Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Asian J Psychiatr. 2024 Feb 12;94:103965. doi: 10.1016/j.ajp.2024.103965. Online ahead of print.
ABSTRACT
BACKGROUND AND HYPOTHESIS: The Positive and Negative Syndrome Scale (PANSS) consists of 30 items and takes up to 50 minutes to administer and score. Therefore, this study aimed to develop and validate a machine learning-based short form of the PANSS (PANSS-MLSF) that reproduces the PANSS scores. Moreover, the PANSS-MLSF estimated the removed-item scores.
STUDY DESIGN: The PANSS-MLSF was developed using an artificial neural network, and the removed-item scores were estimated using the eXtreme Gradient Boosting classifier algorithm. The reliability of the PANSS-MLSF was examined using Cronbach’s alpha. The concurrent validity was examined by the association (Pearson’s r) between the PANSS-MLSF and the PANSS. The convergent validity was examined by the association (Pearson’s r) between the PANSS-MLSF and the Clinical Global Impression-Severity, Mini-Mental State Examination, and Lawton Instrumental Activities of Daily Living Scale. The agreement of the estimated removed-item scores with their original scores was examined using Cohen’s kappa.
STUDY RESULTS: Our analysis included data from 573 patients with moderate severity. The two versions of the PANSS-MLSF comprised 15 items and 9 items were proposed. The PANSS-MLSF scores were similar to the PANSS scores (mean squared error=2.6-24.4 points). The reliability, concurrent validity, and convergent validity of the PANSS-MLSF were good. Moderate to good agreement between the estimated removed-item scores and the original item scores was found in 60% of the removed items.
CONCLUSION: The PANSS-MLSF offers a viable way to reduce PANSS administration time, maintain score comparability, uphold reliability and validity, and even estimate scores for the removed items.
PMID:38394743 | DOI:10.1016/j.ajp.2024.103965
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 5 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Developing a machine learning-based short form of the positive and negative syndrome scale
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Statins as an adjuvant therapy for patients with schizophrenia: An up-to-date systematic review and meta-analysis Statins as an adjuvant therapy for patients with schizophrenia: An up-to-date systematic review and meta-analysis Parkinsonism, Psychomotor Slowing, Negative and Depressive Symptoms in Schizophrenia Spectrum and Mood Disorders: Exploring Their Intricate Nexus Using a Network Analytic Approach The Effects of Art Therapy and Psychosocial Skills Training on Symptoms and Social Functioning in Patients with Schizophrenia and Their Relatives The effect of cognitive impairment based on Mini-Mental State Examination (MMSE) on suicidal tendency in patients with schizophrenia: A large cross-sectional study Variations to plasma H(2)O(2) levels and TAC in chronical medicated and treatment-resistant male schizophrenia patients: Correlations with psychopathology Circulating microRNA Profiles Identify a Patient Subgroup with High Inflammation and Severe Symptoms in Schizophrenia Experiencing Acute Psychosis Association of cytokines levels, psychopathology and cognition among CR-TRS patients with metabolic syndrome Association of empathy with clinical symptoms and cognitive function in chronic schizophrenia patients with and without suicide attempts Aberrant salience mediates the interplay between emotional abuse and positive symptoms in schizophrenia Aberrant salience mediates the interplay between emotional abuse and positive symptoms in schizophrenia Sex-specific associations of plasma neutrophil gelatinase-associated lipocalin (NGAL) with cognition in patients with drug-naive schizophrenia Serum S100B Protein and White Matter Changes in Schizophrenia before and after Medication Using machine learning to develop a five-item short form of the children's depression inventory Relationship between plasma risperidone concentrations and clinical features in chronic schizophrenic patients in China Further clarification of cognitive processes of prospective memory in schizophrenia by comparing eye-tracking and ecologically-valid measurements The effect of online group based acceptance and commitment therapy on psychotic symptoms and functioning levels of individuals with early psychosis The Effect of an Emotion Recognition and Expression Program on the Alexithymia, Emotion Expression Skills and Positive and Negative Symptoms of Patients with Schizophrenia in a Community Mental Health Center The effect of repetitive transcranial magnetic stimulation on the negative symptoms of chronic schizophrenia and serum brain-derived neurotrophic factor Efficacy and Safety of Xanomeline-Trospium Chloride in Schizophrenia: A Randomized Clinical Trial Navigated and individual α-peak-frequency-guided transcranial magnetic stimulation in male patients with treatment-refractory schizophrenia Deciphering the interplay between psychopathological symptoms, sensorimotor, cognitive and global functioning: a transdiagnostic network analysis Exploring the latent cognitive structure in schizophrenia: implications for antipsychotic treatment responses Exploring the latent cognitive structure in schizophrenia: implications for antipsychotic treatment responses The Mediating Role of Anxiety/Depression Between Auditory Verbal Hallucinations and the Level of Insight in Schizophrenia A 12-month longitudinal naturalistic follow-up of cariprazine in schizophrenia A 12-month longitudinal naturalistic follow-up of cariprazine in schizophrenia Adaptation of the Child sexual abuse myth scale to Turkish culture: A reliability and validity study Eveningness chronotype influences social functioning by deteriorating depressive symptoms in remitted patients with schizophrenia Sex differences in prevalence and clinical correlates of internet addiction among Chinese adolescents with schizophrenia Subgroups of Clinical High Risk for Psychosis Based on Baseline Antipsychotic Exposure: Clinical and Outcome Comparisons Across a 2-Year Follow-up Period Association between childhood maltreatment and suicidal ideation among Chinese patients with chronic schizophrenia: the mediating role of insomnia Assessment of symptom severity in psychotic disorder patients based on heart rate variability and accelerometer mobility data Disorganization in first episode affective psychosis: Treatment response and clinical considerations from a 2-year follow-up study in a "real world" setting Network analysis of comorbid aggressive behavior and testosterone among bipolar disorder patients: a cross-sectional study NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia Relationships between erythrocyte membrane mono- and poly- unsaturated fatty acid composition and clinical/cognitive indices in antipsychotic-free schizophrenia patients In Vivo Reactive Astrocyte Imaging in Patients With Schizophrenia Using Fluorine 18-Labeled THK5351 Duration of untreated psychosis and its associated sociodemographic and clinical factors in first-episode psychosis: A study from Eastern Nepal The altered volume of striatum: A neuroimaging marker of treatment in first-episode and drug-naive schizophrenia Investigating the Effectiveness of Brexpiprazole in Subjects with Schizophrenia Spectrum Illness and Co-Occurring Substance Use Disorder: A Prospective, Multicentric, Real-World Study Co-administration of probiotic and vitamin D significantly improves cognitive function in schizophrenic patients: A double-blinded randomized controlled trial Cognitive Impairments in Drug-Naive Patients With First-Episode Negative Symptom-Dominant Psychosis Cognitive Impairments in Drug-Naive Patients With First-Episode Negative Symptom-Dominant Psychosis Gender differences in cognitive improvements after two months of atypical antipsychotic treatment in first episode schizophrenia Borderline personality disorder vs. schizophrenia spectrum disorders in young people recruited within an "Early Intervention in Psychosis" service: clinical and outcome comparisons Sex-specific associations between sex hormones and clinical symptoms in late-life schizophrenia Efficacy and safety of lurasidone for schizophrenia: A systematic review and meta‑analysis of eight short‑term, randomized, double‑blind, placebo‑controlled clinical trials D-serine and D-amino acid oxidase levels in patients with schizophrenia spectrum disorders in the first episode and 6-month follow-up Interleukin-1β moderates the relationships between middle frontal- mACC /insular connectivity and depressive symptoms in bipolar II depression Comparative analysis of resting-state EEG-based multiscale entropy between schizophrenia and bipolar disorder Prevalence of metabolic syndrome and its associated factors in first-treatment drug-naive schizophrenia patients: A large-scale cross-sectional study Machine learning-based model to predict delirium in patients with advanced cancer treated with palliative care: a multicenter, patient-based registry cohort Machine learning approach for the development of a crucial tool in suicide prevention: The Suicide Crisis Inventory-2 (SCI-2) Short Form Development and Validation of the Five-Factor Borderline Inventory-Super Short Form and Screener Development and Validation of the Five-Factor Borderline Inventory-Super Short Form and Screener The Ethiopian Cognitive Assessment battery in Schizophrenia (ECAS): a validation study Examining Lurasidone Efficacy in Patients with Schizophrenia Spectrum Illness and Concurrent Alcohol and Substance Use Disorder: A Prospective, Multicentric, Real-World Investigation Clinical and psychopathological characteristics of patients with late-onset schizophrenia and schizophrenia-like psychoses in clusters identified by biological parameters Clinical and psychopathological characteristics of patients with late-onset schizophrenia and schizophrenia-like psychoses in clusters identified by biological parameters Validity and reliability of an Arabic-language version of the postpartum specific anxiety scale research short-form in Jordan Validity and reliability of an Arabic-language version of the postpartum specific anxiety scale research short-form in Jordan Spanish validation of the short version of the racing and crowded thoughts questionnaire (RCTQ-13) Evaluation of Met and Unmet Needs in Patients with Severe Psychiatric Disorders and its Relation to the Quality of Life: A Cross-Sectional Study
Evidence Blueprint
Developing a machine learning-based short form of the positive and negative syndrome scale
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Developing a machine learning-based short form of the positive and negative syndrome scale
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Relationship between blood-based inflammatory indices and clinical score of schizophrenia patients: A cross-sectional study Randomized, double-blind, sham-controlled trial to evaluate the efficacy and tolerability of electroconvulsive therapy in patients with clozapine-resistant schizophrenia The Therapeutic Role of Intermittent Theta Burst Stimulation in Schizophrenia: A Systematic Review and Meta-analysis Relationships among the gut microbiome, brain networks, and symptom severity in schizophrenia patients: A mediation analysis Exploring depression in people with schizophrenia spectrum disorders: A cross-sectional analysis of the clinical relationship with Positive and Negative Syndrome Scale dimensions Eight-month intensive meditation-based intervention improves refractory hallucinations and delusions and quality of life in male inpatients with schizophrenia: a randomized controlled trial Efficacy and feasibility of aerobic exercise interventions as an adjunctive treatment for patients with schizophrenia: a meta-Analysis Statins as an adjuvant therapy for patients with schizophrenia: An up-to-date systematic review and meta-analysis Statins as an adjuvant therapy for patients with schizophrenia: An up-to-date systematic review and meta-analysis Population Pharmacodynamic Models of Risperidone on PANSS Total Scores and Prolactin Levels in Schizophrenia Parkinsonism, Psychomotor Slowing, Negative and Depressive Symptoms in Schizophrenia Spectrum and Mood Disorders: Exploring Their Intricate Nexus Using a Network Analytic Approach Psychomotor slowing in schizophrenia is associated with cortical thinning of primary motor cortex: A three cohort structural magnetic resonance imaging study Relapse in clinically stable adult patients with schizophrenia or schizoaffective disorder: evidence-based criteria derived by equipercentile linking and diagnostic test accuracy meta-analysis The Relationship Between Depressive Symptoms and Psychological Variables in Patients With Schizophrenia The Effects of Art Therapy and Psychosocial Skills Training on Symptoms and Social Functioning in Patients with Schizophrenia and Their Relatives The neutrophil-to-Lymphocyte ratio is associated with clinical symptoms in first-episode medication-naïve patients with schizophrenia Relationships between Adherence to Guideline Recommendations for Pharmacological Therapy among Clinicians and Psychotic Symptoms in Patients with Schizophrenia Sex-differential association of suicide attempts with thyroid dysfunction in first-episode and drug-naïve young major depressive disorder patients with comorbid anxiety The effect of cognitive impairment based on Mini-Mental State Examination (MMSE) on suicidal tendency in patients with schizophrenia: A large cross-sectional study From gut to brain: A network model of intestinal permeability, inflammation, and psychotic symptoms in schizophrenia Variations to plasma H(2)O(2) levels and TAC in chronical medicated and treatment-resistant male schizophrenia patients: Correlations with psychopathology A multicenter, single-arm, open-label interventional study of adherence to brexpiprazole during switching from previous antipsychotic drugs in patients with schizophrenia or schizoaffective disorder Circulating microRNA Profiles Identify a Patient Subgroup with High Inflammation and Severe Symptoms in Schizophrenia Experiencing Acute Psychosis Gut and oral microbiome modulate molecular and clinical markers of schizophrenia-related symptoms: A transdiagnostic, multilevel pilot study Gender differences in prevalence and clinical risk factors of suicide attempts in young adults with first-episode drug-naive major depressive disorder Association of cytokines levels, psychopathology and cognition among CR-TRS patients with metabolic syndrome Factors Associated with Symptom Stabilization that Allow for Successful Transition from Once-Monthly Paliperidone Palmitate to Three-Monthly Paliperidone Palmitate: A Post Hoc Analysis Examined Clinical Characteristics in Chinese Patients… Suicidal ideation in Chinese patients with chronic schizophrenia: prevalence, clinical correlates, and relationship with alexithymia Association of empathy with clinical symptoms and cognitive function in chronic schizophrenia patients with and without suicide attempts Systematic Review and Meta-analysis of Exercise Interventions for Psychotic Disorders: The Impact of Exercise Intensity, Mindfulness Components, and Other Moderators on Symptoms, Functioning, and Cardiometabolic Health Aberrant salience mediates the interplay between emotional abuse and positive symptoms in schizophrenia Aberrant salience mediates the interplay between emotional abuse and positive symptoms in schizophrenia Prevalence and clinical correlates of thyroid dysfunction in first-episode and drug-naïve major depressive disorder patients with metabolic syndrome The association of SOD and HsCRP with the efficacy of sulforaphane in schizophrenia patients with residual negative symptoms Cognitive Inflexibility Predicts Negative Symptoms Severity in Patients with First-Episode Psychosis: A 1-Year Follow-Up Study Sex-specific associations of plasma neutrophil gelatinase-associated lipocalin (NGAL) with cognition in patients with drug-naive schizophrenia Effect of Lurasidone on Social Functioning in Schizophrenia: Post Hoc Analysis of the JEWEL Study Serum S100B Protein and White Matter Changes in Schizophrenia before and after Medication Using machine learning to develop a five-item short form of the children's depression inventory Clinical correlates and thyroid hormones of metabolic syndrome in first-episode and drug-naïve major depressive disorder outpatients with and without hyperglycemia: a comprehensive cross-sectional study Relationship between plasma risperidone concentrations and clinical features in chronic schizophrenic patients in China Further clarification of cognitive processes of prospective memory in schizophrenia by comparing eye-tracking and ecologically-valid measurements Effects of mind-body therapies on schizophrenia: A systematic review and network meta-analysis Prevalence and correlates of suicide attempts in young patients with first-episode and drug-naïve major depressive disorder: A large cross-sectional study Characteristics of patients with schizophrenia switching from oral antipsychotics to once-monthly paliperidone palmitate (PP1M): a systematic review The effect of online group based acceptance and commitment therapy on psychotic symptoms and functioning levels of individuals with early psychosis The Effect of an Emotion Recognition and Expression Program on the Alexithymia, Emotion Expression Skills and Positive and Negative Symptoms of Patients with Schizophrenia in a Community Mental Health Center The effect of repetitive transcranial magnetic stimulation on the negative symptoms of chronic schizophrenia and serum brain-derived neurotrophic factor Efficacy and Safety of Xanomeline-Trospium Chloride in Schizophrenia: A Randomized Clinical Trial Navigated and individual α-peak-frequency-guided transcranial magnetic stimulation in male patients with treatment-refractory schizophrenia Developing a Short-Form Buss-Warren Aggression Questionnaire Based on Machine Learning Deciphering the interplay between psychopathological symptoms, sensorimotor, cognitive and global functioning: a transdiagnostic network analysis Smartphone video games improve cognitive function in patients with chronic schizophrenia: a randomized controlled trial The effect of functional remission and cognitive insight on criminal behavior in patients with schizophrenia Exploring the latent cognitive structure in schizophrenia: implications for antipsychotic treatment responses Exploring the latent cognitive structure in schizophrenia: implications for antipsychotic treatment responses Altered neutrophil-to-lymphocyte ratio in patients with non-affective first episode psychosis and its relationship with symptom severity and cognitive impairment L-Theanine adjunct to risperidone in the treatment of chronic schizophrenia inpatients: a randomized, double-blind, placebo-controlled clinical trial Association between suicidal behavior and impaired glucose metabolism in first-episode drug-naïve patients with schizophrenia Relationship between drug-induced movement disorders and psychosis in adults living in precarious housing or homelessness Efficacy of low-dose risperidone in combination with sertraline in first-episode drug-naïve patients with schizophrenia: a randomized controlled open-label study The Mediating Role of Anxiety/Depression Between Auditory Verbal Hallucinations and the Level of Insight in Schizophrenia German version of the Northoff scale for subjective experience in catatonia (NSSC-dv) : A validated instrument for examination of the subjective experience in catatonia Sleep Quality in Patients With Schizophrenia in a Tertiary Care Center in Northern India