Evidence
Cell Rep. 2024 Sep 6;43(9):114701. doi: 10.1016/j.celrep.2024.114701. Online ahead of print.
ABSTRACT
Balancing plasticity and stability in neural circuits is essential for an animal’s ability to learn from its environment while preserving proper processing and perception of sensory information. However, unlike the mechanisms that drive plasticity in neural circuits, the activity-induced molecular mechanisms that convey functional stability remain poorly understood. Focusing on the visual cortex of adult mice and combining transcriptomics, electrophysiology, and in vivo calcium imaging, we find that the daily appearance of light induces, in excitatory neurons, a large gene program along with rapid and transient increases in the ratio of excitation and inhibition (E/I ratio) and neural activity. Furthermore, we find that the light-induced transcription factor NPAS4 drives these daily normalizations of the E/I ratio and neural activity rates and that it stabilizes the neurons’ response properties. These findings indicate that daily sensory-induced transcription normalizes the E/I ratio and drives downward firing rate homeostasis to maintain proper sensory processing and perception.
PMID:39244753 | DOI:10.1016/j.celrep.2024.114701
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Daily light-induced transcription in visual cortex neurons drives downward firing rate homeostasis and stabilizes sensory processing
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Modulation of structural and functional plasticity in the hippocampus across the murine estrous cycle
- Chronic stress alters synaptic I/E balance of pyramidal neurons but not PV interneurons in the infralimbic and prelimbic cortices of C57BL/6J mice
- Degraded tactile coding in the Cntnap2 mouse model of autism
- Distinct neural plasticity enhancing visual perception
- Distinct neural plasticity enhancing visual perception
- Neural Circuit Mechanisms of Sinisan formula for the Treatment of adolescent Depression: prefrontal cortex to dorsal raphe nucleus
- Neural Circuit Mechanisms of Sinisan formula for the Treatment of adolescent Depression: prefrontal cortex to dorsal raphe nucleus
- Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans
- Horizontal cortical connections shape intrinsic traveling waves into feature-selective motifs that regulate perceptual sensitivity
- Horizontal cortical connections shape intrinsic traveling waves into feature-selective motifs that regulate perceptual sensitivity
- Movement-related increases in subthalamic activity optimize locomotion
- Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs
- Disentangling temporal and rate codes in primate somatosensory cortex
- Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the Apoe gene
- A light-responsive neural circuit suppresses feeding
- Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test
- The mechanics of correlated variability in segregated cortical excitatory subnetworks
- Visual effects on tactile stimulation and its perception: A pilot study using near-infrared spectroscopy
- Perpetual step-like restructuring of hippocampal circuit dynamics
- Aperiodic EEG predicts variability of visual temporal processing
- ARNT2 controls prefrontal somatostatin interneurons mediating affective empathy
- Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins
- Impaired pain in mice lacking first-order posterior medial thalamic neurons
- Stress and inflammation target dorsolateral prefrontal cortex function: Neural mechanisms underlying weakened cognitive control
- Altered functional connectivity of primary olfactory cortex-hippocampus-frontal cortex in subjective cognitive decline during odor stimulation
- Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity
- Multi-timescale neural dynamics for multisensory integration
- Fast inhibition slows and desynchronizes mouse auditory efferent neuron activity
- Regulation of stress-induced sleep perturbations by dorsal raphe VGLUT3 neurons in male mice
- Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus
- Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus
- Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex
- Adolescent Thalamo-Prefrontal Inhibition Leads to Changes in Intrinsic Prefrontal Network Connectivity
- The distribution of neurotransmitters in the brain circuitry: mesolimbic pathway and addiction
- Environmental enrichment reduces restricted repetitive behavior by altering gray matter microstructure
- Neural activity ramps in frontal cortex signal extended motivation during learning
- PV and SST neurons in the anterior cingulate cortex regulate social disorders in adulthood induced by sensory abnormalities in childhood
- Affective visual circuit dysfunction in trauma and stress-related disorders
- Astrocyte D1/D5 dopamine receptors govern non-Hebbian long-term potentiation at sensory synapses onto lamina I spinoparabrachial neurons
- Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses
- Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky
- Dopamine Release in the Nucleus Accumbens Core Encodes the General Excitatory Components of Learning
- Network state changes in sensory thalamus represent learned outcomes
- Cortical plasticity is associated with blood-brain barrier modulation
- Cortical plasticity is associated with blood-brain barrier modulation
- NEGR1 Modulates Mouse Affective Discrimination by Regulating Adult Olfactory Neurogenesis
- Chronic social defeat stress induces pathway-specific adaptations at lateral habenula neuronal outputs
- Engineered modular neuronal networks-on-chip represent structure-function relationship
- Context and space coding in mossy cell population activity
- EEG-fMRI in awake rat and whole-brain simulations show decreased brain responsiveness to sensory stimulations during absence seizures
- Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice
- Peak alpha frequency in schizophrenia, bipolar disorder, and healthy volunteers: Associations with visual information processing and cognition
- Prefrontal cortex neurons encode ambient light intensity differentially across regions and layers
- Bidirectional fear modulation by discrete anterior insular circuits in male mice
- The neurophysiological mechanisms of medial prefrontal-perirhinal cortex circuit mediating temporal order memory decline in early stage of AD rats
- Conflicting sensory information sharpens the neural representations of early selective visuospatial attention
- Conditional Deletion of the AMPA-GluA1 and NMDA-GluN1 Receptor Subunit Genes in Midbrain D1 Neurons does not Alter Cocaine Reward in Mice
- Conditional Deletion of the AMPA-GluA1 and NMDA-GluN1 Receptor Subunit Genes in Midbrain D1 Neurons does not Alter Cocaine Reward in Mice
- An atlas of GPCRs in dopamine neurons: Identification of the free fatty acid receptor 4 as a regulator of food and water intake
- CXCL10 impairs synaptic plasticity was modulated by cGAS-STING pathway after stroke in mice
- Mitochondrial plasticity and synaptic plasticity crosstalk; in health and Alzheimer's disease
- Phenotyping of FGF12AV52H mutation in mouse implies a complex FGF12 network
- Proteomic characterization of the medial prefrontal cortex in chronic restraint stress mice
- Neurons of Macaque Frontal Eye Field Signal Reward-Related Surprise
Evidence Blueprint
Daily light-induced transcription in visual cortex neurons drives downward firing rate homeostasis and stabilizes sensory processing
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Daily light-induced transcription in visual cortex neurons drives downward firing rate homeostasis and stabilizes sensory processing
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- A developmental critical period for ocular dominance plasticity of binocular neurons in mouse superior colliculus
- Stimulus information guides the emergence of behavior-related signals in primary somatosensory cortex during learning
- Higher-order thalamocortical circuits are specified by embryonic cortical progenitor types in the mouse brain
- Sound-evoked adenosine release in cooperation with neuromodulatory circuits permits auditory cortical plasticity and perceptual learning
- Sound-evoked adenosine release in cooperation with neuromodulatory circuits permits auditory cortical plasticity and perceptual learning
- Investigating the Serotonergic Modulation of Orientation Tuning of Neurons in Primary Visual Cortex of Anesthetized Mice
- Feedforward and disinhibitory circuits differentially control activity of cortical somatostatin interneurons during behavioral state transitions
- Neural correlates of object identity and reward outcome in the sensory cortical-hippocampal hierarchy: coding of motivational information in perirhinal cortex
- A distinct cortical code for socially learned threat
- Modulation of structural and functional plasticity in the hippocampus across the murine estrous cycle
- Chronic stress alters synaptic I/E balance of pyramidal neurons but not PV interneurons in the infralimbic and prelimbic cortices of C57BL/6J mice
- Neural population dynamics reveals disruption of spinal circuits' responses to proprioceptive input during electrical stimulation of sensory afferents
- Degraded tactile coding in the Cntnap2 mouse model of autism
- Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics
- Theta phase-entrainment of single cell spiking in rat somatosensory barrel cortex and secondary visual cortex is enhanced during multisensory discrimination behavior
- Visual experience induces 4-8 Hz synchrony between V1 and higher-order visual areas
- Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in Grin2b-mutant mice
- Shift in excitation-inhibition balance underlies perceptual learning of temporal discrimination
- Transformation of motion pattern selectivity from retina to superior colliculus
- Integration of spatially opposing cues by a single interneuron guides decision-making in C. elegans
- Distinct neural plasticity enhancing visual perception
- Distinct neural plasticity enhancing visual perception
- EGFR tyrosine kinase inhibitor lazertinib activates a subset of mouse sensory neurons via TRPA1
- Distinct roles of excitatory and inhibitory neurons in the medial prefrontal cortex in the expression and reconsolidation of methamphetamine-associated memory in male mice
- Preconfigured architecture of the developing mouse brain
- Preconfigured architecture of the developing mouse brain
- Inhibitory feedback from the motor circuit gates mechanosensory processing in Caenorhabditis elegans
- GABA and Glx predict EEG responses of visual sensitivity in autism
- Prefrontal projections modulate recurrent circuitry in the insular cortex to support short-term memory
- Prefrontal projections modulate recurrent circuitry in the insular cortex to support short-term memory
- Single-cell RNA sequencing uncovers the cell type-dependent transcriptomic changes in the retrosplenial cortex after peripheral nerve injury
- Pathway-selective optogenetics reveals the functional anatomy of top-down attentional modulation in the macaque visual cortex
- Suppression of Cofilin function in the somatosensory cortex alters social contact behavior in the BTBR mouse inbred line
- Presynaptic kainate receptors onto somatostatin interneurons are recruited by activity throughout development and contribute to cortical sensory adaptation
- Neural Circuit Mechanisms of Sinisan formula for the Treatment of adolescent Depression: prefrontal cortex to dorsal raphe nucleus
- Neural Circuit Mechanisms of Sinisan formula for the Treatment of adolescent Depression: prefrontal cortex to dorsal raphe nucleus
- Inhibitory gating of thalamocortical inputs onto rat gustatory insular cortex
- Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans
- MDGA2 Constrains Glutamatergic Inputs Selectively onto CA1 Pyramidal Neurons to Optimize Neural Circuits for Plasticity, Memory, and Social Behavior
- Laminar Dynamics of Target Selection in the Posterior Parietal Cortex of the Common Marmoset
- Cortical reactivations predict future sensory responses
- Neural Oscillations and Multisensory Processing
- Horizontal cortical connections shape intrinsic traveling waves into feature-selective motifs that regulate perceptual sensitivity
- Neural adaptations to congenital deafness: enhanced tactile discrimination through cross-modal neural plasticity - an fMRI study
- Compensation between FOXP transcription factors maintains proper striatal function
- Horizontal cortical connections shape intrinsic traveling waves into feature-selective motifs that regulate perceptual sensitivity
- Differential cortical and subcortical visual processing with eyes shut
- Cell- and pathway-specific disruptions in the accumbens of Fragile X mouse
- Corticotropin-releasing hormone neurons control trigeminal neuralgia-induced anxiodepression via a hippocampus-to-prefrontal circuit
- Neural circuits regulating visceral pain
- Nucleus accumbens local circuit for cue-dependent aversive learning
- Adenosine mediates the amelioration of social novelty deficits during rhythmic light treatment of 16p11.2 deletion female mice
- Movement-related increases in subthalamic activity optimize locomotion
- Feedforward connectivity patterns from visual areas to the front of the brain contain information about sensory stimuli regardless of awareness or report
- Cortex-restricted deletion of Foxp1 impairs barrel formation and induces aberrant tactile responses in a mouse model of autism
- Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs
- Disentangling temporal and rate codes in primate somatosensory cortex
- Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation
- Two contrasting mediodorsal thalamic circuits target the mouse medial prefrontal cortex
- Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the Apoe gene
- Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs
- Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice
- Gating of Social Behavior by Inhibitory Inputs from Hippocampal CA1 to Retrosplenial Agranular Cortex
- Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms