Evidence
Stress. 2024 Jan;27(1):2317856. doi: 10.1080/10253890.2024.2317856. Epub 2024 Apr 2.
ABSTRACT
In humans, exposure to early life adversity has profound implications for susceptibility to developing neuropsychiatric disorders later in life. Studies in rodents have shown that stress experienced during early postnatal life can have lasting effects on brain development. Glucocorticoids and sex steroids are produced in endocrine glands and the brain from cholesterol; these molecules bind to nuclear and membrane-associated steroid receptors. Unlike other steroids that can also be made in the brain, neurosteroids bind specifically to neurotransmitter receptors, not steroid receptors. The relationships among steroids, neurosteroids, and stress are multifaceted and not yet fully understood. However, studies demonstrating altered levels of progestogens, androgens, estrogens, glucocorticoids, and their neuroactive metabolites in both developmental and adult stress paradigms strongly suggest that these molecules may be important players in stress effects on brain circuits and behavior. In this review, we discuss the influence of developmental and adult stress on various components of the brain, including neurons, glia, and perineuronal nets, with a focus on sex steroids and neurosteroids. Gaining an enhanced understanding of how early adversity impacts the intricate systems of brain steroid and neurosteroid regulation could prove instrumental in identifying novel therapeutic targets for stress-related conditions.
PMID:38563163 | DOI:10.1080/10253890.2024.2317856
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Developmental and adult stress: effects of steroids and neurosteroids
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Expanding the therapeutic potential of neuro(active)steroids: a promising strategy for hyperdopaminergic behavioral phenotypes
- Early-life risperidone alters locomotor responses to apomorphine and quinpirole in adulthood
- Lumbar transforaminal epidural steroid injections with particulate vs. nonparticulate steroid: an evidence-informed review on shifting gear to a personalized medicine paradigm
- Genotypic variation in the promoter region of the CRH-248 gene interacts with early rearing experiences to disrupt the development of the HPA axis in infant rhesus macaques (Macaca mulatta)
- Using Organoids to Model Sex Differences in the Human Brain
- Neurotrophins and Their Receptors: BDNF's Role in GABAergic Neurodevelopment and Disease
- A user-friendly machine learning approach for cardiac structures assessment
- An Unusual Case Presentation of Non-Pathergy Induced Severe Pyoderma Gangrenosum Localized to the Perianal and Intragluteal Regions
- A strike to the head: Parallels between the pediatric and adult human and the rodent in traumatic brain injury
- Reduced hippocampal volume unmasks distinct impacts of cumulative adverse childhood events (ACEs) on psychotic-like experiences in late childhood and early adolescence
- Neurosteroids and their Therapeutic Potential: Remembering the Contribution of Dr. Sabina Luchetti, Netherlands Institute for Neuroscience, Amsterdam, Netherlands
- Male-Biased Vulnerability of Mouse Brain Tryptophan/Kynurenine and Glutamate Systems to Adolescent Exposures to Concentrated Ambient Ultrafine Particle Air Pollution
- Inhibition of prefrontal cortex parvalbumin interneurons mitigates behavioral and physiological sequelae of chronic stress in male mice
- Cannabidiol effects on fear processing and implications for PTSD: Evidence from rodent and human studies
- Chronic stress induces wide-spread hyperalgesia: the involvement of spinal CCK1 receptors
- Circadian rhythms tied to changes in brain morphology in a densely-sampled male
- Sex-dependent susceptibility to brain metabolic dysfunction and memory impairment in response to pre- and postnatal high-fat diet
- Neurobiological basis of stress resilience
- CD177 on neutrophils engages stress-related behavioral changes in male mice
- The HEALthy Brain and Child Development Study (HBCD): NIH collaboration to understand the impacts of prenatal and early life experiences on brain development
- The Role of Psychosocial Stress on Cardiovascular Disease in Women: JACC State-of-the-Art Review
- Childhood unpredictability is associated with increased risk for long- and short-term depression and anhedonia symptoms following combat deployment
- Sex-biasing influence of autism-associated Ube3a gene overdosage at connectomic, behavioral, and transcriptomic levels
- Dip2a regulates stress susceptibility in the basolateral amygdala
- Exposure to tungsten particles via inhalation triggers early toxicity marker expression in the rat brain
- Association of gut dysbiosis with first-episode psychosis (Review)
- Heart and shoal: social cues and oxytocin receptors impact stress recovery in the zebrafish
- Heart and shoal: social cues and oxytocin receptors impact stress recovery in the zebrafish
- The causal effect of mental health on labor market outcomes: The case of stress-related mental disorders following a human-made disaster
- Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy-An observational Ponte di Legno Toxicity Working Group Study
- Association of gut dysbiosis with first‑episode psychosis (Review)
- Neuropsychiatric manifestations due to anticholinergic agents and anabolic steroids ingestion: A case series and literature review
- The role of microglia in early neurodevelopment and the effects of maternal immune activation
- Ramelteon protects against social defeat stress-associated abnormal behaviors
- Sex-Specific Effects of Chronic Stress Prior to Cocaine Exposure on Cue- vs Drug-Induced Relapse after Prolonged Abstiinence
- Memory under stress: from adaptation to disorder
- Do steroid abusers have more temporomandibular joint symptoms? A study with 97 bodybuilders
- Cultural psychological factors in posttraumatic symptom development and expression: a study protocol
- Early-life bisphenol A exposure causes neuronal pyroptosis in juvenile and adult male rats through the NF-κB/IL-1β/NLRP3/caspase-1 signaling pathway: exploration of age and dose as effective covariates using an in vivo and in silico modeling approach
- Multiple Sex- and Circuit-Specific Mechanisms Underlie Exercise-Induced Stress Resistance
- "It made me feel more alive": A qualitative analysis of quality of life improvements following completion of trauma-focused therapy for posttraumatic stress disorder
- ISRIB ameliorates spatial learning and memory impairment induced by adolescent intermittent ethanol exposure in adult male rats
- Psilocybin Facilitates Fear Extinction: Importance of Dose, Context, and Serotonin Receptors
- ISRIB ameliorates spatial learning and memory impairment induced by adolescent intermittent ethanol exposure in adult male rats
- Hippocampal astrocytes induce sex-dimorphic effects on memory
- Hippocampal astrocytes induce sex-dimorphic effects on memory
- Cannabidiol promotes intestinal cholesterol uptake mediated by Pregnane X receptor
- Activation of Neuropeptide Y (NPY) receptors in the basolateral amygdala (BLA) inhibits projections to the bed nucleus of the stria terminalis (BNST) and buffers stress-induced decreases in social interaction in male rats
- Bisphenol A (BPA) and neurological disorders: An Overview
- Bisphenol A (BPA) and neurological disorders: An Overview
- Bisphenol A (BPA) and neurological disorders: An Overview
- Stress-Related Roles of Exosomes and Exosomal miRNAs in Common Neuropsychiatric Disorders
- Unlocking new avenues for neuropsychiatric disease therapy: the emerging potential of Peroxisome proliferator-activated receptors as promising therapeutic targets
- Unlocking new avenues for neuropsychiatric disease therapy: the emerging potential of Peroxisome proliferator-activated receptors as promising therapeutic targets
- Childhood adiposity underlies numerous adult brain traits commonly attributed to midlife obesity
- Transgenerational epigenetic self-memory of Dio3 dosage is associated with Meg3 methylation and altered growth trajectories and neonatal hormones
- Chronic social defeat stress increases brain permeability to ghrelin in male mice
- Regulation of stress-induced sleep perturbations by dorsal raphe VGLUT3 neurons in male mice
- Dopamine receptors and key elements of the neurotrophins (BDNF, CDNF) expression patterns during critical periods of ontogenesis in the brain structures of mice with autism-like behavior (BTBR) or its absence (57BL/6 J)
- Exogenous glucocorticoids to improve extinction learning for post-traumatic stress disorder patients with hypothalamic-pituitary-adrenal-axis dysregulation: a study protocol description
- Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3/IKK/NF-κB signaling via gut microbial tryptophan metabolites
- Diagnostic Challenges in Neuro-Psychiatric Systemic Lupus Erythematosus: A Case of a Patient With Psychosis Secondary to Lupus Cerebritis in the Setting of a Steroid Taper
- Involvement of serotonergic receptors in depressive processes and their modulation by β-arrestins: A review
- Comparing the effect of prolonged exposure therapy (PET) and metacognitive therapy (MCT) on the quality of life among veterans with PTSD
Evidence Blueprint
Developmental and adult stress: effects of steroids and neurosteroids
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Developmental and adult stress: effects of steroids and neurosteroids
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Developmental and adult stress: effects of steroids and neurosteroids
- Zuranolone - synthetic neurosteroid in treatment of mental disorders: narrative review
- Synthetic neuroactive steroids
- Expanding the therapeutic potential of neuro(active)steroids: a promising strategy for hyperdopaminergic behavioral phenotypes
- Early-life risperidone alters locomotor responses to apomorphine and quinpirole in adulthood
- Lumbar transforaminal epidural steroid injections with particulate vs. nonparticulate steroid: an evidence-informed review on shifting gear to a personalized medicine paradigm
- Genotypic variation in the promoter region of the CRH-248 gene interacts with early rearing experiences to disrupt the development of the HPA axis in infant rhesus macaques (Macaca mulatta)
- Hair steroid before and after COVID-19 in preschoolers: the moderation of family characteristics
- A late-life neurogenetic signature of exposure to combat stress - A monozygotic discordant twin study
- Juvenile variable stress modulates, in female but not in male Wistar rats, ethanol intake in adulthood
- Adulthood effects of developmental exercise in rats
- Early-Life Exposure to Paraquat Aggravates Sex-Specific and Progressive Abnormal Non-Motor Neurobehavior in Aged Mice
- Sex differences in body temperature and neural power spectra in response to repeated restraint stress
- Using Organoids to Model Sex Differences in the Human Brain
- Neurotrophins and Their Receptors: BDNF's Role in GABAergic Neurodevelopment and Disease
- Maternal Substance Use and Early-Life Adversity: Inducing Drug Dependence in Offspring, Interactions, Mechanisms, and Treatments
- A user-friendly machine learning approach for cardiac structures assessment
- Paeoniflorin exerts anti-PTSD effects in adult rats by modulating hippocampus and amygdala histone acetylation modifications in response to early life stress
- An Unusual Case Presentation of Non-Pathergy Induced Severe Pyoderma Gangrenosum Localized to the Perianal and Intragluteal Regions
- Early exposure to maternal stress and risk for atopic dermatitis in children: A systematic review and meta-analysis
- Transcriptional signatures of early-life stress and antidepressant treatment efficacy
- Comparative Study of Virus and Lymphocyte Distribution with clinical Data suggests early high dose Immunosuppression as potential Key Factor for the Therapy of Patients with BoDV-1 Infection
- Imbalanced glucocorticoid and mineralocorticoid stress hormone receptor function has sex-dependent and independent regulatory effects in the mouse hippocampus
- Witnessed trauma exposure induces fear in mice through a reduction in endogenous neurosteroid synthesis
- Witnessed trauma exposure induces fear in mice through a reduction in endogenous neurosteroid synthesis
- Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior
- A strike to the head: Parallels between the pediatric and adult human and the rodent in traumatic brain injury
- A bupropion modulatory site in Gloeobacter violaceus ligand-gated ion channel
- Stress and suicidal ideation among Chinese college students: The role of meaning in life
- Neuroendocrine and cellular mechanisms in stress resilience: From hormonal influence in the CNS to mitochondrial dysfunction and oxidative stress
- Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women
- Reduced hippocampal volume unmasks distinct impacts of cumulative adverse childhood events (ACEs) on psychotic-like experiences in late childhood and early adolescence
- Neurosteroids and their Therapeutic Potential: Remembering the Contribution of Dr. Sabina Luchetti, Netherlands Institute for Neuroscience, Amsterdam, Netherlands
- Male-Biased Vulnerability of Mouse Brain Tryptophan/Kynurenine and Glutamate Systems to Adolescent Exposures to Concentrated Ambient Ultrafine Particle Air Pollution
- Functions and pharmacology of α2β2 nicotinic acetylcholine receptors; in and out of the shadow of α4β2 nicotinic acetylcholine receptors
- Early adversity changes the economic conditions of mouse structural brain network organization
- Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus
- Neuroprotectant Activity of Novel Water-Soluble Synthetic Neurosteroids on Organophosphate Intoxication and Status Epilepticus-induced Long-term Neurological Dysfunction, Neurodegeneration and Neuroinflammation
- Female adolescents' early life stress and body mass index: Differential effects of anger and anxiety in response to rejection
- Acute and long-term effects of adolescence stress exposure on rodent adult hippocampal neurogenesis, cognition, and behaviour
- Role of α1-GABAA receptors in the serotonergic dorsal raphe nucleus in models of opioid reward, anxiety, and depression
- Inhibition of prefrontal cortex parvalbumin interneurons mitigates behavioral and physiological sequelae of chronic stress in male mice
- The Multifaceted Role of Oxytocinergic System and OXTR Gene
- GABAergic mechanisms in alcohol dependence
- Stress inoculation during adolescence attenuates social stress-induced increase in ethanol intake in adult male mice
- Cannabidiol effects on fear processing and implications for PTSD: Evidence from rodent and human studies
- Acute, but not repeated, cocaine exposure alters allopregnanolone levels in the midbrain of male and female rats
- Maternal prenatal distress exposure negatively associates with the stability of neonatal frontoparietal network
- Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility
- Integrating the Patient's Voice into the Research Agenda for Treatment of Chemosensory Disorders
- Chronic stress induces wide-spread hyperalgesia: the involvement of spinal CCK1 receptors
- Role of Brain Liver X Receptor in Parkinson's Disease: Hidden Treasure and Emerging Opportunities
- Central role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to anxiety in mice
- Comparison of the Protective Effects of Casein Hydrolysate Containing Tyr-Pro-Val-Glu-Pro-Phe and Casein on the Behaviors and Peripheral and Brain Functions in Mice with Chronic-Stress-Induced Anxiety and Insomnia
- Comparison of the Protective Effects of Casein Hydrolysate Containing Tyr-Pro-Val-Glu-Pro-Phe and Casein on the Behaviors and Peripheral and Brain Functions in Mice with Chronic-Stress-Induced Anxiety and Insomnia
- Circulating myeloid-derived MMP8 in stress susceptibility and depression
- Gender differences in the associations of psychosocial trauma and acute medical stressors with immune system activation and dementia risk
- Epigenetic mechanisms linking early-life adversities and mental health
- Evaluating the neuroprotective effects of progesterone receptors on experimental traumatic brain injury: The PI3K/Akt pathway
- Circadian rhythms tied to changes in brain morphology in a densely-sampled male
- Sex-dependent susceptibility to brain metabolic dysfunction and memory impairment in response to pre- and postnatal high-fat diet
- Neurobiological basis of stress resilience
- Early-life exposure to PM2.5 leads to ASD-like phenotype in male offspring rats through activation of PI3K-AKT signaling pathway
- Neonatal stress disrupts the glymphatic system development and increases the susceptibility to Parkinson's disease in later life