Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Horm Metab Res. 2024 Apr 9. doi: 10.1055/a-2284-5667. Online ahead of print.
ABSTRACT
The current understanding of the correlation between insulin resistance (IR) and cognitive dysfunction is limited. Therefore, the objective of this systematic review and meta-analysis was to assess the association between the triglyceride glucose (TyG) index, a recently suggested indicator of IR, and cognitive impairment and dementia in the adult population. Observational studies pertinent to our research were identified through comprehensive searches of the PubMed, Embase, and Web of Science databases. To account for potential heterogeneity, the random-effects models were employed to aggregate the findings. This meta-analysis included ten observational studies involving 5602409 participants. Compared to those with the low TyG index, subjects with the high TyG index were significantly associated with the risk of cognitive impairment [risk ratio (RR): 1.39, 95% confidence interval (CI): 1.22 to 1.59, p<0.001; I2=45%) and dementia (RR: 1.30, 95% CI: 1.06 to 1.60, p=0.01; I2=50%). The association was consistent for Alzheimer’s disease (RR: 1.35, 95% CI: 1.04 to 1.76, p=0.03; I2=54%) and vascular dementia (RR: 1.18, 95% CI: 1.13 to 1.24, p<0.001; I2=0%). Subgroup analyses showed that the association between TyG index with cognitive impairment and dementia were stronger in cross-sectional studies than that in cohort studies (p for subgroup difference=0.02), but not significantly modified by age, sex, or diabetic status of the participants. In conclusion, a high TyG index may be associated with higher risk of cognitive impartment and dementia in adult population.
PMID:38593823 | DOI:10.1055/a-2284-5667
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Association Between Triglyceride Glucose Index with Cognitive Impairment and Dementia in Adult Population: A Meta-Analysis
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Effect of digital technology interventions for cognitive function improvement in mild cognitive impairment and dementia: A systematic review and meta-analysis Association between insulin resistance and multiple sclerosis: a systematic review and meta-analysis Orthostatic hypotension and cognitive impairment: Systematic review and meta-analysis of longitudinal studies Association of socioeconomic status and poststroke cognitive function: A systematic review and meta-analysis Oral anticoagulants and cognitive impairment in patients with atrial fibrillation: A systematic review with meta-analysis and trial sequential analysis Triglyceride Glucose Index is Associated with Ultrasonographic Fatty Liver Indicator in Children and Adolescents with Non-alcoholic Fatty Liver Disease Visual Impairment and Suicide Risk: A Systematic Review and Meta-Analysis Is White Matter Hyperintensity Burden Associated with Cognitive and Motor Impairment in Patients with Parkinson's Disease? A Systematic Review and Meta-Analysis Triglyceride-glucose index predicts postoperative delirium in elderly patients with type 2 diabetes mellitus: a retrospective cohort study Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study The association of ultra-processed food intake with neurodegenerative disorders: a systematic review and dose-response meta-analysis of large-scale cohorts The association between endocrine disrupting chemicals and nonalcoholic fatty liver disease: A systematic review and meta-analysis Correlation between the triglyceride-glucose index and chronic kidney disease among adults with metabolic-associated fatty liver disease: fourteen-year follow-up Correlation between the triglyceride-glucose index and chronic kidney disease among adults with metabolic-associated fatty liver disease: fourteen-year follow-up Multimodal cognitive and behavioral interventions for patients with MCI: a systematic review and meta-analysis on cognition and mood Effect of transcranial direct current stimulation and transcranial magnetic stimulation on the cognitive function of individuals with Alzheimer's disease: a systematic review with meta-analysis and meta-regression Association between metabolic dysfunction-associated steatotic liver disease and risk of incident pancreatic cancer: a systematic review and meta-analysis of cohort studies Lithium Exposure and Risk of Major Neurocognitive Disorders: A Systematic Review and Meta-analysis Preoperative cognitive function as a risk factor of postoperative delirium in cancer surgeries: A systematic review and meta-analysis The effects of weight loss interventions on children and adolescents with non-alcoholic fatty liver disease: A systematic review and meta-analysis Diagnostic accuracy of cognitive screening tools validated for older adults in Iran: a systematic review and meta-analysis Associations between estimated glucose disposal rate and arterial stiffness and mortality among US adults with non-alcoholic fatty liver disease Associations between estimated glucose disposal rate and arterial stiffness and mortality among US adults with non-alcoholic fatty liver disease Global Prevalence of Social Anxiety Disorder in Children, Adolescents and Youth: A Systematic Review and Meta-analysis Neuroinflammation in dementia: A meta-analysis of PET imaging studies Influence of glucagon-like peptide-1 receptor agonists on fat accumulation in patients with diabetes mellitus and non-alcoholic fatty liver disease or obesity: A systematic review and meta-analysis of randomized control trials Loneliness and social isolation among informal carers of individuals with dementia: A systematic review and meta-analysis Effects of movement training based on rhythmic auditory stimulation in cognitive impairment: a meta-analysis of randomized controlled clinical trial Relationship between Helicobacter pylori infection and risk of metabolic dysfunction-associated steatotic liver disease: An updated meta-analysis Herpes zoster vaccination and the risk of dementia: A systematic review and meta-analysis The Effects of Chronic Administration of Stimulant and Non-stimulant Medications on Executive Functions in ADHD: A Systematic Review and Meta-Analysis A meta-analysis of cognitive reappraisal and personal resilience Motoric cognitive risk syndrome as a predictor of adverse health outcomes: A systematic review and meta-analysis Positive association between insulin resistance and fatty liver disease in psoriasis: evidence from a cross-sectional study Prevalence and risk of nonalcoholic fatty liver disease among adult psoriatic patients: A systematic review, meta-analysis, and trial sequential analysis Lithium therapy's potential to lower dementia risk and the prevalence of Alzheimer's disease: a meta-analysis Cardiovascular impact of post-traumatic stress disorder: a systematic review and meta-analysis Effectiveness of cognitive stimulation therapy (CST) for mild to moderate dementia: A systematic literature review and meta-analysis of randomised control trials using the original CST protocol Evaluation of Artificial Intelligence Algorithms for Diabetic Retinopathy Detection: Protocol for a Systematic Review and Meta-Analysis Association of preoperative neutrophil-to-lymphocyte ratio with the risk of postoperative delirium in elderly patients undergoing noncardiac surgery: a systematic review and meta-analysis Risk factors for inadequate bowel preparation before colonoscopy: A meta-analysis Global Prevalence of Anxiety, Depression, and Stress Among Patients with Skin Diseases: A Systematic Review and Meta-analysis The efficacy and safety of lecanemab 10 mg/kg biweekly compared to a placebo in patients with Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials Efficacy of resilience-related psychological interventions in patients with long-term diseases: A meta-analysis of randomised controlled trials Strategies used during the cognitive evaluation of older adults with dual sensory impairment: a scoping review Shining a Light on Trace Elements: A Systematic Review and Meta-analysis of Serum Concentrations in Febrile seizure Shining a Light on Trace Elements: A Systematic Review and Meta-analysis of Serum Concentrations in Febrile seizure The predictive accuracy of machine learning for the risk of death in HIV patients: a systematic review and meta-analysis Effects of mindfulness-based interventions on symptoms and interoception in trauma-related disorders and exposure to traumatic events: Systematic review and meta-analysis Perimenopausal physical activity and dementia risk: A systematic review Postoperative cognitive dysfunction: Review of pathophysiology, diagnostics and preventive strategies Grief-focused cognitive behavioral therapies for prolonged grief symptoms: A systematic review and meta-analysis Attentional bias modification and attention control training in PTSD: a systematic review and meta-analysis Association between alcohol consumption and peripheral artery disease: Two de novo prospective cohorts and a systematic review with meta-analysis Association between alcohol consumption and peripheral artery disease: Two de novo prospective cohorts and a systematic review with meta-analysis Biomarkers of neurodegeneration in schizophrenia: systematic review and meta-analysis Association between processed and unprocessed red meat consumption and risk of nonalcoholic fatty liver disease: A systematic review and dose-response meta-analysis Hidden dangers: Does multisensory impairments accompanying visual impairment increase dementia risk Factors contributing to sepsis-associated encephalopathy: a comprehensive systematic review and meta-analysis A meta-analysis of cognitive and functional outcomes in severe brain trauma cases Intravenous infusion of dexmedetomidine during the surgery to prevent postoperative delirium and postoperative cognitive dysfunction undergoing non-cardiac surgery: a meta-analysis of randomized controlled trials Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Systematic Review and Meta-Analysis of Cohort Studies Industrial workers and bullying: a systematic review and meta-analysis of workplace violence Effects of different exercise interventions on chemotherapy-related cognitive impairment in patients with breast cancer: a study protocol for systematic review and network meta-analysis
Evidence Blueprint
Association Between Triglyceride Glucose Index with Cognitive Impairment and Dementia in Adult Population: A Meta-Analysis
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Association Between Triglyceride Glucose Index with Cognitive Impairment and Dementia in Adult Population: A Meta-Analysis
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Triglyceride-glucose index and obstructive sleep apnea: a systematic review and meta-analysis Sodium-glucose cotransporter-2 inhibitors and their potential role in dementia onset and cognitive function in patients with diabetes mellitus: a systematic review and meta-analysis Effect of digital technology interventions for cognitive function improvement in mild cognitive impairment and dementia: A systematic review and meta-analysis Association between insulin resistance and multiple sclerosis: a systematic review and meta-analysis Orthostatic hypotension and cognitive impairment: Systematic review and meta-analysis of longitudinal studies Associations of problematic smartphone use with depressive symptoms and suicidal ideation in university students before and after the COVID-19 outbreak: A meta-analysis Hypertensive Disorders of Pregnancy (HDP) and the risk of Maternal Dementia: A Systematic Review and Meta-Analysis Association of socioeconomic status and poststroke cognitive function: A systematic review and meta-analysis Dairy intake and risk of cognitive decline and dementia: A systematic review and dose-response meta-analysis of prospective studies Association between the Triglyceride-Glucose Index and Non-Alcoholic Fatty Liver Disease in patients with Atrial Fibrillation Reperfusion Therapies for Ischemic Stroke in Dementia and Cognitive Impairment: A Systematic Review and Meta-Analysis The relationship between vitamin K and T2DM: a systematic review and meta-analysis Oral anticoagulants and cognitive impairment in patients with atrial fibrillation: A systematic review with meta-analysis and trial sequential analysis Triglyceride Glucose Index is Associated with Ultrasonographic Fatty Liver Indicator in Children and Adolescents with Non-alcoholic Fatty Liver Disease Increased risk of osteoporosis in patients with cognitive impairment: a systematic review and meta-analysis Effects of engagement, persistence and adherence on cognitive training outcomes in older adults with and without cognitive impairment: a systematic review and meta-analysis of randomised controlled trials Association between triglyceride glucose index and suicide attempts in patients with first-episode drug-naïve major depressive disorder Visual Impairment and Suicide Risk: A Systematic Review and Meta-Analysis Association of amyloid-beta with depression or depressive symptoms in older adults without dementia: a systematic review and meta-analysis Prevalence of orofacial pain in individuals with mild cognitive impairment or dementia: A systematic review and meta-analysis Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic population Triglyceride glucose-waist circumference: the optimum index to screen nonalcoholic fatty liver disease in non-obese adults Is White Matter Hyperintensity Burden Associated with Cognitive and Motor Impairment in Patients with Parkinson's Disease? A Systematic Review and Meta-Analysis Clinical Effectiveness of Pharmacological and Non-Pharmacological Treatments for the Management of Anxiety in Community Dwelling People Living With Dementia: A Systematic Review and Meta-analysis Triglyceride-glucose index predicts postoperative delirium in elderly patients with type 2 diabetes mellitus: a retrospective cohort study Early menopause and premature ovarian insufficiency are associated with increased risk of dementia: A systematic review and meta-analysis of observational studies Does the presence of chronic pain affect scores on cognitive screening tests/brief cognitive measures for dementia? A systematic review and meta-analysis Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study Association between aspirin use and risk of dementia: a systematic review and meta-analysis The Metabolic Score for Insulin Resistance Index is Superior to the Triglyceride and Glucose Index in Identifying Nonalcoholic Fatty Liver Disease in Hyperuricemia Subjects Hypertensive disorders of pregnancy and the risk of dementia: a systematic review and meta-analysis of cohort studies Symptoms and age of prodromal Alzheimer's disease in Down syndrome: a systematic review and meta-analysis Effectiveness of multiple health behavior change interventions in reducing symptoms of anxiety in the adult population: A systematic review and meta-analysis of randomized controlled trials The association of ultra-processed food intake with neurodegenerative disorders: a systematic review and dose-response meta-analysis of large-scale cohorts Quality of life, cognitive and behavioural impairment in people with motor neuron disease: a systematic review Quality of life, cognitive and behavioural impairment in people with motor neuron disease: a systematic review The association between endocrine disrupting chemicals and nonalcoholic fatty liver disease: A systematic review and meta-analysis Correlation between the triglyceride-glucose index and chronic kidney disease among adults with metabolic-associated fatty liver disease: fourteen-year follow-up Correlation between the triglyceride-glucose index and chronic kidney disease among adults with metabolic-associated fatty liver disease: fourteen-year follow-up Impact of type, intensity, frequency, duration and volume of physical activity on dementia and mild cognitive impairment in older adults: protocol for a systematic review and meta-analysis Primitive reflexes and dementia in older adults: a meta-analysis of observational and cohort studies Cognitive functioning in children and adolescents with depression: A systematic review and meta-analysis Multimodal cognitive and behavioral interventions for patients with MCI: a systematic review and meta-analysis on cognition and mood Effect of transcranial direct current stimulation and transcranial magnetic stimulation on the cognitive function of individuals with Alzheimer's disease: a systematic review with meta-analysis and meta-regression Inflammation, Anti-inflammatory Interventions, and Post-stroke Cognitive Impairment: a Systematic Review and Meta-analysis of Human and Animal Studies Association between metabolic dysfunction-associated steatotic liver disease and risk of incident pancreatic cancer: a systematic review and meta-analysis of cohort studies A systematic review and meta-analysis of thigmotactic behaviour in the open field test in rodent models associated with persistent pain The effect of dual-task training on cognitive ability, physical function, and dual-task performance in people with dementia or mild cognitive impairment: A systematic review and meta-analysis Lithium Exposure and Risk of Major Neurocognitive Disorders: A Systematic Review and Meta-analysis Preoperative cognitive function as a risk factor of postoperative delirium in cancer surgeries: A systematic review and meta-analysis Neuropsychological Assessments of Cognitive Impairment in Major Depressive Disorder: A Systematic Review and Meta-Analysis with Meta-Regression Umbrella Systematic Review and Meta-Analysis: Physical Activity as an Effective Therapeutic Strategy for Improving Psychosocial Outcomes in Children and Adolescents The effects of weight loss interventions on children and adolescents with non-alcoholic fatty liver disease: A systematic review and meta-analysis Diagnostic accuracy of cognitive screening tools validated for older adults in Iran: a systematic review and meta-analysis Associations between estimated glucose disposal rate and arterial stiffness and mortality among US adults with non-alcoholic fatty liver disease Associations between estimated glucose disposal rate and arterial stiffness and mortality among US adults with non-alcoholic fatty liver disease Efficacy of scalp stimulation for multidomain cognitive impairment in patients with post-stroke cognitive impairment and dementia: A network meta-analysis and meta-regression of moderators The Potential of Social Policies in Preventing Dementia: An Ecological Study Using Systematic Review and Meta-Analysis Global Prevalence of Social Anxiety Disorder in Children, Adolescents and Youth: A Systematic Review and Meta-analysis Characteristics of Single vs. Multiple Suicide Attempters Among Adult Population: A Systematic Review and Meta-Analysis Cholinesterase inhibitors and falls, syncope and injuries in patients with cognitive impairment: a systematic review and meta-analysis The association between post-traumatic stress disorder (PTSD) and cognitive impairment: A systematic review of neuroimaging findings Male- and female-specific reproductive risk factors across the lifespan for dementia or cognitive decline: a systematic review and meta-analysis Neuroinflammation in dementia: A meta-analysis of PET imaging studies