Int Rev Neurobiol. 2024;177:295-317. doi: 10.1016/bs.irn.2024.04.013. Epub 2024 Jun 28.
ABSTRACT
Cannabidiol (CBD) is a major phytocannabinoid in the Cannabis sativa plant. In contrast to Δ9-tetrahydrocannabinol (THC), CBD does not produce the typical psychotomimetic effects of the plant. In addition, CBD has attracted increased interest due to its potential therapeutic effects in various psychiatric disorders, including schizophrenia. Several studies have proposed that CBD has pharmacological properties similar to atypical antipsychotics. Despite accumulating evidence supporting the antipsychotic potential of CBD, the mechanisms of action in which this phytocannabinoid produces antipsychotic effects are still not fully elucidated. Here, we focused on the antipsychotic properties of CBD indicated by a series of preclinical and clinical studies and the evidence currently available about its possible mechanisms. Findings from preclinical studies suggest that CBD effects may depend on the animal model (pharmacological, neurodevelopmental, or genetic models for schizophrenia), dose, treatment schedule (acute vs. repeated) and route of administration (intraperitoneal vs local injection into specific brain regions). Clinical studies suggest a potential role for CBD in the treatment of psychotic disorders. However, future studies with more robust sample sizes are needed to confirm these positive findings. Overall, although more studies are needed, current evidence indicates that CBD may be a promising therapeutic option for the treatment of schizophrenia.
JAMA Psychiatry. 2024 Sep 11. doi: 10.1001/jamapsychiatry.2024.2652. Online ahead of print.ABSTRACTIMPORTANCE: Psychiatry mainly deals with conditions that are mediated by brain function but are not...
Eur Child Adolesc Psychiatry. 2024 Sep 11. doi: 10.1007/s00787-024-02573-w. Online ahead of print.ABSTRACTWe assessed genetic and environmental influences on social isolation across childhood and the...
Mult Scler. 2024 Sep 11:13524585241275491. doi: 10.1177/13524585241275491. Online ahead of print.ABSTRACTBACKGROUND: It is unknown whether people with aquaporin-4 antibody positive (AQP4-IgG+) neuromyelitis optica spectrum disorder...
BMC Psychol. 2024 Sep 10;12(1):480. doi: 10.1186/s40359-024-01981-6.ABSTRACTAIM: In line with the publication of clinical information related to the therapeutic process of repetitive transcranial magnetic stimulation...
Brain Res Bull. 2024 Sep 8:111075. doi: 10.1016/j.brainresbull.2024.111075. Online ahead of print.ABSTRACTOBJECTIVES: Neuregulin 1 (NRG1) is a risk gene for schizophrenia and involved in neurodevelopment...
JMIR Res Protoc. 2024 Sep 10;13:e56977. doi: 10.2196/56977.ABSTRACTBACKGROUND: It is well established that individuals with schizophrenia experience deficits in emotional perception that can impact long-term...
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