatosensory barrel cortex and secondary visual cortex is enhanced during multisensory discrimination behavior Mutations in human prion-like domains: pathogenic but not always amyloidogenic Morphology, Not Only Volume: A Study on Empty Nose Syndrome and Inferior Turbinates Circularly polarized blue fluorescence based on chiral heteroleptic six-coordinate bis-pyrazolonate-Zn2+ complexes Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression Improves Mitophagy in Alzheimer's Disease Models Long-Term High-Fat Diet Consumption Aggravates β-Amyloid Deposition and Tau Pathology Accompanied by Microglial Activation in an Alzheimer's Disease Model Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR Imbalanced mitochondrial dynamics contributes to the pathogenesis of X-linked adrenoleukodystrophy Adolescent alcohol binge drinking and withdrawal: behavioural, brain GFAP-positive astrocytes and acute methamphetamine effects in adult female rats The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons Deep Learning-Based Identification of Intraocular Pressure-Associated Genes Influencing Trabecular Meshwork Cell Morphology Raman-AFM-fluorescence-guided impact of linoleic and eicosapentaenoic acids on subcellular structure and chemical composition of normal and cancer human colon cells Prognostic factors of renal cell cancer in elderly patients: a population-based cohort study
Evidence Blueprint
Assembly of Helical Nanostructures: Solvent-Induced Morphology Transition and the Effect on Cell Adhesion
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Assembly of Helical Nanostructures: Solvent-Induced Morphology Transition and the Effect on Cell Adhesion
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Suicide Gene Delivery by Morphology-Adaptable Enantiomeric Peptide Assemblies for Combined Ovarian Cancer Therapy Atomic Scale Structure of Self-assembled Lipidated Peptide Nanomaterials Berberis integerrima bioactive molecules loaded in chitosan-based electrospun nanofibers for soybean oil oxidative protection Epileptic activity triggers rapid ROCK1-dependent astrocyte morphology changes Supramolecular presentation of bioinstructive peptides on soft multilayered nanobiomaterials stimulates neurite outgrowth Effect of Recombinant Spidroins Self-Assembly on Rheological Behavior of Their Dispersions and Structure of Electrospun Nanofibrous Materials Optimization of Bioactive Compound Extraction from Eggplant Peel by Response Surface Methodology: Ultrasound-Assisted Solvent Qualitative and Quantitative Effect Crowding alters F-actin secondary structure and hydration δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions Self-Assembling Nanoarchitectonics of Twisted Nanofibers of Fluorescent Amphiphiles as Chemo-Resistive Sensor for Methanol Detection Saline as solvent and ethanol-based purification process for the extraction of proteins and isoflavones from wet okara Bioinspired Colorimetric Double Inverse Opal Photonic Crystal Indicators for Ethanol Concentration Sensing in Fermentation Engineering Nuclear morphology is shaped by loop-extrusion programs Toolkits for detailed and high-throughput interrogation of synapses in C. elegans Abnormal microglial density and morphology in the brain of cyclooxygenase 2 knockin mice Synthesis and self-assembly behaviors of α-galactosyl ceramide (1,2)-polysaccharide analogue Accurate ethanol determination in Chinese Baijiu based on red-emitted carbon quantum dots (CQDs) and a simple pH correction HydrogelFinder: A Foundation Model for Efficient Self-Assembling Peptide Discovery Guided by Non-Peptidal Small Molecules Multimeric structure of a subfamily III haloalkane dehalogenase-like enzyme solved by combination of cryo-EM and X-ray crystallography Differentiating aliphatic and aromatic alcohols using triazine-based supramolecular organogelators: end group-specific selective gelation with chain length of alcohols Ethanol-Induced Hepatic Ferroptosis Is Mediated by PERK-Dependent MAMs Formation: Preventive Role of Quercetin Imaging Amyloid-β Membrane Interactions: Ion-Channel Pores and Lipid-Bilayer Permeability in Alzheimer's Disease Genetically targeted chemical assembly of polymers specifically localized extracellularly to surface membranes of living neurons Species -shared and -unique gyral peaks on human and macaque brains Morphological and electrophysiological characterization of a novel displaced astrocyte in the mouse retina BCFtools/liftover: an accurate and comprehensive tool to convert genetic variants across genome assemblies Reduction of alcohol-induced mitochondrial damage with ginsenoside Rg1 studied by atomic force microscopy Alcohol Promotes Lipogenesis in Sebocytes-Implications for Acne Click-chemistry mediated synthesis of OTBN-1,2,3-Triazole derivatives exhibiting STK33 inhibition with diverse anti-cancer activities Alcoholic Solvent-Mediated Excited-State Proton Transfer Dynamics of a Novel Dihydroxynaphthalene Dye Investigating the Antioxidant and Color Properties of Bee Pollens of Various Plant Sources Quantitative assessment of mitochondrial morphology relevant for studies on cellular health and environmental toxicity Alcohol induces hepatocytes necroptosis through the LC3/RIPK1/RIPK3 pathway Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria Ethanol inhibits pancreatic acinar cell autophagy through upregulation of ATG4B, mediating pathologic responses of alcoholic pancreatitis Accelerating Computation of Acidity Constants and Redox Potentials for Aqueous Organic Redox Flow Batteries by Machine Learning Potential-Based Molecular Dynamics Differential regulation of MAP2 by phosphorylation events in proline-rich versus C-terminal domains Co-encapsulated astaxanthin and kaempferol nanoparticles: fabrication, characterization, and their potential synergistic effects on treating non-alcoholic fatty liver disease Regulation of Presynaptic Release Machinery by Cell Adhesion Molecules Relevance of alcoholic solvents in the growth of ZnO nanoparticles and ZnO hierarchical nanorod structures on their optical and opto-electrical properties Ethanol causes non-communicable disease through activation of NLRP3 inflammasome: a review on mechanism of action and potential interventions Elevated levels of alcohol dehydrogenase aggravate ethanol-evoked cardiac remodeling and contractile anomalies through FKBP5-yap-mediated regulation of ferroptosis and ER stress Nano-scale smooth surface of the compact-TiO2 layer via spray pyrolysis for controlling the grain size of the perovskite layer in perovskite solar cells Indicaxanthin prevents eryptosis induced by cigarette smoke extract by interfering with active Fas-mediated signaling Direct Extraction and Determination of Free Nicotine in Cigarette Smoke Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study Fabrication of porous poly(L-lactide-co-ε-caprolactone) micropowder for microbubble effect and ultrasound-mediated drug delivery Optimization of peptide synthesis time and sustainability using novel eco-friendly binary solvent systems with induction heating on an automated peptide synthesizer Photo-thermal Cooperative Carbonylation of Ethanol with CO2 on Cu2O-SrTiCuO3-x Lactoferrin Alleviates Ethanol-Induced Injury via Promoting Nrf2 Nuclear Translocation in BRL-3A Rat Liver Cells Emotion recognition in EEG signals using deep learning methods: A review Alcohol-induced Conformational Changes and Thermodynamic Signatures in the Binding of Polyphenols to Proline-rich Salivary Proteins Chromosomal inversion polymorphisms shape human brain morphology A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies Dual color miniscope imaging of microvessels and neuronal activity in the hippocampus CA1 region of freely moving mice following alcohol administration Pyrazoline Derivatives as Promising MAO-A Targeting Antidepressants: An Update White epaxial muscle aerobic and anaerobic potential and muscle fiber structure in surface and cave morphotypes of the Mexican cavefish (Astyanax mexicanus) cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice Hyperspectral Mapping of Human Primary and Stem Cells at Cell-Matrix Interfaces Brain-specific serine/threonine-protein kinase 1 is a substrate of protein kinase C epsilon involved in sex-specific ethanol and anxiety phenotypes Oxytocin Attenuates Yohimbine-Induced Reinstatement of Alcohol-Seeking in Female Rats via the Central Amygdala Tau seeding without tauopathy Steven Starks, M.D., M.B.A., Assumes Office of APA Assembly Speaker Sake yeast symbiosis with lactic acid bacteria and alcoholic fermentation